Objective To investigate the role of quality care to improve the non-small cell lung cancer related fatigue in patients with cancer and quality of life. Methods A total of 110 cases of non-small cell lung cancer patients were randomly divided into intervention group and control group,each of 55 cases, two groups were given conventional can-cer chemotherapy treatments, the intervention group received quality care interventions on this basis, used self-assess-ment amendment Piper fatigue scale (RPFS), Anderson symptom assessment scale (MDASI), the quality of life of cancer patients before and after assessment scale(EORTC QLQ-C30) evaluated two interventions state. Results The differences of emotional, cognitive and RPFS scores and intervention were statistically significant between before and after inter-vention in the intervention group(P<0.05), and compared with the control group, the differences were statistically sig nificant (P<0.05), the differences of MDASI scale fatigue, sleep, nausea, anguish, sadness, numbness, general activities, relationships, enjoyment of life scores between the intervention group and control group after the intervention, were sta-tistically significant (P<0.05). The differences of EORTC QLQ-C30 scale physical function, role function, emotional function, cognitive function, social function, overall health score between intervention group and control group after in-tervention were statistically significant (P<0.05). Conclusion Quality care could relieve patients with non-small cell lung cancer-related fatigue and improve cancer-related symptoms and quality of life.