Objective:To investigate the effects of aerobic exercise training combined with cognitive behavioral therapy on blood pressure, exercise tolerance, and sleep quality in patients with sleep disorders complicated by high-normal blood pressure.Methods:A total of 60 individuals with sleep disorders complicated by high-normal blood pressure, who underwent community health screening and received treatment at the Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital) from February 2022 to February 2024, were prospectively included in this study. The patients were randomly assigned to two groups using a random number table: a cognitive therapy group and a combined intervention group, with 30 patients in each group. The cognitive therapy group received cognitive behavioral therapy, while the combined intervention group received both aerobic exercise training and cognitive behavioral therapy. Changes in blood pressure, the proportion of patients with elevated blood pressure, exercise tolerance, and Pittsburgh Sleep Quality Index (PSQI) score were compared between the two groups. Additionally, the overall effective rate of treatment for sleep disorders was evaluated for both groups.Results:Before intervention, there was no statistically significant difference in blood pressure between cognitive therapy and combined intervention groups ( P > 0.05). After intervention, the 24-hour mean systolic blood pressure was (121.63 ± 3.47) mmHg (1 mmHg = 0.133 kPa) for the cognitive therapy group and (114.56 ± 3.07) mmHg for the combined intervention group. The 24-hour mean diastolic blood pressure was (81.03 ± 2.78) mmHg for the cognitive therapy group and (77.59 ± 2.09) mmHg for the combined intervention group. Both the 24-hour mean systolic and diastolic blood pressures in each group significantly decreased when compared with the values recorded before intervention ( t = 10.54, 17.52, 5.52, 10.68, all P < 0.05). After intervention, both the 24-hour mean systolic and diastolic blood pressures in the combined intervention group were significantly lower than those in the cognitive therapy group ( t = 8.36, 5.41, both P < 0.001). Before intervention, there was no statistically significant difference in the proportion of patients with elevated blood pressure between the two groups ( P > 0.05). After intervention, the proportion of patients with elevated blood pressure was 40.00% (12/30) in the cognitive therapy group and 66.67% (20/30) in the combined group. Both groups showed a significant increase in the proportion of patients with elevated blood pressure compared with pre-intervention values ( χ2 = 4.02, 11.38, both P < 0.05). After intervention, the proportion of patients with elevated blood pressure in the combined intervention group was significantly higher than that in the cognitive therapy group ( χ2 = 4.28, P < 0.05). Before intervention, there was no significant difference in exercise tolerance between the two groups ( P > 0.05). After intervention, the combined intervention group showed significant increases in anaerobic threshold [(1 475.25 ± 415.65) mL/min] and oxygen pulse [(14.78 ± 2.86) mL/beat] compared with pre-intervention values ( t = 3.58, 7.49, both P < 0.05). However, there was no significant difference in the carbon dioxide ventilation equivalent (VE/VCO 2@VCP) at the ventilatory compensation point compared with pre-intervention levels ( P > 0.05). After intervention, the anaerobic threshold and oxygen pulse in the combined intervention group were significantly higher than those in the cognitive therapy group [(1 137.41 ± 349.86) mL/min, (9.94 ± 2.05) mL/beat] ( t = -3.40, -7.53, both P < 0.05). There was no significant difference in exercise tolerance in the cognitive therapy group between pre- and post-intervention ( P > 0.05). Before intervention, there was no significant difference in PSQI score between cognitive therapy and combined intervention groups ( P > 0.05). After intervention, score for sleep quality [(1.65 ± 0.26) points , (1.24 ± 0.23) points], sleep onset time [(1.51 ± 0.19) points, (1.33 ± 0.18) points], sleep time [(1.47 ± 0.23) points, (1.31 ± 0.20) points], sleep efficiency [(1.31 ± 0.20) points, (1.05 ± 0.19) points], sleep disturbance [(0.93 ± 0.15) points, (0.77 ± 0.20) points], hypnotic medication use [(0.96 ± 0.22) points, (0.67 ± 0.17) points], and daytime function [(1.19 ± 0.25) points, (1.02 ± 0.22) points] decreased in both groups compared with pre-intervention scores ( t = 8.21, 15.58, 9.86, 14.76, 10.02, 15.36, 8.78, 17.59, 7.84, 12.36, 5.74, 11.98, 12.03, 17.14, all P < 0.05). After intervention, PSQI score in the combined intervention group was significantly lower than that in the cognitive therapy group ( t = 6.46, 3.76, 2.87, 5.16, 3.50, 5.71, 2.79, all P < 0.05). The total effective rate for treating sleep disorders in the combined intervention group was 86.67% (26/30), which was significantly higher than that in the cognitive therapy group [63.33% (19/30), χ2 = 4.35, P < 0.05). Conclusions:Aerobic exercise training combined with cognitive behavioral therapy can improve exercise tolerance, reduce blood pressure, and enhance sleep quality in patients with sleep disorders and high-normal blood pressure.

Objective:To investigate the effects of aerobic exercise training combined with cognitive behavioral therapy on blood pressure, exercise tolerance, and sleep quality in patients with sleep disorders complicated by high-normal blood pressure.Methods:A total of 60 individuals with sleep disorders complicated by high-normal blood pressure, who underwent community health screening and received treatment at the Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital) from February 2022 to February 2024, were prospectively included in this study. The patients were randomly assigned to two groups using a random number table: a cognitive therapy group and a combined intervention group, with 30 patients in each group. The cognitive therapy group received cognitive behavioral therapy, while the combined intervention group received both aerobic exercise training and cognitive behavioral therapy. Changes in blood pressure, the proportion of patients with elevated blood pressure, exercise tolerance, and Pittsburgh Sleep Quality Index (PSQI) score were compared between the two groups. Additionally, the overall effective rate of treatment for sleep disorders was evaluated for both groups.Results:Before intervention, there was no statistically significant difference in blood pressure between cognitive therapy and combined intervention groups ( P > 0.05). After intervention, the 24-hour mean systolic blood pressure was (121.63 ± 3.47) mmHg (1 mmHg = 0.133 kPa) for the cognitive therapy group and (114.56 ± 3.07) mmHg for the combined intervention group. The 24-hour mean diastolic blood pressure was (81.03 ± 2.78) mmHg for the cognitive therapy group and (77.59 ± 2.09) mmHg for the combined intervention group. Both the 24-hour mean systolic and diastolic blood pressures in each group significantly decreased when compared with the values recorded before intervention ( t = 10.54, 17.52, 5.52, 10.68, all P < 0.05). After intervention, both the 24-hour mean systolic and diastolic blood pressures in the combined intervention group were significantly lower than those in the cognitive therapy group ( t = 8.36, 5.41, both P < 0.001). Before intervention, there was no statistically significant difference in the proportion of patients with elevated blood pressure between the two groups ( P > 0.05). After intervention, the proportion of patients with elevated blood pressure was 40.00% (12/30) in the cognitive therapy group and 66.67% (20/30) in the combined group. Both groups showed a significant increase in the proportion of patients with elevated blood pressure compared with pre-intervention values ( χ2 = 4.02, 11.38, both P < 0.05). After intervention, the proportion of patients with elevated blood pressure in the combined intervention group was significantly higher than that in the cognitive therapy group ( χ2 = 4.28, P < 0.05). Before intervention, there was no significant difference in exercise tolerance between the two groups ( P > 0.05). After intervention, the combined intervention group showed significant increases in anaerobic threshold [(1 475.25 ± 415.65) mL/min] and oxygen pulse [(14.78 ± 2.86) mL/beat] compared with pre-intervention values ( t = 3.58, 7.49, both P < 0.05). However, there was no significant difference in the carbon dioxide ventilation equivalent (VE/VCO 2@VCP) at the ventilatory compensation point compared with pre-intervention levels ( P > 0.05). After intervention, the anaerobic threshold and oxygen pulse in the combined intervention group were significantly higher than those in the cognitive therapy group [(1 137.41 ± 349.86) mL/min, (9.94 ± 2.05) mL/beat] ( t = -3.40, -7.53, both P < 0.05). There was no significant difference in exercise tolerance in the cognitive therapy group between pre- and post-intervention ( P > 0.05). Before intervention, there was no significant difference in PSQI score between cognitive therapy and combined intervention groups ( P > 0.05). After intervention, score for sleep quality [(1.65 ± 0.26) points , (1.24 ± 0.23) points], sleep onset time [(1.51 ± 0.19) points, (1.33 ± 0.18) points], sleep time [(1.47 ± 0.23) points, (1.31 ± 0.20) points], sleep efficiency [(1.31 ± 0.20) points, (1.05 ± 0.19) points], sleep disturbance [(0.93 ± 0.15) points, (0.77 ± 0.20) points], hypnotic medication use [(0.96 ± 0.22) points, (0.67 ± 0.17) points], and daytime function [(1.19 ± 0.25) points, (1.02 ± 0.22) points] decreased in both groups compared with pre-intervention scores ( t = 8.21, 15.58, 9.86, 14.76, 10.02, 15.36, 8.78, 17.59, 7.84, 12.36, 5.74, 11.98, 12.03, 17.14, all P < 0.05). After intervention, PSQI score in the combined intervention group was significantly lower than that in the cognitive therapy group ( t = 6.46, 3.76, 2.87, 5.16, 3.50, 5.71, 2.79, all P < 0.05). The total effective rate for treating sleep disorders in the combined intervention group was 86.67% (26/30), which was significantly higher than that in the cognitive therapy group [63.33% (19/30), χ2 = 4.35, P < 0.05). Conclusions:Aerobic exercise training combined with cognitive behavioral therapy can improve exercise tolerance, reduce blood pressure, and enhance sleep quality in patients with sleep disorders and high-normal blood pressure.

Objective: To explore the pain experiences of adult burn patients so as to lay foundation for practical analgesic measures. Methods: Using phenomenological method in qualitative research, semi-structured interviews were conducted on 12 adult burn patients hospitalized in our burn units from May to November 2015, aiming at pain experiences from immediately after burns to 3 to 7 months after being discharged from hospital. Then the Colaizzi′s analysis method was applied to analyze, induce, and refine themes of interview data. Results: After analysis, pain experiences of adult burn patients were generalized into 6 themes: deep pain experiences, heavy psychological burden, limited daily life, poor assessment and treatment of pain, different attributions of pain, and different ways of coping of pain. Conclusions Burn pain brings harm to the patients′ physiology, mentality, and daily life. Nevertheless, pain processing modes of medical staff and patients themselves are the key factors affecting patients′ pain experiences. Therefore, according to the deficiency of current situation of pain management, the targeted analgesic intervention measures should be carried out from the perspectives of medical staff and patients.

Objective To detect altered levels and clinical significance of serum miR-216a and prognosis monitoring in acute pancreatitis (AP) patients.Methods Serum miR-216a levels were determined by quantitative reverse-transcription PCR (qRT-PCR) assay among 80 mild acute pancreatitis (MAP) patients,80 severe acute pancreatitis (SAP) patients and 74 healthy controls.And amylase (AMY),lipase (LPS),Ca2+,glucose (Glu),hematocrit (HCT),triglyceride (TG),total cholesterol (TC) and C reactive protein (CRP) were measured by biochemical analyzer.The clinical usefulness of miR-216a for AP patients was assessed by ROC curve analysis and correlation analysis.Results Compared with healthy controls (11.12 × 10-5 [5.83 × 10-5,19.12 × 10-5],the serum miR216a levels were significantly increased in AP patients(38.49 × 10-5 [24.05 × 10-5,62.02 × 10-5],(U =-9.10,P ＜ 0.01) . The serum miR-216a levels in MAP and SAP patients were (36.46 × 10-5 [22.29 × 10-5,55.80 × 10-5] vs 40.44 × 10-5 [25.84 × 10-5,65.48 × 10-5]),there was no significant difference between MAP and SAP patients (U =-0.96,P ＞ 0.05).The areas under ROC curve (AUCROC) of miR-216a for differential healthy controls and AP patients was 0.870 (95％ CI:0.825-0.915),cut-off value is 0.61.AUCROC of miR-216a for differential healthy controls and MAP patients was 0.865 (95％ CI:0.808-0.921),cut-off value is 0.59.And AUCROC of miR-216a for differential healthy controls and SAP patients was 0.876 (95％ CI:0.822-0.930),cut-off value is 0.66.Moreover,after the clinical improvement of the patients,the levels of serum miR-216a were significantly lowered from (41.88 × 10-5 [24.24 × 10-s,64.44 × 10-5]) to (20.58 × 10-5 [11.01 × 10-5,41.91 × 10-5]),the differences was significant(U =5.24,P ＜ 0.0l).Correlation analysis showed that miR-216a was positively correlated with CRP (r =0.215,P =0.006) in AP patients.Conclusion The levels of miR-216a in serum of AP patients were increased,which is a potential biomarker for the diagnosis and prognosis monitoring of AP.

OBJECTIVETo analyze the epidemiological characteristics of hospitalized children with burn injuries in Fujian Medical University Union Hospital, so as to provide evidence to complete an adequate, timely, and effective prevention and treatment system of children with burn injuries.

METHODSMedical records of children with burn injuries, aged 14 and under, hospitalized in the Department of Burns from July 2012 to June 2015 were collected. Data of gender and age, location and cause of injury, time of injury, state of injury, admission time after injury, first aid, length of hospital stay, and treatment and so on were recorded. They were divided into 4 age brackets: less than or equal to 1 year old, more than 1 year old and less than or equal to 3 years old, more than 3 years old and less than or equal to 7 years old, more than 7 years old and less than or equal to 14 years old, then gender and cause of injury of children in the 4 age brackets were analyzed. Admission months of the children were divided into spring (March to May), summer (June to August), autumn (September to November) and winter (December to February of the following year), and then the cause of injury of children in each season was analyzed. Severities of male and female children, length of hospital stay of children with different causes of injury were analyzed. Data were processed with chi-square test, Wilcoxon rank-sum test.

RESULTSOut of 2 608 inpatients with burn injuries, 1 407 children with burn injuries, aged 14 and under, accounting for 53.9%, were admitted in the recent 3 years. The ratio of male to female was 1.6 ∶1.0. Children more than 1 year old and less than or equal to 3 years old ranked the largest number (68.3%, 961/1 407) in the 4 age brackets. There was statistically significant difference in constituent ratios of gender of children among the 4 age brackets (χ(2)=11.00, P=0.012). One thousand three hundred and seventy-two children were burned indoors (97.5%), while 35 children were burned outdoors (2.5%). Scalding with hot fluids was the most common cause of burn (95.0%, 1 337/1 407). There was statistically significant difference in constituent ratios of injury cause of children among the 4 age brackets (χ(2)=107.23, P<0.01). There was statistically significant difference in constituent ratios of injury cause of children more than 7 years old and less than or equal to 14 years old compared with those of the other 3 age brackets (with χ(2) values from 12.88 to 119.85, P values below 0.01). Most burn accidents occurred between 17: 00-20: 59 (33.5%, 472/1 407). Burns were more likely to happen in April to October. July (10.4%, 146/1 407) and August (10.5%, 148/1 407) were the crest-time. Most of the children were burned in summer (35.3%, 496/1 407). There was statistically significant difference in the injury cause of children among each season (χ(2)=14.61, P=0.024). The burn degrees of male and female children were mainly mild or moderate, and there was no statistically significant difference in the severity (Z=-0.39, P>0.05). The trunk was the most involved anatomic site (61.1%, 859/1 407). Most of children were admitted to hospital within 2 hours post burn (79.7%, 1 121/1 407). Majority of children were taken off clothes as first aid on spot or did not receive any treatment. Most of the children were discharged within 2 weeks after admission (80.0%, 1 126/1 407). There was statistically significant difference in length of hospital stay of children with causes of hot liquid scald, flame burn, electric burn, high temperature solid burn, chemical burn (χ(2) =17.33, P=0.002). Most of the children were treated with non-surgical methods, and the majority of the children got better condition or totally recovered and then discharged.

CONCLUSIONSThe majority of hospitalized children with burn injuries in our unit are young boys in preschool period, who were burnt by hot fluid at the time of dinner and bathing at home during summer. So we should make more effort on popularization of prevention about burn.

Adolescent ; Burns ; classification ; epidemiology ; Burns, Chemical ; Burns, Electric ; Child ; Child, Hospitalized ; statistics & numerical data ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Inpatients ; Length of Stay ; Male

Objective To explore the current status of hospitalized burn children's quality of life,so as to lay foundation for carrying out the related intervention in future.Methods Using qualitative research method,semi-structured interviews were conducted on 11 parents of burn children hospitalized in Department of Burns of Fujian Medical University Union Hospital from March to May 2016.Then the data were analyzed and concluded with phenomenological analysis method to refine the themes.Results Parents' description about the current status of hospitalized burn children's quality of life could be summed up into four areas:physiology,psychology,social development,and family;and in six themes:obvious itching symptom,limited movement development,night terror and constant cry because of fear,reduced social game,negative attachment type,and parents under multiple pressures.Conclusions Burn brings serious harm to children's physical and mental development,as well as negative effects on the parents,thus lowering the children's quality of life.Medical workers should increase knowledge and attention of it,and carry out targeted health management project.

Objective To explore the effect of Shexiang baoxin Pillls on super‐elder patients with myocardial infarction ,and observe and analyze its prognosis .Methods Two hundred super‐elder patients with myocardial infarction were selected in the hos‐pital from December 2013 to November 2014 ,they were randomly divided into control group(n=100) and observation group(n=100) .The control group used conventional drug treatment ,and the observation group treated with Shexiang baoxin pillls on the ba‐sis of the control group .Three months wasr a treatment period .To observe the clinical therapeutic effect ,echocardiography was used to detected the left ventricular wall thickness ,left ventricular end‐diastolic diameter (LVEDD) ,left ventricular ejection fraction (LVEF) before and after treatment .Observed 6 minutes walking distance .Total cholesterol (TC) ,blood lipid ,low density lipopro‐tein (LDL‐C) ,c‐reactive protein (CRP) ,and other indicators were detected .Results The total effective rate of the observation group was [72 .00% (72/100)] was higher than the control group [65 .00% (65/100)] ,P<0 .05 .The re‐hospitalization rate of the observation group was [23 .00% (23/100)] was lower than the control group [34 .00% (34/100)] ,P<0 .05 .The left ventricular posterior wall thickness and LVEDD of the observation group after treatment were(10 .12 ± 0 .40)mm and(49 .11 ± 1 .39)mm , which were lower than the control group after treatment [(11 .06 ± 0 .52)mm and (51 .36 ± 1 .46)mm] ,LVEF (% ) of the observa‐tion group after treatment was (0 .51 ± 0 .12)% ,which was higher than the control group after treatment (0 .47 ± 0 .11)% ,all P<0 .05 .TC ;LDL‐C and CRP of the observation group after treatment were (5 .19 ± 0 .32) mmol/L ,(2 .83 ± 0 .30) mmol/L and (54 . 11 ± 4 .83) mg/L ,they were lower than the control group after treatment [(5 .48 ± 0 .37) mmol/L ,(3 .10 ± 0 .33) mmol/L and (62 . 38 ± 4 .36) mg/L] ,all P<0 .05 .6 min walking distance of the observation group after treatment was (376 .38 ± 19 .41)m ,it was higher than the control group after treatment(331 .04 ± 22 .18)m ,P<0 .05 .The complications of the observing group[38 .00% (38/100)] was lower than the control group after treatment 47 .00% (47/100) ,P<0 .05 .Conclusion There is better clinical effect on super‐elder patients with myocardial infarction by Shexiang baoxin Pillls ,which can reduce hospitalization rates again ,improve left heart function and blood lipid levels ,reduce complications .

Objective To explore the hypertensive vulnerability of residents living in Xuzhou City to provide evidence for effective intervention. Methods Based on multi-stage stratified randomized sampling methed,a total of 4980 residents aged 15 to 69 years from 9 counties of Xuzhou City were selected and completed a standard questionnaire. Hypertensive vulnerability was compared by using Chi-square test. Results The prevalence of hypertension was 13.62% among 15 to 69 years old participants. The residents who had no idea of normal level of blood pressure accounted for 45. 26%. The residents who thought it was unnecessary to measure blood pressure every year since 35 year-old accounted for 29. 68%. Those who did not know individual's salt intake per day accounted for 57. 23%. The participants who had no information on hypertension prevention or control accounted for 21.53% and 12. 05%, respectively. The higher hypertensive vulnerability was associated with lower educational level or monthly income per capita; higher hypertensive vulnerability of patients is less than normal crowed. The rates of current smoking, alcohol consumption,salt over-intake and non-blood pressure measurement were 16. 45%, 11.10% ,30. 00%, and 32. 05% respectively. The higher educational level, higher monthly income per capita or older age crowd ,the lower rate of non-blood pressure measurement, the higher rate of alcohol consumption ; salt over-intake was different in different education levels ( χ2 = 23.37, P＜0. 05 ) ; the older age group were in a higher proportion of current smokers;the behavior vulnerabilities were no difference between the patients and normal crowds. Conclusion Hypertensive vulnerability of residents living in Xuzhou City is high. Hypertension education and healthy living style should be improved to effectively prevent the development of hypertension.

Objective To study risk factors for high-normal blood pressure (HNBP) in residents of urban Xuzhou, Jiangsu province, China. Methods A cross-sectional survey was conducted among 17 500 residents in urban area of Xuzhou from June to December 2008 by cluster sampling with self-designed questionnaire to collect their demographic information and measurements of body height, weight and blood pressure. Data were approached to univariate and multivariate non-conditional logistic regression analysis. Results In total, 17 306 residents finished the survey, with an overall response rate of 98.9percent. Results of univariate analysis revealed that 13 variables such as living region, sex, age,occupation, annual average family income, history of dyslipidemia, smoking, alcohol drinking, intake of pork, and vegetables, daily length of sleeping, body mass index (BMI), abdominal obesity, all were related to HNBP ( P ＜ 0. 05 ). Results of multivariate logistic regression analysis showed that living region, sex,age, annual average family income, alcohol drinking, intake of vegetable, BMI, abdominal obesity all associated with HNBP (P＜0. 05). Conclusions Older age, history of alcohol drinking, increased BMI,abdominal obesity all are risk factors to prompt occurrence of HNBP, and intake of large amount of vegetables is its protective factor.

Humans ; Severe Acute Respiratory Syndrome ; diagnosis ; therapy