Atherosclerosis(As)is a chronic inflammatory vascular disease and serves as the pathological basis for various cardiovascular diseases.Epigallocatechin-3-O-gallate(EGCG)is the most abundant and biologically active com-pound in green tea,possessing multiple pharmacological effects such as anti-inflammatory,antiviral,and antioxidative stress properties.In recent years,studies have found that EGCG can regulate lipid metabolism,improve vascular endo-thelial function,and enhance plaque stability,demonstrating its potential value in combating As.This article provides a systematic review of the mechanisms underlying EGCG's anti-As effects,aiming to offer multi-faceted theoretical support for its further research and clinical application in the prevention and treatment of As.

Atherosclerosis(As)is a chronic inflammatory vascular disease and serves as the pathological basis for various cardiovascular diseases.Epigallocatechin-3-O-gallate(EGCG)is the most abundant and biologically active com-pound in green tea,possessing multiple pharmacological effects such as anti-inflammatory,antiviral,and antioxidative stress properties.In recent years,studies have found that EGCG can regulate lipid metabolism,improve vascular endo-thelial function,and enhance plaque stability,demonstrating its potential value in combating As.This article provides a systematic review of the mechanisms underlying EGCG's anti-As effects,aiming to offer multi-faceted theoretical support for its further research and clinical application in the prevention and treatment of As.

Objective To study the effects of intermittent hypoxia training ( IHT) plus rehabilitation exercise on the cognitive function and motor dysfunction in the patients with cerebral infarction. Methods Fifty-four patients with cerebral infarction were enrolled for the study, and were randomly divided into the IHT +rehabilitation group ( or group A) and the conventional rehabilitation group ( or group B) . The patients in group A had IHT, in addition to the conventional rehabilitation treatment as received by group B. All the patients had 5 treatment sessions a week for a succession of 4 weeks. The cognitive function and motor dysfunction both before and after intervention in the patients of the 2 groups were evaluated with Fugl-Meyer motor assessment ( FMA) and MMSE. Results Following intervention, the FMA cores in the patients of the 2 groups all improved as compared with those before intervention(P<0. 05). The MMSE scores of group A increased from (22. 2 ± 1. 16) before intervention to (26. 4 ± 1. 01) after intervention. Statistical significance could be seen when comparisons were made between the 2 groups(P <0. 05). As for the MMSE scores of group B after intervention, there was no statistical significance, when they were compared with those before intervention( P>0.05). The MMSE scores of group A were better than those of group B after intervention(P <0. 05). Conclusion IHT plus rehabilitation exercise could effectively improve the cognitive function and motor function of the patients with cerebral infarction.

Objective To study the effects of intermittent hypoxia training ( IHT) plus rehabilitation exercise on the cognitive function and motor dysfunction in the patients with cerebral infarction. Methods Fifty-four patients with cerebral infarction were enrolled for the study, and were randomly divided into the IHT +rehabilitation group ( or group A) and the conventional rehabilitation group ( or group B) . The patients in group A had IHT, in addition to the conventional rehabilitation treatment as received by group B. All the patients had 5 treatment sessions a week for a succession of 4 weeks. The cognitive function and motor dysfunction both before and after intervention in the patients of the 2 groups were evaluated with Fugl-Meyer motor assessment ( FMA) and MMSE. Results Following intervention, the FMA cores in the patients of the 2 groups all improved as compared with those before intervention(P<0. 05). The MMSE scores of group A increased from (22. 2 ± 1. 16) before intervention to (26. 4 ± 1. 01) after intervention. Statistical significance could be seen when comparisons were made between the 2 groups(P <0. 05). As for the MMSE scores of group B after intervention, there was no statistical significance, when they were compared with those before intervention( P>0.05). The MMSE scores of group A were better than those of group B after intervention(P <0. 05). Conclusion IHT plus rehabilitation exercise could effectively improve the cognitive function and motor function of the patients with cerebral infarction.

High-affinity α-glucosidase inhibitors were screened from Cichorium glundulosum Boiss.et Hout seed (CGS) extract by ultra-filtration affinity-liquid chromatography-mass spectrometry (UF-LC-MS) and molecular docking.By taking 4-nitrobenzene-α-D-glucopyranoside (PNPG) as substrate and acarbose as positive control to evaluate the inhibitory activity of CGS extract, IC50 of acarbose and CGS extract were 0.003 mg/mL and 0.447 mg/mL, respectively.Meanwhile, 4 compounds from CGS extract by UF-LC-MS were screened and identified.Then by using autodock software, the compounds that combined with α-glucosidase were well screened out, including chlorogenic acid and isochlorogenic acid A.The inhibitory activity of chlorogenic acid and chlorogenic acid A against α-glucosidase was verified in vitro.The results showed that the inhibitory activity of the compounds toward α-glucosidase presented the sequence of acarbose>isochlorogenic acid A>chlorogenic acid.The inhibition rate of isochlorogenic acid A was close to acarbose.The experimental results illustrated that UF-LC-MS and molecular docking could be used to screen high affinity enzyme inhibitors from CGS.