Objective:To observe and evaluate the predictive value of serum cystatin C (Cys-C) on the risk of sight-threatening diabetic retinopathy (STDR).Methods:A non-randomized controlled cross-sectional clinical study. Ninety-two patients with type 2 diabetes mellitus (T2DM) who were admitted to Department of Ophthalmology of Beijing Tsinghua Changgung Hospital from January 2022 to October 2022 were included in the study. Among them, 50 were male, 42 cases were female, with the mean age of (58.24±12.49) years. The mean duration of T2DM was (13.18±8.35) years, of which 38 cases had a duration of ≥10 years. Twenty-nine cases complicated with hypertension, of which 16 cases had a duration of ≥10 years. Seventeen cases complicated with chronic kidney disease stage 2 and 23 cases were treated with lipid-lowering drugs. Hemoglobin Alc, serum Cys-C, serum lipids and renal function were tested, and urinary microalbumin/creatinine ratio (ACR) was calculated. According to the 2003 American Academy of Ophthalmology "Clinical Guidelines for Diabetic Retinopathy (DR)" and international clinical DR severity grading standards, the patients were divided into STDR and non-STDR groups, with 44 and 48 cases in each group, respectively. STDR was defined as severe non-proliferative DR, proliferative DR, and macular edema. Logistic regression was used to analyze the independent risk factors of STDR in T2DM patients. Receiver operating characteristic curve (ROC curve) was used to calculate and analyze the area under ROC curve (AUC) and the predictive value of serum Cys-C and ACR in predicting STDR in T2DM patients.Results:Serum Cys-C levels in STDR and non-STDR groups were 1.10 (0.94, 1.28) and 0.91 (0.83, 1.02) mg/L, respectively, with ACR of 4.29 (1.05, 21.89) and 1.39 (0.77, 3.80) mg/mmol, respectively. Compared with non-STDR group, serum Cys-C and ACR in STDR group were higher, and the difference was statistically significant ( Z=-3.984, -3.280; P<0.05). Multivariate logistic regression analysis showed that serum Cys-C was an independent risk factor for STDR (odds ratio=1.337, 95% confidence interval 1.145-2.090, P=0.033), and the risk of STDR increased by 33.7% for every 0.1 mg/L increase in serum Cys-C. ROC analysis results showed that serum Cys-C> 1.065 mg/L combined with ACR> 5.84 mg/mmol predicted the AUC of STDR in T2DM patients was 0.661, with the specificity of 95.8%. Conclusions:The high serum Cys-C level is an independent risk factor for STDR in T2DM patients. Serum Cys-C has high predictive value for the occurrence of STDR.

Sarcopenia, a common complication of cirrhosis, has an incidence rate as high as 40% ~ 70%. Furthermore, adverse events such as shortened survival, lower quality of life, prolonged hospital stay, increased complications, a higher mortality rate, and sometimes altering the liver transplantation prognostic outcome in patients with liver cirrhosis are closely related. In recent years, some progress has been made in the research on the treatment of sarcopenia, but there is no clear treatment plan at present; thus, research and development by researchers and clinicians still need to be strengthened. This article briefly describes the relevant treatment methods for sarcopenia in patients with cirrhosis.

Objective To investigate the effect of early treatment and knowledge education on the prognosis of the patients with corneal foreign body in the marine fishermen .Methods Retrospective analysis was made on the 3146 marine fishermen with corneal foreign body (3652 eyes) who sought medical care in Rongcheng Second People 's Hospital from December 2013 to December 2016.In according with whether or not they had received pre-occupational knowledge education and skill training , the subjects were divided into the observation group (1680 cases, 1842 eyes) and the control group (1466 cases, 1810 eyes).Features of disease classification, treatment time and effects on visual acuity were observed and analyzed , then, prevention and treatment strategies were made accordingly .Results In the observation group, there were 991 patients who sought medical care in 24 hours after injury, accounting for 59.0 ％, while in the control group, there were 430 patients who sought medical care in 24 hours after injury, accounting for 29.3％.There was statistical significance, when comparisons were made between the 2 groups(P <0.01).The incidence of grade A foreign body in the observation group (49.0％) was significantly higher than that in the control group (26.0％), and the incidence of grade C and D foreign bodies in the observation group was significantly lower than those in the control group(P <0.05).The incidence of such complications as corneal stroma infiltration and corneal scar formation in the observation group was significantly lower than that in the control group ( P <0.01 ). Conclusions Knowledge education could effectively reduce the incidence of corneal foreign body in fishermen and reduce the effects of complications and prognosis on visual acuity .

Objective To investigate the effect of early treatment and knowledge education on the prognosis of the patients with corneal foreign body in the marine fishermen .Methods Retrospective analysis was made on the 3146 marine fishermen with corneal foreign body (3652 eyes) who sought medical care in Rongcheng Second People 's Hospital from December 2013 to December 2016.In according with whether or not they had received pre-occupational knowledge education and skill training , the subjects were divided into the observation group (1680 cases, 1842 eyes) and the control group (1466 cases, 1810 eyes).Features of disease classification, treatment time and effects on visual acuity were observed and analyzed , then, prevention and treatment strategies were made accordingly .Results In the observation group, there were 991 patients who sought medical care in 24 hours after injury, accounting for 59.0 ％, while in the control group, there were 430 patients who sought medical care in 24 hours after injury, accounting for 29.3％.There was statistical significance, when comparisons were made between the 2 groups(P <0.01).The incidence of grade A foreign body in the observation group (49.0％) was significantly higher than that in the control group (26.0％), and the incidence of grade C and D foreign bodies in the observation group was significantly lower than those in the control group(P <0.05).The incidence of such complications as corneal stroma infiltration and corneal scar formation in the observation group was significantly lower than that in the control group ( P <0.01 ). Conclusions Knowledge education could effectively reduce the incidence of corneal foreign body in fishermen and reduce the effects of complications and prognosis on visual acuity .