Objective:To construct a bi-parameter radiomics model of magnetic resonance based on radiomics features of T2 fat suppression weighted images of magnetic resonance and diffusion-weighted apparent diffusion coefficient mapping,and to study the diagnostic value of the bi-parameter radiomics model for prostate cancer with clinical significance. Method:The imaging and pathological data of 93 patients with prostate cancer,who were confirmed at the First People's Hospital of Tianshui from January 2021 to February 2024,were retrospectively analyzed. They were divided into training set (65 cases) and testing set (28 cases) by using 7:3 principle of random number grouping method. The magnetic resonance T2 weighted fat suppression images and apparent diffusion coefficient mapping based on diffusion weighted imaging were preprocessed,and the regions of interest (ROI) were delineated. 1197 radiomics features were extracted. Machine learning support vector machine method was used to construct a bi-parameter omics model,which combined T2 weighted fat suppression images and apparent diffusion coefficient mapping based on diffusion weighted imaging. And then,the efficiency of this bi-parameter omics model of diagnosing prostate cancer with clinical significance was evaluated. Result:The area under curve (AUC) values of receiver operating characteristic (ROC) curve of training group and testing group based on the MRI bi-parameter model were respectively 0.928 and 0.894 in diagnosing prostate cancer with clinical significance. The sensitivity and specificity of that were respectively 84.2％ and 95.7％. Conclusion:The constructed bi-parameter radiomics model through training and testing has higher diagnostic value for prostate cancer with clinical significance,and it is relatively objective and accurate,which can provide reliable basis for clinical diagnosis and treatment of prostate cancer with clinical significance.

Objective:To construct a bi-parameter radiomics model of magnetic resonance based on radiomics features of T2 fat suppression weighted images of magnetic resonance and diffusion-weighted apparent diffusion coefficient mapping,and to study the diagnostic value of the bi-parameter radiomics model for prostate cancer with clinical significance. Method:The imaging and pathological data of 93 patients with prostate cancer,who were confirmed at the First People's Hospital of Tianshui from January 2021 to February 2024,were retrospectively analyzed. They were divided into training set (65 cases) and testing set (28 cases) by using 7:3 principle of random number grouping method. The magnetic resonance T2 weighted fat suppression images and apparent diffusion coefficient mapping based on diffusion weighted imaging were preprocessed,and the regions of interest (ROI) were delineated. 1197 radiomics features were extracted. Machine learning support vector machine method was used to construct a bi-parameter omics model,which combined T2 weighted fat suppression images and apparent diffusion coefficient mapping based on diffusion weighted imaging. And then,the efficiency of this bi-parameter omics model of diagnosing prostate cancer with clinical significance was evaluated. Result:The area under curve (AUC) values of receiver operating characteristic (ROC) curve of training group and testing group based on the MRI bi-parameter model were respectively 0.928 and 0.894 in diagnosing prostate cancer with clinical significance. The sensitivity and specificity of that were respectively 84.2％ and 95.7％. Conclusion:The constructed bi-parameter radiomics model through training and testing has higher diagnostic value for prostate cancer with clinical significance,and it is relatively objective and accurate,which can provide reliable basis for clinical diagnosis and treatment of prostate cancer with clinical significance.

Objective: To explore the value of quantitative acoustic radiation force impulse (ARFI) imaging in evaluation of liver elasticity in patients with chronic heart failure (HF). Methods: Totally 30 left HF patients (LHF group), 30 right HF patients (RHF group) and 30 healthy volunteers (control group) underwent routine ultrasound examination and biochemical examination, and then Young's modulus value of liver was detected using quantitative ARFI imaging. Correlations between Young's modulus value of liver and biochemical indexes, diameter of inferior vena cava, diameter of liver vein and oblique diameter of right lobe of liver were analyzed in patients with chronic HF. Results: Young's modulus value of liver in LHF group and RHF group were higher than that in control group (both P<0.05), and in RHF group was higher than in LHF group (P<0.05). Young's modulus value of liver in chronic HF patients positively correlated with brain natriuretic peptide, total bilirubin, gamma glutamyl transferase, alkaline phosphatase, diameter of inferior vena cava, diameter of left liver vein, diameter of middle hepatic vein and diameter of right liver vein (r=0.325, 0.382, 0.355, 0.379, 0.451, 0.445, 0.395, 0.645, all P<0.05), while no correlation was noticed between Young's modulus of liver and ejection fraction of left ventricle nor oblique diameter of right lobe of liver (all P>0.05). Conclusion: Quantitative ARFI imaging can be used to estimate the elasticity of liver in chronic HF patients. Liver elasticity is associated with the severity of heart failure.

Objective To explore the change of of plasma TSP-1 level in patients with coronary atherosclerosis and its relationship with the degree of coronary artery stenosis and related plasma cytokines.Methods A total of 79 patients with chest pain were divided into low score group (n =27),medium score group (n =26),and high score group (n =26) according to Gensini score.Another 27 normal controls were included as control group.The levels of plasma TSP-1,hs-CRP,MMP-9 and TGF-β1 were detected by enzyme-linked immunoassay,and the relationship between TSP-1 and Gensini score,hs-CRP,MMP-9 and TGF-β1was analyzed.Results There were significant differences in level of plasma TSP-1 between four groups (P ＜ 0.05).The level of TSP-1 in plasma was correlated with hs-CRP (r =0.4979,P ＜ 0.001),MMP-9 (r =0.3940,P ＜ 0.001) and TGF-β1 (r =0.4889,P ＜ 0.001).The multiple stepwise linear regression analysis showed that there was a correlation between the degree of coronary artery stenosis and the plasma TSP-1 level.Conclusion Plasma TSP-1 level can be used as a biomarker for coronary stenosis.

Objective To explore the change of of plasma TSP-1 level in patients with coronary atherosclerosis and its relationship with the degree of coronary artery stenosis and related plasma cytokines.Methods A total of 79 patients with chest pain were divided into low score group (n =27),medium score group (n =26),and high score group (n =26) according to Gensini score.Another 27 normal controls were included as control group.The levels of plasma TSP-1,hs-CRP,MMP-9 and TGF-β1 were detected by enzyme-linked immunoassay,and the relationship between TSP-1 and Gensini score,hs-CRP,MMP-9 and TGF-β1was analyzed.Results There were significant differences in level of plasma TSP-1 between four groups (P ＜ 0.05).The level of TSP-1 in plasma was correlated with hs-CRP (r =0.4979,P ＜ 0.001),MMP-9 (r =0.3940,P ＜ 0.001) and TGF-β1 (r =0.4889,P ＜ 0.001).The multiple stepwise linear regression analysis showed that there was a correlation between the degree of coronary artery stenosis and the plasma TSP-1 level.Conclusion Plasma TSP-1 level can be used as a biomarker for coronary stenosis.

Objective To explore the application value of pulmonary artery monitoring program for intracranial and cervical artery angiography with dual-energy CT.Methods Sixty patients performed intracranial and cervical artery angiography with dual-energy CT were divided into two groups according to the random number table.Group A (optimization group,30 patients):the monitoring points were located in the main pulmonary artery,with threshold 150 HU,trigger delay time 8-9 s,pitch 0.9,and the iohexol (350 mg I/ml) 60-65 ml.Group B (conventional group,30 patients):the monitoring points were located in aortic arch,with threshold 100 HU,trigger delay time 5 s,and the iohexol (350 mg I/ml)60-70 ml.Patients with the body weight less than 75 kg were injected with the flow rate of 4.0 ml/s,and those weight greater than 75 kg or with body mass index (BMI) greater than 27 kg/m2 were 4.5 ml/s,following 40 ml saline solution with the same flow rate respectively.All images were transferred to Siemens Syngo workstation for further processing and analysis.The attenuation values were measured on axial images in the common carotid artery,internal and external carotid artery,vertebral and basilar artery,the horizontal segment of the middle cerebral artery,the subclavian vein of injection side,the proximal,middle and distal segment of jugular vein,the straight sinus and the superior sagittal sinus.Two experienced observers blinded independently evaluated the image quality of CTA,the impact of contrast material residues artifacts of subclavian vein of injected side and the affect of venous return factors on arterial image display.Images of volume rendering technique(VR),the maximum intensity projection (MIP),and curved planar reformation (CPR) were reconstructed using dual energy bone removal and Inspace and 3D software.The mean intraluminal attenuation of contrast material (HU),the volume of contrast material and the mean image quality scores were compared with t test between the two groups.Chi-square test was used to compare of image contrast agents residual artifacts,the absence segments of the root of the neck artery,and the degree of the jugular vein return in two groups.Results The mean CT values were 372-414 HU for each segment of artery showing no significant differences between two groups (P ＞ 0.05).In group A,the CT values of the jugular vein in proximal,middle,distal segment of the two sides were (95 ± 36),(95 ± 36),(131 ±58),(133 ± 57),(174 ± 68),and (180 ± 66) HU respectively.In group B,CT values were (135 ± 58),(137 ±59),(170 ±58),(181 ±58),(218 ±62),and (224 ±68) HU.The CT value of jugular venous in group A was significantly lower than that in group B (t =-3.30--2.54,P ＜ 0.05).Case numbers of contrast agent residual artifacts of injection side subclavian vein and the absence segments of root of the neck artery at the beginning in group A (5,11) were less than that in group B (12,24) (x2 =4.02,5.65,P ＜0.05).The degree of the jugular vein return in group A were lesser severely than that in group B (x2 =6.79,6.37,P ＜0.05).Below the level of carotid artery bifurcation:slight 5 patients,severe 1 patient in group A vs.slight 15 patients,severe 9 patients in group B.Above the level of carotid artery bifurcation:slight 9 patients,severe 6 patients in group A vs.slight 12 patients,severe 17 patients in group B.Image quality scores of group A (3.84 ± 0.40) was higher than that of group B (3.64 ± 0.63) (t =4.26,P ＜0.05).Conclusions Pulmonary Artery Monitoring combines with 60-65 ml contrast material optimization scheme for intracranial and cervical artery angiography with dual energy CT can significantly reduce the degree of jugular venous return and contrast material residues artifacts of subclavian vein of injected side.This technique is helpful to improve the work efficiency and image quality.

OBJECTIVE To study the causes of recurrence and treatment methods in patients with recurrent sinonasal melanoma. METHODS From 1993 to 2003, a retrospective analysis of consecutive 11 cases with recurrent sinonasal melanoma was conducted. RESULTS Four out of the 11 cases with recurrent sinonasal melanoma were caused by misdiagnosis, while the other 7 cases recurred after operation with pathological diagnosis. Among the 7 cases, 5 were found recurrences after operation alone, and the other 2 after the operation and radiation therapy. The recurrence lesions located in nasal and paranasal sinus in 7 cases, in orbit, skull base, soft and hard palate in 1 case, in parotid gland and skin in 1 case. In face, orbit and extended skull base in 1 case. Cervical lymph node recurrence developed in 1 patient. The time of first relapse was 10 months after therapy. The 1-, 2-and 3-year survival rates after reoperation were 72.7 %, 18.2 % and 9.1 % respectively. CONCLUSION The reasonable treatment and decrease the misdignosis are the main measures to improve the cure rate of recurrent sinonasal melanoma.

Objective To investigate the inhibitory effect of curcumin on the telomerase activity of HeLa cells.Methods The growth inhibition rate of HeLa cells treated with curcumin was measured with MTT method.The expression of hTERT mRNA was studied using RT-PCR.Telomerse activity was examined by TRAP-ELISA.Results The growth of HeLa cells treated with curcumin was inhibited in concentration dependent manner and the expression of hTERT mRNA and the level of telomerase activity were down-regulated significantly.Conclusion Curcumin can inhibit telomerase activity of HeLa cells.The underlying mechanism might be related to the down-regulation of hTERT transcription.

Caveolin-1(Cav-1) is a scaffold protein of caveolae that acts as a tumor modulator by interacting with cell adhesion molecules and signaling receptors.Evidence from a variety of studies indicate that caveolin-1 exhibits the heterogeneity of Cav-1 expression in different tumors.Current research has clearly established a role for Cav-1 as a a novel prognostic marker,Future studies will undoubtedly offer novel exciting opportunities to develop anti-cancer therapies.