Objective: The purpose of this study is to examine the factors influencing the health status of first-year high school students leisure activity time, considering of the city size. Methods: This study utilized the first cohort survey of the Korean Children and Youth Panel Survey.The analysis was used data from survey targeting first-year high school students of 2021. The city size was divided into large cities and medium and small-sized cities, and T-test was conducted to examine differences in factors by city size, and multiple regression analysis was conducted to identify factors influencing health status according to leisure activity time on weekdays and weekends by city size. Results: In large cities, exercise and physical activity time and other than that, Time to play with friends had a positive effect(+), Time to play with a smartphone had a negative effect(-) on both weekdays and weekends. In medium and small-sized cities, Exercise and physical activity time and Time to play while watching TV had a positive influence(+) on both weekdays and weekends, while Time to play with a smartphone had a negative influence(-). Conclusion There were the same questions for factors influencing health status, but other questions also appeared. Leisure activities that have a positive(+) impact on health status by city size are supported so that leisure activities can be actively carried out, while leisure activities that have a negative(-) impact are participate in other leisure activities together to improve health. It is believed that this plan should be considered.

Objective: The purpose of this study is to examine the factors influencing the satisfaction of the housing environment of householders living in apartments in the region according to the difference in the elderly population ratio. Methods: The analysis was conducted from the 2021 housing survey in Chungcheongbuk-do and Jeollanam-do region, where the elderly population ratio is the high and low regions. The subjects of the study consisted of 552 people in Chungcheongbuk-do and 616 people in Jeollanam-do, and analysis was performed with t-test and multiple regression. Results: In the Chungcheongbuk-do region(p<0.05), Ease access to commercial facilities, Ease access to medical facilities, Ease access to public institution, Ease access to cultural facilities, Ease access to city parks and green spaces, Ease access to public transportation, Level of air pollution, Relationship with neighbors, and Jeollanam-do region showed positive influences(p<0.05) in Waterproof condition, Safety from fire, Ease access to commercial facilities, Ease access to cultural facilities, Ease access to public transportation, Educational environment, Level of air pollution, Relationship with neighbors. There was a difference(p<0.05) between regions in Waterproof condition, Safety from fire, Ease access to medical facilities, Ease access to public institution, Ease access to city parks and green spaces, Educational environment. Conclusion The factors influencing housing environment satisfaction according to the elderly population ratio by region were different. it is judged necessary to consider regional population groups when establishing and promoting city development and housing environment improvement project plans.

Objective: The purpose of this study is to examine the factors influencing the health status of first-year high school students leisure activity time, considering of the city size. Methods: This study utilized the first cohort survey of the Korean Children and Youth Panel Survey.The analysis was used data from survey targeting first-year high school students of 2021. The city size was divided into large cities and medium and small-sized cities, and T-test was conducted to examine differences in factors by city size, and multiple regression analysis was conducted to identify factors influencing health status according to leisure activity time on weekdays and weekends by city size. Results: In large cities, exercise and physical activity time and other than that, Time to play with friends had a positive effect(+), Time to play with a smartphone had a negative effect(-) on both weekdays and weekends. In medium and small-sized cities, Exercise and physical activity time and Time to play while watching TV had a positive influence(+) on both weekdays and weekends, while Time to play with a smartphone had a negative influence(-). Conclusion There were the same questions for factors influencing health status, but other questions also appeared. Leisure activities that have a positive(+) impact on health status by city size are supported so that leisure activities can be actively carried out, while leisure activities that have a negative(-) impact are participate in other leisure activities together to improve health. It is believed that this plan should be considered.

Objective: The purpose of this study is to examine the factors influencing the satisfaction of the housing environment of householders living in apartments in the region according to the difference in the elderly population ratio. Methods: The analysis was conducted from the 2021 housing survey in Chungcheongbuk-do and Jeollanam-do region, where the elderly population ratio is the high and low regions. The subjects of the study consisted of 552 people in Chungcheongbuk-do and 616 people in Jeollanam-do, and analysis was performed with t-test and multiple regression. Results: In the Chungcheongbuk-do region(p<0.05), Ease access to commercial facilities, Ease access to medical facilities, Ease access to public institution, Ease access to cultural facilities, Ease access to city parks and green spaces, Ease access to public transportation, Level of air pollution, Relationship with neighbors, and Jeollanam-do region showed positive influences(p<0.05) in Waterproof condition, Safety from fire, Ease access to commercial facilities, Ease access to cultural facilities, Ease access to public transportation, Educational environment, Level of air pollution, Relationship with neighbors. There was a difference(p<0.05) between regions in Waterproof condition, Safety from fire, Ease access to medical facilities, Ease access to public institution, Ease access to city parks and green spaces, Educational environment. Conclusion The factors influencing housing environment satisfaction according to the elderly population ratio by region were different. it is judged necessary to consider regional population groups when establishing and promoting city development and housing environment improvement project plans.

Objective: The purpose of this study is to examine the factors influencing the health status of first-year high school students leisure activity time, considering of the city size. Methods: This study utilized the first cohort survey of the Korean Children and Youth Panel Survey.The analysis was used data from survey targeting first-year high school students of 2021. The city size was divided into large cities and medium and small-sized cities, and T-test was conducted to examine differences in factors by city size, and multiple regression analysis was conducted to identify factors influencing health status according to leisure activity time on weekdays and weekends by city size. Results: In large cities, exercise and physical activity time and other than that, Time to play with friends had a positive effect(+), Time to play with a smartphone had a negative effect(-) on both weekdays and weekends. In medium and small-sized cities, Exercise and physical activity time and Time to play while watching TV had a positive influence(+) on both weekdays and weekends, while Time to play with a smartphone had a negative influence(-). Conclusion There were the same questions for factors influencing health status, but other questions also appeared. Leisure activities that have a positive(+) impact on health status by city size are supported so that leisure activities can be actively carried out, while leisure activities that have a negative(-) impact are participate in other leisure activities together to improve health. It is believed that this plan should be considered.

Objective: The purpose of this study is to examine the factors influencing the satisfaction of the housing environment of householders living in apartments in the region according to the difference in the elderly population ratio. Methods: The analysis was conducted from the 2021 housing survey in Chungcheongbuk-do and Jeollanam-do region, where the elderly population ratio is the high and low regions. The subjects of the study consisted of 552 people in Chungcheongbuk-do and 616 people in Jeollanam-do, and analysis was performed with t-test and multiple regression. Results: In the Chungcheongbuk-do region(p<0.05), Ease access to commercial facilities, Ease access to medical facilities, Ease access to public institution, Ease access to cultural facilities, Ease access to city parks and green spaces, Ease access to public transportation, Level of air pollution, Relationship with neighbors, and Jeollanam-do region showed positive influences(p<0.05) in Waterproof condition, Safety from fire, Ease access to commercial facilities, Ease access to cultural facilities, Ease access to public transportation, Educational environment, Level of air pollution, Relationship with neighbors. There was a difference(p<0.05) between regions in Waterproof condition, Safety from fire, Ease access to medical facilities, Ease access to public institution, Ease access to city parks and green spaces, Educational environment. Conclusion The factors influencing housing environment satisfaction according to the elderly population ratio by region were different. it is judged necessary to consider regional population groups when establishing and promoting city development and housing environment improvement project plans.

Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABO-incompatible (ABOi) transplantation patients is often challenging because patients without ABMR are frequently immunopositive for C4d. The aim of this study was to determine whether C4d positivity with microvascular inflammation (MVI), in the absence of any detectable donor-specific antibodies (DSAs) in ABOi patients, could be considered as ABMR. Methods: A retrospective study of 214 for-cause biopsies from 126 ABOi kidney transplantation patients was performed. Patients with MVI score of ≥2 and glomerulitis score of ≥1 (n = 62) were divided into three groups: the absolute ABMR group (DSA-positive, C4d-positive or C4d-negative; n = 36), the C4d-positive group (DSA-negative, C4d-positive; n = 22), and the C4d-negative group (DSA-negative, C4d-negative; n = 4). The Banff scores, estimated glomerular filtration rates (eGFRs), and graft failure rates were compared among groups. Results: C4d-positive biopsies showed higher glomerulitis, peritubular capillaritis, and MVI scores compared with C4d-negative specimens. The C4d-positive group did not show significant differences in eGFRs and graft survival compared with the absolute ABMR group. Conclusion: The results indicate that C4d positivity, MVI score of ≥2, and glomerulitis score of ≥1 in ABOi allograft biopsies may be categorized and treated as ABMR cases.

Identifying risk factors and improving prognostication for mortality among patients with sepsis-associated acute kidney injury (AKI) undergoing continuous kidney replacement therapy (CKRT) is important in improving the adverse prognosis of this patient population. This study aimed to compare the prognostic value of existing systemic inflammation biomarkers and determine the optimal systemic inflammation biomarker in patients with sepsis-associated AKI receiving CKRT. Methods: This multi-center, retrospective, observational cohort study included 1,500 patients with sepsis-associated AKI treated with intensive care and CKRT. The main predictor was a panel of 13 different systemic inflammation biomarkers. The primary outcome was 28-day mortality after CKRT initiation. Secondary outcomes included 90-day mortality after CKRT initiation, CKRT duration, kidney replacement therapy dependence at discharge, and lengths of intensive care unit (ICU) and hospital stays. Results: When added to the widely accepted Acute Physiology and Chronic Health Evaluation II score, platelet-to-albumin ratio (PAR) and neutrophil-platelet score (NPS) had the highest improvements in prognostication of 28-day mortality, where the corresponding increases in C-statistic were 0.01 (95% confidence interval [CI], 0.00–0.02) and 0.02 (95% CI, 0.01–0.03). Similar findings were observed for 90-day mortality. The 28- and 90-day mortality rates were significantly lower for the higher PAR and NPS quartiles. These associations remained significant even after adjustment for potential confounding variables in multivariable Cox proportional hazards models. Conclusion: Of the available systemic inflammation biomarkers, the addition of PAR or NPS to conventional ICU prediction models improved the prognostication of patients with sepsis-associated AKI receiving intensive care and CKRT.

This study investigated the association between serum phosphate level and mortality in acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT) and evaluated whether this association differed according to disease severity. Methods: Data from eight tertiary hospitals in Korea were retrospectively analyzed. The patients were classified into four groups (low, normal, high, and very high) based on their serum phosphate level at baseline. The association between serum phosphate level and mortality was then analyzed, with further subgroup analysis being conducted according to disease severity. Results: Among the 3,290 patients identified, 166, 955, 1,307, and 862 were in the low, normal, high, and very high phosphate groups, respectively. The 90-day mortality rate was 63.9% and was highest in the very high group (76.3%). Both the high and very high groups showed a significantly higher 90-day mortality rate than did the normal phosphate group (high: hazard ratio [HR], 1.35, 95% confidence interval [CI], 1.21–1.51, p < 0.001; very high: HR, 2.01, 95% CI, 1.78–2.27, p < 0.001). The low group also exhibited a higher 90-day mortality rate than did the normal group among those with high disease severity (HR, 1.47; 95% CI, 1.09–1.99; p = 0.01) but not among those with low disease severity. Conclusion: High serum phosphate level predicted increased mortality in AKI patients undergoing CKRT, and low phosphate level was associated with increased mortality in patients with high disease severity. Therefore, serum phosphate levels should be carefully considered in critically ill patients with AKI.

Purpose: There are increased therapeutic usages of rituximab in kidney transplantation (KT). However, few studies have evaluated the effect of rituximab on cancer development following KT. This study aimed to evaluate the effect of rituximab on the cancer occurrence and mortality rate according to each type of cancer. Methods: Five thousand consecutive recipients who underwent KT at our center were divided into era1 (1990–2007) and era2-rit– (2008–2018), and era2-rit+ (2008–2018) groups. The era2-rit+ group included patients who received single-dose rituximab (200–500 mg) as a desensitization treatment 1–2 weeks before KT. Results: The 5-year incidence rates of malignant tumors after KT were 3.1%, 4.3%, and 3.5% in the era1, era2-rit–, and era2-rit+ group, respectively. The overall incidence rate of cancer after transplantation among the 3 study groups showed no significant difference (P = 0.340). The overall cancer-related mortality rate was 17.1% (53 of 310). Hepatocellular carcinoma (HCC) had the highest mortality rate (61.5%) and relative risk of cancer-related death (hazard ratio, 8.29; 95% confidence interval, 2.40–28.69; P = 0.001). However, we found no significant association between rituximab and the incidence of any malignancy. Conclusion Our results suggest that single-dose rituximab for desensitization may not increase the risk of malignant disease or cancer-related mortality in KT recipients. HCC was associated with the highest risk of cancer-related mortality in an endemic area of HBV infection.