A total of 535 4th∼6th grade students in the Gyeonggi area were surveyed in an effort to increase vegetable preference and intake. They were divided into 3 groups according to the frequency of salad consumption (High-frequency group, HF, more than once a week G; Intermediate-frequency, IFG, 1∼3 times/month;Low-frequency group, LFG, less than once a month). The proportion of subjects who preferred salad over other vegetable dishes was much lower in the LFG than in the other groups. Compared to the HFG, more students in the LFG gave ‘dressing’ as the main reason for their preferring salads, and ‘because of vegetables in salad’ and ‘not knowing the necessity of eating salad’ as the main reasons. Compared to the HFG and MFG, the proportion of students responding ‘less than twice a week’ for vegetable and fruit consumption and ‘more than 2 hours/day on the internet/games’ was higher, while the preferences for namul, salads, saengchae, baechukimchi, chonggakkimchi, nabakkimchi, and fruits were lower in the LFG. The numbers of unfamiliar vegetables and dressings were lower in the HFG than in the other groups and were negatively correlated with the frequency of fruit and vegetable consumption and the preferences for aengchaes, bokkeum, salad, and namul. Also, this study compared the preferences for 14 vegetables and 9 dressings as ingredients of salads by gender, grade, and frequency of eating salads.

A total of 535 4th∼6th grade students in the Gyeonggi area were surveyed in an effort to increase vegetable preference and intake. They were divided into 3 groups according to the frequency of salad consumption (High-frequency group, HF, more than once a week G; Intermediate-frequency, IFG, 1∼3 times/month;Low-frequency group, LFG, less than once a month). The proportion of subjects who preferred salad over other vegetable dishes was much lower in the LFG than in the other groups. Compared to the HFG, more students in the LFG gave ‘dressing’ as the main reason for their preferring salads, and ‘because of vegetables in salad’ and ‘not knowing the necessity of eating salad’ as the main reasons. Compared to the HFG and MFG, the proportion of students responding ‘less than twice a week’ for vegetable and fruit consumption and ‘more than 2 hours/day on the internet/games’ was higher, while the preferences for namul, salads, saengchae, baechukimchi, chonggakkimchi, nabakkimchi, and fruits were lower in the LFG. The numbers of unfamiliar vegetables and dressings were lower in the HFG than in the other groups and were negatively correlated with the frequency of fruit and vegetable consumption and the preferences for aengchaes, bokkeum, salad, and namul. Also, this study compared the preferences for 14 vegetables and 9 dressings as ingredients of salads by gender, grade, and frequency of eating salads.

Lung cancer is the leading cause of cancer death in Republic of Korea. After their initial diagnosis, only 10-20% of patients with advanced non-small cell lung cancer (NSCLC) survive for 5 years of longer. Given enormous advances in therapeutics such as novel targeted therapies and immunotherapies, survival rates are improving for advanced patients with NSCLC; 5-year survival rates range from 15% to 50%, contingent upon the biomarker. Detection of the specific molecular alteration as biomarker is thus crucial for identifying subgroups of NSCLC that contain therpapeutically targetable oncogenic drivers. This review examines the process of diagnosing lung adenocarcinoma with dominant biomarkers in order to customize treatment with appropriate targeted therapy.

Lung cancer is the leading cause of cancer death in Republic of Korea. After their initial diagnosis, only 10-20% of patients with advanced non-small cell lung cancer (NSCLC) survive for 5 years of longer. Given enormous advances in therapeutics such as novel targeted therapies and immunotherapies, survival rates are improving for advanced patients with NSCLC; 5-year survival rates range from 15% to 50%, contingent upon the biomarker. Detection of the specific molecular alteration as biomarker is thus crucial for identifying subgroups of NSCLC that contain therpapeutically targetable oncogenic drivers. This review examines the process of diagnosing lung adenocarcinoma with dominant biomarkers in order to customize treatment with appropriate targeted therapy.

A total of 535 4th∼6th grade students in the Gyeonggi area were surveyed in an effort to increase vegetable preference and intake. They were divided into 3 groups according to the frequency of salad consumption (High-frequency group, HF, more than once a week G; Intermediate-frequency, IFG, 1∼3 times/month;Low-frequency group, LFG, less than once a month). The proportion of subjects who preferred salad over other vegetable dishes was much lower in the LFG than in the other groups. Compared to the HFG, more students in the LFG gave ‘dressing’ as the main reason for their preferring salads, and ‘because of vegetables in salad’ and ‘not knowing the necessity of eating salad’ as the main reasons. Compared to the HFG and MFG, the proportion of students responding ‘less than twice a week’ for vegetable and fruit consumption and ‘more than 2 hours/day on the internet/games’ was higher, while the preferences for namul, salads, saengchae, baechukimchi, chonggakkimchi, nabakkimchi, and fruits were lower in the LFG. The numbers of unfamiliar vegetables and dressings were lower in the HFG than in the other groups and were negatively correlated with the frequency of fruit and vegetable consumption and the preferences for aengchaes, bokkeum, salad, and namul. Also, this study compared the preferences for 14 vegetables and 9 dressings as ingredients of salads by gender, grade, and frequency of eating salads.

Lung cancer is the leading cause of cancer death in Republic of Korea. After their initial diagnosis, only 10-20% of patients with advanced non-small cell lung cancer (NSCLC) survive for 5 years of longer. Given enormous advances in therapeutics such as novel targeted therapies and immunotherapies, survival rates are improving for advanced patients with NSCLC; 5-year survival rates range from 15% to 50%, contingent upon the biomarker. Detection of the specific molecular alteration as biomarker is thus crucial for identifying subgroups of NSCLC that contain therpapeutically targetable oncogenic drivers. This review examines the process of diagnosing lung adenocarcinoma with dominant biomarkers in order to customize treatment with appropriate targeted therapy.

Lung cancer is the leading cause of cancer death in Republic of Korea. After their initial diagnosis, only 10-20% of patients with advanced non-small cell lung cancer (NSCLC) survive for 5 years of longer. Given enormous advances in therapeutics such as novel targeted therapies and immunotherapies, survival rates are improving for advanced patients with NSCLC; 5-year survival rates range from 15% to 50%, contingent upon the biomarker. Detection of the specific molecular alteration as biomarker is thus crucial for identifying subgroups of NSCLC that contain therpapeutically targetable oncogenic drivers. This review examines the process of diagnosing lung adenocarcinoma with dominant biomarkers in order to customize treatment with appropriate targeted therapy.

Background and Objectives: Zonulin is a human protein that regulates intercellular tight junctions and increases the permeability of the intestinal epithelium. In light of the increasing focus on zonulin’s role in numerous chronic inflammatory diseases, this study aimed to investigate whether differences exist in serum zonulin levels and bronchial epithelium zonulin expression in vivo between asthma and normal groups, using a mouse model. Methods: Sixteen mice were utilized in this study, divided evenly between the normal and asthma groups. Serum zonulin levels, the expression of zonulin antibody in the bronchial epithelium, and serum cytokine levels were evaluated in both groups. Enzyme-linked immunosorbent assay and RNA in situ hybridization were utilized for the analysis. Results: The asthma group exhibited significantly higher levels of serum zonulin. High zonulin antibody expression was also observed in the bronchial epithelium of the asthma group. Given that our mouse model demonstrated a significant difference in interleukin (IL)-4 and IL-6 between the normal and asthma groups, zonulin may be associated not only with type 2 responses but also with various subtypes of asthma. Further studies are required to investigate this relationship in greater detail. Conclusion Zonulin may play a role in the complex pathophysiology of asthma and could serve as a biomarker in various asthma-related situations.

Background: There is a correlation between the severe fever with thrombocytopenia syndrome (SFTS) viral load and disease severity; however, measurement of viral load is difficult in general laboratory and it takes time to obtain a viral load value. Here, the laboratory parameters for predicting the dynamic changes in SFTS viral load were identified.In addition, we tried to evaluate a specific time point for the early determination of clinical deterioration using dynamic change of laboratory parameters. Materials and Methods: This observational study included SFTS patients in Korea (2013 - 2020). Cross-correlation analysis at lagged values was used to determine the temporal correlation between the SFTS viral loads and time-series variables. Fifty-eight SFTS patients were included in the non-severe group (NSG) and 11 in the severe group (SG). Results: In the cross-sectional analyses, 10 parameters -white blood cell, absolute neutrophil cell, lymphocyte, platelet, activated partial thromboplastin time (aPTT), C-reactive protein, aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK)- were assessed within 30 days from the onset of symptoms; they exhibited three different correlation patterns: (1) positive, (2) positive with a time lag, and (3) negative. A prediction score system was developed for predicting SFTS fatality based on age and six laboratory variables -platelet, aPTT, AST, ALT, LDH, and CPKin 5 days after the onset of symptoms; this scoring system had 87.5% sensitivity and 86.0% specificity (95% confidence interval: 0.831 - 1.00, P <0.001). Conclusion Three types of correlation patterns between the dynamic changes in SFTS viral load and laboratory parameters were identified. The dynamic changes in the viral load could be predicted using the dynamic changes in these variables, which can be particularly helpful in clinical settings where viral load tests cannot be performed. Also, the proposed scoring system could provide timely treatment to critical patients by rapidly assessing their clinical course.

This study compared the pattern of purchasing nutritional supplements and obtaining nutrition information and the Nutrition Quotient of adults who exercise regularly according to the frequency of muscle training (LM, muscle training less than two days/week; MM, 2∼3 days/week; HM, more than three days/week). Compared to the other groups, significantly more men in the HM group answered that they had purchased supplements and would repurchase them. They presented “increasing muscle mass” as the purpose of buying them and “types and contents” as the major factor to consider before buying. The supplements that significantly more subjects in the HM group purchased than in the other groups were protein supplements, BCAA (Branched-chain amino acid), arginine, and caffeine supplements for men and protein supplements, BCAA and carnitine for women. Compared to the other groups, significantly more men and women in the HM group reported “trainer” as the major source of nutrition information, and significantly more men in the HM group reported “increasing muscle mass” as the 1st topic of nutrition education that they wanted to receive and were satisfied with the information that they obtained. Most of all, males and females in the HM group had significantly a higher Nutrition Quotient than in the other groups. The differences between males and females in variables regarding exercise, the patterns of using supplements and acquiring nutrition information, and Nutrition Quotient were also found. These results can provide basic data for developing educational materials emphasizing the wise consumption of nutrition information, including supplement intake.