Objectives: Assessing healthcare quality at the national level is essential for evaluating health system performance and identifying areas requiring improvement. This study examined long-term trends in healthcare quality in Korea from 2008 to 2023 using internationally comparable indicators. Methods: We conducted a trend analysis of healthcare quality in Korea using the Organization for Economic Cooperation and Development (OECD) Health Care Quality and Outcomes framework and quality indicators. Indicators across multiple domains, including acute care, primary care, prescribing in primary care, mental healthcare, and patient experiences, were analyzed and compared with OECD averages. Results: Healthcare quality in Korea improved across several domains. Thirty-day mortality for acute myocardial infarction decreased from 14.2% in 2008 to 10.2% in 2023, while mortality for ischemic stroke declined from 8.7% to 5.5%. Avoidable hospitalizations decreased substantially, with hospitalizations for chronic obstructive pulmonary disease declining by 59.7%. The proportion of patients with diabetes receiving cholesterol-lowering treatment increased from 44.1% to 82.5%. However, the proportion of broad-spectrum antibiotic prescriptions remained substantially higher than the OECD average (40.3 vs. 15.5%). In mental healthcare, excess mortality ratios increased from 4.3 in 2010 to 4.9 in 2023 for schizophrenia and from 3.5 to 4.3 for bipolar disorder, while post-discharge suicide rates showed little improvement. Patient experience indicators related to patient-physician communication improved and approached OECD averages. Conclusions Healthcare quality in Korea improved substantially between 2008 and 2023, particularly in acute care outcomes and chronic disease management. However, persistent challenges remain in areas such as antibiotic use, polypharmacy, and mental healthcare. These findings provide internationally comparable evidence to inform future health policy and healthcare quality improvement efforts.

Melanin is a bio-pigment molecule synthesized by melanocytes. Its role is to shield the skin from ultraviolet radiation. Nonetheless, aberrant melanin production, whether excessive or deficient, can lead to conditions such as vitiligo, freckles, melanocytic nevi, and even melanoma. The biosynthetic pathway of melanin is known as melanogenesis, which is regulated by various transcription factors and enzymatic processes. Piperine (PPN), an alkaloid compound extracted from Piper retrofractum Vahl., was investigated for its potential anti-fungal and anti-inflammatory effects. Our hypothesis centered on the inhibition of melanin biosynthesis in response to PPN treatment. Subsequently, it was observed that PPN treatment resulted in a dose-dependent reduction in melanin production, accompanied by a decrease in tyrosinase activity. Furthermore, PPN was found to downregulate the protein levels of key melanogenesis-related genes. Additionally, PPN was observed to elevate the phosphorylation levels of ERK. To assess the role of ERK signaling in PPN-induced melanogenesis regulation, PD98059, an ERK inhibitor, was used. When Melan-A cells were treated with PD98059, the reduced expression level of MITF and melanin content induced by piperine were restored. Additionally, phosphorylation of ERK increased the phosphorylation of MITF at Ser73. This phosphorylated MITF leads to ubiquitination, and ultimately, the protein level of MITF decreases through proteasomal degradation. Likewise, when Melan-A cells were treated with MG132, a proteasomal inhibitor, the reduced expression level of MITF and melanin content induced by piperine were restored.Consequently, PPN can be a potential candidate for application as a skin whitening agent or in formulations to mitigate hyperpigmentation.

Melanin is a bio-pigment molecule synthesized by melanocytes. Its role is to shield the skin from ultraviolet radiation. Nonetheless, aberrant melanin production, whether excessive or deficient, can lead to conditions such as vitiligo, freckles, melanocytic nevi, and even melanoma. The biosynthetic pathway of melanin is known as melanogenesis, which is regulated by various transcription factors and enzymatic processes. Piperine (PPN), an alkaloid compound extracted from Piper retrofractum Vahl., was investigated for its potential anti-fungal and anti-inflammatory effects. Our hypothesis centered on the inhibition of melanin biosynthesis in response to PPN treatment. Subsequently, it was observed that PPN treatment resulted in a dose-dependent reduction in melanin production, accompanied by a decrease in tyrosinase activity. Furthermore, PPN was found to downregulate the protein levels of key melanogenesis-related genes. Additionally, PPN was observed to elevate the phosphorylation levels of ERK. To assess the role of ERK signaling in PPN-induced melanogenesis regulation, PD98059, an ERK inhibitor, was used. When Melan-A cells were treated with PD98059, the reduced expression level of MITF and melanin content induced by piperine were restored. Additionally, phosphorylation of ERK increased the phosphorylation of MITF at Ser73. This phosphorylated MITF leads to ubiquitination, and ultimately, the protein level of MITF decreases through proteasomal degradation. Likewise, when Melan-A cells were treated with MG132, a proteasomal inhibitor, the reduced expression level of MITF and melanin content induced by piperine were restored.Consequently, PPN can be a potential candidate for application as a skin whitening agent or in formulations to mitigate hyperpigmentation.

Melanin is a bio-pigment molecule synthesized by melanocytes. Its role is to shield the skin from ultraviolet radiation. Nonetheless, aberrant melanin production, whether excessive or deficient, can lead to conditions such as vitiligo, freckles, melanocytic nevi, and even melanoma. The biosynthetic pathway of melanin is known as melanogenesis, which is regulated by various transcription factors and enzymatic processes. Piperine (PPN), an alkaloid compound extracted from Piper retrofractum Vahl., was investigated for its potential anti-fungal and anti-inflammatory effects. Our hypothesis centered on the inhibition of melanin biosynthesis in response to PPN treatment. Subsequently, it was observed that PPN treatment resulted in a dose-dependent reduction in melanin production, accompanied by a decrease in tyrosinase activity. Furthermore, PPN was found to downregulate the protein levels of key melanogenesis-related genes. Additionally, PPN was observed to elevate the phosphorylation levels of ERK. To assess the role of ERK signaling in PPN-induced melanogenesis regulation, PD98059, an ERK inhibitor, was used. When Melan-A cells were treated with PD98059, the reduced expression level of MITF and melanin content induced by piperine were restored. Additionally, phosphorylation of ERK increased the phosphorylation of MITF at Ser73. This phosphorylated MITF leads to ubiquitination, and ultimately, the protein level of MITF decreases through proteasomal degradation. Likewise, when Melan-A cells were treated with MG132, a proteasomal inhibitor, the reduced expression level of MITF and melanin content induced by piperine were restored.Consequently, PPN can be a potential candidate for application as a skin whitening agent or in formulations to mitigate hyperpigmentation.

Objectives: This study aimed to develop play-based nutrition education (PBNE) materials for young children and to evaluate their applicability and effectiveness. Methods: An online survey of 1,253 primary caregivers of preschool children was conducted, and the findings were used to develop age-specific utilization guides, slides, activity sheets, activity cards, posters, educational videos, and parent newsletters. Selected materials were implemented in child-care centers through the Children’s Foodservice Management Centers between October and November 2023. The effectiveness of the PBNE program was assessed by examining changes in mushroom consumption as well as food awareness and preferences, before and after the intervention. Results: A total of eight media formats and 320 educational contents were developed, and mushrooms were as the pilot theme among the 12 possible food items. Following the intervention, children’s positive awareness of mushrooms increased, and > 96% of participants attempted to consume them. Teachers in child-care centers rated the appropriateness and applicability of the content, its contribution to behavioral improvement, and their overall satisfaction at > 4.9 out of 5 points. Conclusion This study developed experiential, PBNE materials aligned with the national standard child- and play-centered curriculum. The materials were effective in enhancing food awareness and promoting attempts at consumption. Future efforts should focus on developing additional experiential teaching tools that incorporate teacher feedback and on strengthening home-linked programs to support healthy seasonal food intake and positive dietary experiences in young children.

Objectives: This study evaluated the nutrition quotient for preschoolers (NQ-P) and analyzed the impact of key factors, such as caregivers’ food literacy, social support, and food environment, on the eating habits of preschool children in Korea. This study also sought to provide foundational data for developing tailored nutrition education programs by identifying the nutrition education needs of caregivers. Methods: This study was conducted among caregivers of preschool children (aged 0–6 years) using an online self-administered survey conducted from August 22 to August 28, 2023. A total of 1,116 survey responses were analyzed. This study assessed children’s NQ-P score, caregivers’ food literacy, social support, food environment, and nutritional education needs. Data were analyzed using SPSS 29.0 (IBM Co.). Results: The average NQ-P score for preschool children was 52, showing a tendency for the balance score to decrease and the moderation score to increase with age. Children from rural and low-income areas exhibited significantly lower NQ-P scores. Caregivers’ food literacy was higher in urban and higher-income groups. Multiple regression analysis revealed that social support, food literacy, income, and food environment significantly affected children's NQ-P scores. The effectiveness of nutrition education varied based on the income level, with nutrition education on healthy eating being the most preferred topic for preschool children. Conclusion This study confirmed that caregivers’ food literacy and social support significantly affected preschool children’s nutritional status. This suggests a need for tailored nutritional education and dietary support policies, particularly for low-income and rural populations.

Objectives: The dietary habits of school-aged children play a critical role in their growth and development, and are strongly influenced by the home environment. Household income is closely associated with caregivers’ food literacy, social support, and food environment. This directly affects the nutritional status of children. This study aimed to provide evidence to inform policies and educational programs for improving dietary habits in children, and to establish a foundation for tailored support strategies for low-income families. Methods: This cross-sectional study included 846 primary caregivers of school-aged children from 17 regions across Korea, recruited through an online survey. Household income, caregivers’ food literacy, social support, and food environment were assessed. Nutritional status in children was measured using the Nutrition Quotient for Children (NQ-C). Statistical analyses included descriptive statistics, chi-square tests, one-way analysis of variance (ANOVA), analysis of covariance (ANCOVA), correlation analyses, and multiple linear regression. Results: Caregivers from higher income households demonstrated significantly greater food literacy and social support (P < 0.001). Children from these households showed high balance scores and a large proportion of these children were in the “high” NQ-C grade. The NQ-C score in children was positively correlated with food literacy (r = 0.425), social support (r = 0.471), and the food environment (r = 0.235) (P < 0.001). Multiple regression analysis showed that food literacy (β = 0.256) and social support (β = 0.348) were significant predictors of nutritional status in children. Conclusion This study confirmed that the nutritional status in children is not only determined solely by household income but is also mediated by caregivers’ food literacy, social support, and food environment. These findings highlighted the limitations of providing only economic support. The findings underscore the need for multifaceted interventions such as strengthening parental nutrition education, expanding social support networks, and improving access to healthy foods.