Gorham-Stout disease(GSD) is a rare osteolytic disorder characterized by spontaneous and progressive osteolysis, along with abnormal angiogenesis and lymphangiogenesis, with no new bone formation. We present a case of a 15-year-old female admitted due to " recurrent right leg pain for 5 years, 11 months after undergoing right femoral fracture surgery". Through comprehensive integration of the patient's clinical phenotype, laboratory tests, imaging findings, pathological examinations, and molecular biological test results, GSD was considered highly likely. A multidisciplinary treatment approach was conducted, including a combination of zoledronic acid and sirolimus to inhibit osteolysis, along with rehabilitation training and orthopedic intervention, providing a personalized and comprehensive treatment strategy.

Objective To observe the volume changes of brain regions and their correlation with cognitive function in temporal lobe epilepsy(TLE)patients.Methods Fifty TLE patients(TLE group)and 34 healthy controls(control group)were prospectively enrolled.Brain 3D-T1WI was collected,brain regions were delineated with automated segmentation technique,and hippocampus was segmented additionally with hippocampal brain template(HBT).The volume of brain regions were compared between groups,and the correlation of brain region volume with Montreal cognitive assessment(MoCA)score were analyzed.Results Compared with control group,in TLE group,bilateral cerebrum white matter,right globus pallidus,left posterior cingulate gyrus,left precentral gyrus,right fusiform gyrus,left cerebellum white matter,corpus callosum,left hippocampus(HBT segmentation and conventional segmentation)and right thalamus volumes decreased significantly(all P＜0.05),while right choroid plexus volume increased significantly(P＜0.05).The volume of left hippocampus(HBT segmentation)and right fusiform gyrus were both positively correlated with MoCA score in TLE group(r=0.335,0.376,P=0.009,0.007).Conclusion Widespread atrophy of brain regions could be seen in TLE patients,which were correlated with cognitive function.

Aim To investigate the role of corylin in angiotensin Ⅱ(Ang Ⅱ)-induced cardiomyocyte hy-pertrophy and its underlying mechanisms.Methods An Ang Ⅱ-induced cardiomyocyte hypertrophy model was established and treated with corylin.Real-time PCR was employed to assess hypertrophic gene mRNA expression,and immunofluorescence was used to meas-ure cardiomyocyte surface area.Western blot and en-zyme activity assay kits were used to evaluate SIRT1 expression and activity.Results Corylin markedly mitigated Ang Ⅱ-induced hypertrophic gene expression and cardiomyocyte surface area enlargement.Moreo-ver,it prevented the Ang Ⅱ-mediated decline in SIRT1 protein levels and deacetylase activity.Further investi-gation indicated that corylin inhibited Ang Ⅱ-driven NF-κB transcriptional activity and the expression of its downstream target genes,such as TNF-α,IL-6,and IL-1β.Notably,SIRT1 silencing abolished the protective effects of corylin against cardiomyocyte hypertrophy,as well as its regulation of the SIRT1/NF-κB signaling pathway.Conclusion Corylin suppresses cardiomyo-cyte hypertrophy by modulating the SIRT1-dependent NF-κB signaling pathway.

Aim To investigate the effect of cordycepin(COR)on gentamicin(GEN)-induced nephrotoxicity and the molecular mechanism of inhibiting oxidative stress and ferroptosis induced by GEN.Methods The oral SD rats were divided into a control group,GEN group,and GEN+COR group.Following the success-ful setting up of the animal model,the serum creatinine(CR)and urea nitrogen(BUN)levels of rats were measured,and renal tissue injury was assessed using HE staining.In addition,the contents of malondialde-hyde and glutathione in kidney tissues of SD rats in each group were detected,and the expressions of fer-roptosis markers GPX4 and SLC7A11 were analyzed by Western blot.Results Compared with the control group,CR and BUN in GEN-stimulated group signifi-cantly increased(P＜0.01),and the level of CR and BUN was effectively reduced after 50 mg·kg-1 COR oral administration.HE results also showed that COR could alleviate the kidney tissue damage caused by GEN.COR could reverse the increase of malondialde-hyde level and the decrease of glutathione level caused by GEN in rat kidney tissue,and COR could restore the decrease of GPX4 and SLC7A11 protein levels induced by GEN.Conclusion COR can reduce GEN-induced kidney injury by inhibiting oxidative stress and ferrop-tosis.

Objective:To observe and compare the application of different scanning fields of view (FOV) in cone beam CT (CBCT) imaging of the temporomandibular joint (TMJ), and to explore the advantages and disadvantages of different CBCT scanning FOV for TMJ imaging. The aim is to provide a reference for the rational selection of CBCT scanning FOV for TMJ imaging in clinical practice.Methods:A total of 46 patients with temporomandibular disorders [22 males, 24 females; median age 24.5 years (range from 12 to 84 years)] were enrolled from the Department of Stomatology,the First Medical Centre, Chinese PLA General Hospital, between January 2023 and January 2025. All patients underwent CBCT scanning of the temporomandibular joints with both large and small fields of view using the same CBCT device, Newtom 5G (QR S.r.l, Italy), including small-field-of-view (sFOV 6 cm×6 cm, 46 cases, 92 sides) and large-field-of-view (lFOV 15 cm×12 cm for 26 cases with 52 sides or 18 cm×16 cm for 20 cases with 40 sides). A self-matched design was used to compare imaging parameters (scan time, exposure time, reconstruction voxel, radiation dose, data volume), image quality, and lesion detection efficacy (articular surface flattening, surface erosion, osteophyte, subcortical sclerosis, subcortical cyst, intra-articular calcification). Additionally, differences in joint spaces, condylar head height, and condylar height were analyzed.Results:In the sFOV group, scan time (72 s vs. 24 s) and exposure time (14.6 s vs. 4.8 s) were significantly longer than those in the lFOV group, with smaller reconstruction voxels (0.15 mm vs. 0.3 mm). Radiation dose in the sFOV group [(199.94±5.52) mGy·cm] was significantly higher than that in the lFOV 15 cm×12 cm subgroup [(96.20±25.34) mGy·cm, t=-20.29, P<0.001] and the 18 cm×16 cm subgroup [(101.73±13.49) mGy·cm, t=-31.34, P<0.001]. In terms of data volume, the sFOV group [(274.18±1.74) MB] was larger than the lFOV 15 cm×12 cm subgroup [(208.83±20.13) MB, t=-16.75, P<0.001], while the lFOV 18 cm×16 cm subgroup [(386.39±1.63) MB] was significantly larger than the sFOV group [(274.83±1.78) MB, t=214.49, P<0.001]. sFOV images showed clearer anatomical margins, distinguishable trabecular bone, and fewer artifacts. The detection rate of subcortical cyst in the sFOV group (50.0%, 46/92) was significantly higher than that in the lFOV group (36.96%, 34/92, χ2=5.61, P=0.018), with a moderate agreement Kappa coefficient of 0.48. Detection rates of articular surface flattening (80.43%, 74/92) and osteophyte (55.43%, 51/92) were identical between groups, with a perfect agreement Kappa coefficient of 1. Detection rates of subcortical sclerosis (69.57% vs. 68.48%) and intra-articular calcification (5.43% vs. 4.34%) were slightly higher in sFOV but without statistical significance ( P>0.05), with high Kappa coefficients of 0.93 and 0.88, respectively. For subcortical erosion, sFOV detection rate (38.04%, 35/92) was higher than lFOV (26.09%, 24/92, Kappa=0.53, moderate agreement), with no significant difference in detection rate (χ2=2.97, P=0.085). There were no statistical differences in joint space or condylar head height measurements between groups ( P>0.05), but condylar height measurements in the sFOV group were significantly greater than those in the lFOV group ( t=4.52, P<0.001). Conclusions:Large FOV provides wide anatomical coverage, optimizes radiation dose and data processing efficiency, and is more convenient for quantitative TMJ measurements.Small FOV offers superior resolution for displaying subtle condylar structures and lesions.Clinically, the choice of scan field should be individualized based on examination objectives (large FOV for holistic assessment/quantitative analysis; small FOV for early bone lesion diagnosis), equipment performance, and patient characteristics.

Objective:To compare minimally invasive surgery with traditional open surgery, analyze the current application status of health economic evaluations in the treatment of digestive tract cancers, such as esophageal cancer, gastric cancer, and colorectal cancer by minimally invasive surgery and provide evidence for the rational selection of clinical treatment, alleviation of disease-related economic burdens, and rational allocation of healthcare resources.Methods:By using five databases, i.e. China National Knowledge Infrastructure, Wanfang data, Chinese Biomedical Literature Database, PubMed, and Embase, a database was established to retrieve all the papers about health economic studies of minimally invasive surgery for esophageal cancer, gastric cancer, and colorectal cancer published until December 31, 2023. Literature was analyzed by using software NoteExpress 3.8, and data were processed using Excel 2021. The quality of included papers was evaluated using the CHEERS 2022 checklist, and Meta-analysis was conducted by using software Stata 17.0.Results:A total of 10 919 relevant papers were retrieved, and 59 studies were included. Only 14 studies (23.7%) used standard health economic evaluation methods. Meta-analysis results revealed no significant differences in direct medical expenditure and total expenditure between minimally invasive surgery and open surgery. However, the expenditure for minimally invasive surgery exhibited a significant increase [mean difference ( MD)=5 973.12 yuan, P<0.001], while hospital stay and indirect expenditure significantly decreased ( MD: -4.85 days and -733.79 yuan, P<0.001). In China, for gastric cancer, the direct medical expenditure of endoscopic surgery was lower than that of open surgery ( MD=-33 000.00 yuan) with no significant difference ( P<0.001). In colorectal cancer cases, the direct medical and surgical expenditures for laparoscopic surgery were higher than those for open surgery ( MD: 4 277.94 yuan and 4 267.80 yuan, P<0.001), while the indirect and total medical expenditures decreased ( MD: -768.34 yuan and -159.10 yuan). Hospital stays in patients who had minimally invasive surgery for all three types of cancer were shorter than those who had open surgery ( P<0.001). Conclusions:In the treatment of gastrointestinal cancer, compared with open surgery, minimally invasive surgery shows higher expenditure, but has advantages, such as shorter hospital stay and lower indirect expenditure, and there were no significant differences in direct medical and total expenditures between the two approaches. When conducting health economic evaluation, factors such as postoperative complications, hospital stay, and patient's economic status should be considered for their impact on total medical expenditure. It is necessary to pay attention to the application of health economic evaluations in healthcare decision-making.

Objective:To investigate disease characteristics of patients with psoriatic arthritis (PsA) based on the PsA cohort in West China Hospital, so as to provide a reference for clinicians in its diagnosis, treatment, and evaluation strategy formulation.Methods:A cross-sectional study was carried out, and a descriptive analysis was conducted on clinical data from PsA patients who were treated at the Department of Dermatology, West China Hospital, Sichuan University between April 2, 2020, and January 21, 2025. Demographic characteristics, clinical manifestations, laboratory and imaging findings, and treatment modalities were analyzed.Results:A total of 530 PsA patients were included, of whom 332 (62.6%) were males and 198 (37.4%) were females, with ages of 44.1 ± 12.4 years. Skin lesions preceded joint symptoms in 452 patients (85.3%), with time intervals ( M [ Q1, Q3]) of 8.0 (3.0, 15.0) years. Overweight or obesity was observed in 319 patients (60.2%), and 188 (35.5%) had comorbid fatty liver. Peripheral joint involvement was common (485 cases, 91.5%), with the proximal interphalangeal joints being most frequently affected by tenderness (172 cases, 35.5%) and swelling (119 cases, 24.5%) ; the number of enthesitis cases identified by ultrasonography (116 cases, 23.9%) was significantly higher than that by clinical examination (82 cases, 15.5%) ; axial joint involvement was observed in 258 patients (48.7%), with the sacroiliac joints most commonly affected (201 cases, 77.9%). Regarding treatment, conventional systemic drugs were predominant in the treatment of psoriasis prior to the diagnosis of PsA; after the diagnosis of PsA, the number of patients receiving targeted therapies increased to 334 (63.0%), with interleukin-17 inhibitors being the most common (140 cases, 26.4%), followed by tumor necrosis factor-α inhibitors (106 cases, 20.0%) and Janus kinase inhibitors (39 cases, 7.4%) . Conclusions:PsA predominantly affects males over 40 years old and is characterized by preceding skin lesions, delayed diagnosis, and multiple comorbidities. High-frequency ultrasound has advantages in the early detection of peripheral enthesitis. Further attention is needed for managing comorbidities such as fatty liver and obesity-related metabolic conditions.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective:To observe and compare the application of different scanning fields of view (FOV) in cone beam CT (CBCT) imaging of the temporomandibular joint (TMJ), and to explore the advantages and disadvantages of different CBCT scanning FOV for TMJ imaging. The aim is to provide a reference for the rational selection of CBCT scanning FOV for TMJ imaging in clinical practice.Methods:A total of 46 patients with temporomandibular disorders [22 males, 24 females; median age 24.5 years (range from 12 to 84 years)] were enrolled from the Department of Stomatology,the First Medical Centre, Chinese PLA General Hospital, between January 2023 and January 2025. All patients underwent CBCT scanning of the temporomandibular joints with both large and small fields of view using the same CBCT device, Newtom 5G (QR S.r.l, Italy), including small-field-of-view (sFOV 6 cm×6 cm, 46 cases, 92 sides) and large-field-of-view (lFOV 15 cm×12 cm for 26 cases with 52 sides or 18 cm×16 cm for 20 cases with 40 sides). A self-matched design was used to compare imaging parameters (scan time, exposure time, reconstruction voxel, radiation dose, data volume), image quality, and lesion detection efficacy (articular surface flattening, surface erosion, osteophyte, subcortical sclerosis, subcortical cyst, intra-articular calcification). Additionally, differences in joint spaces, condylar head height, and condylar height were analyzed.Results:In the sFOV group, scan time (72 s vs. 24 s) and exposure time (14.6 s vs. 4.8 s) were significantly longer than those in the lFOV group, with smaller reconstruction voxels (0.15 mm vs. 0.3 mm). Radiation dose in the sFOV group [(199.94±5.52) mGy·cm] was significantly higher than that in the lFOV 15 cm×12 cm subgroup [(96.20±25.34) mGy·cm, t=-20.29, P<0.001] and the 18 cm×16 cm subgroup [(101.73±13.49) mGy·cm, t=-31.34, P<0.001]. In terms of data volume, the sFOV group [(274.18±1.74) MB] was larger than the lFOV 15 cm×12 cm subgroup [(208.83±20.13) MB, t=-16.75, P<0.001], while the lFOV 18 cm×16 cm subgroup [(386.39±1.63) MB] was significantly larger than the sFOV group [(274.83±1.78) MB, t=214.49, P<0.001]. sFOV images showed clearer anatomical margins, distinguishable trabecular bone, and fewer artifacts. The detection rate of subcortical cyst in the sFOV group (50.0%, 46/92) was significantly higher than that in the lFOV group (36.96%, 34/92, χ2=5.61, P=0.018), with a moderate agreement Kappa coefficient of 0.48. Detection rates of articular surface flattening (80.43%, 74/92) and osteophyte (55.43%, 51/92) were identical between groups, with a perfect agreement Kappa coefficient of 1. Detection rates of subcortical sclerosis (69.57% vs. 68.48%) and intra-articular calcification (5.43% vs. 4.34%) were slightly higher in sFOV but without statistical significance ( P>0.05), with high Kappa coefficients of 0.93 and 0.88, respectively. For subcortical erosion, sFOV detection rate (38.04%, 35/92) was higher than lFOV (26.09%, 24/92, Kappa=0.53, moderate agreement), with no significant difference in detection rate (χ2=2.97, P=0.085). There were no statistical differences in joint space or condylar head height measurements between groups ( P>0.05), but condylar height measurements in the sFOV group were significantly greater than those in the lFOV group ( t=4.52, P<0.001). Conclusions:Large FOV provides wide anatomical coverage, optimizes radiation dose and data processing efficiency, and is more convenient for quantitative TMJ measurements.Small FOV offers superior resolution for displaying subtle condylar structures and lesions.Clinically, the choice of scan field should be individualized based on examination objectives (large FOV for holistic assessment/quantitative analysis; small FOV for early bone lesion diagnosis), equipment performance, and patient characteristics.

Objective:To compare minimally invasive surgery with traditional open surgery, analyze the current application status of health economic evaluations in the treatment of digestive tract cancers, such as esophageal cancer, gastric cancer, and colorectal cancer by minimally invasive surgery and provide evidence for the rational selection of clinical treatment, alleviation of disease-related economic burdens, and rational allocation of healthcare resources.Methods:By using five databases, i.e. China National Knowledge Infrastructure, Wanfang data, Chinese Biomedical Literature Database, PubMed, and Embase, a database was established to retrieve all the papers about health economic studies of minimally invasive surgery for esophageal cancer, gastric cancer, and colorectal cancer published until December 31, 2023. Literature was analyzed by using software NoteExpress 3.8, and data were processed using Excel 2021. The quality of included papers was evaluated using the CHEERS 2022 checklist, and Meta-analysis was conducted by using software Stata 17.0.Results:A total of 10 919 relevant papers were retrieved, and 59 studies were included. Only 14 studies (23.7%) used standard health economic evaluation methods. Meta-analysis results revealed no significant differences in direct medical expenditure and total expenditure between minimally invasive surgery and open surgery. However, the expenditure for minimally invasive surgery exhibited a significant increase [mean difference ( MD)=5 973.12 yuan, P<0.001], while hospital stay and indirect expenditure significantly decreased ( MD: -4.85 days and -733.79 yuan, P<0.001). In China, for gastric cancer, the direct medical expenditure of endoscopic surgery was lower than that of open surgery ( MD=-33 000.00 yuan) with no significant difference ( P<0.001). In colorectal cancer cases, the direct medical and surgical expenditures for laparoscopic surgery were higher than those for open surgery ( MD: 4 277.94 yuan and 4 267.80 yuan, P<0.001), while the indirect and total medical expenditures decreased ( MD: -768.34 yuan and -159.10 yuan). Hospital stays in patients who had minimally invasive surgery for all three types of cancer were shorter than those who had open surgery ( P<0.001). Conclusions:In the treatment of gastrointestinal cancer, compared with open surgery, minimally invasive surgery shows higher expenditure, but has advantages, such as shorter hospital stay and lower indirect expenditure, and there were no significant differences in direct medical and total expenditures between the two approaches. When conducting health economic evaluation, factors such as postoperative complications, hospital stay, and patient's economic status should be considered for their impact on total medical expenditure. It is necessary to pay attention to the application of health economic evaluations in healthcare decision-making.