Purpose: We present a case of Uveitis-Glaucoma-Hyphema (UGH) syndrome secondary to intraocular lens (IOL) subluxation and associated Soemmering ring.Case summary: A 56-year-old female presented with recurrent episodes of right eye uveitis, vitritis, and vitreous hemorrhage, along with progressive vision loss that had not responded to treatment at a private clinic. On examination, her best-corrected visual acuity (BCVA) was 0.4, and intraocular pressure (IOP) was elevated at 34 mmHg. Slit-lamp and fundoscopic evaluation revealed a subluxated IOL and an adjacent Soemmering ring in contact with the iris, accompanied by anterior chamber inflammatory cells, hyphema, and vitreous hemorrhage. A diagnosis of UGH syndrome secondary to IOL subluxation was made. The patient underwent pars plana vitrectomy with the removal of the subluxated IOL and Soemmering ring, followed by scleral fixation of a new IOL using the Yamane technique. Postoperative recovery was favorable, with resolution of anterior chamber inflammation. At follow-up, BCVA had improved to 1.0, and IOP had normalized to 14 mmHg without the need for antiglaucoma medications. Conclusions UGH syndrome resulting from IOL subluxation and a Soemmering ring can be managed effectively via timely surgical intervention, restoring visual acuity and normalizing IOP.

Purpose: To report a case of sequential hydrophilic acrylic intraocular lens (IOL) opacification in both eyes following Ahmed valve implantation in a patient with neovascular glaucoma secondary to diabetes.Case summary: A 59-year-old man was referred to our clinic with ocular pain and elevated intraocular pressure (IOP) three months after undergoing bilateral cataract surgery with hydrophilic acrylic IOL implantation. Examination revealed bilateral proliferative diabetic retinopathy and neovascularization of the iris and anterior chamber angle. The IOP measured 24 mmHg in the right eye and 57 mmHg in the left eye. The patient was diagnosed with neovascular glaucoma secondary to diabetes. Due to uncontrolled IOP, Ahmed valve implantation was initially performed in the left eye. Two years later, the patient experienced decreased visual acuity in the left eye, and a round central opacification of the IOL optic was noted. The opacified IOL was explanted, and a new IOL was implanted with scleral fixation. During follow-up, Ahmed valve implantation was also required in the right eye due to progression of neovascular glaucoma. Two years postoperatively, similar pattern of IOL opacification was observed in the right eye, necessitating the same surgical management. Conclusions Hydrophilic acrylic IOL opacification may occur following Ahmed valve implantation, and is potentially related to altered aqueous humor dynamics, pH changes, and chronic inflammatory responses.