Purpose: Exercise is an effective non-pharmacological approach for alleviating treatment-related adverse effects and enhancing physical fitness in breast cancer survivors. A Kinect-based mixed reality device (KMR), with real-time feedback and user data collection, is an innovative exercise intervention for breast cancer survivors. This study aimed to investigate the effect of KMR exercise program on quality of life (QOL) and physical function in breast cancer survivors. Materials and Methods: Seventy-seven participants were randomly assigned to either the KMR exercise group or home stretching group with an 8-week intervention. Physical function (shoulder range of motion, body composition, aerobic capacity, and hand grip strength) was evaluated before and after the intervention period. Participants completed questionnaires such as the Disabilities of the Arm, Shoulder, and Hand (DASH), Functional Assessment of Cancer Therapy-Breast, and International Physical Activity Questionnaire (IPAQ) to assess upper extremity disabilities, QOL, and physical activity levels. Results: Significant group-by-time interaction was found for flexion of the operated arm (154.3±12.5 to 165.8±11.2), and the non-operated arm (158.2±13.8 to 166.5±12.2), abduction of the non-operated arm (154.8±31.6 to 161.1±28.1), and adduction of the operated arm (46.5±9.1 to 52.6±7.2). Significant improvements were also observed in DASH (46.8±9.1 to 40.8±9.3) and IPAQ (1,136.3±612.8 to 1,287±664.1). Conclusion The KMR exercise program effectively improved the physical function, alleviated edema, reduced upper extremity disability, and enhanced the QOL in breast cancer survivors. Coupled with significant group-by-time interactions for various outcomes, the results emphasize the potential benefits of incorporating the KMR exercise program to improve the QOL in breast cancer survivors.

Purpose: Exercise is an effective non-pharmacological approach for alleviating treatment-related adverse effects and enhancing physical fitness in breast cancer survivors. A Kinect-based mixed reality device (KMR), with real-time feedback and user data collection, is an innovative exercise intervention for breast cancer survivors. This study aimed to investigate the effect of KMR exercise program on quality of life (QOL) and physical function in breast cancer survivors. Materials and Methods: Seventy-seven participants were randomly assigned to either the KMR exercise group or home stretching group with an 8-week intervention. Physical function (shoulder range of motion, body composition, aerobic capacity, and hand grip strength) was evaluated before and after the intervention period. Participants completed questionnaires such as the Disabilities of the Arm, Shoulder, and Hand (DASH), Functional Assessment of Cancer Therapy-Breast, and International Physical Activity Questionnaire (IPAQ) to assess upper extremity disabilities, QOL, and physical activity levels. Results: Significant group-by-time interaction was found for flexion of the operated arm (154.3±12.5 to 165.8±11.2), and the non-operated arm (158.2±13.8 to 166.5±12.2), abduction of the non-operated arm (154.8±31.6 to 161.1±28.1), and adduction of the operated arm (46.5±9.1 to 52.6±7.2). Significant improvements were also observed in DASH (46.8±9.1 to 40.8±9.3) and IPAQ (1,136.3±612.8 to 1,287±664.1). Conclusion The KMR exercise program effectively improved the physical function, alleviated edema, reduced upper extremity disability, and enhanced the QOL in breast cancer survivors. Coupled with significant group-by-time interactions for various outcomes, the results emphasize the potential benefits of incorporating the KMR exercise program to improve the QOL in breast cancer survivors.

Purpose: Exercise is an effective non-pharmacological approach for alleviating treatment-related adverse effects and enhancing physical fitness in breast cancer survivors. A Kinect-based mixed reality device (KMR), with real-time feedback and user data collection, is an innovative exercise intervention for breast cancer survivors. This study aimed to investigate the effect of KMR exercise program on quality of life (QOL) and physical function in breast cancer survivors. Materials and Methods: Seventy-seven participants were randomly assigned to either the KMR exercise group or home stretching group with an 8-week intervention. Physical function (shoulder range of motion, body composition, aerobic capacity, and hand grip strength) was evaluated before and after the intervention period. Participants completed questionnaires such as the Disabilities of the Arm, Shoulder, and Hand (DASH), Functional Assessment of Cancer Therapy-Breast, and International Physical Activity Questionnaire (IPAQ) to assess upper extremity disabilities, QOL, and physical activity levels. Results: Significant group-by-time interaction was found for flexion of the operated arm (154.3±12.5 to 165.8±11.2), and the non-operated arm (158.2±13.8 to 166.5±12.2), abduction of the non-operated arm (154.8±31.6 to 161.1±28.1), and adduction of the operated arm (46.5±9.1 to 52.6±7.2). Significant improvements were also observed in DASH (46.8±9.1 to 40.8±9.3) and IPAQ (1,136.3±612.8 to 1,287±664.1). Conclusion The KMR exercise program effectively improved the physical function, alleviated edema, reduced upper extremity disability, and enhanced the QOL in breast cancer survivors. Coupled with significant group-by-time interactions for various outcomes, the results emphasize the potential benefits of incorporating the KMR exercise program to improve the QOL in breast cancer survivors.

Both insufficient and excessive sleep durations have been recognized as important risk factors for mortality. Nevertheless, the impact of sleep duration on cause-specific mortality and potential effect modifiers has not been investigated extensively. Therefore, this study aimed to assess the association between sleep duration and mortality categorized by cause of death and potential effect modifiers using data from the National Health and Nutrition Examination Survey (NHANES). Methods: We established a prospective cohort based on NHANES participants aged 50 years or older, linked to the National Death Index (NDI) in the United States between 2009 and 2018. The NDI included all-cause, cardiovascular, and respiratory deaths. Sleep duration was assessed during the NHANES examination period. A survey-weighted Cox proportional hazards model was used to evaluate the association between sleep and mortality. Results: A total of 13,947 participants with available NHANES data were included in this study. A U-shaped association between sleep duration and mortality was observed for all-cause and cardiovascular mortality, meanwhile, respiratory mortality was linked to moderately short sleep (>5 and <7 hours). For total mortality, the association with severe short sleep (5 hours or less; p<0.01) was generally stronger than the association with long sleep (>8 hours; p=0.029), with the effect of severe short sleep being significantly prominent in males (p<0.01), non-Hispanic White (0.001), high-income (0.056), and those with a body mass index ≥23.0 kg/m2 (0.001) than those in their counterparts. Conclusions: This study suggests that sleep duration is associated with the mortality risk. Our results provide evidence for a more targeted allocation of public health resources to improve sleep and health.

Both insufficient and excessive sleep durations have been recognized as important risk factors for mortality. Nevertheless, the impact of sleep duration on cause-specific mortality and potential effect modifiers has not been investigated extensively. Therefore, this study aimed to assess the association between sleep duration and mortality categorized by cause of death and potential effect modifiers using data from the National Health and Nutrition Examination Survey (NHANES). Methods: We established a prospective cohort based on NHANES participants aged 50 years or older, linked to the National Death Index (NDI) in the United States between 2009 and 2018. The NDI included all-cause, cardiovascular, and respiratory deaths. Sleep duration was assessed during the NHANES examination period. A survey-weighted Cox proportional hazards model was used to evaluate the association between sleep and mortality. Results: A total of 13,947 participants with available NHANES data were included in this study. A U-shaped association between sleep duration and mortality was observed for all-cause and cardiovascular mortality, meanwhile, respiratory mortality was linked to moderately short sleep (>5 and <7 hours). For total mortality, the association with severe short sleep (5 hours or less; p<0.01) was generally stronger than the association with long sleep (>8 hours; p=0.029), with the effect of severe short sleep being significantly prominent in males (p<0.01), non-Hispanic White (0.001), high-income (0.056), and those with a body mass index ≥23.0 kg/m2 (0.001) than those in their counterparts. Conclusions: This study suggests that sleep duration is associated with the mortality risk. Our results provide evidence for a more targeted allocation of public health resources to improve sleep and health.

Both insufficient and excessive sleep durations have been recognized as important risk factors for mortality. Nevertheless, the impact of sleep duration on cause-specific mortality and potential effect modifiers has not been investigated extensively. Therefore, this study aimed to assess the association between sleep duration and mortality categorized by cause of death and potential effect modifiers using data from the National Health and Nutrition Examination Survey (NHANES). Methods: We established a prospective cohort based on NHANES participants aged 50 years or older, linked to the National Death Index (NDI) in the United States between 2009 and 2018. The NDI included all-cause, cardiovascular, and respiratory deaths. Sleep duration was assessed during the NHANES examination period. A survey-weighted Cox proportional hazards model was used to evaluate the association between sleep and mortality. Results: A total of 13,947 participants with available NHANES data were included in this study. A U-shaped association between sleep duration and mortality was observed for all-cause and cardiovascular mortality, meanwhile, respiratory mortality was linked to moderately short sleep (>5 and <7 hours). For total mortality, the association with severe short sleep (5 hours or less; p<0.01) was generally stronger than the association with long sleep (>8 hours; p=0.029), with the effect of severe short sleep being significantly prominent in males (p<0.01), non-Hispanic White (0.001), high-income (0.056), and those with a body mass index ≥23.0 kg/m2 (0.001) than those in their counterparts. Conclusions: This study suggests that sleep duration is associated with the mortality risk. Our results provide evidence for a more targeted allocation of public health resources to improve sleep and health.

Background: Sarcopenia is a muscle-wasting condition that affects older individuals. It can lead to changes in movement patterns, which can increase the risk of falls and other injuries. Methods: Older women participants aged ≥65 years who could walk independently were recruited and classified into two groups based on knee extension strength (KES). Participants with low KES scores were assigned to the possible sarcopenia group (PSG; n=7) and an 8-week exercise intervention was implemented. Healthy seniors with high KES scores were classified as the reference group (RG; n=4), and a 3-week exercise intervention was conducted. Kinematic movement data were recorded during the intervention period. All participants' exercise repetitions were used in the data analysis (number of data points=1,128). Results: The PSG showed significantly larger movement patterns in knee rotation during wide squats compared to the RG, attributed to weakened lower limb strength. The voting classifier, trained on the movement patterns from wide squats, determined that significant differences in overall movement patterns between the two groups persisted until the end of the exercise intervention. However, after the exercise intervention, significant improvements in lower limb strength in the PSG resulted in reduced knee rotation range of motion and max, thereby stabilizing movements and eliminating significant differences with the RG. Conclusion This study suggests that exercise interventions can modify the movement patterns in older individuals with possible sarcopenia. These findings provide fundamental data for developing an exercise management system that remotely tracks and monitors the movement patterns of older adults during exercise activities.

Background: Sarcopenia is a muscle-wasting condition that affects older individuals. It can lead to changes in movement patterns, which can increase the risk of falls and other injuries. Methods: Older women participants aged ≥65 years who could walk independently were recruited and classified into two groups based on knee extension strength (KES). Participants with low KES scores were assigned to the possible sarcopenia group (PSG; n=7) and an 8-week exercise intervention was implemented. Healthy seniors with high KES scores were classified as the reference group (RG; n=4), and a 3-week exercise intervention was conducted. Kinematic movement data were recorded during the intervention period. All participants' exercise repetitions were used in the data analysis (number of data points=1,128). Results: The PSG showed significantly larger movement patterns in knee rotation during wide squats compared to the RG, attributed to weakened lower limb strength. The voting classifier, trained on the movement patterns from wide squats, determined that significant differences in overall movement patterns between the two groups persisted until the end of the exercise intervention. However, after the exercise intervention, significant improvements in lower limb strength in the PSG resulted in reduced knee rotation range of motion and max, thereby stabilizing movements and eliminating significant differences with the RG. Conclusion This study suggests that exercise interventions can modify the movement patterns in older individuals with possible sarcopenia. These findings provide fundamental data for developing an exercise management system that remotely tracks and monitors the movement patterns of older adults during exercise activities.

Background: Sarcopenia is a muscle-wasting condition that affects older individuals. It can lead to changes in movement patterns, which can increase the risk of falls and other injuries. Methods: Older women participants aged ≥65 years who could walk independently were recruited and classified into two groups based on knee extension strength (KES). Participants with low KES scores were assigned to the possible sarcopenia group (PSG; n=7) and an 8-week exercise intervention was implemented. Healthy seniors with high KES scores were classified as the reference group (RG; n=4), and a 3-week exercise intervention was conducted. Kinematic movement data were recorded during the intervention period. All participants' exercise repetitions were used in the data analysis (number of data points=1,128). Results: The PSG showed significantly larger movement patterns in knee rotation during wide squats compared to the RG, attributed to weakened lower limb strength. The voting classifier, trained on the movement patterns from wide squats, determined that significant differences in overall movement patterns between the two groups persisted until the end of the exercise intervention. However, after the exercise intervention, significant improvements in lower limb strength in the PSG resulted in reduced knee rotation range of motion and max, thereby stabilizing movements and eliminating significant differences with the RG. Conclusion This study suggests that exercise interventions can modify the movement patterns in older individuals with possible sarcopenia. These findings provide fundamental data for developing an exercise management system that remotely tracks and monitors the movement patterns of older adults during exercise activities.

Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties based on its antioxidative function. Aptamin C, a complex of vitamin C with its specific aptamer, has been reported to maintain or even enhance the efficacy of vitamin C while increasing its stability. To investigate in vivo distribution of Aptamin C, Gulo knockout mice, which, like humans, cannot biosynthesize vitamin C, were administered Aptamin C orally for 2 and 4 weeks.The results showed higher vitamin C accumulation in all tissues when administered Aptamin C, especially in the spleen. Next, the activity of natural killer (NK) cells were conducted. CD69, a marker known for activating for NK cells, which had decreased due to vitamin C deficiency, did not recover with vitamin C treatment but showed an increasing with Aptamin C. Furthermore, the expression of CD107a, a cell surface marker that increases during the killing process of target cells, also did not recover with vitamin C but increased with Aptamin C. Based on these results, when cultured with tumor cells to measure the extent of tumor cell death, an increase in tumor cell death was observed. To investigate the signaling mechanisms and related molecules involved in the proliferation and activation of NK cells by Aptamin C showed that Aptamin C treatment led to an increase in intracellular STAT3 activation. In conclusion, Aptamin C has a higher capability to activate NK cells and induce tumor cell death compared to vitamin C and it is mediated through the activation of STAT3.