For patients with edentulous maxillae, creating a prosthetic treatment plan involves considering anatomical factors, aesthetics, the patient’s financial situation, and oral hygiene capabilities. In this case, CAD-CAM technology was used to accurately plan implant placements for a full arch fixed restoration based on the design of the final prosthesis. A customized surgical guide ensured precise implant placement and a provisional restoration was created using CAD-CAM. The definitive prosthesis was then created based on the second provisional restoration that has been previously used and adjusted by the patient. This approach achieved an excellent functional and aesthetic outcome, highlighting the benefits of digital approach and its potential for further clinical applications.

For patients with edentulous maxillae, creating a prosthetic treatment plan involves considering anatomical factors, aesthetics, the patient’s financial situation, and oral hygiene capabilities. In this case, CAD-CAM technology was used to accurately plan implant placements for a full arch fixed restoration based on the design of the final prosthesis. A customized surgical guide ensured precise implant placement and a provisional restoration was created using CAD-CAM. The definitive prosthesis was then created based on the second provisional restoration that has been previously used and adjusted by the patient. This approach achieved an excellent functional and aesthetic outcome, highlighting the benefits of digital approach and its potential for further clinical applications.

For patients with edentulous maxillae, creating a prosthetic treatment plan involves considering anatomical factors, aesthetics, the patient’s financial situation, and oral hygiene capabilities. In this case, CAD-CAM technology was used to accurately plan implant placements for a full arch fixed restoration based on the design of the final prosthesis. A customized surgical guide ensured precise implant placement and a provisional restoration was created using CAD-CAM. The definitive prosthesis was then created based on the second provisional restoration that has been previously used and adjusted by the patient. This approach achieved an excellent functional and aesthetic outcome, highlighting the benefits of digital approach and its potential for further clinical applications.

For patients with edentulous maxillae, creating a prosthetic treatment plan involves considering anatomical factors, aesthetics, the patient’s financial situation, and oral hygiene capabilities. In this case, CAD-CAM technology was used to accurately plan implant placements for a full arch fixed restoration based on the design of the final prosthesis. A customized surgical guide ensured precise implant placement and a provisional restoration was created using CAD-CAM. The definitive prosthesis was then created based on the second provisional restoration that has been previously used and adjusted by the patient. This approach achieved an excellent functional and aesthetic outcome, highlighting the benefits of digital approach and its potential for further clinical applications.

For patients with edentulous maxillae, creating a prosthetic treatment plan involves considering anatomical factors, aesthetics, the patient’s financial situation, and oral hygiene capabilities. In this case, CAD-CAM technology was used to accurately plan implant placements for a full arch fixed restoration based on the design of the final prosthesis. A customized surgical guide ensured precise implant placement and a provisional restoration was created using CAD-CAM. The definitive prosthesis was then created based on the second provisional restoration that has been previously used and adjusted by the patient. This approach achieved an excellent functional and aesthetic outcome, highlighting the benefits of digital approach and its potential for further clinical applications.

Background: Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy is the primary approach to dyslipidemia management in T2D, however, the role of non-statin therapy remains unclear. Ezetimibe reduces cholesterol burden by inhibiting intestinal cholesterol absorption. Fibrates lower triglyceride levels and increase high-density lipoprotein cholesterol (HDL-C) levels via peroxisome proliferator- activated receptor alpha agonism. Therefore, when combined, these drugs effectively lower non-HDL-C levels. Despite this, few clinical trials have specifically targeted non-HDL-C, and the efficacy of triple combination therapies, including statins, ezetimibe, and fibrates, has yet to be determined. Methods: This is a multicenter, prospective, randomized, open-label, active-comparator controlled trial involving 3,958 eligible participants with T2D, cardiovascular risk factors, and elevated non-HDL-C (≥100 mg/dL). Participants, already on moderate-intensity statins, will be randomly assigned to either Ezefeno (ezetimibe/fenofibrate) addition or statin dose-escalation. The primary end point is the development of a composite of major adverse cardiovascular and diabetic microvascular events over 48 months. Conclusion This trial aims to assess whether combining statins, ezetimibe, and fenofibrate is as effective as, or possibly superior to, statin monotherapy intensification in lowering cardiovascular and microvascular disease risk for patients with T2D. This could propose a novel therapeutic approach for managing dyslipidemia in T2D.

Myositis ossificans (MO) is defined as a lesion where abnormal ossification forms in soft tissues, such as muscle, fascia, and ligament, usually as a result of trauma. It commonly appears in areas such as the thigh, hip, and elbow, though it can affect any part of the body. In the forensic field, MO resulting from trauma is reported to be valuable evidence of repeated physical abuse. This case report describes a deceased adult male with an intellectual disability, whose cause of death was multiple injuries from assault. Postmortem computed tomography (PMCT) and autopsy findings revealed MO of both thighs associated with repeated physical abuse. This case also showed typical findings of MO on PMCT imaging, characterized by well-defined, high-density lesions within the quadriceps. Adults with intellectual disabilities are at high risk of abuse and assault. Therefore, autopsy findings of MO can serve as important evidence in forensic practice, considering the possibility of repeated abuse.

Myositis ossificans (MO) is defined as a lesion where abnormal ossification forms in soft tissues, such as muscle, fascia, and ligament, usually as a result of trauma. It commonly appears in areas such as the thigh, hip, and elbow, though it can affect any part of the body. In the forensic field, MO resulting from trauma is reported to be valuable evidence of repeated physical abuse. This case report describes a deceased adult male with an intellectual disability, whose cause of death was multiple injuries from assault. Postmortem computed tomography (PMCT) and autopsy findings revealed MO of both thighs associated with repeated physical abuse. This case also showed typical findings of MO on PMCT imaging, characterized by well-defined, high-density lesions within the quadriceps. Adults with intellectual disabilities are at high risk of abuse and assault. Therefore, autopsy findings of MO can serve as important evidence in forensic practice, considering the possibility of repeated abuse.

Myositis ossificans (MO) is defined as a lesion where abnormal ossification forms in soft tissues, such as muscle, fascia, and ligament, usually as a result of trauma. It commonly appears in areas such as the thigh, hip, and elbow, though it can affect any part of the body. In the forensic field, MO resulting from trauma is reported to be valuable evidence of repeated physical abuse. This case report describes a deceased adult male with an intellectual disability, whose cause of death was multiple injuries from assault. Postmortem computed tomography (PMCT) and autopsy findings revealed MO of both thighs associated with repeated physical abuse. This case also showed typical findings of MO on PMCT imaging, characterized by well-defined, high-density lesions within the quadriceps. Adults with intellectual disabilities are at high risk of abuse and assault. Therefore, autopsy findings of MO can serve as important evidence in forensic practice, considering the possibility of repeated abuse.