1.A head direction cell model based on a spiking neural network with landmark-free calibration.
Naigong YU ; Jingsen HUANG ; Ke LIN ; Zhiwen ZHANG
Journal of Biomedical Engineering 2025;42(5):970-976
In animal navigation, head direction is encoded by head direction cells within the olfactory-hippocampal structures of the brain. Even in darkness or unfamiliar environments, animals can estimate their head direction by integrating self-motion cues, though this process accumulates errors over time and undermines navigational accuracy. Traditional strategies rely on visual input to correct head direction, but visual scenes combined with self-motion information offer only partially accurate estimates. This study proposed an innovative calibration mechanism that dynamically adjusts the association between visual scenes and head direction based on the historical firing rates of head direction cells, without relying on specific landmarks. It also introduced a method to fine-tune error correction by modulating the strength of self-motion input to control the movement speed of the head direction cell activity bump. Experimental results showed that this approach effectively reduced the accumulation of self-motion-related errors and significantly enhanced the accuracy and robustness of the navigation system. These findings offer a new perspective for biologically inspired robotic navigation systems and underscore the potential of neural mechanisms in enabling efficient and reliable autonomous navigation.
Animals
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Neural Networks, Computer
;
Calibration
;
Spatial Navigation/physiology*
;
Head Movements/physiology*
;
Neurons/physiology*
;
Models, Neurological
;
Head/physiology*
;
Action Potentials/physiology*
2.The Relationship Between Mutation of p53 Gene, p21 Gene and Bacteria L- Form in Gallbladder Carcinoma
Xingyuan JIAO ; Jiefu HUANG ; Jingsen SHI ;
Chinese Journal of Bases and Clinics in General Surgery 2003;0(03):-
0.05). The positive expression rate of p21 and p53 in gallbladder carcinoma was 62.5%(25/40) and 65.0%(26/40) respectively. The expression values of p21 and p53 in chronic cholecystitis was 2.5%(1/40) and 5.0%(2/40) respectively, which was significantly different from that of gallbladder carcinoma ( P
3.The evaluation of complications after endovenous laser treatment for patients with varicose veins of the lower extremities
Shaoying LU ; Guangyu QI ; Xintian HUANG ; Jincai CHEN ; Jingsen SHI
Chinese Journal of General Surgery 2001;0(09):-
Objective To explore causes of complications after endovenous laser treatment (EVLT) , for patients with superficial varicosities of the lower extremities. Methods In this study, 207 patients with a total of 268 lower limbs were treated by EVLT combined with surgical procedures. According to CEAP classification, there were C2 in 268 limbs, C3 in 56 limbs, C4 in 101, C5 in 23 and C6 in 18. Simple EVLT was performed for 25 limbs in 21 patients; EVLT combined with external banding valvuloplasty of superficial femoral vein for 23 limbs in 23 patients; EVLT combined with ligation of great saphenous vein (CSV) and denudation of superficial varicosities for 220 limbs in 163 patients. Results An average of 10?5 (3-24) months of follow up was achieved in 175 cases. Early complications (within the first 2-weeks after operation) included bruising or ecchymosis (178 cases, 66.42%) and skin burning (56, 20.90% ). Three month complication included painful induration or trabs (235 cases, 87. 69% ) as well as thrombophlebitis (28, 10. 45% ). Long-term complication (after 3 months) included skin numbness or pain at medial knee or ankle region (15,5. 60% ). Recanalization of CSV occurred in 4( 1. 49% ) treated limbs. Residual or reoccurred varicose veins were found in 13(4. 85% ) cases. Movement related swelling appeared in 6(2. 24% ) lower limbs. Conclusion EVLT is effective for patients with superficial varicosities of the lower extremities. Minor complications most often subsided within 3 months. Strict surgical protocol and high ligation of the GSV could prevent local recurrence of the varicose veins and the recanalization of GSV.

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