ObjectiveThis paper aims to observe the syndrome improvement and negative antigen conversion rate of Qingxuan Daozhi formula in the treatment of influenza in children （heat accumulation in the lung and stomach syndrome）. MethodsThrough a multi-center randomized controlled methodology design，confirmed influenza cases were collected from October 2022 to April 2023 in the pediatrics department of eight hospitals，such as Dongfang Hospital of Beijing University of Chinese Medicine. A total of 180 children with influenza and heat accumulation in the lung and stomach syndrome conforming to the standard were recruited through the clinic. The sick children meeting the inclusion criteria were randomly divided into groups by a block-randomized method. The children in the experimental group were treated with Qingxuan Daozhi formula for five days，and those in the control group were treated with Oseltamivir Phosphate Granules for five days. The primary efficacy indicator was the negative conversion rate of influenza antigen detection. Secondary efficacy indicators were the Canadian acute respiratory illness and flu scale （CARIFS） and the incidence of complications，severe cases， and critical cases. Follow-up observation was conducted on the day of enrollment，48 hours after medication，72 hours after medication， and （6+1） d after medication. ResultsOne hundred and eighty participants were randomly assigned to the experimental group （90 cases） or the control group （90 cases）. All participants were followed up during the study. Comparison of influenza antigen detection results in the primary efficacy indicators showed that the average time of negative influenza antigen conversion in the experimental group was （5.29±1.25） d，and that in the control group was （5.40±1.68） d，without a statistically significant difference. After five days of intervention，52 cases in the experimental group and 51 cases in the control group converted to negative，without a statistically significant difference. CARIFS score results in the secondary efficacy indicators showed that during 72 hours after intervention，there were statistically significant differences between the experimental group and the control group in three dimensions， including headache，muscle soreness， and the need for extra care （P<0.05）. On the （6+1） days after the intervention，the differences in both the experimental group and the control group were statistically significant in 10 dimensions， including sore throat，bad sleep，uncomfortable feeling，poor spirit and fatigue，crying more than usual，the need for extra care，symptom，function，influence on parents，and total score （P<0.05）. The comparison results within the group in the dimensional scores of symptom， function， and influence on parents，as well as the CARIFS total score showed that with the delay of follow-up time，scores of both groups decreased significantly，with a statistically significant difference （P<0.01）. Inter-group comparison results showed that the mean score of the experimental group was higher than that of the control group at the time of enrollment. With the progress of intervention，the score of the experimental group was significantly decreased compared with that of the control group. At the end of follow-up，the mean score of the experimental group was lower than that of the control group，with no statistically significant difference. In terms of the incidence of complications，severe cases， and critical cases， there were no complications，severe cases， and critical cases in the two groups，without a statistically significant difference. ConclusionThe symptom improvement effect and negative antigen conversion rate of Qingxuan Daozhi formula in the treatment of influenza in children （heat accumulation in the lung and stomach syndrome） are not inferior to Oseltamivir Phosphate granules， and children's acceptance is better. It can be more widely used in clinical treatment of influenza in children （heat accumulation in the lung and stomach syndrome）.

[Objective] To analyse and predict the tendencies of using erythrocyte blood in Changsha based on the autoregressive integrated moving average (ARIMA) model, long short-term memory (LSTM) and ARIMA-LSTM combination model, so as to provide reliable basis for designing a feasible and effective blood inventory management strategy. [Methods] The data of erythrocyte usage from hospitals in Changsha between January 2012 and December 2023 were collected, and ARIMA model, LSTM model and ARIMA-LSTM combination model were established. The actual erythrocyte consumption from January to May 2024 were used to assess and verify the prediction effect of the models. The extrapolation prediction accuracy of the models were tested using two evaluation indicators: mean absolute percentage error (MAPE) and root mean square error (RMSE), and then the prediction performance of the model was compared. [Results] The RMSE of LSTM model, optimal model ARIMA(1,1,1)(1,1,1)12 and ARIMA-LSTM combination model were respectively 5 206.66, 3 096.43 and 2 745.75, and the MAPE were 18.78%,11.54% and 9.76% respectively, which indicated that the ARIMA-LSTM combination model was more accurate than the ARIMA model and LSTM model, and the prediction results was basically consistent with the actual situation. [Conclusion] The ARIMA-LSTM model can better predict the clinical erythrocyte consumption in Changsha in the short term.

Volume overload is one of the major causes of recurrent hospital admissions in patients with heart failure, and proper volume management is critical to patient treatment and prognosis. This paper introduces the concept of mobile health, describes the application forms and effects of mobile health in volume management of heart failure patients, summarizes the shortcomings of existing research and prospects for the future, so as to provide reference for further promoting the application of mobile health in volume management of heart failure patients in China.

Objective To explore the aesthetic effect of adsorptive denture restoration on completely edentulous patients and the im-pact on masticatory function and language function.Methods A study was conducted from June 2020 to June 2023 among 85 com-pletely edentulous patients.The patients were randomly divided into 2 groups.The routine group(n=43)underwent traditional com-plete denture restoration,while the observation group(n=42)underwent adsorptive denture restoration.Comparison was made between groups on the success rate of denture restoration,adaptation time,satisfaction with denture restoration,aesthetic effect,masticatory function,language function,retention stability,comfort level,the OHIP-14 scores before restoration and at 6 months after restoration,frequencies of follow-up visits and adjustments,and the incidence of complications.Results Compared with the routine group,the ob-servation group had a significantly higher success rate of one-time denture wearing,significantly shorter adaptation time and significantly higher satisfaction with restoration,with statistically significant differences(P＜0.05).After restoration,height of the lower face(Sn-Gn)increased significantly,while the midface to lower face ratio(G-Sn/Sn-Gn)and nasolabial angle(Cm-Sn-Ls)decreased signifi-cantly in both groups.The changes of Sn-Gn,G-Sn/Sn-Gn and Cm-Sn-Ls in the observation group after restoration were significantly greater(P＜0.05).Bite force,masticatory efficiency,language function score,retention stability score and wearing comfort level score of the observation group were significantly higher(P＜0.05).After restoration,the scores for physiological function,psychological func-tion and activities of daily living of the two groups decreased significantly.The observation group had significantly lower life quality scores(P＜0.05).The frequencies of follow-up visits and adjustments and the total incidence of complications were significantly lower in obser-vation group(P＜0.05).Conclusion Compared with traditional complete denture restoration,adsorptive denture restoration can achieve more obvious aesthetic effect on completely edentulous patients,and improve the basic function of dentures more significantly.In addition,adsorptive denture restoration has characteristics of shorter adaptation time,better prognosis and lower risk of complications.

Objective To explore the aesthetic effect of adsorptive denture restoration on completely edentulous patients and the im-pact on masticatory function and language function.Methods A study was conducted from June 2020 to June 2023 among 85 com-pletely edentulous patients.The patients were randomly divided into 2 groups.The routine group(n=43)underwent traditional com-plete denture restoration,while the observation group(n=42)underwent adsorptive denture restoration.Comparison was made between groups on the success rate of denture restoration,adaptation time,satisfaction with denture restoration,aesthetic effect,masticatory function,language function,retention stability,comfort level,the OHIP-14 scores before restoration and at 6 months after restoration,frequencies of follow-up visits and adjustments,and the incidence of complications.Results Compared with the routine group,the ob-servation group had a significantly higher success rate of one-time denture wearing,significantly shorter adaptation time and significantly higher satisfaction with restoration,with statistically significant differences(P＜0.05).After restoration,height of the lower face(Sn-Gn)increased significantly,while the midface to lower face ratio(G-Sn/Sn-Gn)and nasolabial angle(Cm-Sn-Ls)decreased signifi-cantly in both groups.The changes of Sn-Gn,G-Sn/Sn-Gn and Cm-Sn-Ls in the observation group after restoration were significantly greater(P＜0.05).Bite force,masticatory efficiency,language function score,retention stability score and wearing comfort level score of the observation group were significantly higher(P＜0.05).After restoration,the scores for physiological function,psychological func-tion and activities of daily living of the two groups decreased significantly.The observation group had significantly lower life quality scores(P＜0.05).The frequencies of follow-up visits and adjustments and the total incidence of complications were significantly lower in obser-vation group(P＜0.05).Conclusion Compared with traditional complete denture restoration,adsorptive denture restoration can achieve more obvious aesthetic effect on completely edentulous patients,and improve the basic function of dentures more significantly.In addition,adsorptive denture restoration has characteristics of shorter adaptation time,better prognosis and lower risk of complications.

Volume overload is one of the major causes of recurrent hospital admissions in patients with heart failure, and proper volume management is critical to patient treatment and prognosis. This paper introduces the concept of mobile health, describes the application forms and effects of mobile health in volume management of heart failure patients, summarizes the shortcomings of existing research and prospects for the future, so as to provide reference for further promoting the application of mobile health in volume management of heart failure patients in China.

Objective:To develop a robotic digestive endoscope system (RDES) and to evaluate its feasibility, safety and control performance by experiments.Methods:The RDES was designed based on the master-slave control system, which consisted of 3 parts: the integrated endoscope, including a knob and button robotic control system integrated with a gastroscope; the robotic mechanical arm system, including the base and arm, as well as the endoscopic advance-retreat control device (force-feedback function was designed) and the endoscopic axial rotation control device; the control console, including a master manipulator and an image monitor. The operator sit far away from the endoscope and controlled the master manipulator to bend the end of the endoscope and to control advance, retract and rotation of the endoscope. The air supply, water supply, suction, figure fixing and motion scaling switching was realized by pressing buttons on the master manipulator. In the endoscopy experiments performed on live pigs, 5 physicians each were in the beginner and advanced groups. Each operator operated RDES and traditional endoscope (2 weeks interval) to perform porcine gastroscopy 6 times, comparing the examination time. In the experiment of endoscopic circle drawing on the inner wall of the simulated stomach model, each operator in the two groups operated RDES 1∶1 motion scaling, 5∶1 motion scaling and ordinary endoscope to complete endoscopic circle drawing 6 times, comparing the completion time, accuracy (i.e. trajectory deviation) and workload.Results:RDES was operated normally with good force feedback function. All porcine in vivo gastroscopies were successful, without mucosal injury, bleeding or perforation. In beginner and advanced groups, the examination time of both RDES and ordinary endoscopy tended to decrease as the number of operations increased, but the decrease in time was greater for operating RDES than for operating ordinary endoscope (beginner group P=0.033; advanced group P=0.023). In the beginner group, the operators operating RDES with 1∶1 motion scaling or 5∶1 motion scaling to complete endoscopic circle drawing had shorter completion time [1.68 (1.40, 2.17) min, 1.73 (1.47, 2.37) min VS 4.13 (2.27, 5.16) min, H=32.506, P<0.001], better trajectory deviation (0.50±0.11 mm, 0.46±0.11 mm VS 0.82±0.26 mm, F=38.999, P<0.001], and less workload [42.00 (30.00, 50.33) points, 43.33 (35.33, 54.00) points VS 52.67 (48.67, 63.33) points, H=20.056, P<0.001] than operating ordinary endoscope. In the advanced group, the operators operating RDES with 1∶1 or 5∶1 motion scaling to complete endoscopic circle drawing had longer completion time than operating ordinary endoscope [1.72 (1.37, 2.53) min, 1.57 (1.25, 2.58) min VS 1.15 (0.86, 1.58) min, H=13.233, P=0.001], but trajectory deviation [0.47 (0.13, 0.57) mm, 0.44 (0.39, 0.58) mm VS 0.52 (0.42, 0.59) mm, H=3.202, P=0.202] and workload (44.62±21.77 points, 41.24±12.57 points VS 44.71±17.92 points, F=0.369, P=0.693) were not different from those of the ordinary endoscope. Conclusion:The RDES enables remote control, greatly reducing the endoscopists' workload. Additionally, it gives full play to the cooperative motion function of the large and small endoscopic knobs, making the control more flexible. Finally, it increases motion scaling switching function to make the control of endoscope more flexible and more accurate. It is also easy for beginners to learn and master, and can shorten the training period. So it can provide the possibility of remote endoscopic control and fully automated robotic endoscope.

Objective:To investigate a brucellosis outbreak caused by contact with unquarantined sheep in Chongqing, and provide reference for prevention and control of brucellosis.Methods:In accordance with the requirements of the "Technical Plan of Brucellosis Prevention and Control Project of Chongqing" and the "Working Specification for Epidemic Disposal of Human Brucellosis" (DB50/T 946-2019), a self-designed brucellosis case questionnaire (version 2021) was used to carry out case investigation and laboratory tests on cases reported by medical institutions, and the data were analyzed descriptively.Results:According to "Working Specification for Epidemic Disposal of Human Brucellosis" (DB50/T 946-2019) in Chongqing, the brucellosis outbreak that occurred in December 2021 was determined to be a cluster outbreak, with a total of two confirmed cases of brucellosis, and a incidence rate of 2/9. The reason of the outbreak was the rearing and slaughtering of unquarantined sheep.Conclusion:We should strengthen the inspection and quarantine of livestock such as cattle and sheep, crack down on informal trade of livestock, and reduce the risk of brucellosis.

Objective To explore the clinical application of salpingectomy with preserving salpingum mesothelium under single-port laparoscopy and its influence on ovarian reserve function and assisted pregnancy outcome.Methods From January 2019 to January 2022,80 cases of salpingectomy in Shuangyashan Double Mine Hospital were selected and randomly divided into control group(n=40)and observation group(n=40).The control group was treated with multi-hole laparoscopic salpingectomy with salpingum mesothelium preserved,while the observation group treated with single-hole laparoscopic salpingectomy with salpingum mesothelium preserved.The operation conditions(operation time,intraoperative blood loss,exhaust time,etc.),anti-Mullerian hormone(AMH)before and one month after operation,ovarian function(basal sinus follicle count),postoperative complications,assisted pregnancy outcome and cosmetic effect were analyzed.Results The exhaust time and postoperative hospitalization time in the observation group were shorter than those in the control group,and the operation time was longer than that in the control group(P＜0.05).One month after operation,AMH in both groups decreased,and the number of sinus follicles in observation group A was lower than that in control group.The complication rate was lower than that of the control group(P＜0.05).After a one-year follow-up,there was no significant difference in ovulation rate and pregnancy rate between the two groups(P＞0.05).Follow-up for 3 months showed that the cosmetic effect of the observation group was better than that of the control group(95.00％vs 72.50％)(P＜0.05).Conclusion Single-port laparoscopic salpingectomy with salpingum mesothelium preservation is safe,cosmetic and minimally invasive,and has little adverse effect on ovarian reserve function,which is helpful for successful pregnancy assistance and worthy of clinical application and promotion.

Humans ; Asthma/drug therapy* ; Biological Therapy