Objective:To observe the clinical effect of the treatment combined with hyperbaric oxygen (HBO) on patients with herpes zoster.Methods:A total of 72 patients with herpes zoster treated in the Department of Dermatology of Zhengzhou Second Hospital from January 2018 to December 2019 were selected and divided into HBO group and control group by random number table method, with 36 patients in each group. The control group received acyclovir and other conventional treatments, while the HBO group received HBO on the basis of the treatments of the control group. The improvement of the skin lesions, scores of numeric rating scales (NRS) on pain, and efficacy of the two groups were observed and evaluated after treatment. After a 3-month follow-up, the occurrence of postherpetic neuralgia (PHN) was statistically analyzed.Results:The time of blistering relieving, incrustation, and complete incrustation of the HBO group were all lower than those of the control group with statistically significant difference ( P<0.05). The NRS scores of both groups were all lower than those before treatment with significantly statistical difference ( P<0.01); and the NRS scores of the HBO group were significantly lower than those of the control group after treatment ( P<0.05). The total effective rate of the HBO group (91.67%) was significantly higher than that of the control group (83.33%). The difference was statistically significant ( χ2=4.31, P=0.04). After treatment, 3 cases of PHN occurred in the HBO group, while 7 cases in the control group; the PHN incidence of the HBO group was lower than that of the control group with significantly statistical difference ( P<0.05). Conclusion:In treating herpes zoster, the treatment combined with HBO can achieve a satisfactory therapeutic effect, which is worthy of popularization and application in clinic.

Objective:To observe and evaluate the clinical effect of hyperbaric oxygen combined therapy on patients with non-arteritic anterior ischemic optic neuropathy (NAION).Methods:A total of 110 patients with NAION admitted to the Department of Ophthalmology of Zhengzhou Second Hospital from January 2017 to January 2019 who met the inclusion criteria were selected and divided into control group (55 cases) and hyperbaric oxygen group (55 cases) by random number table method. The control group was given conventional therapies such as hormone shock, microcirculation improvement, and nerve nutrition, while the hyperbaric oxygen group was given conventional treatment and hyperbaric oxygen therapy, with chamber pressure of 2.0 ATA, once a day, 10 times for a course of treatment for 30 days. The visual acuity, mean sensitivity (MS), mean defect (MD), pattern visual evoked potential (PVEP) amplitude, and latency period of the two groups were observed and analyzed to evaluate the efficacy of treatment. The effect of hyperbaric oxygen combined therapy on serum human chondroglycoprotein-39 (chtinase-3-like-1 protein, YKL-40) in patients with NAION was also observed.Results:Before treatment, there were no statistically significant differences in visual acuity, mean sensitivity, mean defect, PVEP amplitude, latency period, and serum YKL-40 between the two groups ( P>0.05). The visual MD in the hyperbaric oxygen group after treatment was lower than that in the control group after treatment and also lower than that before treatment in the same group, and the differences were statistically significant ( P<0.05). The visual acuity and MS in the hyperbaric oxygen group after treatment were higher than those in the control group and also those before treatment in the same group, and the differences were statistically significant ( P<0.05). The PVEP amplitudes of the patients in the hyperbaric oxygen group were higher than those in the control group and also those before treatment in the same group, and the latency period was earlier than that in the control group and also that before treatment in the same group, with statistically significant differences ( P<0.05). The level of serum YKL-40 reached the peak after 7 days of treatment. After 3, 7, 15 and 30 days of treatment, the levels of serum YKL-40 were all lower than those of the control group on the same day, with statistically significant differences ( P<0.05). After treatment, the total effective rate of the hyperbaric oxygen group (83.63%) was higher than that of the control group (74.55%), but there was no statistically significant difference ( P>0.05). Conclusion:Hyperbaric oxygen combined therapy can significantly improve the vision acuity, MS, MD, PVEP amplitude, and latency period of the patients with NAION, and reduce inflammatory response, which is beneficial to improve clinical efficacy.

Objective:To observe the clinical effect of the treatment combined with hyperbaric oxygen (HBO) on patients with herpes zoster.Methods:A total of 72 patients with herpes zoster treated in the Department of Dermatology of Zhengzhou Second Hospital from January 2018 to December 2019 were selected and divided into HBO group and control group by random number table method, with 36 patients in each group. The control group received acyclovir and other conventional treatments, while the HBO group received HBO on the basis of the treatments of the control group. The improvement of the skin lesions, scores of numeric rating scales (NRS) on pain, and efficacy of the two groups were observed and evaluated after treatment. After a 3-month follow-up, the occurrence of postherpetic neuralgia (PHN) was statistically analyzed.Results:The time of blistering relieving, incrustation, and complete incrustation of the HBO group were all lower than those of the control group with statistically significant difference ( P<0.05). The NRS scores of both groups were all lower than those before treatment with significantly statistical difference ( P<0.01); and the NRS scores of the HBO group were significantly lower than those of the control group after treatment ( P<0.05). The total effective rate of the HBO group (91.67%) was significantly higher than that of the control group (83.33%). The difference was statistically significant ( χ2=4.31, P=0.04). After treatment, 3 cases of PHN occurred in the HBO group, while 7 cases in the control group; the PHN incidence of the HBO group was lower than that of the control group with significantly statistical difference ( P<0.05). Conclusion:In treating herpes zoster, the treatment combined with HBO can achieve a satisfactory therapeutic effect, which is worthy of popularization and application in clinic.

Objective:To observe and evaluate the clinical effect of hyperbaric oxygen combined therapy on patients with non-arteritic anterior ischemic optic neuropathy (NAION).Methods:A total of 110 patients with NAION admitted to the Department of Ophthalmology of Zhengzhou Second Hospital from January 2017 to January 2019 who met the inclusion criteria were selected and divided into control group (55 cases) and hyperbaric oxygen group (55 cases) by random number table method. The control group was given conventional therapies such as hormone shock, microcirculation improvement, and nerve nutrition, while the hyperbaric oxygen group was given conventional treatment and hyperbaric oxygen therapy, with chamber pressure of 2.0 ATA, once a day, 10 times for a course of treatment for 30 days. The visual acuity, mean sensitivity (MS), mean defect (MD), pattern visual evoked potential (PVEP) amplitude, and latency period of the two groups were observed and analyzed to evaluate the efficacy of treatment. The effect of hyperbaric oxygen combined therapy on serum human chondroglycoprotein-39 (chtinase-3-like-1 protein, YKL-40) in patients with NAION was also observed.Results:Before treatment, there were no statistically significant differences in visual acuity, mean sensitivity, mean defect, PVEP amplitude, latency period, and serum YKL-40 between the two groups ( P>0.05). The visual MD in the hyperbaric oxygen group after treatment was lower than that in the control group after treatment and also lower than that before treatment in the same group, and the differences were statistically significant ( P<0.05). The visual acuity and MS in the hyperbaric oxygen group after treatment were higher than those in the control group and also those before treatment in the same group, and the differences were statistically significant ( P<0.05). The PVEP amplitudes of the patients in the hyperbaric oxygen group were higher than those in the control group and also those before treatment in the same group, and the latency period was earlier than that in the control group and also that before treatment in the same group, with statistically significant differences ( P<0.05). The level of serum YKL-40 reached the peak after 7 days of treatment. After 3, 7, 15 and 30 days of treatment, the levels of serum YKL-40 were all lower than those of the control group on the same day, with statistically significant differences ( P<0.05). After treatment, the total effective rate of the hyperbaric oxygen group (83.63%) was higher than that of the control group (74.55%), but there was no statistically significant difference ( P>0.05). Conclusion:Hyperbaric oxygen combined therapy can significantly improve the vision acuity, MS, MD, PVEP amplitude, and latency period of the patients with NAION, and reduce inflammatory response, which is beneficial to improve clinical efficacy.

Objective: To observe and explore the therapeutic efficacy of hyperbaric oxygen (HBO) in the treatment of non-arteritic anterior ischemic optic neuropathy (NAION). Methods: A total of 139 NAION patients were randomly divided into a control group of 72 and a hyperbaric oxygen group of 67. Both groups were given conventional drugs including prednisolone, mecobalamin and compound anisodine, while the hyperbaric oxygen group was additionally provided with hyperbaric oxygen treatment at a pressure of 0.2MPa once a day for 30 days. Each day′s treatment lasted for 110 minutes, including 20 minutes at increasing pressure, 20 minutes decreasing and 60 minutes with the pressure stable at 0.2MPa. Before and after the 30-day treatment, the visual acuity and visual mean sensitivity (MS) of the two groups were observed and compared. Results: There was no significant difference between the control group and the hyperbaric oxygen group in terms of average visual acuity or visual MS before the treatment. Afterward the average visual acuity (4.88±0.25) and visual MS (16.68±1.19) of the hyperbaric oxygen group were significantly higher than before the treatment and significantly better than those of the control group. The total effective rate of the hyperbaric oxygen group was 91%, significantly higher than that of the control group (75%). Conclusions Conventional treatment combined with hyperbaric oxygen therapy can significantly promote the visual acuity and visual MS of NAION patients.

Objective To analyze the present status of hyperbaric oxygen ( HBO) medicine in Henan Province and explore its development strategy. Methods Questionnaire survey, on-site investigation and mathematical statistics were used to investigate and analyze the number and distribution of HBO medical institutions, the types and numbers of HBO chambers, the number and titles of qualified professionals engaged in HBO and academic researches in Henan Province. Ultimately, countermeasures and development strategy were recommended in the study. Results There are totally 153 medical institutions engaged in HBO treatment, but its regional distribution is not ideal. There are 181 HBO chambers in Henan Province, with the chamber types being relatively complete, and the growth rate of multi-people chambers is quite obvious. From 2013 to 2018, the number of professionals engaged in HBO medicine increased year by year. Professional titles, age of professionals and academic structure tend to be more reasonable. Doctors are insufficient in some of the chamber-operating posts. In recent years, academic exchanges of HBO medicine have expanded to a certain extent, however, greater efforts should be made in clinical research. Conclusion Further efforts should be made in the following fields: regional distribution of HBO chambers, further improvement of professional structure of the chamber-operating personnel, clinical research should be strengthened and academic level in the field of HBO medicine should be further enhanced.

Objective To analyze the present status of hyperbaric oxygen ( HBO) medicine in Henan Province and explore its development strategy. Methods Questionnaire survey, on-site investigation and mathematical statistics were used to investigate and analyze the number and distribution of HBO medical institutions, the types and numbers of HBO chambers, the number and titles of qualified professionals engaged in HBO and academic researches in Henan Province. Ultimately, countermeasures and development strategy were recommended in the study. Results There are totally 153 medical institutions engaged in HBO treatment, but its regional distribution is not ideal. There are 181 HBO chambers in Henan Province, with the chamber types being relatively complete, and the growth rate of multi-people chambers is quite obvious. From 2013 to 2018, the number of professionals engaged in HBO medicine increased year by year. Professional titles, age of professionals and academic structure tend to be more reasonable. Doctors are insufficient in some of the chamber-operating posts. In recent years, academic exchanges of HBO medicine have expanded to a certain extent, however, greater efforts should be made in clinical research. Conclusion Further efforts should be made in the following fields: regional distribution of HBO chambers, further improvement of professional structure of the chamber-operating personnel, clinical research should be strengthened and academic level in the field of HBO medicine should be further enhanced.

Objective To observe the expression of triggering receptor expressed on myeloid cells (TREM),Caspase-3 and interleukin (IL)-6 in optic nerve tissue of ischemic optic neuropathy (ION).Methods Twenty Sprague-Dawley rats were randomly divided into control group and model group,10 rats in each group.The permanent ligation of bilateral internal carotid arteries (BICA) was performed for 14 days to establish subacute ION model as model group.The control group were separated BICA without ligation.The expressions of TREM-1,TREM-2,Caspase-3 and IL-6 in rat retina were detected by reverse transcription PCR and Western blot,respectively.Results Compared with the control group,the expressions of TREM-1,Caspase-3,IL-6mRNA (t=6.058,7.86,6.055) and protein (t=9.671,9.524,14.501) in the optic nerve tissue of the model group were increased,while the expression ofTREM-2 mRNA and protein (t=9.283) was decreased,and the difference was statistically significant (P＜0.05).Conclusion In ischemic optic nerve tissue,TREM-1 mRNA and protein were significantly expressed,the expressions of TREM-2 mRNA and protein decreased significantly.

Objective To observe the effect of hyperbaric oxygen (HBO) on oxidative stress and apoptosis in the rats with ischemic optic neuropathy.Methods Thirty Sprague-Dawley (SD) rats were randomly divided into 3 groups:the sham surgery group,the model group and the HBO group,each consisting of 10 rats.The sham surgery group just received surgery,but without ischemic optic neuropathy.The rats in the model and HBO groups were treated with ischemic optic neuropathy,but the HBO group received HBO therapy after surgery.The expression levels of Nrf2 mRNA and NF-κB mRNA in the optic nerve were detected by realtime fluorescence quantitative PCR,the expression levels of Nrf2 nucleoprotein and NF-κB protein in the optic nerve were identified by Western-blotting and the levels of blood peroxide (CAT),superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of various groups were detected by ELISA.Results The expression levels of Nrf2 mRNA,Nrf2 nucleoprotein,NF-κB mRNA and NF-κB protein in the optic nerve of the model group were all higher than those of the sham surgery group,and there was statistical significance when comparisons were made between them (P ＜0.05).The activity of CAT,SOD and GSH-Px in the model group was lower than that in the sham surgery group,and statistical significance could also be seen when comparisons were made between them (P ＜ 0.05).The expression levels of Nrf2 mRNA,Nrf2 nucleoprotein,and the activity of CAT,SOD and GSH-Px in the HBO group were all significantly higher than those of the model group,and statistical significance could also be noted when comparisons were made between them (P ＜0.05).The expression levels of NF-κB mRNA and NF-κB in the HBO group were significantly lower than those of the model group,and statistical significance could also be found when comparisons were made between them (P ＜ 0.05).Conclusions HBO therapy could up-regulate the expression level of Nrf2 nucleoprotein,increase the activity of CAT,SOD and GSH-Px,inhibit the expression level of NF-κB and improve the capacity of anti-oxygenation and anti-apoptosis in the rats with ischemic optic neuropathy.

Objective To observe the effect of hyperbaric oxygen (HBO) on oxidative stress and apoptosis in the rats with ischemic optic neuropathy.Methods Thirty Sprague-Dawley (SD) rats were randomly divided into 3 groups:the sham surgery group,the model group and the HBO group,each consisting of 10 rats.The sham surgery group just received surgery,but without ischemic optic neuropathy.The rats in the model and HBO groups were treated with ischemic optic neuropathy,but the HBO group received HBO therapy after surgery.The expression levels of Nrf2 mRNA and NF-κB mRNA in the optic nerve were detected by realtime fluorescence quantitative PCR,the expression levels of Nrf2 nucleoprotein and NF-κB protein in the optic nerve were identified by Western-blotting and the levels of blood peroxide (CAT),superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of various groups were detected by ELISA.Results The expression levels of Nrf2 mRNA,Nrf2 nucleoprotein,NF-κB mRNA and NF-κB protein in the optic nerve of the model group were all higher than those of the sham surgery group,and there was statistical significance when comparisons were made between them (P ＜0.05).The activity of CAT,SOD and GSH-Px in the model group was lower than that in the sham surgery group,and statistical significance could also be seen when comparisons were made between them (P ＜ 0.05).The expression levels of Nrf2 mRNA,Nrf2 nucleoprotein,and the activity of CAT,SOD and GSH-Px in the HBO group were all significantly higher than those of the model group,and statistical significance could also be noted when comparisons were made between them (P ＜0.05).The expression levels of NF-κB mRNA and NF-κB in the HBO group were significantly lower than those of the model group,and statistical significance could also be found when comparisons were made between them (P ＜ 0.05).Conclusions HBO therapy could up-regulate the expression level of Nrf2 nucleoprotein,increase the activity of CAT,SOD and GSH-Px,inhibit the expression level of NF-κB and improve the capacity of anti-oxygenation and anti-apoptosis in the rats with ischemic optic neuropathy.