The Vaccine Adverse Event Reporting System (VAERS) in the United States is the earliest vaccine safety surveillance system in the world, established in 1990. The VAERS database can be used to detect new, unusual, or rare adverse events following vaccine to identify potential safety issues with marketed vaccines. This paper introduces the basic situation and data acquisition methods of VAERS database, summarizes the format, content, relevance and practical application methods of VAERS data packet, and reviews the research on vaccine safety data analysis and signal mining by foreign scholars using VAERS data in recent years, so as to provide reference for Chinese scholars in use of VAERS database and the data opening of surveillance data of suspected adverse event following immunization in China.

The Vaccine Adverse Event Reporting System (VAERS) in the United States is the earliest vaccine safety surveillance system in the world, established in 1990. The VAERS database can be used to detect new, unusual, or rare adverse events following vaccine to identify potential safety issues with marketed vaccines. This paper introduces the basic situation and data acquisition methods of VAERS database, summarizes the format, content, relevance and practical application methods of VAERS data packet, and reviews the research on vaccine safety data analysis and signal mining by foreign scholars using VAERS data in recent years, so as to provide reference for Chinese scholars in use of VAERS database and the data opening of surveillance data of suspected adverse event following immunization in China.