Food-derived bioactive peptides (FBPs), particularly those with ten or fewer amino acid residues and a molecular weight below 1300 Da, have gained increasing attention for their safe, diverse structures and specific biological activities. The development of FBP-based functional foods and potential medications depends on understanding their structure‒activity relationships (SARs), stability, and bioavailability properties. In this review, we provide an in-depth overview of the roles of FBPs in treating various diseases, including Alzheimer's disease, hypertension, type 2 diabetes mellitus, liver diseases, and inflammatory bowel diseases, based on the literature from July 2017 to Mar. 2023. Subsequently, attention is directed toward elucidating the associations between the bioactivities and structural characteristics (e.g., molecular weight and the presence of specific amino acids within sequences and compositions) of FBPs. We also discuss in silico approaches for FBP screening and their limitations. Finally, we summarize recent advancements in formulation techniques to improve the bioavailability of FBPs in the food industry, thereby contributing to healthcare applications.
Humans ; Peptides/therapeutic use* ; Structure-Activity Relationship ; Functional Food ; Diabetes Mellitus, Type 2/drug therapy* ; Biological Availability ; Alzheimer Disease/drug therapy* ; Inflammatory Bowel Diseases/drug therapy* ; Hypertension/drug therapy* ; Liver Diseases/drug therapy* ; Bioactive Peptides, Dietary

Humans ; SARS-CoV-2 ; COVID-19 ; Antibodies ; Antibodies, Viral/therapeutic use* ; Antibodies, Neutralizing/therapeutic use*

Objective To investigate the application effect of comprehensive nursing care for severe hand-foot-mouth disease (HFMD) complicated with encephalitis. Methods A total of 70 children cases with severe HFMD complicated with encephalitis induced by enterovirus 71 infection admitted in our hospital from May 2012 to August 2013 were di-vided into observation group 35 cases and control group 35 cases. The control group was given symptomatic care, the observation group was given comprehensive nursing intervention. The fever and herpes subsided time, fatigue and limb shaking disappearance time, the average length of stay in hospital and the rate of complications were compared between two groups. Results The fever and herpes subsided time, fatigue and limb shaking disappearance time, the average hos-pitalization time in the observation group were shorter than the control group statistically (P<0.05 or P<0.01), hospital-ization time of the observation group was significantly shorter than the control group(P<0.01). The occurrence of compli-cations in the observation group were reduced in the observation group compared to the control group (P<0.01). Conclu-sion Comprehensive nursing intervention in children cases with severe type of HFMD complicated with encephalitis, combined with regular treatment, can reduce the incidence of complications and promote disease recovery.