Guidelines for Digital Ancient Books of TCM Indexing(T/CIATCM 119-2024)is based on the theoretical knowledge,disciplinary methods,and practical applications of TCM classical cataloging.Taking digital ancient books of TCM as the object,it systematically reveals the content of TCM knowledge,which is an essential indexing processing standard for building an intelligent retrieval system for TCM ancient books,and can provide support for the deep development and innovative utilization of TCM knowledge.It can not only promote the co-construction and sharing of ancient book resources in the TCM industry,but also promote the standardization construction and application of TCM information.This standard specifies the principles,methods,and examples of free indexing of digital ancient books of TCM based on their original content.It is applicable to the indexing and processing of digital ancient books of TCM for TCM professional libraries and related institutions,and to the data processing and construction of various types of TCM ancient book databases.

Objective:To explore the effect of interactive intelligent system on management effect and the influence of that on data collection for intensive care equipment of hospital.Methods:The interactive intelligent system conducted management intervention for equipment from the intelligent system based on quick response(QR)codes,usage registration,maintenance and upkeep of equipment,warranty and preventive maintenance for fault,training for operator,and status display.Seventy-two intensive care equipment in clinical use in the department of intensive care unit(ICU)of Beijing Tongren Hospital Affiliated to Capital Medical University from March 2021 to February 2023 were selected.The management for equipment during March 2021 and February 2022 adopted the conventional management method.From March 2022 to February 2023,the management for equipment adopted the management of interactive intelligent system(intelligent management method).The management quality,data collection and management effect for equipment between the two management methods were compared.A self-made satisfaction questionnaire was adopted to investigate the satisfaction of managers,who used equipment,for the management after the two management methods were used to conduct intervention.Results:After the intervention with intelligent management method for equipment was implemented,the management quality scores of the equipment of infusion and injection,medical monitoring,rehabilitation and treatment,life support,emergency rescue,and disinfection and sterilization were respectively(93.49±4.51),(94.31±4.89),(92.63±4.34),(95.23±4.12),(94.43±4.39)and(94.56±5.12)points,all which were higher than those of conventional management method,and the differences were statistically significant(t=6.253,5.198,6.149,5.673,5.243,6.029,P<0.05),respectively.The scores of completeness,accuracy,overlap,value and rationality of collecting equipment data of the intelligent management method were respectively(95.63±4.12),(96.23±3.61),(96.11±3.29),(95.45±4.39)and(96.21±3.73),all which were higher than those of the conventional management method,and the differences were statistically significant(t=5.149,5.541,6.292,4.784,5.112,P<0.05),respectively.The costs of component purchase,daily maintenance,personnel management,technical consultation and operation of the intelligent management method were all lower than those of the conventional management method,and the differences were statistically significant(t=4.495,5.237,6.112,5.395,5.676,P<0.05),respectively.The satisfaction of managers,who used equipment,for the intervention of adopting intelligent management method in management method,daily maintenance,repair and prevention,skill improvement and data recording for equipment were higher than those of adopting conventional management method,and the differences were statistically significant(x2=6.263,4.096,6.114,5.945,6.535,P<0.05).Conclusion:The application of the interactive intelligent system in the management for equipment of the department of intensive care unit of hospital can improve the quality of management for equipment,and enhance the effect of collecting data,and reduce the operating cost of equipment,which can achieve a higher satisfaction for management.

Objective:To explore the effect of interactive intelligent system on management effect and the influence of that on data collection for intensive care equipment of hospital.Methods:The interactive intelligent system conducted management intervention for equipment from the intelligent system based on quick response(QR)codes,usage registration,maintenance and upkeep of equipment,warranty and preventive maintenance for fault,training for operator,and status display.Seventy-two intensive care equipment in clinical use in the department of intensive care unit(ICU)of Beijing Tongren Hospital Affiliated to Capital Medical University from March 2021 to February 2023 were selected.The management for equipment during March 2021 and February 2022 adopted the conventional management method.From March 2022 to February 2023,the management for equipment adopted the management of interactive intelligent system(intelligent management method).The management quality,data collection and management effect for equipment between the two management methods were compared.A self-made satisfaction questionnaire was adopted to investigate the satisfaction of managers,who used equipment,for the management after the two management methods were used to conduct intervention.Results:After the intervention with intelligent management method for equipment was implemented,the management quality scores of the equipment of infusion and injection,medical monitoring,rehabilitation and treatment,life support,emergency rescue,and disinfection and sterilization were respectively(93.49±4.51),(94.31±4.89),(92.63±4.34),(95.23±4.12),(94.43±4.39)and(94.56±5.12)points,all which were higher than those of conventional management method,and the differences were statistically significant(t=6.253,5.198,6.149,5.673,5.243,6.029,P<0.05),respectively.The scores of completeness,accuracy,overlap,value and rationality of collecting equipment data of the intelligent management method were respectively(95.63±4.12),(96.23±3.61),(96.11±3.29),(95.45±4.39)and(96.21±3.73),all which were higher than those of the conventional management method,and the differences were statistically significant(t=5.149,5.541,6.292,4.784,5.112,P<0.05),respectively.The costs of component purchase,daily maintenance,personnel management,technical consultation and operation of the intelligent management method were all lower than those of the conventional management method,and the differences were statistically significant(t=4.495,5.237,6.112,5.395,5.676,P<0.05),respectively.The satisfaction of managers,who used equipment,for the intervention of adopting intelligent management method in management method,daily maintenance,repair and prevention,skill improvement and data recording for equipment were higher than those of adopting conventional management method,and the differences were statistically significant(x2=6.263,4.096,6.114,5.945,6.535,P<0.05).Conclusion:The application of the interactive intelligent system in the management for equipment of the department of intensive care unit of hospital can improve the quality of management for equipment,and enhance the effect of collecting data,and reduce the operating cost of equipment,which can achieve a higher satisfaction for management.

Guidelines for Digital Ancient Books of TCM Indexing(T/CIATCM 119-2024)is based on the theoretical knowledge,disciplinary methods,and practical applications of TCM classical cataloging.Taking digital ancient books of TCM as the object,it systematically reveals the content of TCM knowledge,which is an essential indexing processing standard for building an intelligent retrieval system for TCM ancient books,and can provide support for the deep development and innovative utilization of TCM knowledge.It can not only promote the co-construction and sharing of ancient book resources in the TCM industry,but also promote the standardization construction and application of TCM information.This standard specifies the principles,methods,and examples of free indexing of digital ancient books of TCM based on their original content.It is applicable to the indexing and processing of digital ancient books of TCM for TCM professional libraries and related institutions,and to the data processing and construction of various types of TCM ancient book databases.

Objective:To analyze the risk factors and prognosis of endoleak after endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm.Methods:The clinical data of patients with infrarenal abdominal aortic aneurysms treated by endovascular repair at the Department of Vascular Surgery,the First Affiliated Hospital of Guangxi Medical University from Jun 2012 to Nov 2021 were retrospectively analyzed.Results:During the first follow-up CTA after surgery,136 out of 299 patients had endoleak.A total of 186 patients had at least one CTA reexamination after discharge. Statistical analysis showed that excessive neck angulation was an independent risk factor for type Ⅰa endoleak ( t=-6.108, P<0.001), wider common iliac artery diameter (left Z=-2.787, P=0.005, Right Z=-2.381, P=0.017) and iliac aneurysm ( χ2=6.398, P=0.011) were risk factors for type Ⅰb endoleak. The survival time of patients in endoleak group was similar to no endoleak group. Conclusions:Excessive neck angulation is an independent risk factor for type Ⅰa endoleak. Most leaks resolve spontaneously ,the prognosis is fair.

In the original publication the PDB numbers were not cited.

Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown. Here, we identified the YnaI channel as the Na/K cation-selective MS channel and solved its structure at 3.8 Å by cryo-EM single-particle method. YnaI exhibits low conductance among the family of MS channels in E. coli, and shares a similar overall heptamer structure fold with previously studied MscS channels. By combining structural based mutagenesis, quantum mechanical and electrophysiological characterizations, we revealed that ion selective filter formed by seven hydrophobic methionine (YnaI) in the transmembrane pore determined ion selectivity, and both ion selectivity and gating of YnaI channel were affected by accompanying anions in solution. Further quantum simulation and functional validation support that the distinct binding energies with various anions to YnaI facilitate Na/K pass through, which was defined as binding-block mechanism. Our structural and functional studies provided a new perspective for understanding the mechanism of how MS channels select ions driven by mechanical force.
Cryoelectron Microscopy ; Escherichia coli Proteins ; chemistry ; isolation & purification ; metabolism ; ultrastructure ; Ion Channels ; chemistry ; isolation & purification ; metabolism ; ultrastructure ; Mechanotransduction, Cellular ; Models, Molecular ; Quantum Theory

Objective To investigate the clinical risk factors of delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH).Methods From January 2015 to April 2016,106 consecutive patients with aSAH treated with endovascular embolization at the Department of Neurosurgery,Nanjing General Hospital of Nanjing Military Command were enrolled retrospectively.The patients were divided into either a DCI group (n =34) or a non-DCI group (n =72) according to whether the occurrence of DCI.The general information of patients were collected,including sex,age,Hunt-Hess grade,modified Fisher grade,world federation of neurosurgical societies (WFNS) grade,acute cerebral edema,early (bleeding 1-3 d) hypoalbuminemia,and hypohemoglobinemia.Univariate and multivariate Logistic regression analyses were used to analyze the risk factors for occurrence of DCI.Results The incidence of DCI was 32.1％ (34/106).The Hunt-Hess grade ≥ Ⅲ,modified Fisher grade ≥ Ⅲ,WFNS grade ≥ Ⅳ,acute cerebral edema,the incidences of hypoalbuminemia and hypohemoglobinemia in the DCI group were higher than those in the non-DCI group.There were significant differences between the 2 groups (all P ＜ 0.05).There were no significant differences in the ratios of sex,age ≥ 55 years,hypertension,diabetes and hyponatremia between the 2 groups (all P ＞ 0.05).In univariate analysis,the Hunt-Hess grade ≥ Ⅲ grade,modified Fisher grade ≥ Ⅲ,WFNS grade ≥ Ⅳ on admission,and hypoalbuminemia were used as the independent variables for multivariate analysis,the results showed that WFNS grade ≥ Ⅳ (OR,8.02;95 ％ CI 2.41-26.70),modified Fisher grades ≥ Ⅲ (OR,4.44;95％ CI 1.38-14.32),and hypoalbuminemia at day 1-3 (OR,5.42;95％ CI 1.40-20.76) were the independent risk factors for occurring DCI in patients with aSAH (all P ＜ 0.05),and the Hunt-Hess grade ≥ Ⅲ was not the risk factor for occurring DCI in patients with aSAH (OR,1.86;95％ CI 0.39-8.88,P ＞ 0.05).Conclusion The patients with hypoalbuminemia,WFNS grade≥Ⅳ on adrnission,and modified Fisher grade ≥ Ⅲ may were the independent risk factors DCI after aSAH,and the clinical diagnosis and treatment should attach great importance to.

Bone sialoprotein-binding protein (Bbp), a MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family protein expressed on the surface of Staphylococcus aureus (S. aureus), mediates adherence to fibrinogen α (Fg α), a component in the extracellular matrix of the host cell and is important for infection and pathogenesis. In this study, we solved the crystal structures of apo-Bbp(273-598) and Bbp(273-598)-Fg α(561-575) complex at a resolution of 2.03 Å and 1.45 Å, respectively. Apo-Bbp(273-598) contained the ligand binding region N2 and N3 domains, both of which followed a DE variant IgG fold characterized by an additional D1 strand in N2 domain and D1' and D2' strands in N3 domain. The peptide mapped to the Fg α(561-575) bond to Bbp(273-598) on the open groove between the N2 and N3 domains. Strikingly, the disordered C-terminus in the apo-form reorganized into a highly-ordered loop and a β-strand G'' covering the ligand upon ligand binding. Bbp(Ala298-Gly301) in the N2 domain of the Bbp(273-598)-Fg α(561-575) complex, which is a loop in the apo-form, formed a short α-helix to interact tightly with the peptide. In addition, Bbp(Ser547-Gln561) in the N3 domain moved toward the binding groove to make contact directly with the peptide, while Bbp(Asp338-Gly355) and Bbp(Thr365-Tyr387) in N2 domain shifted their configurations to stabilize the reorganized C-terminus mainly through strong hydrogen bonds. Altogether, our results revealed the molecular basis for Bbp-ligand interaction and advanced our understanding of S. aureus infection process.
Bacterial Proteins ; chemistry ; genetics ; metabolism ; Carrier Proteins ; chemistry ; genetics ; metabolism ; Crystallography, X-Ray ; Fibrinogen ; metabolism ; Ligands ; Models, Molecular ; Mutation ; Peptide Fragments ; chemistry ; metabolism ; Protein Binding ; Protein Structure, Tertiary ; Staphylococcus aureus

OBJECTIVETo study the efficacy of community management model of bronchial asthma in children.

METHODThrough community outreach and clinic, 120 cases of children with asthma were enrolled from the 11 000 children aged 0 to 14 in Zhanlanlu area, and a community management model of asthma was established according to the Global Initiative for Asthma requirements combined with the actual situation of the community, both physicians and patients participated in case identification, file creation, and long-term standardized management. Through repeated medical education, the telephone hotline and interactive network of asthma among physicians, children and parents, a physician-patient relationship was established. The data of standardized medication, scheduled re-visit to the hospital, frequency of asthma attacks, antibiotic use, medical expenses, the loss of parents work hours etc. before and after the implementation of community management model were analyzed and compared.

RESULTAfter implementation of community management model, the use of systemic corticosteroids (19.4%), oral medication (31.6%) was significantly lower than those before implementation (68.3% and 90.0%) (χ(2) = 51.9, 41.1, P < 0.01), use of inhaled corticosteroids (76.5%) and oral leukotriene receptor antagonist (79.6%) was significantly higher compared with control and before management level (10.0%), χ(2) = 106.0, P < 0.01. The days of attacks of asthma (4.6 ± 2.3), the use of antibiotics (16.2 ± 6.1), (5.7 ± 2.9) and the cost of treatment significantly decreased. In 16 cases (13.3%) two-way referral was applied. In this study, the dropout rate was 18.3%, by telephone and network supervision of lost cases, re-education, made some children return to management, eventually the dropout rate was 9.2%.

CONCLUSIONEnrollment of children with bronchial asthma into community management model made the children adhere to the management regularly and a standardized management was achieved.

Adolescent ; Adrenal Cortex Hormones ; administration & dosage ; therapeutic use ; Anti-Asthmatic Agents ; administration & dosage ; therapeutic use ; Asthma ; drug therapy ; therapy ; Child ; Child Health Services ; methods ; organization & administration ; Child, Preschool ; Community Health Services ; methods ; organization & administration ; Community Networks ; Disease Management ; Drug Administration Schedule ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Patient Compliance ; Patient Education as Topic ; organization & administration ; Self Care