Medical treatment is the main treatment of inflammatory bowel disease (IBD) , including 5-aminosalicylates (5-ASA) , corticosteroids, biological agents and adjuvant therapeutic drugs like antibiotics. This article mainly introduces the role of antibiotics in the adjuvant therapy of inflammatory bowel disease and its associated mechanisms, in order to provide reference basis for the reasonable use of antibiotics in the IBD patients.

Medical treatment is the main treatment of inflammatory bowel disease (IBD) , including 5-aminosalicylates (5-ASA) , corticosteroids, biological agents and adjuvant therapeutic drugs like antibiotics. This article mainly introduces the role of antibiotics in the adjuvant therapy of inflammatory bowel disease and its associated mechanisms, in order to provide reference basis for the reasonable use of antibiotics in the IBD patients.

Objective To study the mechanism of RING finger protein 34 ( RNF34 ) involved in innate immunity . Methods Recombinant PCR was used and transient expression of the plasmid was achieved in HEK 293T cells.The cells were stimulated with Sendai virus ( SeV) or N-RIG-Ⅰfor the indicated time while luciferase activity was observed using the dual-luciferase reporter assay kit .Results We constructed the plasmid pcDNA 3-Flag-RNF34 and its three mutations .The study found that when stimulated by SeV , RNF34 could inhibit the activity of NF-κB and IFN-βmore significantly than RNF34-ΔFYVE, RNF34-ΔCID and RNF34-ΔRING.We also found that RNF 34 and its three mutants had similar inhibitory effect when the activation of NF-κB and IFN-βwas stimulated by the N-RIG-Ⅰ.Conclusion RNF34 negatively regulates innate immunity by acting on the RIG-Ⅰ-MAVS signaling pathway .