Abstract Physical inactivity and prolonged sedentary time are currently important health issues for children and adolescents. More evidences are required in the field of physical activity and sedentary behavior among children and adolescents. Therefore, it is necessary to summarize and review the relevant research progress regarding health implications of physical inactivity and sedentary behavior,and possible role of built environment. With the ultimate goal of health promotion for children and adolescents, the priority strategy might focus on increasing physical activity and reducing sedentary behavior through modifying the built environment.