Objective:To analyze the clinical characteristics of different types of anomalous origin of the coronary artery.Methods:A case-series study was conducted.Based on the clinical data of children diagnosed with anomalous origin of the coronary artery at Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine from January 2013 to January 2023, the diseases of different types of anomalous origin of the coronary artery were summarized.Results:A total of 177 children with anomalous origin of the coronary artery were treated.Among them, 122 children developed the anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA), including 54 males and 68 females, with a median age of 1.2 years; 6 children developed the anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA), including 3 males and 3 females, with a median age of 4.3 years; 9 children developed the anomalous left coronary artery from the right coronary sinus (ALCA), including 6 males and 3 females, with a median age of 9.5 years; 40 children developed the anomalous right coronary artery from the left coronary sinus (ARCA), including 24 males and 16 females, with a median age of 7.7 years.Most children diagnosed with ALCAPA had onset within 1 year of age, with chronic heart failure as the main manifestation, and young children were often accompanied by severe mitral regurgitation.A total of 111 children underwent surgery, and 11 children died.Six children with ARCAPA had no obvious clinical symptoms and were treated by operation according to the principle of double coronary circulation after diagnosis.Nine children with ALCA started with syncope, chest pain or abdominal pain after exercise.Eight of the children underwent surgical treatment, including 1 who received a heart transplant.Of the 40 children with ARCA, 23 children had clinical manifestations, with chest tightness, syncope, and chest pain after exercise as chief complaints; 16 children were tested positive for treadmill exercise before surgery; and a total of 13 children received surgical treatment.Conclusions:Different types of anomalous origin of the coronary artery vary in severity.The clinical manifestations of the anomalous origin of the left coronary artery are generally serious, and most of such patients have the risk of cardiac insufficiency or sudden death.Once diagnosed, surgical treatment should be performed timely.The clinical manifestations of the anomalous origin of the right coronary artery are relatively mild, and only a few may have serious consequences, which are usually treated according to the principle of individualization or double coronary circulation.

Objective:To investigate the effect of management system on pregnancy outcome in patients with polycystic ovary syndrome (PCOS) of childbearing age.Methods:A total of 1203 patients with PCOS aged 20-45 years were collected in Reproductive Center of Zhongshan Boai Hospital from June 2016 to May 2018. Totally 755 who would like to be included in the long term management system were collected as study group and received basic blood pressure and weight control and serum monitoring, scientific education was performed through WeChat platform established for PCOS management and other methods. Other 448 patients with PCOS were not included in the long-term management system (control group), and their pregnancy outcomes were followed up.Results:The total pregnancy rate of study group was higher than that of control group (25.74% vs.18.13%, P=0.010), and the total abortion rate of study group was lower than that of control group (14.19% vs. 22.58%, P=0.199). Conclusion:Comprehensive management of PCOS patients of childbearing age can improve the public's cognition and acceptance of PCOS as a chronic disease, improve the compliance and pregnancy outcome of PCOS patients.

Objective:To investigate the effect of management system on pregnancy outcome in patients with polycystic ovary syndrome (PCOS) of childbearing age.Methods:A total of 1203 patients with PCOS aged 20-45 years were collected in Reproductive Center of Zhongshan Boai Hospital from June 2016 to May 2018. Totally 755 who would like to be included in the long term management system were collected as study group and received basic blood pressure and weight control and serum monitoring, scientific education was performed through WeChat platform established for PCOS management and other methods. Other 448 patients with PCOS were not included in the long-term management system (control group), and their pregnancy outcomes were followed up.Results:The total pregnancy rate of study group was higher than that of control group (25.74% vs.18.13%, P=0.010), and the total abortion rate of study group was lower than that of control group (14.19% vs. 22.58%, P=0.199). Conclusion:Comprehensive management of PCOS patients of childbearing age can improve the public's cognition and acceptance of PCOS as a chronic disease, improve the compliance and pregnancy outcome of PCOS patients.