Objective To study the clinical efficacy of self-madeQingre-Jiedu burn ointment on burn wound healing.Methods From November 2013 to October 2016, 94 burned patients in hospital were randomly divided into the observation group and control group, 47 cases each group. On the basis of conventional wound treatment, the control group was treated with compound sulfadiazine zinc coating, and the observation group was treated with self-madeQingre-Jiedu burn ointment topical coating. The analgesic effect and the clinical curative effect were observed and analyzed in the two groups. The Serum inflammatory cytokines like C-reactive protein(CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), growth factors [transforming growth factor-α (TGF-α), epidermal growth factor (EGF) levels and postoperative wound scar score (VSS) were compared before and after treatment.Results The rate of wound analgesic in the observation group was 85.1％ (40/47) and the control group 59.6％ (28/47). The difference was statistically significant (χ2=7.656,P<0.05). The total effective rate of the observation group was 93.6％ (44/47) and the control group 78.7％ (37/47). The difference was statistically significant (P<0.05). After treatment, the CRP (39.85 ± 8.41ng/Lvs. 57.45 ± 11.63 ng/L,t=8.408), TNF-α (2.65 ± 0.87 ng/Lvs. 4.53 ± 1.23 ng/L,t=8.555), IL-6 (72.36 ± 10.25 ng/Lvs. 93.68 ± 12.54 ng/L,t=9.025) levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the TGF-α (53.69±6.51)pg/mlvs. 46.61 ± 6.51 pg/ml,t=6.192) and the levels in the observation group were significantly higher than those in the control group (P<0.05). Conclusions The self-madeQingre-Jiedu burn ointments could heal the burn wound and reduce scars, and promote the growth factors.