Objective:To explore the effects of traditional Chinese medical fumigation and washing combined with new nursing models on perianal edema in patients receiving radiotherapy for gynecological tumors.Methods:Totally128 patients who received radiotherapy for gynecological tumors in the Department of Radiotherapy at Jiangsu Cancer Hospital from May 2019 to February 2020 were selected and divided into the intervention group and the control group by convenient sampling, with 64 cases in each group. Patients in the control group received routine treatment and care, while patients in the intervention group received traditional Chinese medical fumigation and washing combined with new nursing models such as perianal observation, health education prescription, psychological nursing intervention, functional rehabilitation exercise, and perianal nursing follow-up. The scores of perianal edema extent, degree of perianal edema, sense of swelling and Numerical Rating Scale (NRS) as well as red blood cell count, hemoglobin concentration, and nursing satisfaction were compared between the two groups.Results:Two patients in each group terminated the study due to their severe illness, and totally 62 patients in each group completed the study. After intervention, the extent and degree of perianal edema in the intervention group were lower than those in the control group, and the difference was statistically significant ( P<0.05) ; the anal swelling score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.05) ; the NRS score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.05) ; the hemoglobin concentration of the intervention group was higher than that of the control group, and the difference was statistically significant ( P<0.05) ; the red blood cell counts of the two groups were not significantly different ( P>0.05) . The nursing satisfaction score in the intervention group was (23.89±4.21) , which was higher than (21.18±5.08) in the control group, and the difference was statistically significant ( P<0.05) . Conclusions:Traditional Chinese medical fumigation and washing combined with new nursing models can ameliorate the degree and extent of perianal edema and sense of swelling and pain in patients, and improve their satisfaction, which is worth promoting in clinical practice.

In this study, the buffering capacity of amphiphilic pH-sensitivity copolymer poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (PEOZ-CHMC) was evaluated. The ammonium sulfate gradient method was used to prepare doxorubicin hydrochloride (DOX x HCl)-loaded liposomes (DOX-L), and then the post-insertion method was used to prepare PEOZ-CHMC and polyethylene glycol-distearoyl phosphatidyl ethanolamine (PEG-DSPE) modified DOX x HCl-loaded liposomes (PEOZ-DOX-L and PEG-DOX-L). The physico-chemical properties, in vitro drugs release behavior, cellular toxicity and intracellular delivery of liposomes were evaluated, separately. The results showed that PEOZ-CHMC has a satisfactory buffering capacity. The sephadex G-50 column centrifugation method and dynamic light scattering were used to determine the encapsulation efficiency (EE) and particle size of liposomes. The EE and particle size of DOX-L were (97.3 ± 1.4) % and 120 nm, respectively, and the addition of PEOZ-CHMC or PEG-DSPE had no influence on EE and particle size. The zeta potentials of three kinds of liposomes were negative. The release behavior of various DOX liposomes in vitro was investigated by dialysis method. In phosphate buffer solution (PBS) at pH 7.4, DOX x HCl was released from PEOZ-DOX-L in a sustained manner. While in PBS at pH 5.0, the release rate of DOX x HCl from PEOZ-DOX-L increased significantly, which suggested DOX x HCl was released from PEOZ-DOX-L in a pH-dependent manner. The intracellular delivery of liposomes was investigated by confocal laser scanning microscopy (CLSM). The CLSM images indicated that PEOZ-DOX-L showed efficient intracellular trafficking including endosomal escape and release DOX x HCl into nucleus, as well as the DOX-L and PEG-DOX-L had no this effect. The cytotoxicity of liposomes against MCF-7 cells was detected by using MTT assay. The results showed that antiproliferative effects of PEOZ-DOX-L enhanced with pH value decreased, whereas DOX-L and PEG-DOX-L did not have any significant difference in inhibitions at different pH conditions. Therefore, the problems of the inhibition of cellular uptake of liposomes and the failed endosomal escape of pH-sensitive liposomes by PEG chain can be overcome by the pH-sensitive liposomes constructed by PEOZ-CHMC.