[Purpose]To analyze and evaluate the application effect of quantitative fecal immuno-chemical test(FIT)in the opportunistic screening of colorectal cancer(CRC)in health examination population.[Methods]10 025 healthy individuals who completed quantitative FIT at the Health Management Cancer of Sichuan Cancer Hospital from January 1,2021 to December 31,2023 were included.Participants with positive FIT results were recommended for diagnostic colonoscopy.Quantitative FIT positivity rate,colonoscopy screening compliance rate,and colorectal lesion de-tection rate in the queue population were analyzed,the detection rate of colorectal lesions and colonoscopy resource load between quantitative FIT positive and negative colonoscopy screening groups at all levels were compared and the diagnostic efficacy of quantitative FIT for non progres-sive lesions and progressive lesions were explored.[Results]The positive rate of quantitative FIT was 6.24％(95％CI:5.77％～6.71％).The compliance rate of colonoscopy screening was 20.93％(95％CI:17.74％～24.12％).Among 284 colonoscopy patients,7 cases were detected with CRC,21 cases with advanced adenomas,52 cases with non advanced adenomas,40 cases with non adenomatous polyps,51 cases with other benign lesions,and 113 cases without abnormalities.The detection rates of non advanced adenomas,advanced adenomas,colorectal cancer,non pro-gressive lesions and progressive lesions in the quantitative FIT positive group were significantly higher than those in the quantitative FIT negative group.The detection rates of those without obvi-ous abnormalities were significantly lower than those in the quantitative FIT negative group,and the differences were statistically significant(all P＜0.05).The resource burden of colonoscopy in the quantitative FIT positive and negative groups was 5.46(95％CI:1.56～9.34)and 38.25(95％CI:30.55～45.95),respectively.The level of FIT measurement gradually increases with the severity of the lesion,and the difference between groups is statistically significant(H=48.308,P＜0.001).Quan-titative FIT has high sensitivity and negative predictive value for non progressive lesions and pro-gressive lesions,with values of 71.15％,85.71％and 90.20％,97.39％,respectively.The AUC values for quantitative FIT screening of non progressive lesions and progressive lesions were 0.653(95％CI:0.572～0.734,P=0.001)and 0.720(95％CI:0.631～0.808,P＜0.001),respectively.[Conclusion]Quantitative FIT,as a suitable technique for CRC opportunistic screening in health check-up population,has good diagnostic efficacy for non progressive lesions and progressive le-sions.Performing colonoscopy on FIT positive individuals can improve lesion detection rates while reducing colonoscopy resource consumption,aligning with China's healthcare resource landscape.

[Purpose]To analyze and evaluate the application effect of quantitative fecal immuno-chemical test(FIT)in the opportunistic screening of colorectal cancer(CRC)in health examination population.[Methods]10 025 healthy individuals who completed quantitative FIT at the Health Management Cancer of Sichuan Cancer Hospital from January 1,2021 to December 31,2023 were included.Participants with positive FIT results were recommended for diagnostic colonoscopy.Quantitative FIT positivity rate,colonoscopy screening compliance rate,and colorectal lesion de-tection rate in the queue population were analyzed,the detection rate of colorectal lesions and colonoscopy resource load between quantitative FIT positive and negative colonoscopy screening groups at all levels were compared and the diagnostic efficacy of quantitative FIT for non progres-sive lesions and progressive lesions were explored.[Results]The positive rate of quantitative FIT was 6.24％(95％CI:5.77％～6.71％).The compliance rate of colonoscopy screening was 20.93％(95％CI:17.74％～24.12％).Among 284 colonoscopy patients,7 cases were detected with CRC,21 cases with advanced adenomas,52 cases with non advanced adenomas,40 cases with non adenomatous polyps,51 cases with other benign lesions,and 113 cases without abnormalities.The detection rates of non advanced adenomas,advanced adenomas,colorectal cancer,non pro-gressive lesions and progressive lesions in the quantitative FIT positive group were significantly higher than those in the quantitative FIT negative group.The detection rates of those without obvi-ous abnormalities were significantly lower than those in the quantitative FIT negative group,and the differences were statistically significant(all P＜0.05).The resource burden of colonoscopy in the quantitative FIT positive and negative groups was 5.46(95％CI:1.56～9.34)and 38.25(95％CI:30.55～45.95),respectively.The level of FIT measurement gradually increases with the severity of the lesion,and the difference between groups is statistically significant(H=48.308,P＜0.001).Quan-titative FIT has high sensitivity and negative predictive value for non progressive lesions and pro-gressive lesions,with values of 71.15％,85.71％and 90.20％,97.39％,respectively.The AUC values for quantitative FIT screening of non progressive lesions and progressive lesions were 0.653(95％CI:0.572～0.734,P=0.001)and 0.720(95％CI:0.631～0.808,P＜0.001),respectively.[Conclusion]Quantitative FIT,as a suitable technique for CRC opportunistic screening in health check-up population,has good diagnostic efficacy for non progressive lesions and progressive le-sions.Performing colonoscopy on FIT positive individuals can improve lesion detection rates while reducing colonoscopy resource consumption,aligning with China's healthcare resource landscape.

Objective:To explore the effect of binary reminiscence therapy on the hope level of elderly patients undergoing colorectal neoplasms surgery and the positive feelings of care of their spouses.Methods:Using the convenient sampling method, 96 patients who underwent surgical treatment for colorectal neoplasms in the First Affiliated Hospital of Zhengzhou University from February to November 2019 and their spouses were selected as the research objects. The 47 patients hospitalized from February to June 2019 and their spouses were set as the control group, and the 49 patients hospitalized from July to November 2019 and their spouses were set as the observation group. The control group received routine perioperative nursing of colorectal neoplasms, while the observation group received binary reminiscence therapy on the basis of routine nursing. The Herth Hope Scale (HHI) and the Positive Aspects of Caregiving Instrument (PAC) were used to evaluate the effects of intervention.Results:There was no statistically significant difference in scores of all dimensions of HHI between the two groups at the time of admission ( P>0.05) . The scores of all dimensions of HHI in the observation group were higher than those in the control group before discharge, and the differences were statistically significant ( P<0.05) . There was no statistically significant difference in PAC scores of the spouses in the two groups at the time of admission ( P>0.05) . The scores of each dimension of PAC in the observation group were higher than those in the control group before discharge, and the differences were statistically significant ( P<0.05) . Conclusions:Binary reminiscence therapy can improve the hope level of patients with colorectal neoplasms and positive feelings of care of their spouses.

Objective:To analyze effects of personal character and occupational values of psychiatric nurses on job burnout.Methods:Using the convenient sampling method, 150 nurses from the psychiatric department in general hospital and psychiatric hospital of Zhengzhou from May 2019 to July 2019 were selected as the research objects. Eysenck Personality Questionnaire Short Scale for Chinese (EPQ-RSC) , Nursing Professional Values Scale-Revised (NPVS-R) AND Maslach Burnout Inventory-General Survey (MBI-GS) used to conduct a questionnaire survey among 150 psychiatric nurses. Pearson correlation analysis was used to analyze the correlation between EPQ-RSC, NPVS-R and MBI-GS, and multiple regression analysis was used to determine the factors affecting the job burnout of psychiatric nurses.Results:EPQ-RSC scores of psychiatric nurses for neuroticism, introversion and extraversion, psychoticism and concealment were (48.52±5.36) , (53.32±10.02) , (50.23±4.85) and (45.36±6.32) , respectively. The total score of NPVS-R was (91.91±14.32) . The scores of emotional exhaustion, cynicism and low sense of accomplishment in MBI-GS were respectively (26.12±4.02) , (12.01±3.51) and (15.32±3.35) .The psychoticism and neuroticism scores in EPQ-RSC of psychiatric nurses were positively correlated with the emotional exhaustion and cynicism scores in MBI-GS, and negatively correlated with the depression scores ( P<0.01) . The introversion and extraversion scores in EPQ-RSC were negatively correlated with emotional exhaustion and cynicism scores in MBI-GS, and positively correlated with the low sense of accomplishment score ( P<0.01) . The total score of NPVS-R was negatively correlated with the emotional exhaustion and cynicism scores in MBI-GS, and positively correlated with the low sense of achievement score ( P<0.001) . Multiple linear regression analysis showed that psychoticism, introversion and extroversion and neuroticism scores in EPQ-RSC and NPVS-R score were the influencing factors of job burnout of psychiatric nurses ( P<0.01) . Conclusions:The personal character and occupational values of psychiatric nurses are obviously related to job burnout, which are related factors that affect job burnout.

ObjectiveThe purpose of this study was to observe the correlation of mTOR and VEGF gene with nephropathy indicators in diabetic rats. Methods Forty-eight male Sprague-Dawley(SD)rats were divided into diabetes mellitus group(DM=28)and control group(NDM=20). Diabetic models were produced by injection of streptozotocin. In the courses of 12,16,20 and 24 weeks,the histology scores(HS)and glomerular basement membrane(GBM)thickness were collected. The protein and mRNA expressions of the gene of mTOR,VEGF and VEGFR2 were observed by immunohistochemistry and real-time quantitative polymerase chain reaction (RT-Q-PCR)by SYBR Green. And the standardized cycle of threshold(SCt)was regarded as the indicators of the mRNA expression. Results HS and GBM thickness were significantly higher in DM rats than those in NDM rats,especially in DM rats of the courses of 20 and 24 weeks(P < 0.01). IHC scores of VEGF and VEGFR2 were higher in total DM rats and were positively correlated with each other. There were positive correlations between HS with VEGF and VEGFR2 in total DM rats(P < 0.05). SCts of VEGF and VEGFR2 were significantly higher and were positively correlated with each other in total DM rats(P < 0.01). SCt of VEGF and GBM thickness showed positive correlation in total DM rats. SCt of VEGF was highest in the course of 12w DM rats. SCt of VEGFR2 gradually decreased following by the diabetic course,and was lowest in the course of 24w. There were no significantly differences in IHC scores and SCt of mTOR between DM and NDM rats. But the IHC scores of mTOR,VEGF and VEGFR2 were positively correlated with each other and with HS in total DM rats(P < 0.05). Conclusion HS and GBM thickness were higher in diabetic rats,especially in the course of 24w,which could reflect the injury of nephropathy. The protein and mRNA of VEGF and VEGFR2 were high expressed in kidney of DM rats and increased with the increasing of diabetic course. The mRNA expression of VEGF was positively correlated with GBM thickness of in diabetic nephropathy(DN). The protein expressions of mTOR,VEGF and VEGFR2 might have synergistic effects in DN of DM rats. But the results could not exclude the influences of different courses,sample size and experimental conditions.