Alzheimer's disease(AD), a neurodegenerative disorder associated with aging, is the most prevalent form of dementia.As the aging population continues to expand, AD presents significant health and caregiving challenges for families and society, making it a pressing international public health concern.In recent years, numerous countries have implemented dementia prevention and treatment strategies that emphasize community-based comprehensive approaches.Currently, the community-based AD prevention and treatment model in China is still in the exploratory phase, with community efforts lacking organization.In alignment with China's action plan for advancing dementia prevention and treatment, and to achieve the strategic objective of "healthy aging, " this consensus is based on the principle of three-level prevention and is tailored to the characteristics of AD disease progression.It aims to develop a comprehensive prevention and treatment strategy for AD that is suitable for communities in China, providing technical guidance and support to establish a scientific basis for formulating community AD prevention and treatment models.

Objective To investigate the MRI manifestations of ovarian serous surface papillary borderline tumor(SSPBT).Methods The data from 10 cases of ovarian SSPBT confirmed by surgical pathology were collected,with a median age of 28.5 years.Two radiologists analyzed the MRI manifestations and laboratory examination results of the lesions.Results Among the 10 patients,7 had bilateral ovarian involvement,with 14 lesions observed on MRI.All lesions were solid and cystic,12 lesions were adjacent to normal ovaries,12 lesions exhibited a flocculent or spongy appearance,and 10 lesions showed the"anemone sign".Contrast-enhanced scans revealed progressive moderate or marked enhancement,without lymphadenopathy or distant metastasis.Elevated serum CA125 levels were found in 8 patients.Conclusion Ovarian SSPBT have relatively characteristic imaging manifestations.Combining patient age,imaging manifestations,and laboratory examination results can often lead to an accurate diagnosis.

Recently, there has been a growing focus on investigating the influence of periodontitis on the aging population. There is epidemiological evidence that indicates periodontitis is associated with mortality, and it has been shown to accelerate the biological processes of aging. However, the precise mechanism by which periodontitis accelerates the process of the aging population remains to be elucidated. This paper reviews relevant research results and finds that periodontitis may be associated with accelerated aging and increased mortality through the following mechanisms: 1) the inflammatory mediators produced by periodontitis are released into the bloodstream and promote “inflammageing”, which accelerates aging through activation of the NF-κB signaling pathway and the senescence-associated secretory phenotype; 2) periodontal pathogens can promote the aging process in the following three ways: ① periodontal pathogens and bacterial products promote “inflammageing” through blood circulation, and they lead to abnormal changes in SIRT1 and mTOR, important aging markers in the blood, which induces mitochondrial dysfunction and accelerates aging; ② porphyromonas gingivalis overactivates the Akt/FoxO1 pathway to directly promote the aging of dendritic cells and produce exosomes that transmit and amplify paracrine immunosenescence; and ③ periodontal pathogens are ectopically colonized in the intestinal tract and lead to gut dysbiosis, thus indirectly accelerating the aging process.

Objective To investigate the MRI manifestations of ovarian serous surface papillary borderline tumor(SSPBT).Methods The data from 10 cases of ovarian SSPBT confirmed by surgical pathology were collected,with a median age of 28.5 years.Two radiologists analyzed the MRI manifestations and laboratory examination results of the lesions.Results Among the 10 patients,7 had bilateral ovarian involvement,with 14 lesions observed on MRI.All lesions were solid and cystic,12 lesions were adjacent to normal ovaries,12 lesions exhibited a flocculent or spongy appearance,and 10 lesions showed the"anemone sign".Contrast-enhanced scans revealed progressive moderate or marked enhancement,without lymphadenopathy or distant metastasis.Elevated serum CA125 levels were found in 8 patients.Conclusion Ovarian SSPBT have relatively characteristic imaging manifestations.Combining patient age,imaging manifestations,and laboratory examination results can often lead to an accurate diagnosis.

Alzheimer's disease(AD), a neurodegenerative disorder associated with aging, is the most prevalent form of dementia.As the aging population continues to expand, AD presents significant health and caregiving challenges for families and society, making it a pressing international public health concern.In recent years, numerous countries have implemented dementia prevention and treatment strategies that emphasize community-based comprehensive approaches.Currently, the community-based AD prevention and treatment model in China is still in the exploratory phase, with community efforts lacking organization.In alignment with China's action plan for advancing dementia prevention and treatment, and to achieve the strategic objective of "healthy aging, " this consensus is based on the principle of three-level prevention and is tailored to the characteristics of AD disease progression.It aims to develop a comprehensive prevention and treatment strategy for AD that is suitable for communities in China, providing technical guidance and support to establish a scientific basis for formulating community AD prevention and treatment models.

Objective To explore the application of Plan-Do-Check-Act(PDCA)cycle management to continuously im-prove the service quality of outpatient pharmacy and enhance patient satisfaction.Methods To address the problem of long wait-ing time for patients in outpatient pharmacy,we applied PDCA cycle to investigate the factors affecting patients'waiting time in the process of medicine collection,analyze the current situation,determine the expected goals,formulate the service quality im-provement plan of outpatient pharmacy,implement the improvement plan,follow up and supervise,and summarize and analyse the problems regularly until it was solved.Results After implementing the PDCA cycle in the management,the service quality of outpatient pharmacy was improved,the waiting time was significantly shortened and the satisfaction of medical treatment was in-creased.Conclusion The application of PDCA cycle method is effective in improving the service quality of outpatient pharmacy.Therefore,it is recommended for broader implementation.

Objective: To investigate the prevalence of metabolic disorder among the high school students in Guangzhou. Methods: A cross-sectional study among 4 620 high school students selected with stratified cluster sampling was conducted in Guangzhou. Height, weight, blood pressure, fasting plasma glucose (FPG) and serum lipid of TC, TG were measured. Household socioeconomic status, medical history, physical activities as well as personal diet and study habits were acquired with structured questionnaire. Results: The prevalence of central obesity was 11.5%. The overall prevalence of IFG and DM was 6.9%. The overall prevalence of both hypercholesteremia and hypertriglyceridemia was 13.4%. The prevalence of hypertension was 11.6%. With multivariable logistic regression, the results showed that: fast eating was associated with increased risk of central obesity (OR=1.79, 95%CI=1.47-2.18) and hypercholesteremia/hypertriglyceridemia (OR=1.27，95%CI=1.04-1.54). While students who ate slow had low risk of central obesity (OR=0.47, 95%CI=0.33-0.68), hypercholesteremia/hypertriglyceridemia(OR=0.71, 95%CI=0.54-0.94) and hypertension (OR=0.65, 95%CI=0.49-0.88). Students with sugar-sweetened beverages once a day or more had higher risk of central obesity (OR=1.60, 95%CI=1.08-2.38) while students without sugar-sweetened beverages consumption had low risk of IFG/DM (OR=0.57, 95%CI= 0.43-0.77) than those who consumed 1-2 times/week. Students without eating out habit had lower risk of hypercholesteremia /hypertriglyceridemia than those with eating out for 1-2 times/week (OR=0.78, 95%CI=0.62-0.98), and students who had lunch out of home or canteen had higher risk of hypercholesteremia /hypertriglyceridemia than those who ate at canteen (OR=1.38，95%CI=1.06-1.81). Conclusion The prevalence of metabolic disorder among high school students in Guangzhou is at a relatively high level. High eating speed, heavy sugared beverages intake and frequently eating out habits are associated with risk of metabolic disorder.

Objective: To explore the effect of reducing complication in branched spongiosum repair for hypospadias Duckett surgery. Methods: Retrospective analysis was performed for the clinical data of 140 surgical infants with hypospadias Duckett surgery from January 2016 to April 2018. According to different covering materials on newly formed urethra, the experimental group (68 cases) cut dysplasia, branched spongiosum and lateral Buck′s fascia from tunica albuginea to coronary groove and then sutured over newly formed urethra, and the control group (72 cases) used Dartos fascia or subcutaneous fascia. The operative age, penile curvature, length of urethral defect, operation time, added value of coronary groove before and after operation, maximum urinary flow rate and complication rate of postoperative follow-up were compared between the two groups, and the therapeutic effect was analyzed. Results: There was no statistically significant difference between two groups in operating time[(135±49)min vs.(135±45)min, P=0.580] and the value added of coronary sulcus[(0.1±0.2)cm vs.(0.1±0.1)cm, P=0.167]. In experimental group, there were 8 cases of urethra percutaneous fistula (11.8%) (coronary groove fistula in 3 cases, 4.4%)and 6 cases of urethral stenosis (8.8%) without urethral dehiscence. In control group, there were 18 cases of urethra percutaneous fistula (25.0%)(coronary groove fistula in 11 cases, 15.3%), 10 cases of urethral stenosis (13.9%), and 2 cases of urethral dehiscence (2.8%). The incidence of postoperative urinary fistula and total complications in experimental group was lower than that in the control group, and the difference was statistically significant (P<0.05), while the incidence of urethral stenosis was not statistically different between two groups (P>0.05). The maximum urine flow rate of experimental group at 6 months after surgery was significantly higher than control group[(9.5±3.8)ml/s vs.(6.8±2.8)ml/s], and the difference was statistically significant (P<0.001). Conclusions Urethral cavernosum reconstruction can significantly reduce the incidence of postoperative coronary groove fistula of hypospadias Duckett surgery and improve the postoperative urine flow rate.

Objective: To explore the effect of problem-based learning (PBL) health education and nursing mode on the occurrence of depression after primiparous women and its hormone levels. Methods: A total of 468 primiparas who were delivered were selected. The number of singular numbers in the order of hospitalization was the control group, and the double number was the experimental group, 234 cases each. The control group used the traditional obstetric care model, and the experimental group used PBL health education model. The Edinburgh Postnatal Depression Scale (EPDS) and Self-rating Anxiety Scale (SAS) scores were compared between the two groups of prenatal women, 7 days, 42 days, and 3 months postpartum. Estrogen, progesterone, and 5-e were also tested. Serotonin levels. Postpartum depression rates were compared between the two groups according to EPDS and SAS scores. At the same time, the satisfaction rate of women on the quality of care in the two groups was investigated. Results: The EPDS scores (8.3 ± 2.5), (9.0 ± 3.8), and (8.1 ± 2.2) points at 7 days, 42 days, and 3 months after birth were significantly lower in the experimental group than in the control group (9.8 ± 2.5), (11.1 ± 3.7), and (9.2 ± 2.1) points. The difference between the two groups was statistically significant (t =2.35, 1.76, 0.26, P < 0.01). The SAS scores (45.44±4.48), (49.28±3.59), and (38.16±4.45) points at 7 days, 42 days, and 3 months after birth were significantly lower in the experimental group than in the control group (51.69±4.93), (55.79±5.72), and (44.81±3.69) points. The difference was statistically significant (t =2.51, 3.65, 9.91, P < 0.01). There were 41 patients with post-production depression at 42 days postpartum, which was significantly higher than 13 patients in the experimental group. The difference was statistically significant (χ²=1.58, P<0.01). Maternal satisfaction in the experimental group was 96.15%(233/234), and in the control group was 89.32%(228/234), the difference was statistically significant (χ²=14.13, P<0.01). Estradiol levels (14 192.26±3 187.41), (2 954.44±326.16), (702.34±46.41) pmol/L at 7 days, 42 days and 3 months after birth were significantly higher in the experimental group than those in the control group (13 694.45±3 212.18), (2 316.16±391.22), (669.47 ± 53.25) pmol/L. The difference was statistically significant (t =5.16, 1.69, 4.26, P < 0.05). The serotonin levels (434.25±8.41), (315.05±12.35) ng/L at 42 days and 3 months after delivery were significantly higher in the experimental group than those in the control group (415.96±12.35), (308.15±11.35) ng/L. The difference was statistically significant (t=1.58, 3.25, P < 0.05). Progesterone levels (28.19±2.36), (8.25±0.98) µg/L at 42 days and 3 months after delivery were significantly lower in the experimental group than those in the control group (34.25±2.44), (9.69±1.25) µg/L. The difference was statistically significant (t =2.24, 5.16, P < 0.05). Conclusions PBL health education model can significantly reduce the risk of postpartum depression in primipara, regulate estrogen, progesterone and serotonin levels, and can be applied in obstetrics.

Objective To explore the clinical curative effects of non-weight-bearing area osteotomy of anterior lateral tibial condyle in treating posterior-lateral condyle fracture of tibial plateau.Methods A retrospective analysis was carried out on 24 cases of posterior-lateral condyle fracture of tibial plateau treated by osteotomy of anterior lateral tibial condyle in this hospital from December 2012 to December 2015,including 15 males and 9 females,aged 26-59 years old with an average age of 42.2 years old.Fracture Schatker classification:type Ⅱ in 16 cases,type Ⅴ in 3 cases and type Ⅵ in 5 cases.All 24 cases adopted surgical treatment via the approach of anterior lateral tibial condyle.During operation,the non-bearing area of lateral tibial condyle was cut to expose and reset the posterior-lateral fractured condyle and fix it with lateral raft steel plate.At the time of last follow-up,the recovery of the knee joint function was evaluated according to the knee scoring system of Hospital for Special Surgery (HSS) in USA.Results Twenty-four patients were postoperatively followed up for 12-24 months,with an average of 13.1 months.The Rasmussen score for the postoperative immediate fracture reduction quality averaged (17.3 ± 0.8)points;there were 19 cases of excellent results and 5 cases of good results,with the excellent and good rate of 100 ％.Twenty-four cases had no incision infection,no internal fixation loosening or breakage.The X ray film showed that the fracture got healing,and the average healing time was (13.1 ± 1.1) weeks(12-15 weeks).No surgery related complications including blood vessel and nerve damage occurred;2 cases appeared small area of superficial necrosis at the edge of the posterior incision,which was healed after dressing.At the last follow-up,the HSS knee score was(93.0±6.4) points,excellent in 19 cases,good in 4 cases,and fair in 1 case,with the excellent and good rate of 95.8％.Conclusion For the patients with posterior-lateral condyle fracture of tibial platform,non-weight-bearing area osteotomy approach of lateral tibial condyle allows enough space to directly expose the fracture area and carry out operation;combined with lateral raft locking steel plate fixation is more reliableto fixthe fractured bone,with convenient operation positioning,good postoperative functional recovery,fewer complications,and satisfied curative effects.