Objective To analyze the correlation of pan-immune inflammation value(PⅡV)and C-reactive protein variation rate(ΔCRP)with myocardial fibrosis in elderly patients with acute myocardial infarction(AMI).Methods A total of 123 elderly AMI patients admitted to our department from January 2022 to July 2024 were enrolled,and then followed up for 6 months postoperatively.According to occurrence of ventricular remodeling or not,they were divided into a remodeling group(26 cases)and a non-remodeling group(97 cases),and based on presence of myocardial fibrosis,they were also assigned into a fibrosis group(31 cases)and a non-fibrosis group(92 cases).Cardiac MRI was performed after admission to diagnose myocardial fibrosis.PⅡV,ΔCRP,type Ⅲ procollagen N-terminal peptide(PⅢNP),and type Ⅰ collagen C-terminal peptide(CICP)levels were compared between the fibrosis and non-fibrosis groups.Pearson correlation analysis was used to assess the relationships of PⅡV and ΔCRP with PⅢNP and CICP.Multivariate logistic regression analysis was applied to identify factors influencing postoperative remodeling.ROC curve analysis was conducted to evaluate the clinical efficacy of PⅡV and ΔCRP in predicting postoperative remodeling.Results The fibrosis group exhibited significantly higher PⅡV,ΔCRP,PⅢNP,and CICP levels than the non-fibrosis group(P＜0.05,P＜0.01).Pearson analysis revealed positive correlations between PⅡV and PⅢNP/CICP(r=0.458,r=0.533,P＜0.01)and between ΔCRP and PⅢNP/CICP(r=0.591,r=0.627,P＜0.01).The remodeling group had obviously higher PⅡV(400.81±71.73 vs 335.45±71.19,t=4.151,P＜0.01)and ΔCRP[1.19±0.30 mg/(L·h)vs 0.90±0.15 mg/(L·h),t=6.878,P＜0.01]than the non-remodeling group.Multivariate logistic regression analysis identified age(OR=3.196,95％CI:1.597～6.398,P＜0.01),coronary Gensini score(OR=1.966,95％CI:1.295～2.984,P＜0.01),PⅡV(OR=3.470,95％CI:1.621～7.427,P＜0.01),and ΔCRP(OR=2.889,95％CI:1.431～5.836,P＜0.01)as risk factors for postoperative remodeling,while out-hospital medication adherence was a protective factor(OR=0.489,95％CI:0.319～0.748,P＜0.01).ROC curve analysis showed an AUC value of PⅡV,ΔCRP and their combination in the prediction was 0.735,0.778 and 0.905,respectively,with the combined two indicators having better efficiency(P＜0.01).Conclusion PⅡV and ΔCRP are closely associated with myocardial fibrosis and postoperative ventricular remodeling in elderly AMI patients.Combined detection of these two markers can optimize risk stratification and provide critical insights for clinical intervention.

Objective To analyze the correlation of pan-immune inflammation value(PⅡV)and C-reactive protein variation rate(ΔCRP)with myocardial fibrosis in elderly patients with acute myocardial infarction(AMI).Methods A total of 123 elderly AMI patients admitted to our department from January 2022 to July 2024 were enrolled,and then followed up for 6 months postoperatively.According to occurrence of ventricular remodeling or not,they were divided into a remodeling group(26 cases)and a non-remodeling group(97 cases),and based on presence of myocardial fibrosis,they were also assigned into a fibrosis group(31 cases)and a non-fibrosis group(92 cases).Cardiac MRI was performed after admission to diagnose myocardial fibrosis.PⅡV,ΔCRP,type Ⅲ procollagen N-terminal peptide(PⅢNP),and type Ⅰ collagen C-terminal peptide(CICP)levels were compared between the fibrosis and non-fibrosis groups.Pearson correlation analysis was used to assess the relationships of PⅡV and ΔCRP with PⅢNP and CICP.Multivariate logistic regression analysis was applied to identify factors influencing postoperative remodeling.ROC curve analysis was conducted to evaluate the clinical efficacy of PⅡV and ΔCRP in predicting postoperative remodeling.Results The fibrosis group exhibited significantly higher PⅡV,ΔCRP,PⅢNP,and CICP levels than the non-fibrosis group(P＜0.05,P＜0.01).Pearson analysis revealed positive correlations between PⅡV and PⅢNP/CICP(r=0.458,r=0.533,P＜0.01)and between ΔCRP and PⅢNP/CICP(r=0.591,r=0.627,P＜0.01).The remodeling group had obviously higher PⅡV(400.81±71.73 vs 335.45±71.19,t=4.151,P＜0.01)and ΔCRP[1.19±0.30 mg/(L·h)vs 0.90±0.15 mg/(L·h),t=6.878,P＜0.01]than the non-remodeling group.Multivariate logistic regression analysis identified age(OR=3.196,95％CI:1.597～6.398,P＜0.01),coronary Gensini score(OR=1.966,95％CI:1.295～2.984,P＜0.01),PⅡV(OR=3.470,95％CI:1.621～7.427,P＜0.01),and ΔCRP(OR=2.889,95％CI:1.431～5.836,P＜0.01)as risk factors for postoperative remodeling,while out-hospital medication adherence was a protective factor(OR=0.489,95％CI:0.319～0.748,P＜0.01).ROC curve analysis showed an AUC value of PⅡV,ΔCRP and their combination in the prediction was 0.735,0.778 and 0.905,respectively,with the combined two indicators having better efficiency(P＜0.01).Conclusion PⅡV and ΔCRP are closely associated with myocardial fibrosis and postoperative ventricular remodeling in elderly AMI patients.Combined detection of these two markers can optimize risk stratification and provide critical insights for clinical intervention.

With the increasing proportion of human papilloma virus(HPV)infection in the pathogenic factors of oro-pharyngeal cancer,a series of changes have occurred in the surgical treatment.While the treatment mode has been im-proved,there are still many problems,including the inconsistency between diagnosis and treatment modes,the lack of popularization of reconstruction technology,the imperfect post-treatment rehabilitation system,and the lack of effective preventive measures.Especially in terms of treatment mode for early oropharyngeal cancer,there is no unified conclu-sion whether it is surgery alone or radiotherapy alone,and whether robotic minimally invasive surgery has better func-tional protection than radiotherapy.For advanced oropharyngeal cancer,there is greater controversy over the treatment mode.It is still unclear whether to adopt a non-surgical treatment mode of synchronous chemoradiotherapy or induction chemotherapy combined with synchronous chemoradiotherapy,or a treatment mode of surgery combined with postopera-tive chemoradiotherapy.In order to standardize the surgical treatment of oropharyngeal cancer in China and clarify the indications for surgical treatment of oropharyngeal cancer,this expert consensus,based on the characteristics and treat-ment status of oropharyngeal cancer in China and combined with the international latest theories and practices,forms consensus opinions in multiple aspects of preoperative evaluation,surgical indication determination,primary tumor re-section,neck lymph node dissection,postoperative defect repair,postoperative complication management prognosis and follow-up of oropharyngeal cancer patients.The key points include:① Before the treatment of oropharyngeal cancer,the expression of P16 protein should be detected to clarify HPV status;② Perform enhanced magnetic resonance imaging of the maxillofacial region before surgery to evaluate the invasion of oropharyngeal cancer and guide precise surgical resec-tion of oropharyngeal cancer.Evaluating mouth opening and airway status is crucial for surgical approach decisions and postoperative risk prediction;③ For oropharyngeal cancer patients who have to undergo major surgery and cannot eat for one to two months,it is recommended to undergo percutaneous endoscopic gastrostomy before surgery to effectively improve their nutritional intake during treatment;④ Early-stage oropharyngeal cancer patients may opt for either sur-gery alone or radiation therapy alone.For intermediate and advanced stages,HPV-related oropharyngeal cancer general-ly prioritizes radiation therapy,with concurrent chemotherapy considered based on tumor staging.Surgical treatment is recommended as the first choice for HPV unrelated oropharyngeal squamous cell carcinoma(including primary and re-current)and recurrent HPV related oropharyngeal squamous cell carcinoma after radiotherapy and chemotherapy;⑤ For primary exogenous T1-2 oropharyngeal cancer,direct surgery through the oral approach or da Vinci robotic sur-gery is preferred.For T3-4 patients with advanced oropharyngeal cancer,it is recommended to use temporary mandibu-lectomy approach and lateral pharyngotomy approach for surgery as appropriate;⑥ For cT1-2N0 oropharyngeal cancer patients with tumor invasion depth＞3 mm and cT3-4N0 HPV unrelated oropharyngeal cancer patients,selective neck dissection of levels ⅠB to Ⅳ is recommended.For cN+HPV unrelated oropharyngeal cancer patients,therapeutic neck dissection in regions Ⅰ-Ⅴ is advised;⑦ If PET-CT scan at 12 or more weeks after completion of radiation shows intense FDG uptake in any node,or imaging suggests continuous enlargement of lymph nodes,the patient should undergo neck dissection;⑧ For patients with suspected extracapsular invasion preoperatively,lymph node dissection should include removal of surrounding muscle and adipose connective tissue;⑨ The reconstruction of oropharyngeal cancer defects should follow the principle of reconstruction steps,with priority given to adjacent flaps,followed by distal pedicled flaps,and finally free flaps.The anterolateral thigh flap with abundant tissue can be used as the preferred flap for large-scale postoperative defects.

Objective:To utilize usculoskeletal ultrasound technology for real-time assessment of related muscle characteris-tics in patients with chronic nonspecific low back pain(NLBP)and to analyze the correlation with visual ana-logue scale(VAS)and Oswestry disability index questionnaire(ODI).Method:A total of 180 patients diagnosed with chronic NLBP in the department of rehabilitation of the Sec-ond Hospital in Fuzhou from December 2022 to June 2023 were selected as NLBP group,and 120 healthy subjects who underwent physical examination at the same time period were selected as the control group.VAS and ODI questionnaires were used to assess the two groups of subjects.Based on musculoskeletal ultrasound technology,the muscle thickness and elastic modulus of transverse abdominal muscle and multifidus muscle in resting and contraction positions were detected in real time.Finally,the correlation analysis was performed be-tween the real-time muscle characteristics monitoring indexes of musculoskeletal ultrasound and the VAS and ODI scores in NLBP patients.Result:The VAS score showed that the healthy group was 0.58±0.73 and the NLBP group was 3.29±0.42.There was a significant difference in VAS score between the two groups(t=40.729,P＜0.001).The ODI score showed that the healthy group was 4.25±0.36 and the NLBP group was 14.41±1.63.The difference of ODI score between the two groups was statistically significant(t=-67.162,P＜0.001).The transverse abdominal muscle test showed that the thickness of the healthy group was 3.89±0.31 mm,and the thickness of the NLBP group was 2.85±0.26 mm.At the contraction position,the thickness of the healthy group was 5.18±0.35 mm,and the thickness of the NLBP group was 3.64±0.29 mm.The multifidus muscle test showed that the thickness of the healthy group was 2.19±0.14 cm,and the thickness of the NLBP group was 1.82±0.16 cm.At the contraction position,the thickness of the healthy group was 3.15±0.22 cm,and the thickness of the NLBP group was 2.41±0.21 cm.Compared with the healthy group,the muscle thickness of the transverse abdominis of the NLBP group(t=-31.401,-48.751;P＜0.001)and multifidus muscle thickness were significantly reduced(t=-20.610,-29.335;P＜0.001).The correlation analysis showed that there was a significant negative correlation between VAS score and transverse abdominal muscle thickness(r=-0.69,P＜0.001)and multifidus muscle thickness(r--0.45,P＜0.001)at rest.There was a significant negative correlation between the VAS score and the thickness of the transverse abdominal muscle(r=-0.59,P＜0.001)and the thickness of the multifidus muscle(r=-0.31,P＜0.001).At rest,there was a significant negative correlation between ODI score and transverse abdominal muscle thickness(r=-0.58,P＜0.001)and multifidus muscle thickness(r=-0.36,P＜0.001).In the contractile position,there was a significant negative correlation between the VAS score and the thickness of the transverse abdominal muscle(r=-0.54,P＜0.001)and the thickness of the multifidus muscle(r=-0.22,P=0.0029).Conclusion:Musculoskeletal ultrasonography can be used as a real-time detection method to evaluate the rele-vant characteristic indexes of NLBP in subjects.

Objective:To utilize usculoskeletal ultrasound technology for real-time assessment of related muscle characteris-tics in patients with chronic nonspecific low back pain(NLBP)and to analyze the correlation with visual ana-logue scale(VAS)and Oswestry disability index questionnaire(ODI).Method:A total of 180 patients diagnosed with chronic NLBP in the department of rehabilitation of the Sec-ond Hospital in Fuzhou from December 2022 to June 2023 were selected as NLBP group,and 120 healthy subjects who underwent physical examination at the same time period were selected as the control group.VAS and ODI questionnaires were used to assess the two groups of subjects.Based on musculoskeletal ultrasound technology,the muscle thickness and elastic modulus of transverse abdominal muscle and multifidus muscle in resting and contraction positions were detected in real time.Finally,the correlation analysis was performed be-tween the real-time muscle characteristics monitoring indexes of musculoskeletal ultrasound and the VAS and ODI scores in NLBP patients.Result:The VAS score showed that the healthy group was 0.58±0.73 and the NLBP group was 3.29±0.42.There was a significant difference in VAS score between the two groups(t=40.729,P＜0.001).The ODI score showed that the healthy group was 4.25±0.36 and the NLBP group was 14.41±1.63.The difference of ODI score between the two groups was statistically significant(t=-67.162,P＜0.001).The transverse abdominal muscle test showed that the thickness of the healthy group was 3.89±0.31 mm,and the thickness of the NLBP group was 2.85±0.26 mm.At the contraction position,the thickness of the healthy group was 5.18±0.35 mm,and the thickness of the NLBP group was 3.64±0.29 mm.The multifidus muscle test showed that the thickness of the healthy group was 2.19±0.14 cm,and the thickness of the NLBP group was 1.82±0.16 cm.At the contraction position,the thickness of the healthy group was 3.15±0.22 cm,and the thickness of the NLBP group was 2.41±0.21 cm.Compared with the healthy group,the muscle thickness of the transverse abdominis of the NLBP group(t=-31.401,-48.751;P＜0.001)and multifidus muscle thickness were significantly reduced(t=-20.610,-29.335;P＜0.001).The correlation analysis showed that there was a significant negative correlation between VAS score and transverse abdominal muscle thickness(r=-0.69,P＜0.001)and multifidus muscle thickness(r--0.45,P＜0.001)at rest.There was a significant negative correlation between the VAS score and the thickness of the transverse abdominal muscle(r=-0.59,P＜0.001)and the thickness of the multifidus muscle(r=-0.31,P＜0.001).At rest,there was a significant negative correlation between ODI score and transverse abdominal muscle thickness(r=-0.58,P＜0.001)and multifidus muscle thickness(r=-0.36,P＜0.001).In the contractile position,there was a significant negative correlation between the VAS score and the thickness of the transverse abdominal muscle(r=-0.54,P＜0.001)and the thickness of the multifidus muscle(r=-0.22,P=0.0029).Conclusion:Musculoskeletal ultrasonography can be used as a real-time detection method to evaluate the rele-vant characteristic indexes of NLBP in subjects.

Objective:To explore the expressions of long non-coding RNA LINC00673 and ISG15 protein in pancreatic cancer and their clinical significances.Methods:The clinical data of 57 patients diagnosed as pancreatic ductal carcinoma (PDAC) at the Affiliated Cancer Hospital of Xiangya Medical College of Central South University from January 2014 to December 2018 were retrospectively analyzed. The relative expressions of LINC00673 in pancreatic cancer tissues and paracancerous normal tissues (within 3 cm from the edge of cancer tissues) were examined by using quantificational reverse transcription-polymerase chain reaction (qRT-PCR). The ISG15 protein expressions in pancreatic cancer tissues and paracancerous normal tissues were examined by using immunohistochemistry. The difference in LINC00673 expression between ISG15 protein positive and negative patients was compared. The correlation between LINC00673 and ISG15 protein expressions in pancreatic cancer was analyzed by Spearman rank correlation analysis. Moreover, the correlations of LINC00673 and ISG15 protein expressions with clinical stage and pathological classification of pancreatic cancer patients were analyzed.Results:The positive expression of ISG15 protein in pancreatic cancer tissues was 40.4% (23/57), which was higher than that in paracancerous normal tissues [15.8% (9/57)] ( χ2 = 7.90, P = 0.004), and the relative expression of LINC00673 in pancreatic cancer tissues was 0.99±0.36, which was lower than that in paracancerous normal tissues (1.26±0.41) ( t = 4.80, P < 0.001). For 23 (40.4%) ISG15-positive patients and 34 (59.7%) ISG15-negative patients, the relative expression of LINC00673 was 0.77±0.46 and 0.45±0.27 ( P < 0.001). Spearman analysis showed that there was a correlation between LINC00673 and ISG15 protein expressions ( ρ = -0.429, P = 0.001). The relative expression of LINC00673 decreased in patients with low differentiated or undifferentiated tumor, vascular invasion and lymph node metastasis (all P < 0.05), but there was no correlation between LINC00673 expression and patients' age, tumor site, preoperative CA199 level, and TNM stage (all P > 0.05); ISG15 protein expression increased in patients with low differentiated or undifferentiated tumor, TNM stage Ⅲ-Ⅳ, vascular invasion and lymph node metastasis (all P < 0.05), but there was no correlation between ISG15 protein expression and patients' gender, age, tumor site, and preoperative CA199 level (all P > 0.05). Conclusions:The expression of LINC00673 in pancreatic cancer is related to vascular invasion, tumor differentiation degree and lymph node metastasis, and the expression of ISG15 in pancreatic cancer is related to vascular invasion, tumor differentiation degree, lymph node metastasis and TNM stage. The combined detection of LINC00673 and ISG15 protein could be a valuable prognostic indicator for pancreatic cancer. The therapies targeting LINC00673 and ISG15 protein signaling pathways are expected to be a potential option for immunotherapy of pancreatic cancer.

Objectives:To verify the reliability and validity of the frailty assessment scale for elderly patients with inguinal hernia and to evaluate the value of its clinical application.Methods:A convenience sampling method was used to collect 129 geriatric patients who underwent inguinal hernia surgery from January 2018 to January 2023 in nine hospitals in Liaoning Province. There were 120 males and 9 females, of whom 89 patients were 60 to <75 years old, 33 patients were 75 to <85 years old and 7 patients were ≥85 years old. The 129 patients included 11 elderly patients with inguinal hernia who had recovered from preoperative infection with COVID-19. Statistical methods such as Cronbach′s coefficient, Kaiser-Meyer-Olkin test, Bartlett′s test, Pearson′s correlation analysis, etc. were calculated to verify the reliability indexes such as feasibility, content validity, structural validity, criterion-related validity, internal consistency reliability, and re-test reliability. Taking the 5-item modified frailty index (5-mFI) as the gold standard, the area under the curve was used to analyze the ability of the two scales to predict the occurrence of postoperative acute urinary retention, postoperative delirium, poor incision healing, operative hematoma seroma, and postoperative complications.Results:The frailty assessment scale for elderly patients with inguinal hernia showed good reliability and validity (valid completion rate of 99.2%; item content validity index of 1.000, and the scale content validity index of 1.000; exploratory factor analysis extracted a total of 1 principal component, and factor loadings of each item of 0.565 to 0.873; the AUC for frailty diagnosis using 5-mFI as the gold standard of 0.795 ( P<0.01) Cronbach′s coefficient of 0.916, retest reliability coefficient of 0.926), it could effectively predict postoperative acute urinary retention, delirium, hematoma seroma in the operative area and total complications (AUC of 0.746, 0.870, 0.806, and 0.738, respectively; all P<0.05), and prediction efficiency was higher than that of 5-mFI (AUC of 0.694, 0.838, 0.626 and 0.641, P<0.05 for delirium only), but both scales were inaccurate in predicting poor incision healing (AUC of 0.519, P=0.913 for the frailty assessment scale and 0.455, P=0.791 for the 5-mFI). Conclusions:The frailty assessment scale for elderly patients with inguinal hernia is reliable and significantly predicts the occurrence of postoperative adverse events in elderly inguinal hernia patients. The scale can also be used for preoperative frailty assessment in elderly patients with inguinal hernia after rehabilitation from COVID-19 infection.

Objectives:To verify the reliability and validity of the frailty assessment scale for elderly patients with inguinal hernia and to evaluate the value of its clinical application.Methods:A convenience sampling method was used to collect 129 geriatric patients who underwent inguinal hernia surgery from January 2018 to January 2023 in nine hospitals in Liaoning Province. There were 120 males and 9 females, of whom 89 patients were 60 to <75 years old, 33 patients were 75 to <85 years old and 7 patients were ≥85 years old. The 129 patients included 11 elderly patients with inguinal hernia who had recovered from preoperative infection with COVID-19. Statistical methods such as Cronbach′s coefficient, Kaiser-Meyer-Olkin test, Bartlett′s test, Pearson′s correlation analysis, etc. were calculated to verify the reliability indexes such as feasibility, content validity, structural validity, criterion-related validity, internal consistency reliability, and re-test reliability. Taking the 5-item modified frailty index (5-mFI) as the gold standard, the area under the curve was used to analyze the ability of the two scales to predict the occurrence of postoperative acute urinary retention, postoperative delirium, poor incision healing, operative hematoma seroma, and postoperative complications.Results:The frailty assessment scale for elderly patients with inguinal hernia showed good reliability and validity (valid completion rate of 99.2%; item content validity index of 1.000, and the scale content validity index of 1.000; exploratory factor analysis extracted a total of 1 principal component, and factor loadings of each item of 0.565 to 0.873; the AUC for frailty diagnosis using 5-mFI as the gold standard of 0.795 ( P<0.01) Cronbach′s coefficient of 0.916, retest reliability coefficient of 0.926), it could effectively predict postoperative acute urinary retention, delirium, hematoma seroma in the operative area and total complications (AUC of 0.746, 0.870, 0.806, and 0.738, respectively; all P<0.05), and prediction efficiency was higher than that of 5-mFI (AUC of 0.694, 0.838, 0.626 and 0.641, P<0.05 for delirium only), but both scales were inaccurate in predicting poor incision healing (AUC of 0.519, P=0.913 for the frailty assessment scale and 0.455, P=0.791 for the 5-mFI). Conclusions:The frailty assessment scale for elderly patients with inguinal hernia is reliable and significantly predicts the occurrence of postoperative adverse events in elderly inguinal hernia patients. The scale can also be used for preoperative frailty assessment in elderly patients with inguinal hernia after rehabilitation from COVID-19 infection.

Chemotherapy is an important adjuvant treatment of glioma, while the efficacy is far from satisfactory, due not only to the biological barriers of blood‒brain barrier (BBB) and blood‒tumor barrier (BTB) but also to the intrinsic resistance of glioma cells via multiple survival mechanisms such as up-regulation of P-glycoprotein (P-gp). To address these limitations, we report a bacteria-based drug delivery strategy for BBB/BTB transportation, glioma targeting, and chemo-sensitization. Bacteria selectively colonized into hypoxic tumor region and modulated tumor microenvironment, including macrophages repolarization and neutrophils infiltration. Specifically, tumor migration of neutrophils was employed as hitchhiking delivery of doxorubicin (DOX)-loaded bacterial outer membrane vesicles (OMVs/DOX). By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect. Moreover, the P-gp expression on tumor cells was silenced by bacteria type III secretion effector to sensitize the efficacy of DOX, resulting in complete tumor eradication with 100% survival of all treated mice. In addition, the colonized bacteria were finally cleared by anti-bacterial activity of DOX to minimize the potential infection risk, and cardiotoxicity of DOX was also avoided, achieving excellent compatibility. This work provides an efficient trans-BBB/BTB drug delivery strategy via cell hitchhiking for enhanced glioma therapy.

【Objective】 To compare the efficacy and safety of blue laser en bloc enucleation and traditional plasmakinetic electrocautery in the treatment of non-muscle invasive bladder cancer (NMIBC). 【Methods】 A total of 50 NMIBC patients treated in our hospital during Oct.2018 and Dec.2019 were enrolled. A randomized, incomplete blinding, parallel control design and non-inferior test method was adopted. The control group (electrocautery group) used plasmakinetic electrocautery for transurethral resection, and the experimental group (blue laser group) used semiconductor blue laser for transurethral en bloc enucleation. The effective resection rate, operation time, postoperative catheter indwelling time, length of hospital stay, perioperative hemoglobin changes and obturator nerve reflex were compared. 【Results】 There were 24 patients in the blue laser group and 26 in the electrocautery group. The effective dissection rate and hemostasis rate in both groups reached 100%. The blue laser group had slightly longer operation time than the electrocautery group (55 min vs.42 min, P=0.009), but lesser hemoglobin decrease (5.7 g/L vs. 10.4 g/L, P=0.007). There were no significant differences in urinary catheter indwelling time, length of hospital stay and reoperation rate between the two groups. The electrocautery group had 3 cases of obturator nerve reflex, while the blue laser group had none. 【Conclusion】 Compared with the traditional electrocautery, blue laser has good vaporization cutting and coagulation hemostatic effects on bladder tumor tissue, and can completely enucleate tumors in a front-firing model with less bleeding and no obturator nerve reflex, which can be used as a new, efficient, safe and easy-to-learn method for NMIBC surgery. However, its effects on postoperative recurrence rate and progression rate still need further studies.