Objective To investigate the impact of a multi-dimensional nursing intervention model on the quality of life and complications of patients undergoing hemofiltration in the intensive care unit(ICU).Methods A total of 100 patients who underwent hemofiltration and were admitted to the department of intensive care medicine of Armed Police Special Medical Center from June 2021 to June 2023 were enrolled as study objectives.Based on nursing methods,the patients were divided into an experimental group and a control group,with 50 cases in each group.The control group received routine nursing intervention,while the experimental group received multi-dimensional nursing intervention.The differences between the two groups were compared in terms of anxiety and depression,sleep quality,quality of life,nursing satisfaction,and incidence of adverse reactions.Results After receiving nursing care,the self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,and Pittsburgh sleep quality index(PSQI)score of both groups were significantly lower than those before nursing,while the generic quality of life inventory-74(GQOLI-74)score was significantly higher than before nursing.Moreover,the experimental group showed significantly lower SDS,SAS,and PSQI scores than the control group(SDS score:34.24±4.19 vs.40.24±4.43,SAS score:41.20±4.33 vs.50.10±5.02,PSQI score:sleep quality was 0.90±0.23 vs.1.55±0.51,sleep latency was 0.47±0.20 vs.0.83±0.34,sleep duration was 1.03±0.21 vs.1.78±0.55,sleep efficiency was 0.73±0.23 vs.1.12±0.21,all P<0.05).The GQOLI-74 scores in the experimental group were higher than those in the control group(somatic function was 64.34±6.93 vs.52.33±5.83,psychological function was 60.24±5.34 vs.54.29±5.88,material life was 64.22±6.24 vs.53.18±5.13,social function was 63.54±5.19 vs.54.10±4.24,all P<0.05).Nursing satisfaction in the experimental group was significantly higher than that in the control group[98.00%(49/50)vs.78.00%(39/50),P<0.05],and the incidence of adverse reactions was significantly lower[6.00%(3/50)vs.22.00%(11/50),P<0.05].Conclusion Implementing a multidimensional nursing intervention for ICU patients undergoing hemofiltration can achieve favorable nursing outcomes.It not only helps reduce the incidence of related complications but also effectively improves patients'quality of life and enhances their satisfaction.

Objective To investigate the impact of a multi-dimensional nursing intervention model on the quality of life and complications of patients undergoing hemofiltration in the intensive care unit(ICU).Methods A total of 100 patients who underwent hemofiltration and were admitted to the department of intensive care medicine of Armed Police Special Medical Center from June 2021 to June 2023 were enrolled as study objectives.Based on nursing methods,the patients were divided into an experimental group and a control group,with 50 cases in each group.The control group received routine nursing intervention,while the experimental group received multi-dimensional nursing intervention.The differences between the two groups were compared in terms of anxiety and depression,sleep quality,quality of life,nursing satisfaction,and incidence of adverse reactions.Results After receiving nursing care,the self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,and Pittsburgh sleep quality index(PSQI)score of both groups were significantly lower than those before nursing,while the generic quality of life inventory-74(GQOLI-74)score was significantly higher than before nursing.Moreover,the experimental group showed significantly lower SDS,SAS,and PSQI scores than the control group(SDS score:34.24±4.19 vs.40.24±4.43,SAS score:41.20±4.33 vs.50.10±5.02,PSQI score:sleep quality was 0.90±0.23 vs.1.55±0.51,sleep latency was 0.47±0.20 vs.0.83±0.34,sleep duration was 1.03±0.21 vs.1.78±0.55,sleep efficiency was 0.73±0.23 vs.1.12±0.21,all P<0.05).The GQOLI-74 scores in the experimental group were higher than those in the control group(somatic function was 64.34±6.93 vs.52.33±5.83,psychological function was 60.24±5.34 vs.54.29±5.88,material life was 64.22±6.24 vs.53.18±5.13,social function was 63.54±5.19 vs.54.10±4.24,all P<0.05).Nursing satisfaction in the experimental group was significantly higher than that in the control group[98.00%(49/50)vs.78.00%(39/50),P<0.05],and the incidence of adverse reactions was significantly lower[6.00%(3/50)vs.22.00%(11/50),P<0.05].Conclusion Implementing a multidimensional nursing intervention for ICU patients undergoing hemofiltration can achieve favorable nursing outcomes.It not only helps reduce the incidence of related complications but also effectively improves patients'quality of life and enhances their satisfaction.

Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL). The Chinese Children's Cancer Group-ALL-2015 protocol was carried out in China, and epidemiology, clinical characteristics, and risk factors associated with VTE were analyzed. We collected data on VTE in a multi-institutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December 2019. First, VTE occurred in 159 (2.08%) patients, including 90 (56.6%) during induction therapy and 108 (67.92%) in the upper extremities. T-ALL had a 1.74-fold increased risk of VTE (95% CI 1.08-2.8, P = 0.022). Septicemia, as an adverse event of ALL treatment, can significantly promote the occurrence of VTE (P < 0.001). Catheter-related thrombosis (CRT) accounted for 75.47% (n = 120); and, symptomatic VTE, 58.49% (n = 93), which was more common in patients aged 12-18 years (P = 0.023), non-CRT patients (P < 0.001), or patients with cerebral thrombosis (P < 0.001). Of the patients with VTE treated with anticoagulation therapy (n = 147), 4.08% (n = 6) had bleeding. The VTE recurrence rate was 5.03% (n = 8). Patients with VTE treated by non-ultrasound-guided venous cannulation (P = 0.02), with residual thrombus (P = 0.006), or with short anticoagulation period (P = 0.026) had high recurrence rates. Thus, preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.
Humans ; Child ; Venous Thromboembolism/etiology* ; East Asian People ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology* ; Risk Factors ; Thrombosis/chemically induced* ; China/epidemiology* ; Anticoagulants/adverse effects* ; Recurrence

BACKGROUND:Neural stem cells (NSCs) hold self-renewal and multi-directional differentiation potential. NSCs differentiation into neurons in high proportion under induction conditions exhibits broad application prospect. OBJECTIVE:To explore the effect of basic fibroblast growth factor (bFGF)-chitosan carrier on the NSCs differentiation into neurons in vitro, and whether the differentiated neurons could form synaptic-like connection with myocytes. METHODS:After purification, the NSCs were co-cultured with chitosan, soluble bFGF or bFGF-chitosan carrier. After 7-day induction, the NSCs differentiation into neurons was observed by immunofluorescence staining of beta tubulin Ⅲ. The NSCs differentiation into cholinergic neurons was observed through double immunofluorescence staining of ChaT and beta tubulin Ⅲ. The synaptic-like connection between the neurons and myocytes was observed by triple staining of beta tubulin Ⅲ and MHC. RESULTS AND CONCLUSION:The percentage of differentiated neurons in the bFGF-chitosan carrier group was 74%, which was significantly higher than that in the other two groups. Additionally, the synaptic-like connection formed between the differentiated neurons and myocytes. To conclude, the bFGF-chitosan carrier promotes the NSCs differentiation into neurons to form synaptic-like connection with the co-cultured myocytes.

Objective To study the effect of artemether (Art) on total antioxidant capacity (T-AOC) in adult Schistosoma japonicum. Methods In vitro, the T-AOC was determined in five-week old worms incubated without or with Art and/or hemin for 24 h, and the worms were continuously incubated for 96 h, then worm survival was assessed. In vivo, T-AOC was determined in worms freshly recovered from mice 6 - 24 h after treatment with Art 300 mg/kg. Results Throughout 96 h incubation no worms were killed by 50 μmol/L Art or 50 μmol/L hemin alone, but approximatdy 80% of them were killed by Art plus hemin. Addition of reduced glutathione and vitamin E could significantly block the cidal action of the combined treatment. No effect on T-AOC was seen in the worms exposed to Art or heroin alone for 24 h, but the combined treatment led to a pronounced T-AOC reduction in female worms in vitro. Such a drug effect on female worms was demonstrated in vivo. After female worms were exposed to Art for 6 - 24 h in vivo, their T-AOC was significantly reduced by 40% - 64%. However, no drug effect on male worms' T-AOC was observed in vivo and in vitro exposed to Art plus hemin. Conclusion Art-induced T-AOC reduction in female worms may sensitize them to lethal damages of endogenous and exogenous oxygen radicals.