Pleural mesothelioma （PM） is a rare malignant tumor originating from the pleura. Most patients are already in the advanced stage at the time of diagnosis， resulting in a low overall survival rate. MicroRNA （miRNA）， as key regulators of tumor epigenetic modification， have an intertwined interactive network with PM drug resistance. The mechanisms of drug resistance in PM to chemotherapeutic drugs include increasing drug efflux， reducing drug intake， enhancing DNA repair， and altering drug targets. The mechanisms of resistance to targeted therapy drugs include activating alternative signaling pathways， establishing a favorable tumor microenvironment， and triggering epithelial-mesenchymal transition. MiRNA plays a key part in the aforementioned resistance mechanisms， with some miRNAs promoting the drug sensitivity of cancer cells， while others contribute to increased drug resistance. In light of these key regulatory functions， targeting the dysregulated expression of endogenous miRNAs in the process of resistance formation using miRNA antagonists or miRNA mimics may be an effective therapeutic strategy to reverse drug resistance in PM.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

Objective:To deeply explore the experience of lactation mastitis women, so as to provide a basis for formulating reasonable support measures.Methods:This study was a qualitative study. From November to December 2022, purposive sampling was used to select 13 patients with lactation mastitis who visited the Breast Specialist Nursing Clinic of Dongfang Hospital, Beijing University of Chinese Medicine as the research subject. This study used semi-structured interviews to collect data, and applied the Colaizzi 7-step analysis method to analyze, summarize, and extract themes.Results:The experience of lactation mastitis patients were mainly summarized as self-emotional experience and interpersonal relationship experience. Self-emotional experiences included feelings of anxiety, stress, helplessness, and self-blame. Interpersonal relationship experiences consisted of feelings of helplessness, useless, decision-making difficulties, desire for help and understanding.Conclusions:Lactation mastitis patients face various negative psychological experiences and burdens. Medical and nursing staff, family caregivers, and society should jointly pay attention to the patients' feelings and provide targeted support measures.