Objective To retrieve,evaluate and summarise evidence on home exercise rehabilitation in patients with stage Ⅱ coronary heart disease(CHD)undergoing cardiac rehabilitation and to provide a reference for healthcare professionals to instruct the patients for home-based exercise rehabilitation.Methods Following the"6S"evidence hierarchy model and a top-down search strategy,a systematic search was conducted across databases of Guidelines International Network(GIN),Scottish Intercollegiate Guidelines Network(SIGN),National Institute for Health and Clinical Excellence(NICE),American Association of Cardiovascular and Pulmonary Rehabilitation(AACVPR),American Heart Association(AHA),European Society of Cardiology(ESC),BMJ Best Practice,UpToDate,Joanna Briggs Institute(JBI)evidence-based healthcare database,PubMed,Web of Science,Cochrane Library,EBSCON,SinoMed,China National Knowledge Infrastructure(CNKI),and Wanfang Data Knowledge Service Platform for guidelines,expert consensus,evidence summaries,systematic reviews,primary study and clinical decisions regarding home-based exercise rehabilitation for patient with CHD phase Ⅱ cardiac rehabilitation.Literature included the articles published on databases from the inception to December 2023.Two researchers independently evaluated the quality of acquired literature and the extracted and integrated the evidence.Results A total of 15 articles were retrieved,including 5 guidelines,3 expert consensuses,2 evidence summaries,3 systematic reviews and 2 clinical decisions.A total of 23 best evidence statements were summarised and further reduced to 5 topics:exercise benefits,exercise assessment,exercise prescription,safety and monitoring,and health education.Conclusion This study summarises the best evidence for home-based exercise rehabilitation in patients with phase Ⅱ cardiac rehabilitation.It recommends that healthcare professionals should consider the clinical context rehabilitation,by taking into account of the needs and preferences of patients and their families,when applying the evidence and developing appropriate and individualised plans for exercise hence to promote the recovery of patients.

Objective To retrieve,evaluate and summarise evidence on home exercise rehabilitation in patients with stage Ⅱ coronary heart disease(CHD)undergoing cardiac rehabilitation and to provide a reference for healthcare professionals to instruct the patients for home-based exercise rehabilitation.Methods Following the"6S"evidence hierarchy model and a top-down search strategy,a systematic search was conducted across databases of Guidelines International Network(GIN),Scottish Intercollegiate Guidelines Network(SIGN),National Institute for Health and Clinical Excellence(NICE),American Association of Cardiovascular and Pulmonary Rehabilitation(AACVPR),American Heart Association(AHA),European Society of Cardiology(ESC),BMJ Best Practice,UpToDate,Joanna Briggs Institute(JBI)evidence-based healthcare database,PubMed,Web of Science,Cochrane Library,EBSCON,SinoMed,China National Knowledge Infrastructure(CNKI),and Wanfang Data Knowledge Service Platform for guidelines,expert consensus,evidence summaries,systematic reviews,primary study and clinical decisions regarding home-based exercise rehabilitation for patient with CHD phase Ⅱ cardiac rehabilitation.Literature included the articles published on databases from the inception to December 2023.Two researchers independently evaluated the quality of acquired literature and the extracted and integrated the evidence.Results A total of 15 articles were retrieved,including 5 guidelines,3 expert consensuses,2 evidence summaries,3 systematic reviews and 2 clinical decisions.A total of 23 best evidence statements were summarised and further reduced to 5 topics:exercise benefits,exercise assessment,exercise prescription,safety and monitoring,and health education.Conclusion This study summarises the best evidence for home-based exercise rehabilitation in patients with phase Ⅱ cardiac rehabilitation.It recommends that healthcare professionals should consider the clinical context rehabilitation,by taking into account of the needs and preferences of patients and their families,when applying the evidence and developing appropriate and individualised plans for exercise hence to promote the recovery of patients.

Objective:To investigate the serum expression of long non-coding RNA overlapping transcription content KCNQ1OT1 (KCNQ1) gene in patients with coronary artery disease (CAD) and its clinical significance.
Methods:A total of 196 patients treated in our hospital were divided into 2 groups:CAD group and Control group, the patients were without CAD. n=98 in each group. Expression levels of serum KCNQ1OT1 and P53 were measured by quantitative RT-PCR;the relationship between KCNQ1OT1, P53 and clinical features in relevant patients were analyzed.
Results:Compared with Control group, CAD group had increased expression of serum KCNQ1OT1 and decreased expression of P53, both P<0.05. Correlation analysis revealed that the expression of KCNQ1OT1 was negatively related to P53 (r=-0.856, P<0.001);multi Logistic regression analysis indicated that serum KCNQ1OT1 was independently related to CAD (P<0.05).
Conclusion:CAD patients had obviously increased serum level of KCNQ1OT1;KCNQ1OT1 was independently related to CAD occurrence.