Objective:To investigate the clinical efficacy of Yiqi Yangyin decoction combined with metformin and irbesartan in treating type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome. Methods:A case-control study was performed to retrospectively analyze the clinical data of 92 patients with type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome. These patients received treatment at the First People's Hospital of Huzhou from February 2021 to April 2023. They were divided into two groups, with 46 patients in each group, based on different treatment methods. The control group received metformin and irbesartan, while the observation group was treated with Yiqi Yangyin decoction in addition to the treatment provided to the control group. Both groups underwent treatment for 1 month. The clinical efficacy of the two groups was evaluated, and the changes in traditional Chinese medicine symptom scores, blood glucose levels, blood pressure, and the occurrence of adverse reactions were compared between the two groups before and after treatment. Results:The total response rate of the observation group was 93.48% (43/46), which was significantly higher than that of the control group [82.61% (38/46), χ2 = 5.63, P < 0.05). After treatment, the traditional Chinese medicine symptom score for the observation group was (9.43 ± 2.11) points, which was significantly lower than that of the control group [(12.11 ± 2.32) points, t = 11.34, P < 0.001]. The fasting blood glucose, 2-hour postprandial blood glucose, and glycosylated hemoglobin levels in the observation group were (7.51 ± 1.34) mmol/L, (9.06 ± 2.11) mmol/L, and (6.23 ± 0.76)%, respectively, all of which were significantly lower than those in the control group [(8.75 ± 2.12) mmol/L, (11.15 ± 2.43) mmol/L, (7.11 ± 1.02)%, t = 4.13, 6.14, 4.01, all P < 0.05]. The systolic blood pressure in the observation group was (125.48 ± 8.14) mmHg (1 mmHg = 0.133 kPa), which was significantly lower than that in the control group [(131.32 ± 9.22) mmHg, t = 6.76, P < 0.001]. The difference in the incidence of adverse reactions between the two groups was not statistically significant ( P > 0.05). Conclusion:Yiqi Yangyin decoction combined with metformin and irbesartan is highly effective in treating type 2 diabetes complicated by hypertension with qi and yin deficiency syndrome. This combined therapy can effectively lower the traditional Chinese medicine symptom score, improve patients' blood glucose and blood pressure levels, and has a low incidence of adverse reactions.

Objective To explore the factors influencing the nosocomial pulmonary infection in patients with ischemic stroke.Methods The clinical data of 214 patients with ischemic stroke treated in the Third People's Hospital of Nantong from March 2020 to February 2022 were retrospectively analyzed.According to the Guidelines for Diagnosis and Treatment of Adult Hospital-acquired Pneumonia and Ventilator-related Pneumonia in China,the patients without lung infection were assigned to control group(n=104),and the patients with lung infection were enrolled in observation group(n=110).Clinical data such as gender,age,time from onset to admission,underlying diseases,nasogastric feeding,National Institute of Health Stroke Scale(NIHSS)score,Glasgow Coma Scale(GCS)score,endotracheal intubation,and ventilator-assisted ventilation were investigated.The risk factors for nosocomial pulmonary infection in patients with ischemic stroke were analyzed.Results There were 56 males and 54 females in the observation group,with a mean age of(73.59±8.21)years.There were 45 males and 59 females in the control group,with a mean age of(65.32±5.62)years.Univariate analysis showed significant differences in the age,nasogastric feeding,NIHSS score,GCS score,endotracheal intubation,and ventilator-assisted ventilation between the two groups(t=8.511,χ2=11.622,t=5.721,t=4.282,χ2=6.868,χ2=6.145,all P<0.05).Multivariate Logistic regression analysis result showed that nasogastric feeding(OR=5.447,95%CI:2.477-11.976),NIHSS score(OR=8.339,95%CI:2.598-26.768),GCS score(OR=7.660,95%CI:3.369-17.413),endotracheal intubation(OR=6.184,95%CI:2.447-15.628),and ventilator-assisted ventilation(OR=4.302,95%CI:1.830-10.110)were independent risk factors for pulmonary infection in patients with ischemic stroke.Conclusion The nasogastric feeding,severity of illness,impairment of consciousness,endotracheal intubation and ventilator-assisted ventilation are independent risk factors for pulmonary infection in patients with ischemic stroke.Therefore,the patients should be evaluated in time and taken targeted preventive measures on admission.

This commentary reviews the updates on laser and aesthetic medicine in recent two years and provide the evidence-based conclusion for recent laser treatments for our patients. Progress has been made in the following respects. Combined laser or drug treatment is better than single treatment for hypertrophic scar. The picosecond laser has recently been shown to be safe and effective for Asian atrophic acne scars. Picosecond laser with or without diffractive lens array (DLA) lens has been proved safe and effective for melasma. The effect of port-wine stains could only be increased by 5%-10% after 10 times of pulsed dye laser (PDL), so that more sessions has less benefit. Radiofrequency and focused ultrasound are still the mainstream devices for photoaging, but recently it has been proved that picosecond laser and CO 2 injection are also safe and effective. Nonablative laser is still the main device for improving facial pores and stretch marks.

Objective:To investigate and compare the effectiveness and safety of infrared bipolar radiofrequency (IR-RF) and nonablative fractional laser (NAFL) including 1 540 nm Er: glass and 1 927 nm thulium-doped laser, so as to choose a better pathway for clinical treatments on periorbital wrinkles.Methods:A prospective randomized self-controlled study was conducted in the Department of Laser and Aesthetic Medicine, Shanghai Ninth People’s Hospital. A total of 27 patients divided into 3 groups by random number table underwent split-face treatments between December 2019 and January 2021. Two of the three treatments were selected randomly for patients in each group: Group A, left side IR-RF vs. right side 1 540 nm NAFL; Group B, left side IR-RF vs. right side 1 927 nm NAFL; Group C, left side 1 540 nm NAFL vs. right side 1 927 nm NAFL. In total 3 sessions were given at 2 months interval. Therapeutic outcomes were evaluated by subjective (GAIS and Fitzpatrick wrinkle score) and objective (VISIA-CR) assessments. Side effects and pain visual evaluation (VAS) were also recorded. Wilcoxon signed-rank tests were used to evaluate the differences among the three therapeutic method , and relationships with VAS and patients’ age.Results:In total 30 patients (10 in each group) were recruited and finally 27 cases completed all treatments and follow-ups: Group A, 9 patients (male 3, female 6); Group B, 8 patients (male 3, female 5); Group C, 10 patients (male 4, female 6). The age distributions: Group A, 33-65 years, mean 36.9 years; Group B, 28-67 years, mean 38.6 years; Group C, 25-58 years, mean 37.8 years. GAIS comparisons: no statistical differences were found in each group between baseline and post-treatment ( P>0.05). Fitzpatrick wrinkle score: the overall analysis showed significant improvements were not found in IR-RF treated-side but were observed in 1 540 nm and 1 927 nm NAFL treated sides ( P<0.05). Furthermore, the 1 927 nm NAFL treated side showed more decreased scores than 1 540 nm NAFL treated side ( P<0.05). The VISIA analysis of feature counts of skin texture showed similar result. Besides, the patients over 50 years old showed significantly improvements compared with the ones under this age threshold in IR-RF treated sides ( P<0.05). The pain VAS in IR-RF treated side was significant lower than NAFL-treated side (2.2 vs. 5.8, P<0.05). Only one patient reported post-inflammatory hyperpigmentation (PIH) in 1540 nm NAFL treated side, which disappeared progressively in 4 months after last treatment. Conclusion:Nonablative fractional laser is effective and safe in improving periorbital wrinkles. Infrared bipolar radiofrequency might be more suitable for elderly patients especially with low pain level.

This commentary reviews the updates on laser and aesthetic medicine in recent two years and provide the evidence-based conclusion for recent laser treatments for our patients. Progress has been made in the following respects. Combined laser or drug treatment is better than single treatment for hypertrophic scar. The picosecond laser has recently been shown to be safe and effective for Asian atrophic acne scars. Picosecond laser with or without diffractive lens array (DLA) lens has been proved safe and effective for melasma. The effect of port-wine stains could only be increased by 5%-10% after 10 times of pulsed dye laser (PDL), so that more sessions has less benefit. Radiofrequency and focused ultrasound are still the mainstream devices for photoaging, but recently it has been proved that picosecond laser and CO 2 injection are also safe and effective. Nonablative laser is still the main device for improving facial pores and stretch marks.

Objective:To investigate and compare the effectiveness and safety of infrared bipolar radiofrequency (IR-RF) and nonablative fractional laser (NAFL) including 1 540 nm Er: glass and 1 927 nm thulium-doped laser, so as to choose a better pathway for clinical treatments on periorbital wrinkles.Methods:A prospective randomized self-controlled study was conducted in the Department of Laser and Aesthetic Medicine, Shanghai Ninth People’s Hospital. A total of 27 patients divided into 3 groups by random number table underwent split-face treatments between December 2019 and January 2021. Two of the three treatments were selected randomly for patients in each group: Group A, left side IR-RF vs. right side 1 540 nm NAFL; Group B, left side IR-RF vs. right side 1 927 nm NAFL; Group C, left side 1 540 nm NAFL vs. right side 1 927 nm NAFL. In total 3 sessions were given at 2 months interval. Therapeutic outcomes were evaluated by subjective (GAIS and Fitzpatrick wrinkle score) and objective (VISIA-CR) assessments. Side effects and pain visual evaluation (VAS) were also recorded. Wilcoxon signed-rank tests were used to evaluate the differences among the three therapeutic method , and relationships with VAS and patients’ age.Results:In total 30 patients (10 in each group) were recruited and finally 27 cases completed all treatments and follow-ups: Group A, 9 patients (male 3, female 6); Group B, 8 patients (male 3, female 5); Group C, 10 patients (male 4, female 6). The age distributions: Group A, 33-65 years, mean 36.9 years; Group B, 28-67 years, mean 38.6 years; Group C, 25-58 years, mean 37.8 years. GAIS comparisons: no statistical differences were found in each group between baseline and post-treatment ( P>0.05). Fitzpatrick wrinkle score: the overall analysis showed significant improvements were not found in IR-RF treated-side but were observed in 1 540 nm and 1 927 nm NAFL treated sides ( P<0.05). Furthermore, the 1 927 nm NAFL treated side showed more decreased scores than 1 540 nm NAFL treated side ( P<0.05). The VISIA analysis of feature counts of skin texture showed similar result. Besides, the patients over 50 years old showed significantly improvements compared with the ones under this age threshold in IR-RF treated sides ( P<0.05). The pain VAS in IR-RF treated side was significant lower than NAFL-treated side (2.2 vs. 5.8, P<0.05). Only one patient reported post-inflammatory hyperpigmentation (PIH) in 1540 nm NAFL treated side, which disappeared progressively in 4 months after last treatment. Conclusion:Nonablative fractional laser is effective and safe in improving periorbital wrinkles. Infrared bipolar radiofrequency might be more suitable for elderly patients especially with low pain level.

Objective:To investigate the risk factors for ischemic stroke in patients with spontaneous extracranial vertebral artery dissection.Methods:From November 2013 to December 2019, patients with spontaneous extracranial vertebral artery dissection admitted to the Department of Neurology, Baotou Central Hospital were enrolled retrospectively. According to whether they had ischemic stroke or not, they were divided into ischemic stroke group and non-ischemic stroke group. The independent risk factors for ischemic stroke in patients with spontaneous extracranial vertebral artery dissection were identified by binary logistic regression analysis. Results:A total of 39 patients were enrolled, 25 were female (64.1%), 14 were males (35.9%), their age was 51.51±14.98 years old, 16 of them (41.0%) had ischemic stroke. The proportion of patients with double-lumen sign, intimal flap sign of occluded lumen (37% vs. 4%; P=0.013) and specific initial symptoms (56% vs. 9%; P=0.003) of the ischemic stroke group were significantly higher than those of the non-ischemic stroke group. Multivariate logistic regression analysis showed that double-lumen sign and intimal flap sign of occluded lumen (odds ratio 47.951, 95% confidence interval 26.284-87.478; P<0.001), and specific initial symptoms (odds ratio 19.232, 95% confidence interval 10.695-34.587; P<0.001) were independently associated with ischemic stroke in patients with spontaneous extracranial vertebral artery dissection. Conclusions:Double-lumen sign, intimal flap sign of occluded lumen and specific clinical symptoms are the independent risk factors for ischemic stroke in patients with spontaneous extracranial vertebral artery dissection.

Based on the requirement of the ongoing healthcare reform on the performance appraisal for public hospitals, Shanghai Tenth People′s Hospital explored the performance appraisal system oriented by clinical ability and cost control from the perspective of medical administration and finance. Performance appraisal programs were made from five aspects: clinical development ability, key efficacy indicators, clinical path, disease-entity structure, cost control, aiming to highlight the functional positioning of tertiary hospitals, change doctors′ behaviors of diagnosis and treatment, lead clinical improvement and maintain healthy economy development.

Obective To study the association between vertebral artery hypoplasia (VAH) and acute posterior circulation ischemic stroke (APCIS).Methods Of the 718 patients admitted to our hospital for carotid artery ultrosonography and head MRI included in this study,381 with unilateral or bilateral VAH served as an observation group and 337 without unilateral or bilateral VAH served as a control group.The incidence of APCIS in two groups was retrospectively analyzed.The risk factors for APCIS were analyzed by multivariate logistic stepwise regression analysis.Results The incidence of embryonal posterior cerebral artery hypoplasia was significantly higher in observation group than in control group (48.03％ vs 15.13％,P=0.000).No significant difference was found in the incidence of APCIS between the two groups (14.16％ vs 10.00％when the age was ≤ 55 years,7.84％ vs 11.24％ when the age was＞＞55 years,xMH2 =0.310,P=0.578).Hypertension and hyperlipidaemia were the risk factors for APCIS (OR=1.913,P=0.019;OR=1.875,P=0.015).Conclusion VAH is rather common in APCIS patients.However,its accomplanied embryonal posterior cerebral artery hypoplasia does not incease the risk of APCIS.

In resent years,brain parenchyma and cerebrovascular sonography have received considerable attention.Monitoring of cerebral vessels and their blood flow velocities and pulsation indexes may reflect the intracranial vascular lesions.However,there are a few studies about transcranial color-code duplex sonography (TCCD) in the monitoring of space-occupying stroke.This technology has the non-invasive,convenient,and economical advantages,and can timely provide clinical information.Using TCCD to monitor pace-occupying stroke may play a positive role in prevention of the diseases and prognosis.