Objective:To investigate the effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen (HBO) therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage.Methods:A total of 74 patients with hypertensive intracerebral hemorrhage treated in 454 Hospital and Nanjing Zijin Hospital from January 2019 to January 2021 were selected and randomly divided into treatment group ( n=37) given minimally invasive aspiration and drainage combined with HBO therapy and control group ( n=37) given minimally invasive aspiration and drainage only. The levels of serum inflammatory factors, cerebrovascular dynamic indicators, arterial blood gas (ABG) levels, and the neurologic function scores in the two groups before and after treatment were compared. Results:Before treatment, there was no significant difference between the two groups in the levels of serum inflammatory factors, cerebrovascular dynamic indicators, ABG levels, and the neurological function scores ( P>0.05); after 30 days of treatment, the levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1(IL-1), and IL-8 in the treatment group were lower than those in the control group, the National Institute of Health Stroke Scale (NIHSS) scores, the values of peripheral resistance (PR) and dynamic resistance (DR) in the treatment group were lower than those in the control group, while the Mini-mental State Examination (MMSE) scores, the mean blood flow velocities (Vm), mean blood flow quantities (Qm), the arterial partial pressures of CO 2 (PaCO 2) and the arterial partial pressures of oxygen (PaO 2), and the blood pH values in the treatment group were higher than those in the control group ( P<0.05), and all the differences were statistically significant ( P<0.05). Conclusion:Minimally invasive aspiration and drainage combined with HBO therapy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the patients’ inflammatory response and promote the recovery of cerebral vascular dynamics and nerve function.

Objective:To investigate the effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen (HBO) therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage.Methods:A total of 74 patients with hypertensive intracerebral hemorrhage treated in 454 Hospital and Nanjing Zijin Hospital from January 2019 to January 2021 were selected and randomly divided into treatment group ( n=37) given minimally invasive aspiration and drainage combined with HBO therapy and control group ( n=37) given minimally invasive aspiration and drainage only. The levels of serum inflammatory factors, cerebrovascular dynamic indicators, arterial blood gas (ABG) levels, and the neurologic function scores in the two groups before and after treatment were compared. Results:Before treatment, there was no significant difference between the two groups in the levels of serum inflammatory factors, cerebrovascular dynamic indicators, ABG levels, and the neurological function scores ( P>0.05); after 30 days of treatment, the levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1(IL-1), and IL-8 in the treatment group were lower than those in the control group, the National Institute of Health Stroke Scale (NIHSS) scores, the values of peripheral resistance (PR) and dynamic resistance (DR) in the treatment group were lower than those in the control group, while the Mini-mental State Examination (MMSE) scores, the mean blood flow velocities (Vm), mean blood flow quantities (Qm), the arterial partial pressures of CO 2 (PaCO 2) and the arterial partial pressures of oxygen (PaO 2), and the blood pH values in the treatment group were higher than those in the control group ( P<0.05), and all the differences were statistically significant ( P<0.05). Conclusion:Minimally invasive aspiration and drainage combined with HBO therapy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the patients’ inflammatory response and promote the recovery of cerebral vascular dynamics and nerve function.

Objective:To explore the predictive value of China Nanjing persistent vegetative state scale (CNPVSS) on the curative effect of the patients with chronic disorder of consciousness, by analyzing the curative effect of the rehabilitation treatment combined with hyperbaric oxygen (HBO) for patients with chronic disorder of consciousness.Methods:A total of 48 patients with chronic disorder of consciousness admitted to Nanjing Zijin Hospital to receive rehabilitation treatment combined with HBO from the September of 2016 to the May of 2019 were selected according with the analytical criteria. Before the treatment, the patients were evaluated by CNPVSS and received electroencephalogram (EEG) and evoked potentials (EPs) examinations. The patients′ consciousness was evaluated again before discharge, the results of CNPVSS and electrophysiological examinations were recorded, and the correlation between the results and the changes of the consciousness was analyzed statistically.Results:The results of CNPVSS was positive correlated with near-term curative effect ( r=0.401, P=0.005); the rate of awakening after treatment was 46.2% among those who were scored as minimally conscious state (MCS) by CNPVSS; the rate of awakening after treatment was 17.1% among those who were at vegetative state (VS) or in a coma; the rate of awakening after treatment of the MCS patients was higher than those of the patients at VS or in a coma ( χ2=4.255, P=0.039). The recordings of right somatosensory evoked potentials (SSEPs) N20 was positive correlated with curative effect ( r=0.312, P=0.031); and the left visual evoked potentials (VEPs) V100 was positive correlated with curative effect ( r=0.285, P=0.049). There were no statistical significance found between other electrophysiological recordings with curative effect. Conclusion:CNPVSS can be an important tool to predict the outcome of the rehabilitation treatment combined with HBO for the patients with chronic disorder of consciousness, and the recordings of SSEPs and VEPs also are of a certain reference value in predicting the prognosis.

Objective:To explore the predictive value of China Nanjing persistent vegetative state scale (CNPVSS) on the curative effect of the patients with chronic disorder of consciousness, by analyzing the curative effect of the rehabilitation treatment combined with hyperbaric oxygen (HBO) for patients with chronic disorder of consciousness.Methods:A total of 48 patients with chronic disorder of consciousness admitted to Nanjing Zijin Hospital to receive rehabilitation treatment combined with HBO from the September of 2016 to the May of 2019 were selected according with the analytical criteria. Before the treatment, the patients were evaluated by CNPVSS and received electroencephalogram (EEG) and evoked potentials (EPs) examinations. The patients′ consciousness was evaluated again before discharge, the results of CNPVSS and electrophysiological examinations were recorded, and the correlation between the results and the changes of the consciousness was analyzed statistically.Results:The results of CNPVSS was positive correlated with near-term curative effect ( r=0.401, P=0.005); the rate of awakening after treatment was 46.2% among those who were scored as minimally conscious state (MCS) by CNPVSS; the rate of awakening after treatment was 17.1% among those who were at vegetative state (VS) or in a coma; the rate of awakening after treatment of the MCS patients was higher than those of the patients at VS or in a coma ( χ2=4.255, P=0.039). The recordings of right somatosensory evoked potentials (SSEPs) N20 was positive correlated with curative effect ( r=0.312, P=0.031); and the left visual evoked potentials (VEPs) V100 was positive correlated with curative effect ( r=0.285, P=0.049). There were no statistical significance found between other electrophysiological recordings with curative effect. Conclusion:CNPVSS can be an important tool to predict the outcome of the rehabilitation treatment combined with HBO for the patients with chronic disorder of consciousness, and the recordings of SSEPs and VEPs also are of a certain reference value in predicting the prognosis.

Objective To investigate the clinical application of the 2011 edition of China Nanjing Persistent Vegetative State (NPVSS 2011).Methods Three hundred and one patients with vegetative state (VS),persistent vegetative state (PVS) and minimally conscious state (MCS) admitted into hospital from February 22,2011 to May 30,2014 were chosen for the study.Patient conditions and treatment efficacy were assessed by using the NPVSS 2011.Results With regard to conscious state at admission into hospital,109 cases were in VS,65 were in PVS and 127 were in MCS.When discharged from hospital,there were 8 VS cases,72 PVS cases,91 MCS cases,and 130 Ⅲ cases that could carry out more complicated instructions.Of all the cases,164 cases had prominent efficacy,31 were improved,106 were invalid,and 130 cases that had consciousness recovery to the state of Ⅲ.Conclusions The CNPVSS could reflect the changing processes of patient conditions,having the features of being simple and clear,conforming to clinical practice,and above all being easy to master and operate.With this reason,it could be applied to clinical practice.

Objective To investigate the clinical application of the 2011 edition of China Nanjing Persistent Vegetative State (NPVSS 2011).Methods Three hundred and one patients with vegetative state (VS),persistent vegetative state (PVS) and minimally conscious state (MCS) admitted into hospital from February 22,2011 to May 30,2014 were chosen for the study.Patient conditions and treatment efficacy were assessed by using the NPVSS 2011.Results With regard to conscious state at admission into hospital,109 cases were in VS,65 were in PVS and 127 were in MCS.When discharged from hospital,there were 8 VS cases,72 PVS cases,91 MCS cases,and 130 Ⅲ cases that could carry out more complicated instructions.Of all the cases,164 cases had prominent efficacy,31 were improved,106 were invalid,and 130 cases that had consciousness recovery to the state of Ⅲ.Conclusions The CNPVSS could reflect the changing processes of patient conditions,having the features of being simple and clear,conforming to clinical practice,and above all being easy to master and operate.With this reason,it could be applied to clinical practice.