Objective : To investigate the antidepressant effects and the underlying mechanisms of tetrahydrocurcumin(THC) and its nanoparticle formulation(THCN). Methods : Forty-six male ICR mice were randomly divided into Con group, LPS group, THC group, THCN group and SER group. A mouse depression model was established by intraperitoneal administration of LPS. The anxiety and depression-like behaviors of mice were evaluated by open field test(OFT) and forced swimming test(FST). Myelin staining was applied to assess the extent of demyelination in the prefrontal cortex of the mice. The prefrontal cortex and hippocampus were further examined for the expression levels of glial fibrillary acidic protein(GFAP) and Toll-like receptor 4(TLR4) through quantitative immunofluorescence assays. Results : Compared with the Con group, the LPS group showed increased anxiety-like and depressive-like behaviors in both the long-term and short-term experiments(P<0.05); the degree of demyelination increased in the LPS group of the long-term experiment(P<0.01); the expression of GFAP was reduced in the LPS group of the short-term experiment(P<0.01), while the expression of TLR4 increased(P<0.05); the expression of TLR4 decreased in the THC group(P<0.01); the expression of GFAP in the prefrontal cortex of the THCN group was reduced(P<0.01), while the expression of TLR4 increased(P<0.05). Compared with the LPS group, the THC group showed reduced depressive-like behaviors in the long-term experiment(P<0.05), while the anxiety-like and depressive-like behaviors of the THCN group and the SER group were reduced(P<0.05), and the anxiety-like and depressive-like behaviors of the THC group and the THCN group were reduced in the short-term experiment(P<0.05); the degree of demyelination was reduced in the THC group, THCN group and SER group in the long-term experiment(P<0.05); the expression of GFAP increased in the THC group of the short-term experiment(P<0.05), while the expression of TLR4 was reduced(P<0.05), and the expression of GFAP increased in the THCN group(P<0.05). Compared with the THC group, the THCN group and the SER group showed reduced anxiety-like behaviors in the long-term experiment(P<0.05); the expression of GFAP in the prefrontal cortex of the THCN group was reduced in the short-term experiment(P<0.05), while the expression of TLR4 in the hippocampal DG area increased in the short-term experiment(P<0.01). Conclusion Tetrahydrocurcumin and its nanoparticle formulation both exert significant ameliorative effects on depression-like behaviors and demyelination in mice induced by lipopolysaccharide. The antidepressant mechanism of THC appears to be mediated through the down-regulation of TLR4 and the up-regulation of GFAP. The mechanism underlying the antidepressant action of THCN seems predominantly focused on the enhancement of GFAP expression.

Objective : To investigate the therapeutic effects and underlying mechanisms of cannabidiol(CBD) and its nano-formulations on depression-like behaviors in mice. Methods : A murine model of acute anxiety and depression was established by intraperitoneal administration of lipopolysaccharide(LPS). A total of 55 mice were randomly assigned into several groups: for the long-term study, a control group(Con), a model group(LPS), a cannabidiol group(CBD), a nano-cannabidiol group(NCBD), and a sertraline(SER) group, each consisting of 7 mice. In the short-term study, mice were divided into four groups: the Con group, LPS group, CBD group, and NCBD group, with 5 mice in each group. Except for the Con group and LPS group, which were given distilled water, the remaining groups were administered 25 and 50 mg/kg of cannabidiol and its nano-formulationviaoral gavage. The open field and forced swimming tests were employed to assess anxiety-and depression-like behaviors inmice. Luxol Fast Blue myelin staining was employed to evaluate myelin sheath morphology in the prefrontal cortex, and immunofluorescence staining was utilized to quantify the protein expression levels of silencing information regulator(SIRT2), ionized calcium binding adaptor molecule-1(Iba-1), and interleukin-1β(IL-1β) in the prefrontal cortex. Results : In the long-term experiment, the LPS group exhibited a significant reduction in shuttle times(P<0.05), an increase in immobility time(P<0.01), and a decrease in the number and length of myelin sheaths(P<0.05) compared to the Con group. Compared to the LPS group, the depressive behaviors in the CBD, NCBD, and SER groups were significantly alleviated(P<0.01), and the number and length of myelin sheaths increased(P<0.05). In the short-term experiment, compared to the Con group, the LPS group exhibited significantly increased anxiety-and depression-like behaviors(P<0.05), downregulated SIRT2 expression(P<0.01), and upregulated Iba-1 and IL-1β expression(P<0.01). The CBD and NCBD groups demonstrated a reduction in anxiety and depression-like behaviors(P<0.05), an increase in SIRT2 expression(P<0.01), and a decrease in Iba-1 and IL-1β expressions(P<0.05) compared to the LPS group. Conclusion CBD and its nano-formulations effectively mitigate anxiety and depression-like behaviors in mice. The underlying mechanisms may be associated with the reversal of SIRT2 protein expression, demyelination changes, microglial activation, and the levels of inflammatory factors in the prefrontal cortex.

Objective In the context of expanding in size and improving the quality of medical consumables,the"one product,one policy"approach has brought challenges to the management of consumables in public hospitals.This study investi-gated the potential management problems in the process of centralized procurement with volume of medical consumables in a pub-lic tertiary hospital in Guangdong Province,and accordingly worked out the corresponding management countermeasures and then assessed their implementation effects.Methods The fishbone diagrams was applied to systematically analyze the potential prob-lems in the implementation process of centralized procurement with volume of medical consumables.Targeted measures were worked out from May to July 2023 in the hospital.The time series data of centralized procurement of coronary stents,pacemak-ers,tubular/end-to-end anastomoses,and spinal products from December 2022 to December 2023 were analyzed.Changes in the monthly implementation rate and contract completion volume pre-and post-intervention were measured to evaluate the effectiveness of the intervention.Results The fishbone diagrams analysis revealed that the primary factors impeding procurement implementa-tion were internal system flaws,personnel management inadequacy,supply issues,and an absence of an information system.Post-intervention,the monthly implementation rate(t=-4.19,P＜0.05)and contract completion(t=-2.38,P＜0.05)significantly improved.Conclusion The implementation of intervention management for centralized procurement with volume of medical consumables can effectively promote the related implementation effect in the department.In the context of centralized pro-curement,clinical and health management personnel need to bolster their professionalism to ensure the procurement management efficiency and quality.It is crucial to deepen policy understanding and implementation,enhance production and distribution process supervision and disciplinary mechanisms,ensure multi-departmental coordination for supply security,and improve hospi-tal information systems and procurement platforms.

Effective cost control and structure optimization of medical consumables in public hospitals can facilitate a shift from extensive cost control to scientific and refine management.On the premise of ensuring medical quality,reducing the burden of patients'diagnosis and treatment and meeting the actual needs of hospital management,this approach aims to realize valuable healthcare outcomes.This study was conducted in a tertiary hospital,which balanced both the medical and economic val-ue of medical consumables.Using an integrated approach to specialty capacity building and disease structure optimization,the hospital restructured the use of medical consumables in Transcatheter Arterial Embolization(TAE)procedures.It developed standardized pathways and usage protocols tailored to specific diseases and surgical requirements.A targeted consumable usage policy framework was introduced,comprising"one department,one policy;one surgery type,one policy;and one consumable,one policy."This included initiatives such as validating the use of drug-loaded embolic microspheres,conducting multi-depart-mental review meetings,strictly regulating indications for these microspheres,limiting personnel involvement,and negotiating re-duced pricing on imported microspheres.Following implementation,the average case-mix index(CMI)for discharged patients undergoing TAE increased from 2.23 to 2.34(P＜0.001),while the average per-case cost of consumables decreased from 19 600 to 15 600(P＜0.001).These measures offer valuable decision-making and operational reference for hospitals nation-wide,supporting efficient,quality-focused consumables management.

During the operation of a task force in the far seas, the measures and equipment of search and rescue are limited for recovering pilots after air crashes into the sea. The crashes in the far seas are more life-threatening than those nearby the coast. The search and rescue system of task force for pilots after air crashes in the far seas is essential to the success rate of the effort, which is of vital strategic value. Foreign militaries have attached great importance to the construction of the search and rescue system of task force for pilots after air crashes in the far seas, which, with advanced rescue equipment, have set up a complete search and rescue system for the recovery of pilots. This article reviewed foreign militaries′ building up status of the search and rescue system of task force for pilots after air crashes in the far seas, analyzed the current problems of the system in Chinese military, discussed the route for the system construction, and put forward the methods of improvement, which provides a reference for the construction of Chinese search and rescue system of task force for pilots after air crashes in the far seas.

As a large maritime power, China faces multiple and complex maritime rights, interests and security issues, which have raised the importance of safeguarding its maritime rights and interests. It is essential to strengthen the maritime search and rescue (SAR) system and improve the capability of maritime SAR. Based on the characteristics of SAR, this article summarized the current status of maritime SAR system in China and analyzed its shortcomings. The article also put forward some suggestions on strengthening the system, which can provide a theoretical reference for improving the buildup of maritime SAR system in China.

To further the study on building up joint search and rescue system in island landing operations, we need to fully recognize the importance of the system in island landing operations with a strong sense of responsibility and urgency. We should, firstly, follow the rules, understand the characteristics of the joint search and rescue system, and develop typical scenarios, to innovatively explore the new modes of joint search and rescue in island landing operations; secondly, find out the needs in building up of the system, by focusing on the key aspects of command, forces, equipment, training, and regulations; thirdly, develop the information systems of the commanding, professional services, and simulation training based on information technology, to improve the efficiency of joint search and rescue in island landing operations.

During the operation of a task force in the far seas, the measures and equipment of search and rescue are limited for recovering pilots after air crashes into the sea. The crashes in the far seas are more life-threatening than those nearby the coast. The search and rescue system of task force for pilots after air crashes in the far seas is essential to the success rate of the effort, which is of vital strategic value. Foreign militaries have attached great importance to the construction of the search and rescue system of task force for pilots after air crashes in the far seas, which, with advanced rescue equipment, have set up a complete search and rescue system for the recovery of pilots. This article reviewed foreign militaries′ building up status of the search and rescue system of task force for pilots after air crashes in the far seas, analyzed the current problems of the system in Chinese military, discussed the route for the system construction, and put forward the methods of improvement, which provides a reference for the construction of Chinese search and rescue system of task force for pilots after air crashes in the far seas.

As a large maritime power, China faces multiple and complex maritime rights, interests and security issues, which have raised the importance of safeguarding its maritime rights and interests. It is essential to strengthen the maritime search and rescue (SAR) system and improve the capability of maritime SAR. Based on the characteristics of SAR, this article summarized the current status of maritime SAR system in China and analyzed its shortcomings. The article also put forward some suggestions on strengthening the system, which can provide a theoretical reference for improving the buildup of maritime SAR system in China.

To further the study on building up joint search and rescue system in island landing operations, we need to fully recognize the importance of the system in island landing operations with a strong sense of responsibility and urgency. We should, firstly, follow the rules, understand the characteristics of the joint search and rescue system, and develop typical scenarios, to innovatively explore the new modes of joint search and rescue in island landing operations; secondly, find out the needs in building up of the system, by focusing on the key aspects of command, forces, equipment, training, and regulations; thirdly, develop the information systems of the commanding, professional services, and simulation training based on information technology, to improve the efficiency of joint search and rescue in island landing operations.