PURPOSE: Youth with type 1 diabetes mellitus (T1DM) are at risk of cardiovascular disease (CVD). We evaluated if metformin or statin use was associated with surrogate measures of improved CVD. METHODS: We included participants from the SEARCH observational study. Participants treated with insulin plus metformin (n=42) or insulin plus statin (n=39) were matched with 84 and 78 participants, respectively, treated with insulin alone. Measures of arterial stiffness obtained were pulse wave velocity (PWV), augmentation index (AI75), and heart rate variability as standard deviation of the normal-to-normal interval (SDNN) and root mean square differences of successive NN intervals (RMSSD).
Adolescent ; Cardiovascular Diseases ; Diabetes Mellitus, Type 1 ; Heart Rate ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Insulin ; Metformin ; Morinda ; Observational Study ; Prospective Studies ; Pulse Wave Analysis ; Vascular Stiffness