Objective To study the effects of intermittent hypoxia training ( IHT) plus rehabilitation exercise on the cognitive function and motor dysfunction in the patients with cerebral infarction. Methods Fifty-four patients with cerebral infarction were enrolled for the study, and were randomly divided into the IHT +rehabilitation group ( or group A) and the conventional rehabilitation group ( or group B) . The patients in group A had IHT, in addition to the conventional rehabilitation treatment as received by group B. All the patients had 5 treatment sessions a week for a succession of 4 weeks. The cognitive function and motor dysfunction both before and after intervention in the patients of the 2 groups were evaluated with Fugl-Meyer motor assessment ( FMA) and MMSE. Results Following intervention, the FMA cores in the patients of the 2 groups all improved as compared with those before intervention(P<0. 05). The MMSE scores of group A increased from (22. 2 ± 1. 16) before intervention to (26. 4 ± 1. 01) after intervention. Statistical significance could be seen when comparisons were made between the 2 groups(P <0. 05). As for the MMSE scores of group B after intervention, there was no statistical significance, when they were compared with those before intervention( P>0.05). The MMSE scores of group A were better than those of group B after intervention(P <0. 05). Conclusion IHT plus rehabilitation exercise could effectively improve the cognitive function and motor function of the patients with cerebral infarction.

Objective To study the effects of intermittent hypoxia training ( IHT) plus rehabilitation exercise on the cognitive function and motor dysfunction in the patients with cerebral infarction. Methods Fifty-four patients with cerebral infarction were enrolled for the study, and were randomly divided into the IHT +rehabilitation group ( or group A) and the conventional rehabilitation group ( or group B) . The patients in group A had IHT, in addition to the conventional rehabilitation treatment as received by group B. All the patients had 5 treatment sessions a week for a succession of 4 weeks. The cognitive function and motor dysfunction both before and after intervention in the patients of the 2 groups were evaluated with Fugl-Meyer motor assessment ( FMA) and MMSE. Results Following intervention, the FMA cores in the patients of the 2 groups all improved as compared with those before intervention(P<0. 05). The MMSE scores of group A increased from (22. 2 ± 1. 16) before intervention to (26. 4 ± 1. 01) after intervention. Statistical significance could be seen when comparisons were made between the 2 groups(P <0. 05). As for the MMSE scores of group B after intervention, there was no statistical significance, when they were compared with those before intervention( P>0.05). The MMSE scores of group A were better than those of group B after intervention(P <0. 05). Conclusion IHT plus rehabilitation exercise could effectively improve the cognitive function and motor function of the patients with cerebral infarction.

Objective To investigate the role of AMP-activated protein kinase (AMPK) signal path in cell autophagy activation at early brain injury in rats after subarachnoid hemorrhage (SAH).Methods Adult male SD rats (weighting 300-350 g) were divided into five groups (n=12):sham-operated group,SAH group,and SAH+AICAR group,SAH+Compound C group and SAH+vehicle group.SAH models in the later four groups were established by endovascular perforation technique,and rats in the later three groups were performed left intracerebroventricular injection of AMPK agonist AICAR,AMPK inhibitor Compound C or normal saline 30 min before modeling;animals were subsequently sacrificed at 24 h after modeling.Immunohistochemical method was used to detect the phosphorylated mammalian target of rapamycin (p-mTOR) expression.Expressions of cortex autophagy related proteins LC3,AMPK and phosphorylated AMPK (p-AMPK) were observed by Western blotting.Loeffler's method was used to evaluate the neurologic behavior scores.Results As compared with those in the sham-operated group,the p-AMPK level,p-mTOR expression level and LC3Ⅱ/LC3Ⅰ ratio were significantly increased,while the behavioral deficit scores were significantly lower in the SAH group,with statistical differences (P＜0.05);the p-mTOR mainly expressed at cortex surrounding the hemorrhage areas,and integration areas of deep cortex and brain white matter.As compared with the sham-operated group and SAH+vehicle group,SAH+AICAR group had significantly increased p-AMPK level,decreased p-mTOR expression level,increased LC3Ⅱ/LC3Ⅰ ratio,and decreased behavioral deficit scores (P＜0.05);as compared with the sham-operated group and SAH+vehicle group,SAH+Compound C group had significantly decreased p-AMPK level,decreased LC3Ⅱ/LC3Ⅰ ratio,and decreased behavioral deficit scores (P＜0.05).Conclusion AMPK is involved in the process ofautophagy activation after SAH through regulating mTOR,and the regulation of AMPK may contribute to neuroprotection related to autophagy.