Obesity, as a chronic recurrent disease, has become a major public health challenge in China. To implement the requirements of the Healthy China Initiative (2019—2030), under domestic guidelines or consensus statements on overweight and obesity, and in alignment with the latest scientific advances globally, the Quality control protocol for adult overweight and obesity screening in health management (examination) institutions (2025 edition) was developed. This protocol was drafted by the Health Management Center of Shanghai Changzheng Hospital and formulated through multiple rounds of deliberation by experts in China’s health examination quality control field. The protocol establishes unified standards for screening facilities, personnel qualifications, and measurement or testing procedures. It defines specific screening items, outlines a standardized screening pathway, and sets requirements for the final medical review, ensuring the scientific validity, effectiveness, and safety of the screening process. The implementation of this protocol will enhance the consistency of weight management practices for adults across health examination institutions and strengthen the quality control of overweight and obesity screening programs.

Objective To explore how digital and intelligent technologies can optimize the storage allocation and picking paths for Traditional Chinese medicine decoction pieces.Methods Based on prescription information and medicine data from the hospital information system(HIS),this study employs MATLAB programming to use an integer linear programming(ILP)algorithm for optimizing the storage allocation of Traditional Chinese medicine decoction pieces.Additionally,a greedy algorithm is applied to optimize the picking paths to reduce the picking distance for pharmacists.Finally,an independent samples paired t-test is used to analyze the experimental data to verify the significance of the optimizations.Results A total of 7 734 prescriptions were collected from the HIS.The results of storage optimization showed that the total distance before optimization was(87.58±0.29)m,which was reduced to(85.35±0.28)m after optimization(P﹤0.000 1).The picking path optimization results showed that the picking path was(85.35±0.28)m before optimization and(40.06±0.11)m after optimization(P﹤0.000 1).The results of the independent samples paired t-test indicate that the path was significantly reduced after both storage and picking path optimizations,with statistical significance.Conclusion By using digital and intelligent methods,informatics pharmacists can effectively shorten the picking paths for Traditional Chinese medicine decoction pieces,improve dispensing efficiency,and reduce patient waiting times.

Objective:To construct a continuity of care plan for adolescent fixed orthodontic patients based on the theory of timing, and provide systematic and standardized nursing interventions for adolescent fixed orthodontic patients.Methods:Guided by the theory of timing, preliminary plan items were formulated through literature review and questionnaire survey. Using the Delphi method, 15 experts were consulted for two rounds to determine the continuity of care plan for adolescent fixed orthodontic patients from October to December, 2023.Results:The effective response rates of the two rounds of questionnaires were 15/15, respectively. The expert authority levels were 0.93 and 0.94, and the Kendall harmony coefficients were 0.28 and 0.38, respectively. The differences were statistically significant (both P<0.001). The final established plan included 5 primary indicators, 23 secondary indicators, and 47 tertiary indicators. Conclusions:The continuity of care plan for adolescent fixed orthodontic patients based on the timing theory is reliable and scientific, and can meet the continuity of care needs of patients at different stages, providing reliable clinical basis for carrying out continuity of care.

Objective To explore how digital and intelligent technologies can optimize the storage allocation and picking paths for Traditional Chinese medicine decoction pieces.Methods Based on prescription information and medicine data from the hospital information system(HIS),this study employs MATLAB programming to use an integer linear programming(ILP)algorithm for optimizing the storage allocation of Traditional Chinese medicine decoction pieces.Additionally,a greedy algorithm is applied to optimize the picking paths to reduce the picking distance for pharmacists.Finally,an independent samples paired t-test is used to analyze the experimental data to verify the significance of the optimizations.Results A total of 7 734 prescriptions were collected from the HIS.The results of storage optimization showed that the total distance before optimization was(87.58±0.29)m,which was reduced to(85.35±0.28)m after optimization(P﹤0.000 1).The picking path optimization results showed that the picking path was(85.35±0.28)m before optimization and(40.06±0.11)m after optimization(P﹤0.000 1).The results of the independent samples paired t-test indicate that the path was significantly reduced after both storage and picking path optimizations,with statistical significance.Conclusion By using digital and intelligent methods,informatics pharmacists can effectively shorten the picking paths for Traditional Chinese medicine decoction pieces,improve dispensing efficiency,and reduce patient waiting times.

Objective:To construct a continuity of care plan for adolescent fixed orthodontic patients based on the theory of timing, and provide systematic and standardized nursing interventions for adolescent fixed orthodontic patients.Methods:Guided by the theory of timing, preliminary plan items were formulated through literature review and questionnaire survey. Using the Delphi method, 15 experts were consulted for two rounds to determine the continuity of care plan for adolescent fixed orthodontic patients from October to December, 2023.Results:The effective response rates of the two rounds of questionnaires were 15/15, respectively. The expert authority levels were 0.93 and 0.94, and the Kendall harmony coefficients were 0.28 and 0.38, respectively. The differences were statistically significant (both P<0.001). The final established plan included 5 primary indicators, 23 secondary indicators, and 47 tertiary indicators. Conclusions:The continuity of care plan for adolescent fixed orthodontic patients based on the timing theory is reliable and scientific, and can meet the continuity of care needs of patients at different stages, providing reliable clinical basis for carrying out continuity of care.

Objectives:To investigate the binary coping mode of hospitalized patients with digestive system tumors and their spouses,and its relationship with anxiety and depression symptoms in both spouses,aiming to provide a reference for medical staff to develop intervention plans to improve the quality of life for patients and their spouses.Methods:A convenience sampling method was used to select 103 patients with digestive system tumors and their spouses who were admitted to a tertiary-level hospital in Shanghai from January to June,2024,and the Dyadic Coping Inventory and the Hospital Anxiety and Depression Scale were used for the survey.Latent profile analysis was utilized to identify different types of binary coping patterns among the couples.One-way ANOVA or χ2 tests were used to compare the intergroup differences in anxiety and depression symptom scores or positive rates among the couples under different binary coping patterns.Results:Of the 110 couples surveyed,103 provided complete and valid responses of questionnaires,resulting in a response rate of 93.64%.The overall binary coping levels of the couples were above average(130.74±30.64,130.35±27.29).The binary coping strategies of patients with digestive system tumors and their spouses could be divided into three potential categories including general coping,high coping and low coping groups.Significantly differences in anxiety symptom score,depression symptom score and positive rate were observed among the subgroups(P=0.001 5,P=0.013 5,P=0.017 5,P=0.001 2).The anxiety and depression symptom scores and positive rate of patients in the low coping group were higher than those in the other two groups.Conclusion:Patients and their spouses in the low coping group represent a high risk of anxiety and depression,warranting early screening and focused attention.Interventions tailored to the couple should be developed and implemented.

Objective To investigate the impacts of phillyrin on exudates and lung injury in rats with acute pleurisy by regulating the NLRP3 inflammatory pathway.Methods Ninety rats were randomly divided into the control group,the model group,the low-dose phillyrin(PH-L,5 mg/kg)group,the medium-dose phillyrin(PH-M,10 mg/kg)group,the high-dose phillyrin(PH-H,20 mg/kg)group and the NLRP3 pathway inhibitor(PJ34,10 mg/kg)group.FVC,FEV 0.1 and FEV 0.3 were detected by lung function analyzer.Electronic balance was used to weigh the mass of chest exudate.The number of white blood cells in exudate was detected by Wright staining.Contents of prostaglandin E2(PGE2),monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)in exudate were detected by ELISA.Automatic blood gas analyzer was used to detect p(CO2)and p(O2)of rats.HE staining was used to observe pathological changes of lung tissue.The expression levels of NLRP3 and Caspase-1 protein were detected by immunohistochemistry.Western blot assay was used to detect the expression of NLRP3 pathway protein.Results Compared with the control group,the quality of pleural exudate and the number of white blood cells,the contents of PGE2,MCP-1,IL-6,TNF-α,the expression of p(CO2)and NLRP3 pathway proteins in exudate of the model group increased obviously,FVC,FEV 0.1,FEV 0.3 and p(O2)decreased obviously,and the lung tissue showed obvious pathological damage(P＜0.05).Compared with the model group,the quality of pleural exudate and the number of white blood cells,the contents of PGE2,MCP-1,IL-6,TNF-α,the expression of p(CO2),NLRP3 pathway proteins in the exudate of rats decreased obviously in the PH group and the PJ34 group,FVC,FEV 0.1,FEV 0.3 and p(O2)increased obviously,the pathological injury of lung tissue was obviously improved(P＜0.05).Compared with the PH-H group,there were no significant differences in the above indexes in the PJ34 group(P＞0.05).Conclusion PH can improve lung injury induced by acute pleurisy in rats by inhibiting the activation of NLRP3 pathway and inhibiting inflammatory reaction.

Objectives:To investigate the binary coping mode of hospitalized patients with digestive system tumors and their spouses,and its relationship with anxiety and depression symptoms in both spouses,aiming to provide a reference for medical staff to develop intervention plans to improve the quality of life for patients and their spouses.Methods:A convenience sampling method was used to select 103 patients with digestive system tumors and their spouses who were admitted to a tertiary-level hospital in Shanghai from January to June,2024,and the Dyadic Coping Inventory and the Hospital Anxiety and Depression Scale were used for the survey.Latent profile analysis was utilized to identify different types of binary coping patterns among the couples.One-way ANOVA or χ2 tests were used to compare the intergroup differences in anxiety and depression symptom scores or positive rates among the couples under different binary coping patterns.Results:Of the 110 couples surveyed,103 provided complete and valid responses of questionnaires,resulting in a response rate of 93.64%.The overall binary coping levels of the couples were above average(130.74±30.64,130.35±27.29).The binary coping strategies of patients with digestive system tumors and their spouses could be divided into three potential categories including general coping,high coping and low coping groups.Significantly differences in anxiety symptom score,depression symptom score and positive rate were observed among the subgroups(P=0.001 5,P=0.013 5,P=0.017 5,P=0.001 2).The anxiety and depression symptom scores and positive rate of patients in the low coping group were higher than those in the other two groups.Conclusion:Patients and their spouses in the low coping group represent a high risk of anxiety and depression,warranting early screening and focused attention.Interventions tailored to the couple should be developed and implemented.

The aging of the population has led to a sharp increase in the demand of the elderly for long-term care services. How to ensure the quality of long-term care services is a hot topic of widespread concern in society. In developed countries, long-term care services have been carried out early, a perfect service quality evaluation system has been formed, and the evaluation results have been effectively used. Long-term care services in China started late, there is no unified evaluation standard for the quality of long-term care services, and the evaluation indicators are diversified. It is necessary to explore a long-term care service quality evaluation system with Chinese characteristics based on foreign experience, covering the whole process of long-term care services. In addition, core indicators need to be selected to reflect the quality of long-term care services, strengthen the application of evaluation results, improve the effectiveness of long-term care service quality evaluation, and promote the sustainable development of long-term care in China.

Objective:To explore the construction of evaluation criteria for long-term care ability of the elderly suitable for China's national conditions.Methods:The evaluation criteria were initially established through literature research and field semi-structured interviews. Through the Delphi method, 15 experts were consulted and the evaluation criteria for the long-term care ability of the elderly were finally established.Results:The effective rate of the two rounds of expert consultation questionnaires was 100%, and the expert authority coefficients were 0.91 and 0.92 respectively. The evaluation criteria for long-term care ability of the elderly were established, including two first-level indicators of self-care ability and disease severity, four second-level indicators of abilities of daily living, mental state and social participation, perception and communication, and disease severity, as well as 39 third-level indicators including recumbent status, cognitive function, level of consciousness, illness and so on.Conclusions:The evaluation criteria for long-term care ability of the elderly are scientific and reliable, which can provide a reference for the classification of long-term care services for the disabled elderly in China.