Patients with endometriosis are often associated with follicular growth retardation and oocyte maturation disorders, severely affecting patient fertility. In patients with endometriosis, the occurrence of apoptosis and oxidative stress events in granulosa cells, impaired cellular energy metabolism and steroid synthesis in patients with endometriosis may be the cause of abnormal follicular development and decreased oocyte quality. The inflammatory response caused by endometrioma, which afterwards leads excessive activation of follicles and fibrosis of the ovarian cortex, which directly reduces ovarian reserve. This article discusses the oxidative stress and apoptosis of follicle granulosa cells, steroid hormone synthesis, energy metabolism abnormality in patients with endometriosis, and explains the adverse effects of endometrioma on ovarian reserve from the perspective of inflammatory response.

Patients with endometriosis are often associated with follicular growth retardation and oocyte maturation disorders, severely affecting patient fertility. In patients with endometriosis, the occurrence of apoptosis and oxidative stress events in granulosa cells, impaired cellular energy metabolism and steroid synthesis in patients with endometriosis may be the cause of abnormal follicular development and decreased oocyte quality. The inflammatory response caused by endometrioma, which afterwards leads excessive activation of follicles and fibrosis of the ovarian cortex, which directly reduces ovarian reserve. This article discusses the oxidative stress and apoptosis of follicle granulosa cells, steroid hormone synthesis, energy metabolism abnormality in patients with endometriosis, and explains the adverse effects of endometrioma on ovarian reserve from the perspective of inflammatory response.