OBJECTIVE：To investigate the effec ts of angiotensin receptor neprilysin inhibitor （ARNI）sacubitril valsartan sodium（SVS）on the short-term prognosis of patients with acute anterior myocardial infarction （AAMI）complicated with acute cardiac insufficiency. METHODS ：A total of 80 patients with AAMI and Killip grade Ⅱ-Ⅳ of cardiac function ，who met the inclusion criteria ，were randomly divided into ARNI group and control group ，with 40 patients in each group. Both groups were given the same basic standardized drug treatment ，vital signs support treatment and percutaneous coronary intervention treatment at the same time. On this basis ，ARNI group was given SVS tablet orally ，with initial dose of 25 mg each time ，twice a day ； thereafter，gradually adjust the dose to 200 mg each time ，twice a day. Control group was given Enalapril maleate tablets orally ， with an initial dose of 5 mg each time ，twice a day ；thereafter，gradually adjust the dose to 10 mg each time ，twice a day. Both groups took medicine for a long time ，and were followed up after 1，3 and 6 months of medication to the clinic. The levels of N-terminal pro-B-type natriuretic peptide （NT-proBNP）， soluble growth stimulation expressed gene 2 protein （sST2） and echocardiography indexes were compared between 2 groups before and after medication. The 6-minute walking test （6MWT）and the incidence of cardiogenic readmission events were recorded in 2 groups after medication. RESULTS ：Compared with before treatment，the indexes of the two groups were significantly improved at 1，3 and 6 months after treatment （P＜0.05）. Compared with control group ，the levels of NT-proBNP and sST 2 in ARNI group decreased significantly （P＜0.05），the levels of left ventricular ejection fraction and 6MWT increased significantly（P＜0.05），and the left ventricular end systolic diameter and left ventricular end diastolic diameter decreased significantly，after 3 and 6 months of treatm ent（P＜0.05）. However ，there was no significant difference in the velocity ratio of peak E to peak A ，pulmonary artery pressure ，right ventricular end diastolic diameter and the incidence of cardiogenic readmission events between 2 groups（P＞0.05）. CONCLUSIONS ：For patients with AAMI complicated with acute cardiac insufficiency ， compared with enalapril ，SVS can significantly improve the cardiac function （especially the left ventricular systolic function ）， reduce the inflammatory reaction of cardiomyocytes ，protect cardiomyocytes ，so as to improve the short-term prognosis of patients.

OBJECTIVEIn this work, we aim to determine the optimum pH value for the preparation of 3% yttria-stabilized tetragonal zirconia polycrystalline (3Y-TZP)/3%Al₂O₃ and optimum calcination temperature of Al₂O₃ precursor and amorphous boron nitride (BN) for Al₂O₃-BN coating 3Y-TZP powders.

METHODSThe 3Y-TZP/3%Al₂O₃ composite powders were prepared through the heterogeneous precipitation method under different pH values (6.5, 7.5, 8.5, and 9.5) and analyzed through transmission electron microscopy (TEM) to determine the optimum coating morphology. Al₂O₃ precursor, which was prepared under the optimum pH value, was calcined at different temperatures (800, 1 000, 1 200, and 1 400 ℃). The amorphous BN coating 3Y-TZP/3%Al₂O₃ powder was prepared via in situ reaction with boric acid and urea (calcined with N₂ at 850 ℃ for 5 and 3 h and 800 ℃ for 5 and 3 h). TEM, energy dispersive spectrometry (EDS), and X-ray diffraction (XRD) were performed to characterize the results.

RESULTSThe optimum coating morphology was obtained at 8.5 pH. When the Al₂O₃ precursor was calcined at 1 200 ℃ and coated with BN (calcined with N₂ at 800 ℃ for 5 h), the Al-B-O compound was less, and t-ZrO₂ was more represented.

CONCLUSIONSThe optimum pH value for 3Y-TZP/3%Al₂O₃ composite preparation is 8.5. For the preparation of Al₂O₃-BN coating 3Y-TZP powders, the optimum calcination temperature of the Al₂O₃ precursor and amorphous BN are 1 200 and 800 ℃, respectively.

Objective TO ibserve the influence if Plan-Di-Check-Actiin (PDCA)educa-tiin in cimpliance if cignitiin and respiratiry functiin in patients with chrinic ibstructive pul-minary disease.Methods A tital if 98 COPD patients were equally divided inti cintril griup and ibservatiin griup.The influence if riutine health educatiin and PDCA educatiin in cignitiin and respiratiry functiin in twi griups were cintrasted by questiinnaire.Results Cimpliance if cignitiin and respiratiry functiin in the ibservatiin griup were superiir ti that in the cintril griup(P <0.05)Conclusion PDCA educatiin ciuld strengthen self-managing if patients and re-duce hispitalizatiin rate.

Objective TO ibserve the influence if Plan-Di-Check-Actiin (PDCA)educa-tiin in cimpliance if cignitiin and respiratiry functiin in patients with chrinic ibstructive pul-minary disease.Methods A tital if 98 COPD patients were equally divided inti cintril griup and ibservatiin griup.The influence if riutine health educatiin and PDCA educatiin in cignitiin and respiratiry functiin in twi griups were cintrasted by questiinnaire.Results Cimpliance if cignitiin and respiratiry functiin in the ibservatiin griup were superiir ti that in the cintril griup(P <0.05)Conclusion PDCA educatiin ciuld strengthen self-managing if patients and re-duce hispitalizatiin rate.