Paraplegia caused by spinal cord injury is a serious neurological complication, for which surgery is currently the main treatment method. Due to different surgical approaches, patients are usually expected to maintain a passive prone position for a long time or switch between the supine and prone positions. Affected by multiple factors such as neurogenic sensory disorders, pathological changes in muscle tone and operative duration, the risk of intraoperative acquired pressure injury (IAPI) is significantly increased. Current clinical prevention strategies for IAPI in these patients predominantly focus on localized pressure relief during positioning, lacking systematic, standardized comprehensive prevention protocols or evidence-based guidelines. To address it, Department of Nursing, Orthopedics Branch, China International Exchange and Promotive Association for Medical and Health Care, Spinal Trauma Professional Committee, Orthopedics Branch, Chinese Medical Doctor Association, Nursing Group of Spine and Spinal Cord Professional Committee of Chinese Association of Rehabilitation Medicine organized experts in relevant fields to formulate Guideline for the prevention of intraoperative acquired pressure injury in paraplegic patients with spinal cord injury ( version 2025), based on evidence-based medical evidence and latest research results and clinical practice at home and abroad. Eleven recommendations were put forward from the aspects of preoperative risk assessment, intraoperative prevention strategies, postoperative handover and monitoring, and supportive mechanisms for IAPI prevention, aiming to standardize the prevention measures and management strategies of IAPI in paraplegic patients with spinal cord injury and accelerate the recovery of patients and improve the therapeutic effect.

Paraplegia caused by spinal cord injury is a serious neurological complication, for which surgery is currently the main treatment method. Due to different surgical approaches, patients are usually expected to maintain a passive prone position for a long time or switch between the supine and prone positions. Affected by multiple factors such as neurogenic sensory disorders, pathological changes in muscle tone and operative duration, the risk of intraoperative acquired pressure injury (IAPI) is significantly increased. Current clinical prevention strategies for IAPI in these patients predominantly focus on localized pressure relief during positioning, lacking systematic, standardized comprehensive prevention protocols or evidence-based guidelines. To address it, Department of Nursing, Orthopedics Branch, China International Exchange and Promotive Association for Medical and Health Care, Spinal Trauma Professional Committee, Orthopedics Branch, Chinese Medical Doctor Association, Nursing Group of Spine and Spinal Cord Professional Committee of Chinese Association of Rehabilitation Medicine organized experts in relevant fields to formulate Guideline for the prevention of intraoperative acquired pressure injury in paraplegic patients with spinal cord injury ( version 2025), based on evidence-based medical evidence and latest research results and clinical practice at home and abroad. Eleven recommendations were put forward from the aspects of preoperative risk assessment, intraoperative prevention strategies, postoperative handover and monitoring, and supportive mechanisms for IAPI prevention, aiming to standardize the prevention measures and management strategies of IAPI in paraplegic patients with spinal cord injury and accelerate the recovery of patients and improve the therapeutic effect.

Hip fracture in the elderly is characterized by high incidence, high disability rate, and high mortality and has been recognized as a public health issue threatening their health. Surgery is the preferred choice for the treatment of elderly patients with hip fracture. However, lower extremity deep venous thrombosis (DVT) has an extremely high incidence rate during the perioperative period, and may significantly increase the risk of patients′ death once it progresses to pulmonary embolism. In response to this issue, the clinical guidelines and expert consensuses all emphasize active application of comprehensive preventive measures, including basic prevention, physical prevention, and pharmacological prevention. In this prevention system, basic prevention is the basis of physical and pharmacological prevention. However,there is a lack of unified and definite recommendations for basic preventive measures in clinical practice. To this end, the Orthopedic Nursing Professional Committee of the Chinese Nursing Association and Nursing Department of the Orthopedic Branch of the China International Exchange and Promotive Association for Medical and Health Care organized relevant nursing experts to formulate Expert consensus on perioperative basic prevention for lower extremity deep venous thrombosis in elderly patients with hip fracture ( version 2024) . A total of 10 recommendations were proposed, aiming to standardize the basic preventive measures for lower extremity DVT in elderly patients with hip fractures during the perioperative period and promote their subsequent rehabilitation.

Objective:To investigate the feasibility and clinical diagnostic value of rapid arterial spin labeling (ASL) imaging in brain glioma.Methods:Patients with glioma admitted to Beijing Tiantan Hospital, Capital Medical University from May 2021 to December 2022 were prospectively enrolled. All patients received MR rapid ASL (scan time: 1 min) and conventional ASL (scan time: 4 min 30 s), where the cerebral blood flow (CBF) perfusion maps were obtained. The qualitative analysis of CBF signal intensity and quantitative analysis of average CBF values from both tumor solid and edema regions were conducted by two radiologists independently. Kappa test and intraclass correlation coefficient ( ICC) were used to analyze the consistency of qualitative and quantitative results, respectively. Results:A total of 30 patients with brain glioma were included. The 2 physicians used rapid ASL to determine low perfusion, isoperfusion, and hyperperfusion in the tumor area in 1, 6, 23 cases and 0, 5, and 25 cases, respectively; and used conventional ASL to determine low perfusion, isoperfusion, and hyperperfusion in the tumor area in 0, 9, and 21 cases, respectively. The results of qualitative analysis of rapid ASL and conventional ASL were highly consistent within and between groups ( Kappa was 0.830 and 0.850 respectively). The results of quantitative analysis of rapid ASL and conventional ASL were highly consistent within and between groups ( ICC 0.940—0.994). Conclusion:Rapid ASL with shorter scanning time could be applied in assessing tissue perfusion in brain glioma and contribute to the clinical diagnosis of gliomas.

Heat shock proteins (HSPs) are a group of highly conserved and functionally diverse molecular chaperones that play a crucial role in maintaining cellular homeostasis and coping with a variety of stress responses. HSP70 is one of the important members of the HSPs family, which is involved in the correct folding of proteins, preventing aggregation, and plays a key role in the formation of germ cells, DNA damage repair, fertilization process and embryo implantation in early embryonic development. HSP70 maintains the healthy development of embryos and protects cells from injury under various stress conditions by promoting the normal development and cellular homeostasis of fertilized eggs after fertilization. Through in-depth study of the complex functions and potential mechanisms of HSP70, it is expected to reveal its role in unexplained infertility, recurrent implantation failure, recurrent abortion and other diseases.

Heat shock proteins (HSPs) are a group of highly conserved and functionally diverse molecular chaperones that play a crucial role in maintaining cellular homeostasis and coping with a variety of stress responses. HSP70 is one of the important members of the HSPs family, which is involved in the correct folding of proteins, preventing aggregation, and plays a key role in the formation of germ cells, DNA damage repair, fertilization process and embryo implantation in early embryonic development. HSP70 maintains the healthy development of embryos and protects cells from injury under various stress conditions by promoting the normal development and cellular homeostasis of fertilized eggs after fertilization. Through in-depth study of the complex functions and potential mechanisms of HSP70, it is expected to reveal its role in unexplained infertility, recurrent implantation failure, recurrent abortion and other diseases.

Hip fracture is considered as the most severe osteoporotic fracture characterized by high disability and mortality in the elderly. Improved surgical techniques and multidisciplinary team play an active role in alleviating prognosis, which places higher demands on perioperative nursing. Dysfunction, complications, and secondary impact of anaesthesia and surgery add more difficulties to clinical nursing. Besides, there still lack clinical practices in perioperative nursing for elderly patients with hip fracture in China. In this context, led by the Orthopedic Nursing Committee of Chinese Nursing Association, the Expert consensus on clinical practice in perioperative nursing for elderly patients with hip fracture ( version 2023) is developed based on the evidence-based medicine. This consensus provides 11 recommendations on elderly patients with hip fracture from aspects of perioperative health education, condition monitoring and inspection, complication risk assessment and prevention, and rehabilitation, in order to provide guiding advices for clinical practice, improve the quality of nursing and ameliorate the prognosis of elderly patients with hip fracture.

Hip fractures are among the most common fractures in the elderly, presenting to be a leading cause of disability and mortality. Surgical treatment is currently the main treatment method for hip fractures. The incidence of perioperative malnutrition is increased after hip fractures in the elderly due to the comorbidities, decreased basal metabolic rate, accelerated protein breakdown, weakened anabolism and surgical stress. However, malnutrition not only increases the incidence of postoperative complications, but also leads to increased mortality, indicating an important role of perioperative nursing management of nutrition for the elderly patients with hip fractures. At present, there still lacks scientific guidance and application standards on perioperative nursing management of nutrition for the elderly patients with hip fractures. Therefore, the Orthopedic Nursing Committee of Chinese Nursing Association and the Editorial Board of Chinese Journal of Trauma organized relevant experts to formulate the Expert consensus on perioperative nursing management of nutrition for elderly patients with hip fractures ( version 2023) according to evidence-based medical evidences and their clinical experiences. Fourteen recommendations were made from aspects of nutrition screening, nutrition assessment, nutrition diagnosis, nutrition intervention and nutrition monitoring to provide guidance for perioperative nursing management of nutrition in elderly patients with hip fractures.

Objective:To systematically evaluate the effect of previous cesarean section (CS) on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods:PubMed, Web of Science, Cochrane Library, Embase, Ovid, Wanfang database, CNKI, VIP database and CBM were searched from inception to August 2022 to collect studies about the effect of CS on pregnancy outcome of IVF-ET. Meta-analysis was performed by Stata16.0 software after information extraction.Results:A total of 20 studies involving 24 753 patients were included. Meta-analysis displayed that the implantation rate, the clinical pregnancy rate and the live birth rate of CS group were significantly lower than those of vaginal delivery (VD) group ( OR=0.79, 95% CI: 0.66-0.95, P=0.013; OR=0.72, 95% CI: 0.63-0.83, P<0.001; OR=0.73, 95% CI: 0.64-0.83, P<0.001), accompanied by increased early abortion rate ( OR=1.18, 95% CI: 1.07-1.30). The results of subgroup analysis showed that compared with VD group, the implantation rate, the clinical pregnancy rate and the premature birth rate of patients with previous cesarean scar defect (PCSD) were significantly reduced ( OR=0.47, 95% CI: 0.31-0.73, P=0.001; OR=0.47, 95% CI: 0.30-0.72, P=0.001; OR=0.41, 95% CI: 0.26-0.65, P<0.001), while the early abortion rate was significantly increased ( OR=2.38, 95% CI: 1.12-5.09, P=0.023). Conclusion:CS significantly reduced the implantation rate, the clinical pregnancy rate and the live birth rate of IVF-ET, and increased the early abortion rate, which might be associated with PCSD. However, due to the quantity and quality of the included studies, the above conclusion needs to be verified by more large-sample and high-quality studies.

Objective:To systematically evaluate the effect of previous cesarean section (CS) on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods:PubMed, Web of Science, Cochrane Library, Embase, Ovid, Wanfang database, CNKI, VIP database and CBM were searched from inception to August 2022 to collect studies about the effect of CS on pregnancy outcome of IVF-ET. Meta-analysis was performed by Stata16.0 software after information extraction.Results:A total of 20 studies involving 24 753 patients were included. Meta-analysis displayed that the implantation rate, the clinical pregnancy rate and the live birth rate of CS group were significantly lower than those of vaginal delivery (VD) group ( OR=0.79, 95% CI: 0.66-0.95, P=0.013; OR=0.72, 95% CI: 0.63-0.83, P<0.001; OR=0.73, 95% CI: 0.64-0.83, P<0.001), accompanied by increased early abortion rate ( OR=1.18, 95% CI: 1.07-1.30). The results of subgroup analysis showed that compared with VD group, the implantation rate, the clinical pregnancy rate and the premature birth rate of patients with previous cesarean scar defect (PCSD) were significantly reduced ( OR=0.47, 95% CI: 0.31-0.73, P=0.001; OR=0.47, 95% CI: 0.30-0.72, P=0.001; OR=0.41, 95% CI: 0.26-0.65, P<0.001), while the early abortion rate was significantly increased ( OR=2.38, 95% CI: 1.12-5.09, P=0.023). Conclusion:CS significantly reduced the implantation rate, the clinical pregnancy rate and the live birth rate of IVF-ET, and increased the early abortion rate, which might be associated with PCSD. However, due to the quantity and quality of the included studies, the above conclusion needs to be verified by more large-sample and high-quality studies.