Purpose: This study analyzed and evaluated qualitative studies of nurses' experiences with cardiopulmonary resuscitation (CPR) to understand their awareness and develop effective strategies. Methods: This study used an integrated literature review method developed by Whittemore and Knafl (2005). The scope of the literature search was broad and encompassed qualitative research exploring the experiences of nurses involved in CPR in hospitals.This search was conducted on March 27, 2023. For domestic literature, databases such as KOREAMed, KMBASE, and RISS were used, while foreign literature was sourced from PubMed, EMBASE, CINAHL, and COCHRANE databases. Results: After careful analysis, nine relevant literature pieces were selected, leading to the derivation of four key themes: “Perception of CPR,” “Positive Experiences during CPR,” “Barriers Impacting CPR Execution,” and “Strategies for Enhancing CPR Effectiveness.” Conclusion To positively reinforce the CPR experiences of nurses, it is necessary to establish educational programs and debriefings that reflect situations for effective coping with sufficient consideration of the medical environment of individual hospitals. Future research should consider comparative analyses of nurses' CPR experiences based on cultural factors and their respective working departments to identify areas for improvement.

Purpose: This study analyzed and evaluated qualitative studies of nurses' experiences with cardiopulmonary resuscitation (CPR) to understand their awareness and develop effective strategies. Methods: This study used an integrated literature review method developed by Whittemore and Knafl (2005). The scope of the literature search was broad and encompassed qualitative research exploring the experiences of nurses involved in CPR in hospitals.This search was conducted on March 27, 2023. For domestic literature, databases such as KOREAMed, KMBASE, and RISS were used, while foreign literature was sourced from PubMed, EMBASE, CINAHL, and COCHRANE databases. Results: After careful analysis, nine relevant literature pieces were selected, leading to the derivation of four key themes: “Perception of CPR,” “Positive Experiences during CPR,” “Barriers Impacting CPR Execution,” and “Strategies for Enhancing CPR Effectiveness.” Conclusion To positively reinforce the CPR experiences of nurses, it is necessary to establish educational programs and debriefings that reflect situations for effective coping with sufficient consideration of the medical environment of individual hospitals. Future research should consider comparative analyses of nurses' CPR experiences based on cultural factors and their respective working departments to identify areas for improvement.

Purpose: This study analyzed and evaluated qualitative studies of nurses' experiences with cardiopulmonary resuscitation (CPR) to understand their awareness and develop effective strategies. Methods: This study used an integrated literature review method developed by Whittemore and Knafl (2005). The scope of the literature search was broad and encompassed qualitative research exploring the experiences of nurses involved in CPR in hospitals.This search was conducted on March 27, 2023. For domestic literature, databases such as KOREAMed, KMBASE, and RISS were used, while foreign literature was sourced from PubMed, EMBASE, CINAHL, and COCHRANE databases. Results: After careful analysis, nine relevant literature pieces were selected, leading to the derivation of four key themes: “Perception of CPR,” “Positive Experiences during CPR,” “Barriers Impacting CPR Execution,” and “Strategies for Enhancing CPR Effectiveness.” Conclusion To positively reinforce the CPR experiences of nurses, it is necessary to establish educational programs and debriefings that reflect situations for effective coping with sufficient consideration of the medical environment of individual hospitals. Future research should consider comparative analyses of nurses' CPR experiences based on cultural factors and their respective working departments to identify areas for improvement.

Purpose: This study analyzed and evaluated qualitative studies of nurses' experiences with cardiopulmonary resuscitation (CPR) to understand their awareness and develop effective strategies. Methods: This study used an integrated literature review method developed by Whittemore and Knafl (2005). The scope of the literature search was broad and encompassed qualitative research exploring the experiences of nurses involved in CPR in hospitals.This search was conducted on March 27, 2023. For domestic literature, databases such as KOREAMed, KMBASE, and RISS were used, while foreign literature was sourced from PubMed, EMBASE, CINAHL, and COCHRANE databases. Results: After careful analysis, nine relevant literature pieces were selected, leading to the derivation of four key themes: “Perception of CPR,” “Positive Experiences during CPR,” “Barriers Impacting CPR Execution,” and “Strategies for Enhancing CPR Effectiveness.” Conclusion To positively reinforce the CPR experiences of nurses, it is necessary to establish educational programs and debriefings that reflect situations for effective coping with sufficient consideration of the medical environment of individual hospitals. Future research should consider comparative analyses of nurses' CPR experiences based on cultural factors and their respective working departments to identify areas for improvement.

Purpose: Breast cancer is known to be influenced by genetic and environmental factors, and several susceptibility genes have been discovered. Still, the majority of genetic contributors remain unknown. We aimed to analyze the plasma proteome of breast cancer patients in comparison to healthy individuals to identify differences in protein expression profiles and discover novel biomarkers. Methods: This pilot study was conducted using bioresources from Seoul National University Bundang Hospital’s Human Bioresource Center. Serum samples from 10 breast cancer patients and 10 healthy controls were obtained. Liquid chromatography-mass spectrometry analysis was performed to identify differentially expressed proteins. Results: We identified 891 proteins; 805 were expressed in the breast cancer group and 882 in the control group. Gene set enrichment and differential expression analysis identified 30 upregulated and 100 downregulated proteins in breast cancer. Among these, 10 proteins were selected as potential biomarkers. Three proteins were upregulated in breast cancer patients, including cluster of differentiation 44, eukaryotic translation initiation factor 2-α kinase 3, and fibronectin 1. Seven proteins downregulated in breast cancer patients were also selected: glyceraldehyde-3-phosphate dehydrogenase, α-enolase, heat shock protein member 8, integrin‑linked kinase, tissue inhibitor of metalloproteinases-1, vasodilatorstimulated phosphoprotein, and 14-3-3 protein gamma. All proteins had been previously reported to be related to tumor development and progression. Conclusion The findings suggest that plasma proteome profiling can reveal potential diagnostic biomarkers for breast cancer and may contribute to early detection and personalized treatment strategies. A further validation study with a larger sample cohort of breast cancer patients is planned.

Cognitive dysfunction, a significant complication of type 2 diabetes mellitus (T2DM), can potentially manifest even from the early stages of the disease. Despite evidence of global brain atrophy and related cognitive dysfunction in early-stage T2DM patients, specific regions vulnerable to these changes have not yet been identified. The study enrolled patients with T2DM of less than five years’ duration and without chronic complications (T2DM group, n=100) and demographically similar healthy controls (control group, n=50). High-resolution T1-weighted magnetic resonance imaging data were subjected to independent component analysis to identify structurally significant components indicative of morphometric networks. Within these networks, the groups’ gray matter volumes were compared, and distinctions in memory performance were assessed. In the T2DM group, the relationship between changes in gray matter volume within these networks and declines in memory performance was examined. Among the identified morphometric networks, the T2DM group exhibited reduced gray matter volumes in both the precuneus (Bonferronicorrected p=0.003) and insular-opercular (Bonferroni-corrected p=0.024) networks relative to the control group. Patients with T2DM demonstrated significantly lower memory performance than the control group (p=0.001). In the T2DM group, reductions in gray matter volume in both the precuneus (r=0.316, p=0.001) and insular-opercular (r=0.199, p=0.047) networks were correlated with diminished memory performance. Our findings indicate that structural alterations in the precuneus and insular-opercular networks, along with memory dysfunction, can manifest within the first 5 years following a diagnosis of T2DM.

Background: This study aimed to evaluate whether fluvoxamine reduces clinical deterioration in adult patients with mild to moderate coronavirus disease 2019 (COVID-19), and to identify risk factors for clinical deterioration in patients admitted to a community treatment center (CTC). Materials and Methods: A randomized, placebo-controlled trial was conducted in a CTC, in Seoul, Korea from January 15, 2021, to February 19, 2021. Symptomatic adult patients with positive results of severe acute respiratory syndrome coronavirus 2 real timepolymerase chain reaction within 3 days of randomization were assigned at random to receive 100 mg of fluvoxamine or placebo twice daily for 10 days. The primary outcome was clinical deterioration defined by any of the following criteria: oxygen requirement to keep oxygen saturation over 94.0%, aggravation of pneumonia with dyspnea, or World Health Organization clinical progression scale 4 or greater. Results: Of 52 randomized participants [median (interquartile range) age, 53.5 (43.3 - 60.0) years; 31 (60.0%) men], 44 (85.0%) completed the trial. Clinical deterioration occurred in 2 of 26 patients in each group (P >0.99). There were no serious adverse events in either group. Clinical deterioration occurred in 15 (6.0%) of 271 patients admitted to the CTC, and all of them were transferred to a hospital. In multivariate analysis, age between 55 and 64, fever and pneumonia at admission were independent risk factors for clinical deterioration. Conclusion In this study of adult patients with symptomatic COVID-19 who were admitted to the CTC, there was no significant differences in clinical deterioration between patients treated with fluvoxamine and placebo (ClinicalTrials.gov Identifier: NCT04711863).

We report a case of coronavirus disease 2019 (COVID-19)-associated radiologically suspected organizing pneumonia with repeated negative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) results from nasopharyngeal swab and sputum samples, but positive result from bronchoalveolar lavage fluid. Performing SARS-CoV-2 RT-PCR in upper respiratory tract samples only could fail to detect COVID-19-associated pneumonia, and SARS-CoV-2 could be an etiology of radiologically suspected organizing pneumonia.

Background: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales bacteremia is associated with significant mortality; however, no optimal antibiotic strategy is available. We aimed to evaluate the clinical outcomes according to the antibiotic regimens and identify risk factors for mortality in patients with KPC-producingK. pneumoniae and Escherichia coli bacteremia. Materials and Methods: This retrospective cohort study included all adult patients with monomicrobial bacteremia (KPC-producing K. pneumoniae or E. coli) between January 2011 and March 2021 at a 2,700-bed tertiary center. Results: Ninety-two patients were identified; 7 with E. coli bacteremia, and 85 with K. pneumoniae bacteremia. Thirty-day mortality was 38.0% (35/92). Non-survivors were more likely to have had nosocomial infection (88.6% vs. 63.2%, P = 0.01), high APACHE II scores (mean [interquartile range], 22.0 [14.0 - 28.0] vs. 14.0 [11.0 - 20.5],P <0.001), and septic shock (51.4% vs. 26.3%, P <0.001) and less likely to have been admitted to the surgical ward (5.7% vs. 22.8%, P= 0.04), undergone removal of eradicable foci (61.5% vs. 90.6%, P = 0.03), and received appropriate combination treatment (57.1% vs. 78.9%, P = 0.03) than survivors. No significant difference in mortality was observed according to combination regimens including colistin, aminoglycoside, and tigecycline. In multivariable analysis, high APACHE II scores (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.06 - 1.23, P <0.001), and appropriate definitive treatment (aOR, 0.25; CI, 0.08 - 0.74,P = 0.01) were independent risk factors for mortality. Conclusion High APACHE II scores and not receiving appropriate definitive treatment were associated with 30-day mortality. Mortality did not significantly differ according to combination regimens with conventional drugs such as aminoglycoside and colistin.

Multisystem inflammatory disease in children is a Kawasaki disease like illness occurring after severe acute respiratory syndrome coronavirus 2 infection in children. As the pandemic progresses, similar syndromes were also reported in adult with a decreased incidence.Multisystem inflammatory syndrome in adults (MIS-A) can be characterized with shock, heart failure, and gastrointestinal symptoms with elevated inflammatory markers after coronavirus disease 2019 (COVID-19) infection. Herein, we describe the first case of MIS-A in South Korea. A 38-year-old man presented to our hospital with a 5-day history of abdominal pain and fever. He had been treated with antibiotics for 5 days at the previous hospital, but symptoms had worsened and he had developed orthopnea on the day of presentation.He suffered COVID-19 six weeks ago. Laboratory data revealed elevated white blood cell counts with neutrophil dominance, C-reactive protein, and B-type natriuretic peptide. Chest X-ray showed normal lung parenchyme and echocardiography showed severe biventricular failure with normal chamber size. We diagnosed him as MIS-A and treated with intravenous immunoglobulin and steroid.