Objective To investigate the correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2)level and cerebral blood supply and prognosis in patients with aneurysm al subarachnoid hemorrhage(aSAH).Methods 150 patients with aSAH admitted to our hospital from January 2021 to December 2023 were selected retrospectively as the observation group(150 cases),and 65 healthy people in our hospital were selected as the control group(65 cases)during the same period.Pearson correlation coefficient was used to analyze the correlation between serum NOX2 level and blood flow velocity of middle cerebral artery(MCA)and anterior cerebral artery(ACA).After 90 days of follow-up,according to the prognosis of aSAH patients,they were divided into good prognosis group(98 cases)and poor prognosis group(52 cases).Multivariate Logistic regression was used to analyze the related factors of poor prognosis in aSAH patients,and ROC curve was drawn to analyze the predictive efficacy of related factors.Results The serum NOX2 of the observation group and the control group were(2 185.20±231.15)pg/ml and(1 025.31±98.24)pg/ml,the Vm of MCA was(64.30±8.22)cm/s and(89.16±9.14)cm/s,and the Vm of ACA was(39.20±3.04)cm/s and(51.03±9.35)cm/s,respectively.The difference between the two groups was statistically significant(P＜0.05).Pearsoni correlation coefficient analysis showed that the serum NOX2 level of aSAH patients was negatively correlated with the Vm of MCA and ACA(r=-0.512/-0.219,P＜0.05).The WBC of the poor prognosis group and the good prognosis group were(9.96±2.76)×10 9/L and(8.35±2.51)× 10 9/L,the blood sugar level was(8.16±2.05)mmol/L and(7.18±1.89)mmol/L,the NOX2 level was(2 278.30±215.26)pg/ml and(1 985.36±221.34)pg/ml,the improved Fisher score was(3.02±0.98)and(2.12±0.61),the WFNS score was(4.01±0.84)and(2.16±0.72),and the proportion of acute hydrocephalus was 25.00％and 9.18％,respectively.The difference between the two groups was statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that NOX2 level(OR=1.008)and improved Fisher score(OR=6.329)were independent risk factors for poor prognosis of aSAH patients(P＜0.05).The ROC curve shows that the NOX2 level and the area under curve(AUC)of the improved Fisher score are 0.844(95％CI:0.776-0.898)and 0.691(95％CI:0.611-0.764)respectively.Conclusion aSAH patients have higher serum NOX2 level,which is closely related to the blood supply of brain tissue.Serum NOX2 level and improved Fisher score are independent risk factors for poor prognosis of patients with aS AH,and serum NOX2 level has better predictive efficacy,which needs to be used as an effective index to predict poor prognosis of patients with aSAH.

Objective To investigate the correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2)level and cerebral blood supply and prognosis in patients with aneurysm al subarachnoid hemorrhage(aSAH).Methods 150 patients with aSAH admitted to our hospital from January 2021 to December 2023 were selected retrospectively as the observation group(150 cases),and 65 healthy people in our hospital were selected as the control group(65 cases)during the same period.Pearson correlation coefficient was used to analyze the correlation between serum NOX2 level and blood flow velocity of middle cerebral artery(MCA)and anterior cerebral artery(ACA).After 90 days of follow-up,according to the prognosis of aSAH patients,they were divided into good prognosis group(98 cases)and poor prognosis group(52 cases).Multivariate Logistic regression was used to analyze the related factors of poor prognosis in aSAH patients,and ROC curve was drawn to analyze the predictive efficacy of related factors.Results The serum NOX2 of the observation group and the control group were(2 185.20±231.15)pg/ml and(1 025.31±98.24)pg/ml,the Vm of MCA was(64.30±8.22)cm/s and(89.16±9.14)cm/s,and the Vm of ACA was(39.20±3.04)cm/s and(51.03±9.35)cm/s,respectively.The difference between the two groups was statistically significant(P＜0.05).Pearsoni correlation coefficient analysis showed that the serum NOX2 level of aSAH patients was negatively correlated with the Vm of MCA and ACA(r=-0.512/-0.219,P＜0.05).The WBC of the poor prognosis group and the good prognosis group were(9.96±2.76)×10 9/L and(8.35±2.51)× 10 9/L,the blood sugar level was(8.16±2.05)mmol/L and(7.18±1.89)mmol/L,the NOX2 level was(2 278.30±215.26)pg/ml and(1 985.36±221.34)pg/ml,the improved Fisher score was(3.02±0.98)and(2.12±0.61),the WFNS score was(4.01±0.84)and(2.16±0.72),and the proportion of acute hydrocephalus was 25.00％and 9.18％,respectively.The difference between the two groups was statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that NOX2 level(OR=1.008)and improved Fisher score(OR=6.329)were independent risk factors for poor prognosis of aSAH patients(P＜0.05).The ROC curve shows that the NOX2 level and the area under curve(AUC)of the improved Fisher score are 0.844(95％CI:0.776-0.898)and 0.691(95％CI:0.611-0.764)respectively.Conclusion aSAH patients have higher serum NOX2 level,which is closely related to the blood supply of brain tissue.Serum NOX2 level and improved Fisher score are independent risk factors for poor prognosis of patients with aS AH,and serum NOX2 level has better predictive efficacy,which needs to be used as an effective index to predict poor prognosis of patients with aSAH.

Objective:To report single-center clinical experience with endovascular recanalization for non-acute symptomatic intracranial vertebral artery occlusion, to assess the feasibility and safety of endovascular recanalization and to propose the benefit group for selected patients.Methods:From January 2019 to December 2021, 92 patients with non-acute symptomatic intracranial vertebral artery occlusion who underwent endovascular recanalization were retrospectively analyzed. The patients were divided into three groups (low, medium and high-risk group) according to occlusion length, occlusion duration, occlusion nature, calcification of the occlusion segment, and occlusion angulation, and the indicators of patients in each group were analyzed, including the general baseline data of the patients, surgical status and follow-up results. The technical success and perioperative complication rates of low, medium and high-risk groups were calculated. Meanwhile, the differences between three groups were evaluated using the χ2 test for trend or ANOVA analysis. Results:The overall technical success rate of endovascular recanalization was 83.7% (77/92), and the perioperative complication rate was 10.9% (10/92). Among the 3 classification groups, the recanalization success rate from the low-risk group to the high-risk group was 100%, 93.3%, 27.8%( P=0.047), and gradually decreased; while the overall perioperative complication rate was 0, 10.0%, 38.9% ( P=0.001), and gradually increased; the proportion of 90-day mRS score 0-2 was 100%, 83.3%, 22.2% ( P=0.026), and progressively decreased; 77 patients with successful recanalization were followed up, the rate of restenosis/reocclusion was 0, 17.9%, 80.0%( P=0.001), and progressively increased. Patients in the low-and intermediate-risk groups performed well with endovascular recanalization. In 88 patients (4 patients lost to follow-up), a median clinical follow-up of 13 (7, 16) months, stroke or death beyond 30 days was 17.4% (16/92). Conclusions:Endovascular recanalization is safe and feasible for reasonably selected patients with non-acute symptomatic intracranial vertebral artery occlusion, especially in low-and medium-risk groups, and it also provides an alternative to conservative therapy for patients with non-acute symptomatic intracranial vertebral artery occlusion.

Objective:Based on single-center clinical results of endovascular recanalization for symptomatic non-acute internal carotid artery occlusion (ICAO), a new patient classification method is proposed to distinguish the most suitable ICAO patient subgroups for endovascular recanalization.Methods:A total of 140 patients with symptomatic non-acute ICAO accepted endovascular recanalization in Department of Cerebrovascular Intervention, He'nan Provincial People's Hospital from January 2019 to December 2021 were selected. These patients were divided into low risk group ( n=57), medium risk group ( n=54) and high risk group ( n=29) according to the occlusion segments, occlusion times, plaque features, calcification at the occlusion site and occlusion segment angulation. The immediate postoperative recanalization rate, perioperative complications, perioperative death, and prognoses 90 d after endovascular recanalization (modified Rankin scale scores of 0-2 as good prognosis) were evaluated in the 3 groups. Results:The immediate postoperative recanalization rate was 82.9% (114/140), perioperative complication rate was 11.4% (16/140), and perioperative mortality was 0.7% (1/140). The success recanalization rate decreased gradually from the low risk group to the high risk group (100%, 85.2%, and 37.9%), while the perioperative complication rate was the opposite (0%, 11.1%, and 34.5%), with significant differences ( P<0.05). Ninety d after endovascular recanalization, 109 patients had good prognosis and 27 had poor prognosis; the good prognosis rate in low risk group, medium risk group and high risk group was 98.2%, 79.6% and 34.5%, respectively, with significant differences ( P<0.05). The vascular restenosis rate in low risk group, medium risk group and high risk group was 0%, 8.7% and 18.2%, and re-occlusion rate was 0%, 6.5% and 27.2%, respectively, 90 d after endovascular recanalization, with significant differences ( P<0.05). Conclusion:Endovascular recanalization is technically feasible for patients with symptomatic non-acute ICAO, especially those met the criterions of low and medium risk groups in our study.

Objective To use evidence-based nursing on patients with artificial airway to the practice of stomach tube, and to evaluate the self made guidance for difficult gastric tube placement in patients with artificial airway.Methods Forty patients with artificial airway and were difficult to put the tube, and admitted to Department of Critical Care Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from April to December in 2016 were enrolled as observation group. Through the evidence-based nursing strategy, the related literatures at home and abroad were collected to search clinical evidence and formulate and implement the nursing program, the gastric tube was inserted into the stomach tube under the direct vision of the laryngoscope. Thirty-six patients of difficult gastric tube placement with artificial airway straightly under the direct vision of the laryngoscope from August 2015 to March 2016 were retrospectively analyzed as the control group. The success rate of first catheterization, indwelling time, throat edema and bleeding of pharyngeal mucosa were compared between the two groups.Results All patients were enrolled in the final analysis. In the control group, 28 patients were successfully placed once, while 8 failed. Only 1 patient in observation group failed to catheterize, and successful placed after symptomatic treatment, the one-time success rate of catheter was significantly higher than that of control group (97.5% vs. 77.8%), and catheter time was significantly shortened (minutes: 4.8±1.2 vs. 5.1±1.0), the difference was statistically significant (bothP < 0.05). There were 2 patients with laryngeal edema in the control group and 4 patients of pharyngeal mucosal hemorrhage. In the observation group, there was no laryngealedema and laryngeal edema occurred in the patients with laryngoscopy, and only 1 patient had a hemorrhage of pharyngeal mucosa.Conclusion Using self made guiding device can effectively insert the difficult gastric tube in patients with artificial airway, and increase the one-time success rate of intubation, shorten the catheter time, and have a trend in reduce complication as compared with traditional gastric tube placement.

Objective To explore suitable stomach intubation methods for patients with cerebral hemorrhage coma. Methods A total of 120 cases of cerebral hemorrhage coma patients treated in Harrison International Peace Hospital Affiliated to Hebei Medical University from January 2016 to June 2017 were selected and divided into 3 groups using random number table. Patients in 3 groups were applied with different stomach intubation methods. Group A used the conventional method; group B used the laryngoscope to direct the tube placement; group C used homemade guiding catheter. One-time success rates of catheter, incidence of adverse reactions and catheter time were compared between groups to explore reasonable methods for patients with cerebral hemorrhage coma. Results The one-time success rate of catheter of group C was higher than that of group B and group A; the difference was statistically significant (P<0.01). The incidence of adverse reactions in group C was lower compared with group A and group B (P<0.01), and catheter time of group C was shorter than that in group A and group B (P< 0.01). Conclusions Application of homemade guiding device in stomach intubation has a high success rate, can shorten the time of indwelling, and reduce the incidence of adverse reactions, so it is suitable for patients with intracerebral hemorrhage coma.

Objective To investigate whether rat grimace scale (RGS)could be used to assess pain in chronic pancreatitis,so as to provide evidence for pain research and clinical assessment of rat pain.Methods Twenty-eight adult male wister rats were evenly randomized into two groups (n =14):an experimental group and a control group.The experimental group was intravenously given 8 mg/kg body weight dibutyltin dichloride (DBTC)to induce chronic pancreatitis,and the control group was injected with ethanol and glycerin solution.Abdominal hypersensitivity,RGS scores and weight at different time points was detected.HE staining was used to detect the histological changes of pancre-atic tissue.Results Compared with the control group,the rats in the experimental group showed chro-nic inflammation in pancreatic tissue in two weeks.There was a significant increase in the number of abdominal withdrawals (P < 0.001 )and RGS in the experimental group.Conclusion Rat grimace scale might lead to a successful transition of basic science findings into clinical application.

Two hundred and sixty-one subjects were recruited from in-patients and subjects for phaysical Check-up,and were divided into normal control group (NC),nonalcoholic fatty liver disease group (NAFLD),type 2 diabetes mellitus group (T2DM),and T2DM accompanied by NAFLD group (DMN).According to the result of ultrasonic examination,the patients with T2DM were further divided into non-NAFLD group,light fatty liver group (NAFLD-L group),moderate fatty liver group(NAFLD-M group),and severe fatty liver(NAFLD-S group).Fasting plasma glucose,blood lipid,liver function,kidney function,and serum retinol-binding protein 4 (RBP4) levels were determined.The risk of various indicators for NAFLD was determined by correlation analysis and logistic regression analysis.The results showed that fasting glucose levels in diabetics with or without NAFLD were significantly higher than those in NC and NAFLD groups(P＜0.01).Triglyceride (TG) level in DMN group was significantly higher than those in other three groups(all P＜0.01),while high density lipoprotein-cholesterol level was lower than those in other three groups(all P＜0.01).Systolic blood pressure and diastolic blood pressure in DMN group were higher than those in NC and T2DM groups (P＜0.05 or P＜0.01).Serum RBP4 level in patients with NAFLD was significantly higher compared with the subjects without NAFLD [45.00 (38.75,51.00) mg/L vs 51.00 (43.00,62.00) mg/L,P ＜0.01],and was rising with the progress of NAFLD [NAFLD-L group 44.00 (37.00,51.00) mg/L,NAFLD-M group 52.00(46.00,63.00) mg/L,and NAFLD-S group 78.5 (72.75,83.00) mg/L,all P＜0.01].Logistic regression analysis showed that the RBP4 level was an independent factor associated with NAFLD (P =0.029).In addition,serum RBP4 level was correlated with body mass index,waist-to-hip ratio,serum gamma-glutamyl transpeptidase,total cholesterol,TG,aspartate aminotransferase,alanine aminotransferase,prealbumin,creatinine,blood urea nitrogen,and uric acid.These resuhs suggest that serum RBP4 is an independent risk factor of NAFLD.

Objective To investigate the effect of early coronary artery bypass grafting (CABG)to the left ventricular wall motion state and the significance of CABG to awake hibernating myocardial in dogs with acute myocardial infarction.Methods The anterior descending coronary of all thirty dogs were ligated into MI model.According to the operation date,the experimental groups included the 1 st week (n =6),the 2nd week (n =4),the 4th week (n =6) and the 6th week (n =6) CABG,and established control group (n =2) for every experimental group.Operators marked hibernate myocardial and determined the room wall motion score by means of dobutamine ultrasound load test (DSE) combining with tissue doppler imaging (DTI)technology before CABG and after eight weeks CABG through thoracotomy surgery for the experimental group and the control group.Every dog was executed and detected the area of MI.Results Four dogs of experimental group and all dogs of control group survived to the end of the study.The change of ventricular room wall motion score in the 1st and the 2nd week CABG was smaller than that in the 4th and the 6th week CABG and MI group(0.03 ±0.06,0.05 ±0.09,0.23 ±0.08,0.27 ±40.06,0.32 ±0.05,P ＜0.05).The change of room wall motion score in all CABG groups was smaller than that in MI group(1.195 ±0.09,1.25 ±0.18,1.30 ±0.18,1.36 ±0.11,1.65 ±0.17,P＜0.05).The hibernate myocardial were more awaken in all CABG groups than that in MI group (0.27 ± 0.12,0.22 ± 0.04,0.31 ± 0.09,0.23 ± 0.03,0.03 ± 0.04,P ＜ 0.05).The area of MI became smaller in 1 and 2 weeks CABG than that in 4 and 6 weeks CABG and MI group(20.75 ± 2.63,21.25 ± 2.5,27.25 ± 1.71,27.75 ± 2.22,P ＜ 0.05).Conclusions Early CABG surgery for dogs acute MI could improve the ventricular room wall motion obviously and wake up more hibernate myocardial.Especially,CABG surgery among two weeks could lessen the effect of MI to the ventricular room wall motion and reduce the scope of myocardial infarction maximatily.

OBJECTIVE: To explore the treatment effect of selective neurotomy of anterior ethmoid nerve and squeezing operation of inferior turbinate in the treatment of perennial allergic rhinitis (PAR). METHOD: Seventy cases of perennial allergic rhinitis were selected and subjected to selective neurotomy of anterior ethmoid nerve and squeezing operation of inferior turbinate,and the treatment effect was observed by analysis of the the symptoms and signs score of all cases preoperatively and postoperatively. RESULT: The total effective rate were 90.0% at 1 year follow-up. CONCLUSION Selective neurotomy of anterior ethmoid nerve and squeezing operation of inferior turbinate were effective for the patients with PAR. It is worthy to be popularized for its convent and rare complications.
Adolescent ; Adult ; Denervation ; methods ; Ethmoid Bone ; innervation ; Female ; Humans ; Male ; Middle Aged ; Rhinitis, Allergic, Perennial ; surgery ; Turbinates ; surgery ; Young Adult