Endometriosis (EMS) is a common disease in women of reproductive age. EMS may cause pain, infertility and mass. Because EMS affects the entire reproductive period of patients, it is easy to relapse, and difficult to cure. Therefore, a long-term management plan for patients with EMS should be formulated, including medical treatment, surgical treatment, and assisted reproductive technology. Fertility needs are one of the main needs of women with EMS of reproductive age. Therefore, long-term follow-up management is needed for women with EMS of reproductive age. The main purpose of treatment and consultation is to treat the pain caused by EMS and reduce the recurrence and progression of EMS, and give fertility guidance to patients when appropriate, and give appropriate treatment when patients are diagnosed with infertility. This article reviewed the long-term management of EMS patients of reproductive age.

Endometriosis (EMS) is a common disease in women of reproductive age. EMS may cause pain, infertility and mass. Because EMS affects the entire reproductive period of patients, it is easy to relapse, and difficult to cure. Therefore, a long-term management plan for patients with EMS should be formulated, including medical treatment, surgical treatment, and assisted reproductive technology. Fertility needs are one of the main needs of women with EMS of reproductive age. Therefore, long-term follow-up management is needed for women with EMS of reproductive age. The main purpose of treatment and consultation is to treat the pain caused by EMS and reduce the recurrence and progression of EMS, and give fertility guidance to patients when appropriate, and give appropriate treatment when patients are diagnosed with infertility. This article reviewed the long-term management of EMS patients of reproductive age.

Objective:To compare the endometrial blood flow in patients with recurrent implantation failure (RIF) and non RIF patients.Methods:A prospective cohort study was perfomed. Infertility patients who underwent frozen-thawed embryo transfer (FET) cycles in the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-Sen University from February 2019 to July 2019 were included. Transvaginal color Doppler ultrasound was used to detect whether there was subendometrial blood flow in the endometrium of RIF patients (RIF group, n=85) and non-RIF patients (non-RIF group, n=17). The proportion of patients without endometrial blood flow signal was compared, as well as endometrial blood flow pulsatility index (PI) and resistance index (RI). Results:Compared with non-RIF group, the proportion of patients without endometrial blood flow signal detected by ultrasound was significantly increased in RIF group [34.12% (29/85) vs. 5.88% (1/17), P=0.020]. PI and RI values of RIF group were significantly higher than those of non-RIF group (0.895 9±0.182 0 vs. 0.779 1±0.271 9, P=0.048; 0.575 6±0.078 4 vs. 0.511 1±0.130 7, P=0.016). Univariate logistic regression analysis showed that endometrial blood flow was an independent risk factors for RIF ( P=0.045). Conclusion:Abnormal endometrial blood flow may be related to RIF, which may cause RIF by reducing the receptivity of endometrium to embryo.

Objective:To compare the endometrial blood flow in patients with recurrent implantation failure (RIF) and non RIF patients.Methods:A prospective cohort study was perfomed. Infertility patients who underwent frozen-thawed embryo transfer (FET) cycles in the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-Sen University from February 2019 to July 2019 were included. Transvaginal color Doppler ultrasound was used to detect whether there was subendometrial blood flow in the endometrium of RIF patients (RIF group, n=85) and non-RIF patients (non-RIF group, n=17). The proportion of patients without endometrial blood flow signal was compared, as well as endometrial blood flow pulsatility index (PI) and resistance index (RI). Results:Compared with non-RIF group, the proportion of patients without endometrial blood flow signal detected by ultrasound was significantly increased in RIF group [34.12% (29/85) vs. 5.88% (1/17), P=0.020]. PI and RI values of RIF group were significantly higher than those of non-RIF group (0.895 9±0.182 0 vs. 0.779 1±0.271 9, P=0.048; 0.575 6±0.078 4 vs. 0.511 1±0.130 7, P=0.016). Univariate logistic regression analysis showed that endometrial blood flow was an independent risk factors for RIF ( P=0.045). Conclusion:Abnormal endometrial blood flow may be related to RIF, which may cause RIF by reducing the receptivity of endometrium to embryo.

Objective To investigate the preparation method of hydroxyapatite by amino acids induced hydrothermal technique.Methods The hydroxyapatite nanorods were obtained using alanine and glycine as templates by hydrothermal method.The samples were characterized by X-ray diffraction (XRD),Fourier infrared spectroscopy (FTIR),transmission electron microscopy (TEM).Results The results showed that amino acids induced the formation of hydroxyapatite.Amino acids could affect crystallinity and dispersion of the formed hydroxyapatite.In addition,the substituent content of carbonate ions in hydroxyapatite was reduced by changing the ratio of amino acids.Conclusion Hydroxyapatite with high crystallinity and low carbonate ions can be prepared by hydrothermal method in the presence of amino acids.

Objective To study the effect of flupentioxl melitracen and pinaverium bromide treatment on the changes of anorectal motility and rectal sensation in the patients of diarrhea-predominant irritable bowel syndrome (IBS-D) accompanying with depression and/or anxiety status. Methods Forty-four patients with IBS-D accompanying with depression and/or anxiety status were divided into group A (flupentioxl melitracen and pinaverium bromide) and group B (pinaverium bromide) by random digits table,and treated for 4 weeks. Twenty-five healthy subjects were included as control group. The anorectal motility and rectal sensation before and after taking medicines were compared. Results When abdominal pressure was increased, the net increased pressure of anal sphincter was (3.0 ± 1.2 ) kPa in group A and (2.9 ± 1.2)kPa in group B. They were lower than that in control group [(3.6 ± 1.6) kPa](P＜ 0.05). The rectal lowest volume of sensory threshold, the maximal volume of tolerance and maximal compliance were (55 ± 20) ml,( 145 ± 78 ) ml, ( 21.9 ± 12.9 ) ml/kPa in group A, ( 56 ± 38 ) ml, ( 150 ± 50 ) ml, (20.8 ± 11.2) ml/kPa in group B. They were lower than those in control group [(80 ± 38 ) ml, ( 190 ± 50 ) ml, (30.8 ± 15.2 ) ml/kPa](P ＜ 0.01 ). The rectal lowest volume of sensory threshold, the maximal volume of tolerance and maximal compliance were higher than those before taking medicines. Only the rectal lowest volume of sensory threshold in group B was higher than that before taking medicines. The rectal lowest volume of sensory threshold, the maximal volume of tolerance and maximal compliance in group A after taking medicines were higher than those in group B (P ＜ 0.05 or ＜ 0.01 ). Conclusions Higher sensitivity, lower tolerance,lower compliance of rectum and weakened anal automatic control function in IBS-D may be associated with diarrhea and frequent defecation. Treatment combining flupentioxl melitracen with pinaverium bromide may preferably improve the aperception functions of rectum in the patients of IBS-D accompanying with depression and/or anxiety status.

Objective To improve imaging diagnosis of Wegener granulomatosis.Methods Ten cases with Wegener granulomatosis were collected and their imaging findings were analyzed retrospectively.Results Eight cases presented sinusitis. CT showed mucosa thicken, accompanied with the destruction of middle-line structure in 3 cases and orbit mass in 2 cases. Seven cases involved lungs. Pulmonary imaging were complicated, showing multiple nodules or masses in 3 cases and multiple variable signs in the others. One case showed left upper bronchus obstruction. Conclusion Imaging of Wegener granulomatosis is complicated. Wegener granulomatosis should be diagnosed accompanied with clinical and pathologic findings.