The emergence of therapy resistance remains a formidable barrier to successful clinical outcomes in oncology, necessitating a deeper understanding of the tumor microenvironment (TME) as a dynamic ecosystem. Adipocytes, once viewed as passive energy reservoirs, are now recognized as active orchestrators of tumor progression and multimodal therapy resistance, particularly in adipose-rich malignancies. This review comprehensively delineates the multifaceted mechanisms through which adipocytes shield cancer cells from therapeutic insults, including chemotherapy, targeted agents, and immunotherapies. We analyze the clinical evidence positioning visceral adiposity as a critical determinant of treatment failure and explore the complex molecular interplay driven by the adipocyte-derived secretome, lipid metabolite-mediated metabolic rewiring, and the horizontal transfer of bioactive cargo via adipocyte-derived extracellular vesicles, and adipocyte-mediated remodeling of the TME. Furthermore, we highlight noncanonical roles such as direct organelle donation, lipid-mediated drug sequestration, the enhancement of DNA repair pathways, and the activation of cell adhesion-dependent survival signaling. We also synthesize recent technological advancements employed to interrogate the intricate adipocyte-cancer interaction. Finally, we discuss emerging therapeutic strategies aimed at disrupting the adipocyte–cancer axis, while critically addressing the translational limitations of these interventions in clinical settings, offering a roadmap for integrating metabolic and anti-inflammatory interventions with standard regimens to overcome adipocyte-driven resistance and advance precision oncology.

OBJECTIVE: To investigate whether the dual route model is applicable to Korean word reading in acquired dyslexia after stroke. METHOD: Sixty-two year old patient with dyslexia after left inferior temporal and occipital lobe infarct was evaluated according to the lexical processing. After evaluation of general cognitive and language function, visual perception, semantic, and lexical stages were assessed. RESULTS: Visual perception was appropriate, and semantic categorization and picture-word matching tasks were 80.6% and 78.6% correct, respectively. Lexical decision task showed no significant differences within word classes, except shorter reaction time in reading words of Korean origin than those of chinese origin (p <0.05). The patient was able to read only 39.8% of tested words, and he could not read all the non-words. Reading of high frequency word was superior (65.4%) to that of low frequency words (10.9%) and semantic errors were not remarkable (p <0.05). CONCLUSION: The patient showed characteristics of recovery from deep to phonologic dyslexia with impairment of grapheme to phoneme conversion (GPC) route. These findings support that dual route model is applicable to Korean word reading.
Asian Continental Ancestry Group ; Dyslexia ; Dyslexia, Acquired ; Humans ; Language Disorders ; Occipital Lobe ; Reaction Time ; Semantics ; Stroke* ; Visual Perception