Collagen contains abundant cell binding motifs, which are conducive to adhesion, migration, and differentiation, maintain cell vitality and promote cell proliferation. However, pure collagen hydrogel has some shortcomings such as poor mechanical properties, poor thermal stability and fast degradation. Numerous studies have shown that the properties of collagen can be improved by combining it with natural polysaccharides such as alginate, chitosan, hyaluronic acid and cellulose. In this paper, the research status and biological application fields of four kinds of composite hydrogels, including collagen-alginate composite hydrogels, collagen-chitosan hydrogels, collagen-hyaluronic acid hydrogels and collagen-cellulose hydrogels, were summarized. The common preparation methods of four kinds of composite hydrogels were introduced, and the future development direction of collagen-based composite hydrogels was prospected.
Hydrogels/chemical synthesis* ; Collagen/chemistry* ; Polysaccharides/chemistry* ; Alginates/chemistry* ; Hyaluronic Acid/chemistry* ; Chitosan/chemistry* ; Biocompatible Materials/chemistry* ; Humans ; Tissue Engineering/methods* ; Cellulose/chemistry* ; Tissue Scaffolds

Silk fibroin (SF)/sodium alginate (SA) hydrogels can be used as drug injection materials. Homogenate was prepared by centrifugation of the pig myocardial extracellular matrix (PMM) and its modification of SF gel material. This paper observes and compares the different components SF, SF/SA, SF/SA/PMM to illustrate the SF/SA/PMM ternary material as a drug delivery composition material. This ternary material can shorten the gel time, and can make the gel form to be maintained better. Meanwhile, it makes the internal structure of the gel looser so that the hole wall becomes thinner and more conducive to the drug release. In addition, it has good biocompatibility proved by pathological analysis, and is able to enhance the mesenchymal stem cells growth activity, which has great significance in carrying out drug control release.
Alginates ; chemical synthesis ; chemistry ; Animals ; Biocompatible Materials ; chemical synthesis ; Delayed-Action Preparations ; chemistry ; Drug Carriers ; chemical synthesis ; chemistry ; Extracellular Matrix ; chemistry ; Fibroins ; chemical synthesis ; chemistry ; Glucuronic Acid ; chemical synthesis ; chemistry ; Hexuronic Acids ; chemical synthesis ; chemistry ; Hydrogels ; chemical synthesis ; chemistry ; Myocardium ; chemistry ; Rats ; Swine ; Tissue Extracts ; chemistry

Poly (acrylic ester) hydrogel materials were widely used in intraocular lens and contact lens because of their excellent optical performance and biocompatibility. In this paper, the bulk copolymerization behavior of hydrophilic hydroxyethyl methacrylat with hydrophobic methyl metharylate was studied; and the optical performance, calcium deposits, equilibrium water content of polymers and its hydrogels obtained by different ratios of monomers were systematically investigated. The experimental results showed that the average light transmittance and the equilibrium water content of the obtained hydrogels increased with the increasing of the hydrophilic monomer content from 0 to 100%; however, the hardness decreased. The highest light transmittance reached 97% and the hardness of Shore A fell from 92 to 25, the equilibrium water content of hydrogel increased from 16% to 64%. The absorbent capacity of copolymers reduced with the adding of cross-linking monomer. When m(hydrophilic monomer): m(hydrophobic monomer) = 90 : 10, the combination property of the polymer and its hydrogel obtained is optimum.
Acrylic Resins ; chemical synthesis ; chemistry ; Biocompatible Materials ; chemical synthesis ; chemistry ; Humans ; Hydrogels ; chemical synthesis ; chemistry ; Lenses, Intraocular ; Polyhydroxyethyl Methacrylate ; chemical synthesis ; chemistry ; Tensile Strength

Gelatin and hydroxyapatite were introduced to polyvinyl alcohol (PVA) hydrogel with an attempt to enhance the performances of PVA hydrogel. Through a reiterative freezing-thawing methods, three kinds of PVA composite hydrogels were prepared. The mechanical performances of these composite hydrogels with the same PVA and HA content but varying gelatin content, such as tensile strength, elasticity modulus, creep curve, relaxation curve and friction coefficient were evaluated by using a computer-controlled universal electronic mechanical testing machine and a UMT-II frictional testing machine. The additional effects of hydroxylapatite and varying gelatin on the performances of composite PVA hydro-gels were analyzed. It was found that the gelatin content directly influenced the physical performances of PVA composite hydrogels; but no linear relationship was recorded. PVA composite hydrogel containing 2wt-% gelatin gave optimal results, i.e. tensile strength of 5.5MPa, compressive elastical modulus of 1.48MPa, creeping rate of 31% in 45 minutes, stress relaxing rate of 40.3%, and the starting friction coefficient of 0.332.
Elastic Modulus ; Friction ; Hydrogels ; chemical synthesis ; chemistry ; Mechanical Phenomena ; Polyvinyl Alcohol ; chemical synthesis ; chemistry ; Tensile Strength

The chitosan thermosensitive hydrogel is liquid at room temperature but gels rapidly when heated to body temperature. This hydrogel are wildly used for cell encapsulation, drug delivery or tissue-engineered scaffolds. The system can sustain the release of macromolecules over a period of several hours to a few days. However, with low-molecular-weight compounds, the release is generally completed within 24 h. To prepare a functional chitosan thermosensitive hydrogel for slow release both broad-spectrum antibiotic chlorhexidine and growth factor recombined human bone morphogenetic protein-2 (rhBMP-2), The beta-cyclodextrin was used to prepare an inclusion complex with chlorhexidine, and then the latter was incorporated into the chitosan thermosensitive hydrogel system. Simultaneously, rhBMP-2 was added into the hydrogel system. By HAAKE viscosity measuring instrument, we contrasted the viscoelastic properties of system with or without objective factors. And the in vitro release kinetics of chlorhexidine and rhBMP-2 was investigated by HPLC (high performance liquid chromatography) and ELISA (enzyme-linked immunosorbent assay) respectively. The results showed that the addition of chlorhexidine/beta-cyclodextrin inclusion complex to the thermosensitive solution did not change the gelling behavior of the thermosensitive system. Further, the in vitro release profiles demonstrated that the release rate of chlorhexidine and rhBMP-2 from hydrogel became slower, controlled delivery over at least 1 month. By first preparing chlorhexidine/beta-cyclodextrin inclusion complex, and then mixing the IC and rhBMP-2 into the chitosan thermosensitive hydrogel, a functional chitosan thermosensitive hydrogel system with ability of slow release both rhBMP-2 and chlorhexidine is successfully made.
Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins ; administration & dosage ; Chitosan ; chemistry ; Chlorhexidine ; administration & dosage ; Delayed-Action Preparations ; chemical synthesis ; Drug Carriers ; chemistry ; Drug Combinations ; Hydrogels ; chemistry ; Recombinant Proteins ; administration & dosage ; Temperature ; Transforming Growth Factor beta ; administration & dosage

Five kinds of pore-forming agents, including PEG-400, chitosan, the polymer of chitosan and glutin, CaCO3 and NazCO3, were used in this experiment to prepare fast responsive and pH sensitive Polyacrylic acid (PAAc) gel which could be used as the material of punctum plug. The mechanism and effects of pore-forming agents on PAAc gel were studied; besides, the experiment also assessed the effects of the three most effective pore-forming agents on gel's water retention and swelling rate. The results showed that the most suitable dose levels of PEG-400, the polymer and Na2CO3 were 1 ml, 0.8 ml and 1 ml respectively, and PEG-400 was most effective with the same dosage; the gel with PEG-400 as pore-forming agent could finish more than 95% of the swelling process in just 5 minutes, it is suitable for use as punctum plug material.
Acrylic Resins ; chemistry ; Carbonates ; chemistry ; Chitosan ; chemistry ; Hydrogels ; chemical synthesis ; chemistry ; Hydrogen-Ion Concentration ; Ophthalmic Solutions ; chemical synthesis ; chemistry ; Polyethylene Glycols ; chemistry ; Polymers ; Porosity

Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel.
Acrylamide ; chemical synthesis ; chemistry ; Aspirin ; pharmacokinetics ; Delayed-Action Preparations ; Gluconates ; chemical synthesis ; chemistry ; Hydrogels ; chemical synthesis ; chemistry ; Lactones ; Polymers ; chemical synthesis ; chemistry