Objective To explore changes of serum levels of tumor necrosis factor alpha(TNF-α),interleukin-10(IL-10),and Helicobacter pylori(HP)positivity rate in patients with early gastric cancer,and the diagnostic value of three factors in early gastric cancer.Methods A total of 312 patients with gastric discomfort were included in this study and used as the observation subjects.Patients were divided into the gastritis group(n=100),the precancerous lesion group(n=110)and the early gastric cancer group(n=102)based on their gastroscopy.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of TNF-α and IL-10.HP infection was detected in the three groups.Multivariate Logistic regression was used to analyze influencing factors of early gastric cancer.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum TNF-α,IL-10 and HP infection in early gastric cancer.Results The levels of TNF-α,IL-10 and HP positivity rate were increased in the gastritis group,the precancerous lesion group and the early gastric cancer group in sequence(all P＜0.05).Hot food,heavy salt,pepsinogen Ⅱ(PG Ⅱ),HP positivity and elevated levels of TNF-α and IL-10 were independent risk factors for early gastric cancer,while elevated PGⅠ was a protective factor(all P＜0.05).The areas under the curve for serum TNF-α,IL-10,HP infection and their combined diagnosis of early gastric cancer were 0.694,0.698,0.763,and 0.870,respectively.The combined diagnostic efficacy of the three was better than that of individual diagnosis(all P＜0.05).Conclusion The serum levels of TNF-α,IL-10 and HP positivity rate are significantly increased in patients with early gastric cancer,and all three have certain diagnostic value for early gastric cancer.

Objective To explore changes of serum levels of tumor necrosis factor alpha(TNF-α),interleukin-10(IL-10),and Helicobacter pylori(HP)positivity rate in patients with early gastric cancer,and the diagnostic value of three factors in early gastric cancer.Methods A total of 312 patients with gastric discomfort were included in this study and used as the observation subjects.Patients were divided into the gastritis group(n=100),the precancerous lesion group(n=110)and the early gastric cancer group(n=102)based on their gastroscopy.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of TNF-α and IL-10.HP infection was detected in the three groups.Multivariate Logistic regression was used to analyze influencing factors of early gastric cancer.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum TNF-α,IL-10 and HP infection in early gastric cancer.Results The levels of TNF-α,IL-10 and HP positivity rate were increased in the gastritis group,the precancerous lesion group and the early gastric cancer group in sequence(all P＜0.05).Hot food,heavy salt,pepsinogen Ⅱ(PG Ⅱ),HP positivity and elevated levels of TNF-α and IL-10 were independent risk factors for early gastric cancer,while elevated PGⅠ was a protective factor(all P＜0.05).The areas under the curve for serum TNF-α,IL-10,HP infection and their combined diagnosis of early gastric cancer were 0.694,0.698,0.763,and 0.870,respectively.The combined diagnostic efficacy of the three was better than that of individual diagnosis(all P＜0.05).Conclusion The serum levels of TNF-α,IL-10 and HP positivity rate are significantly increased in patients with early gastric cancer,and all three have certain diagnostic value for early gastric cancer.

Objective To systematically explore the traditional Chinese medicine(TCM)common symptoms,syndrome elements,clinical syndrome differentiation,and medication rules of coronary microvascular disease(CMVD),and to provide a reference for quantitative criteria of clinical differentiation of CMVD,specification of the diagnosis and efficacy evaluation of TCM clinical syndrome,and guidance of clinical medication.Methods The databases including CNKI,Wanfang,VIP,and SinoMed were searched for research papers on the treatment of CMVD by TCM published from database inception to May 16,2023.Relevant information of the included literature was extracted and the database was established.Then,the frequency statistics of symptoms,syndrome elements,syndrome types and Chinese medicinals were carried out.Latent structural models were constructed using Latern 5.0 and Rstudio softwares respectively for comprehensive clustering and association rule analysis,so as to explore the symptom characteristics,syndrome elements distribution,common syndromes and medication rules for TCM treatment of CMVD.Results A total of 107 literature were included,involving 36 syndromes,17 syndrome elements,121 symptoms and 143 Chinese medicinals.It was speculated that the main syndrome element of CMVD was blood stasis,followed by qi deficiency,qi stagnation,phlegm turbidity,yin deficiency and yang deficiency.The main type of syndrome was qi deficiency and blood stasis,followed by heart blood stasis obstruction,qi stagnation and blood stasis,phlegm blended with stasis,qi-yin deficiency,etc..The main medicinals were Chuanxiong Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Angelica Sinensis Radix and Astragali Radix.The medicinals used in the treatment of CMVD were classified as blood-activating and stasis-resolving drugs,deficiency-tonifying drugs,qi-regulating drugs in terms of their efficacy.Conclusion The location of CMVD is in heart,and related to liver and kidney.The syndrome of CMVD is deficiency in origin and excess in superficiality.Blood stasis runs through the development of the disease.The treatment is mainly to activate blood circulation and remove stasis,activate meridians and relieve pain,which should be supplemented with the therapies of tonifying and invigorating qi,soothing the liver and regulating qi,dispelling phlegm and dissipating masses according to the patients'syndromes.

Objective:To construct a risk identification and early warning management model,and to explore its value in the risk control and management of active medical devices maintenance and repair. Methods:The risk identification and early warning knowledge base of active medical equipment maintenance and repair was constructed from three aspects:basic data,core data and auxiliary data. The risk evaluation index system was designed in combination with the equipment operating status,and the weight was assigned by coefficient of variation and the extension cloud algorithm was used to evaluate the risk level,so as to form a hierarchical early warning trigger path and a three-dimensional early warning intervention scheme of personnel,system and process. A total of 287 active medical devices in clinical use in the Second Hospital of Shanxi Medical University from 2022 to 2023 were selected,and 261 devices used in the period from January to December 2022 were managed by conventional management methods,270 active medical devices (including 244 in use under conventional management method) used from January to December 2023 were managed by active medical equipment maintenance and repair risk identification and early warning model (referred to as risk identification model management). The equipment maintenance and repair management effects of the two management methods were compared from the aspects of safety level assessment and risk hazard statistics,and business capability of personnel involved in equipment management were assessed and evaluated. Results:The risk rate of active medical equipment managed by risk identification model was 7.8％ (21/270),which was lower than that of conventional management method,and the difference was statistically significant (x2=8.773,P<0.05). Among the 2839 maintenance and repair activities carried out by the risk identification model management method,safety risk hazards of large medical equipment,ECG monitoring equipment,life support emergency equipment and medical testing equipment occurred 75,19,82 and 11 times,respectively,with the hidden danger rates of 2.6％,0.7％,2.9％ and 0.4％,which were all lower than those of the conventional management method,and the difference was statistically significant (x2=27.989,24.580,46.654,12.604,P<0.05). The pass rates of 92 medical equipment managers participating in the risk identification model management method in maintenance management,quality monitoring,fault handling and risk response were 95.7％ (88/92),98.9％ (91/92),92.4％ (85/92) and 97.8％ (90/92),respectively,which were higher than those of the conventional management method,the difference was statistically significant (x2=4.901,4.016,6.368,5.176,P<0.05). Conclusion:The risk identification and early warning model based on coefficient of variation weighting and extension cloud algorithm can reduce the risk level of active medical devices maintenance and repair,control the occurrence probability of potential safety hazards,and improve the support level of maintenance and repair management.

Objective:To construct a risk identification and early warning management model,and to explore its value in the risk control and management of active medical devices maintenance and repair. Methods:The risk identification and early warning knowledge base of active medical equipment maintenance and repair was constructed from three aspects:basic data,core data and auxiliary data. The risk evaluation index system was designed in combination with the equipment operating status,and the weight was assigned by coefficient of variation and the extension cloud algorithm was used to evaluate the risk level,so as to form a hierarchical early warning trigger path and a three-dimensional early warning intervention scheme of personnel,system and process. A total of 287 active medical devices in clinical use in the Second Hospital of Shanxi Medical University from 2022 to 2023 were selected,and 261 devices used in the period from January to December 2022 were managed by conventional management methods,270 active medical devices (including 244 in use under conventional management method) used from January to December 2023 were managed by active medical equipment maintenance and repair risk identification and early warning model (referred to as risk identification model management). The equipment maintenance and repair management effects of the two management methods were compared from the aspects of safety level assessment and risk hazard statistics,and business capability of personnel involved in equipment management were assessed and evaluated. Results:The risk rate of active medical equipment managed by risk identification model was 7.8％ (21/270),which was lower than that of conventional management method,and the difference was statistically significant (x2=8.773,P<0.05). Among the 2839 maintenance and repair activities carried out by the risk identification model management method,safety risk hazards of large medical equipment,ECG monitoring equipment,life support emergency equipment and medical testing equipment occurred 75,19,82 and 11 times,respectively,with the hidden danger rates of 2.6％,0.7％,2.9％ and 0.4％,which were all lower than those of the conventional management method,and the difference was statistically significant (x2=27.989,24.580,46.654,12.604,P<0.05). The pass rates of 92 medical equipment managers participating in the risk identification model management method in maintenance management,quality monitoring,fault handling and risk response were 95.7％ (88/92),98.9％ (91/92),92.4％ (85/92) and 97.8％ (90/92),respectively,which were higher than those of the conventional management method,the difference was statistically significant (x2=4.901,4.016,6.368,5.176,P<0.05). Conclusion:The risk identification and early warning model based on coefficient of variation weighting and extension cloud algorithm can reduce the risk level of active medical devices maintenance and repair,control the occurrence probability of potential safety hazards,and improve the support level of maintenance and repair management.

Objective To study the relationship between serum UA level and early outcome in acute ischemic stroke (AIS) patients. Methods Four hundred and twenty-one AIS patients admitted to the First Affiliated Hospital of Xi'an Jiaotong University from March 2015 to March 2016 were divided into good outcome group (n = 232) and poor outcome group (n = 189) according to their modified Rankin scale (mRS) score. Their demographic data, risk factors for vascular disease, laboratory testing parameters, imaging and clinical data and NIHSS score were recorded and compared. The relationship between serum UA level and early poor outcome in AIS patients was analyzed by unconditioned logistic regression analysis. Results The incidence of AF and cerebral infarction in the territory of anterior cerebral artey and middle cerebral artery, SBP, serum TC,LDL and urea levels,NIHSS and mRS score, and mortality were significantly higher and the hospital stay time was significantly longer while the serum UA level and GCS score were significantly lower in poor outcome group than in good outcome group (P＜0.05,P＜0.01). Unconditioned logistic regression analysis showed that SBP,NIHSS score and serum UA level were the major risk factors for the early poor outcome in AIS patients (OR = l.017,95％CI:1.003-1.031,P = 0.018;OR = 1.274,95％CI:1.178-1.378,P=0.000;OR=0.993,95％CI:0.989-0.996, P = 0.000). Conclusion The low serum UA level is related with the early poor outcome in AIS patients.

Objective To compare the clinical effect and operation difficulty of the combined skin flap with reversed proper palmar digital arterial dorsal branch island flap and cross-finger flap and the abdominal flap in the treatment of distal finger degloving injury.Methods Inclusion criteria:①Soft tissue defect far beyond the level of distal interphalangeal joints.②The inured finger was from second to fifth.③Single finger injury.④ Iniury time within 8 h.Exclusive criteria:①With tendon injury.② Multiple finger injuries.③Followed-up time within 6 months.Between February,2009 and September,2016,52 patients (52 fingers) with distal finger degloving injury were reviewed,there were 32 males and 20 females,aged from 18 to 60 (36.02±11.00) years.The time from injury to operation was 2.5-8.0 (4.81±1.28) h.Affected fingers included index finger in 15 cases,middle finger in 22 cases,ring finger in 10 cases,and little finger in 5 cases.Twenty patients (20 fingers) were treated by combined skin flap with reversed digital arterial dorsal branch island flap and cross-finger flap(group combined-flap).The cubital skin was grafted onto the donor sites.Thirty-two patients (32 fingers) were treated by abdominal flap (group abdominal-flap).Results The patients were followed-up 6-25 (9.25±3.97) months.The operation time:group combined-flap was 80-130 (98.46±8.34) min and group abdominal-flap was 85-125(107.84±8.63)min.There was no significant difference in two groups (P＞0.05).Pedicle division time:group combined-flap was 15-24 (16.75±1.74) d and group abdominal-flap was 24-45 (28.31±5.12) d.There was a significant difference in two groups (P＜0.05).And the pedicle division time in group combined-flap was much shorter than in group abdominal-flap.Flap function at last follow-up,the excellent and good rate of the flap in group combined-flap and group abdominal-flap was 90.00％ and 59.38％,respectively.There was a significant difference in two groups (P＜0.05),and the flap function in group combined-flap was much better than in group abdominal-flap.Affected finger function at last follow-up,the excellent and good rate of the affected fingers was 95.00％ and 71.88％.There was a significant difference in two groups (P＜0.05),and the affected finger function in group combined-flap was much better than in group abdominal-flap.Conclusion The combined skin flap with reversed digital arterial dorsal branch island flap and cross-finger flap is a simple and high-survival-rate flap,whose texture,appearance and clinical outcome for repair of distal finger degloving injury are much better than traditional abdominal flap.

Objective To investigate the clinical value of CT lymphangiography (CTL) combined with direct lymphangiography (DLG) in primary intestinal lymphangiectasia (PIL). Methods Sixteen patients diagnosed as PIL with intestinal enteroscopy were recruited in this retrospective study. All the patients were performed DLG and CTL one week before exploratory laparotomy. Subjective assessment in DLG included weak lymphatic fluid drainage, lymphangiectasia, lymphatic reflux, fistula and thoracic outlet reflux or obstruction. While for CTL combined with DLG, the intestinal and extra-intestinal lesions were evaluated, including lymph node, edema, lymphangiectasia and abnormal distribution, fistula, and lymphangiomatosis. All the diagnosis was compared with intestinal endoscopy results. Results For DLG, 16 weak lymphatic fluid drainages, 9 lymphangiectasia, 1 fistula with abdomen and 14 thoracic outlets weak lymphatic fluid drainage or obstruction were found. For DLG combined with CTL, 16 intestinal lumens dilatation and 14 circumferential intestinal thickening were found in intestinal lesions. While for extra-intestinal lesions, the imaging features included edematous findings (12 in mesentery, 7 ascites only, 2 hydrothorax and ascites, and 3 pericardial, thoracic and abdominal effusions), abdominal lymph nodes (6 cases), lymphangiectasia and abnormal distributions (14 cases), fistulas (lymph-intestinal luminal fistula in 4 cases, and lymph-abdominal fistula in 3 cases), lymphangiomatosis (3 cases), and thoracic duct outlet dysfunction and reflux (14 cases).The number of cases diagnosed as intestinal lymphangiectasia, intestinal luminal lymph exudation and lymph fistula were 16, 10 and 6 with intestinal endoscopy, while the number were 11, 0, and 4 with CTL combination with DLG. Conclusion Combination of CTL with DLG is valuable in the diagnosis of PIL.

BACKGROUND:Studies have shown that posterior orthopedic internal fixation and anterior orthopedic internal fixation al can get good clinical outcomes for treatment of adult idiopathic scoliosis, however, it has not been reported on what kind of methods could achieve a better clinical outcome for treatment of Lenke3 type adult idiopathic scoliosis, have less risk of pedicle screws breakage and more reliable long-term efficacy. OBJECTIVE:To establish the Lenke 3 type adult idiopathic scoliosis finite element model and thoracic screw guide target 3D model using finite element analysis software, so as to provide scientific basis for biomechanical analysis and scientific pedicle screw implantation. METHODS:The CT scan image from T 1 to sacrum of one 28 years old volunteer with Lenke 3 type adult idiopathic scoliosis was imported into Mimics 16.0 software by Dicom form. Integral idiopathic scoliosis three dimensional model was established by geometry clear technology. Nail guide target of thoracic vertebra was established on vertebral model by design module in Mimics 16.0 software. The point cloud form of three dimensional model was imported into Geomagic Studio 11.0 software. Series of image processing of model were conducted. At last, three dimensional model was imported into ANSYS 14.0 finite element analysis software in order to build finite element model with biological properties. RESULTS AND CONCLUSION:Complete Lenke 3 type adult idiopathic scoliosis three dimensional finite element model was established successful y. It concluded 440 975 tetrahedron units and 580 bar units, total y 441 555 units and 1 077 318 nodes. Total y 12 nail guide target models of thoracic vertebra were established, including 4 682 tetrahedron units and 7 390 nodes. Lenke 3 type adult idiopathic scoliosis three dimensional finite element model and nail guide target of thoracic vertebral model with a realistic appearance were established successful y in this experiment. These results confirm that Lenke 3 type adult idiopathic scoliosis three dimensional finite element model provides scientific basis for further biomechanical experiments. Meanwhile, the construction of nail guide target model of thoracic vertebra provide a new scientific method for thoracic pedicle screw placement.

Objective: To study a new method of alveolar cleft bone grafting. Methods: Group A: 62 cases (74 sides) alveolar cleft patients were transplanted with self-ilium spongy bone. Group B: 26 cases (30 sides) alveolar process patients used autologous ilium combined with DDM. Anterior occlusal radiographs and panoramic oral radiogram were taken before and after the operation to observe if there was new bone formation in the bone grafting area. According to Bergland grade criterion, analyzed the X-ray results after 3 months of the operation. Results: Group A: 17cases(17 sides) in class 1 group(23%), 17 cases(20 sides) in class 2 group(27%), 13 cases(14 sides) in class 3 group (19%), 15 case(23 sides) in class 4 group(31%). The overall survival rate of ABGR was 68.9%, and the clinical success rate was 50 %;Group B:16 cases(16 sides) in class 1 group(53.3%), 7 cases(8 sides) in class 2 group(26.7%), 2 cases(4 sides) in class 3 group (13.3%), 1 case(2 sides) in class 4 group(6.7%). The overall survival rate of ABGR was 93.3%, and the clinical success rate was 80%. Conclusion: Ilium spongy bone combined with DDM is good for alveolar process cleft bone grafting. It is better to use decalcified dentinal matrix of human than autologous ilium spongy bone.