The hemodynamics within the aortic lumen is highly complex,and the mechanical stimuli generated by blood flow play a crucial role in the occurrence and progression of aortic dilation disease.Endothelial cells,as key components of the vascular endothelium,respond precisely to microenvironmental changes caused by blood flow through mechanoreceptors,including ion channels,receptor tyrosine kinases,and membrane structures.These mechanoreceptors convert mechanical stresses into biochemical signals,thereby affecting the physiological functions and pathological changes of blood vessels.In recent years,significant advances have been made in understanding the mechanisms by which endothelial mechanoreceptors are involved in aortic dilation diseases.This review summarizes the research progress of mechanoreceptor-mediated endothelial cell function in regulating aortic dilation diseases and provides a perspective on future research directions,with the aim of offering new insights and potential targets for the development of clinical treatment strategies.

The hemodynamics within the aortic lumen is highly complex,and the mechanical stimuli generated by blood flow play a crucial role in the occurrence and progression of aortic dilation disease.Endothelial cells,as key components of the vascular endothelium,respond precisely to microenvironmental changes caused by blood flow through mechanoreceptors,including ion channels,receptor tyrosine kinases,and membrane structures.These mechanoreceptors convert mechanical stresses into biochemical signals,thereby affecting the physiological functions and pathological changes of blood vessels.In recent years,significant advances have been made in understanding the mechanisms by which endothelial mechanoreceptors are involved in aortic dilation diseases.This review summarizes the research progress of mechanoreceptor-mediated endothelial cell function in regulating aortic dilation diseases and provides a perspective on future research directions,with the aim of offering new insights and potential targets for the development of clinical treatment strategies.

This article focuses on neuroendocrine neoplasms and early cancer of the digestive system,and explores the relationship between rare and common diseases.By comparing the similarities and differences in clin-ical manifestations,endoscopic manifestations,biological behaviors and clinical outcomes between neuroendocrine neoplasms and early cancer of the digestive system,the potential association between rare and common diseases was revealed.This article aims to deepen the understanding of these two diseases,improve the detection rate of rare diseases such as neuroendocrine neoplasms,and promote their accurate diagnosis,thereby creating more op-portunities for early intervention and treatment,and ultimately improving the prognosis of patients.

This article focuses on neuroendocrine neoplasms and early cancer of the digestive system,and explores the relationship between rare and common diseases.By comparing the similarities and differences in clin-ical manifestations,endoscopic manifestations,biological behaviors and clinical outcomes between neuroendocrine neoplasms and early cancer of the digestive system,the potential association between rare and common diseases was revealed.This article aims to deepen the understanding of these two diseases,improve the detection rate of rare diseases such as neuroendocrine neoplasms,and promote their accurate diagnosis,thereby creating more op-portunities for early intervention and treatment,and ultimately improving the prognosis of patients.

Objective:To retrospectively analyze the treatment status of tyrosine kinase inhibitors (TKI) in newly diagnosed patients with chronic myeloid leukemia (CML) in China.Methods:Data of chronic phase (CP) and accelerated phase (AP) CML patients diagnosed from January 2006 to December 2022 from 77 centers, ≥18 years old, and receiving initial imatinib, nilotinib, dasatinib or flumatinib-therapy within 6 months after diagnosis in China with complete data were retrospectively interrogated. The choice of initial TKI, current TKI medications, treatment switch and reasons, treatment responses and outcomes as well as the variables associated with them were analyzed.Results:6 893 patients in CP ( n=6 453, 93.6%) or AP ( n=440, 6.4%) receiving initial imatinib ( n=4 906, 71.2%), nilotinib ( n=1 157, 16.8%), dasatinib ( n=298, 4.3%) or flumatinib ( n=532, 7.2%) -therapy. With the median follow-up of 43 ( IQR 22-75) months, 1 581 (22.9%) patients switched TKI due to resistance ( n=1 055, 15.3%), intolerance ( n=248, 3.6%), pursuit of better efficacy ( n=168, 2.4%), economic or other reasons ( n=110, 1.6%). The frequency of switching TKI in AP patients was significantly-higher than that in CP patients (44.1% vs 21.5%, P<0.001), and more AP patients switched TKI due to resistance than CP patients (75.3% vs 66.1%, P=0.011). Multi-variable analyses showed that male, lower HGB concentration and ELTS intermediate/high-risk cohort were associated with lower cytogenetic and molecular responses rate and poor outcomes in CP patients; higher WBC count and initial the second-generation TKI treatment, the higher response rates; Ph + ACA at diagnosis, poor PFS. However, Sokal intermediate/high-risk cohort was only significantly-associated with lower CCyR and MMR rates and the poor PFS. Lower HGB concentration and larger spleen size were significantly-associated with the lower cytogenetic and molecular response rates in AP patients; initial the second-generation TKI treatment, the higher treatment response rates; lower PLT count, higher blasts and Ph + ACA, poorer TFS; Ph + ACA, poorer OS. Conclusion:At present, the vast majority of newly-diagnosed CML-CP or AP patients could benefit from TKI treatment in the long term with the good treatment responses and survival outcomes.

Objective To investigate the effects of knowledge-attitude-practice(KAP)model based nursing interventions on positional care in patients after vitrectomy combined with intraocular filling.Methods A total of 62 patients who underwent vitrectomy combined with intraocular silicone filling,between February 2022 and November 2023,in the Department of Ophthalmology of a Grade ⅢA hospital in Tongling were selected as the study subjects.The patients were randomly divided into a control group(n=32)and an intervention group(n=32).The control group received routine nursing care,while the intervention group received KAP-model based nursing care.The two groups were compared in terms of the time of positional maintenance,the average time per day for maintaining a head-down face-down position in the first 3 days after surgery,general comfort questionnaire(GCQ),postural compliance,numerical rating scale(NRS)for pains,self-rating anxiety scale(SAS)and incidence of postoperative complications.Results In comparison with the control group,the intervention group had a longer positional maintenance time and longer average time per day for maintaining a head-down face-down position in the first 3 days after surgery(13.25±1.25 vs 15.86±1.36,20.87±1.04 vs 17.56±1.29,both P<0.001).The overall postural compliance rate in the intervention group was significantly higher(96.88％vs 76.67％,P<0.001).GCQ scores of the intervention group were higher(87.96±5.15 vs 70.24±4.89,P<0.001).NRS scores in the intervention group were significantly lower(2.41±0.26 vs 3.34±0.34,P<0.001).SAS scores in the intervention group were significantly lower(37.26±4.21 vs 44.37±4.71,P<0.001).The total incidence of postoperative complications in the intervention group was lower(3.12％vs 23.33％,P<0.05).Conclusion After vitrectomy combined with intraocular silicone filling,the implementation KAP-model based nursing care interventions prolongs the time of positional maintenance in the patients,improves positional comfort and compliance,reduces pains and relieve anxiety,as well as reduces the incidence of postoperative complications.

Objective To investigate the effects of knowledge-attitude-practice(KAP)model based nursing interventions on positional care in patients after vitrectomy combined with intraocular filling.Methods A total of 62 patients who underwent vitrectomy combined with intraocular silicone filling,between February 2022 and November 2023,in the Department of Ophthalmology of a Grade ⅢA hospital in Tongling were selected as the study subjects.The patients were randomly divided into a control group(n=32)and an intervention group(n=32).The control group received routine nursing care,while the intervention group received KAP-model based nursing care.The two groups were compared in terms of the time of positional maintenance,the average time per day for maintaining a head-down face-down position in the first 3 days after surgery,general comfort questionnaire(GCQ),postural compliance,numerical rating scale(NRS)for pains,self-rating anxiety scale(SAS)and incidence of postoperative complications.Results In comparison with the control group,the intervention group had a longer positional maintenance time and longer average time per day for maintaining a head-down face-down position in the first 3 days after surgery(13.25±1.25 vs 15.86±1.36,20.87±1.04 vs 17.56±1.29,both P<0.001).The overall postural compliance rate in the intervention group was significantly higher(96.88％vs 76.67％,P<0.001).GCQ scores of the intervention group were higher(87.96±5.15 vs 70.24±4.89,P<0.001).NRS scores in the intervention group were significantly lower(2.41±0.26 vs 3.34±0.34,P<0.001).SAS scores in the intervention group were significantly lower(37.26±4.21 vs 44.37±4.71,P<0.001).The total incidence of postoperative complications in the intervention group was lower(3.12％vs 23.33％,P<0.05).Conclusion After vitrectomy combined with intraocular silicone filling,the implementation KAP-model based nursing care interventions prolongs the time of positional maintenance in the patients,improves positional comfort and compliance,reduces pains and relieve anxiety,as well as reduces the incidence of postoperative complications.

Objective:To discuss the effect of experiential diet education on the compliance of low-protein diet in patients with chronic kidney disease(CKD), provide basis for improving the compliance of low protein diet in patients with CKD.Methods:A total of 119 patients with CKD stage 3 who were hospitalized from March 2018 to September 2019 in the Division of Nephrology of Beijing Anzhen Hospital, Capital Medical University were selected. They were divided into the following two groups according to the admission time: the control group (58 cases) from March to December 2018 received traditional education, and the observation group(61 cases) from January to September 2019 received systematic experiential diet education on the basis of the control group. At the time of discharge, the eating experience of the observation group was investigated. Three months after discharge, the LPD compliance of the patients in the two groups were investigated by questionnaire, and statistical analyses were performed. And the reason why the observation group could not continue to use CKD nutrition package was analyzed.Results:The score of compliance was (49.44±6.38) points in the observation group and (45.50±6.45) points in the control group, the difference was statistically significant ( t value was 2.68, P<0.05). At the time of discharge, the satisfaction of the observation group was more than 70%, but only 6 patients (9.8%,6/61) adhered to the nutritional package after 3 months. The main reasons why 55 patients could not insist were expensive cost and inconvenient production. Conclusions:Experiential diet education for patients with CKD is a brand-new education model combining routine education and diet experience practice. It can effectively improve the compliance of patients with LPD, which is worth being popularized.

From December 2019, the new coronavirus pneumonia (COVID-19) broke out in Wuhan, Hubei, and spread rapidly to the nationwide. On January 20, 2020, the National Health Committee classified COVID-19 pneumonia as one of B class infectious diseases and treated it as class A infectious disease. During the epidemic period, the routine diagnosis and treatment of tumor patients was affected with varying degrees. In this special period, we performed the superiority of the multi-disciplinary team of diagnosis and treatment, achieved accurate diagnosis and treatment of patients with hepatobiliary malignant tumors, provided support for these patients with limited medical resources, and helped them to survive during the epidemic period.On the basis of fully understanding the new coronavirus pneumonia, the treatment strategy should be changed timely during the epidemic, and more appropriate treatment methods should be adopted to minimize the adverse effect of the epidemic on tumor treatment.

Objective:To verify the capability of small intestinal capsule endoscopy with intelligent assistant system based on deep convolutional neural network (DCNN) in the identification and diagnosis of small intestinal bleeding.Methods:A total of 158 235 small intestinal capsule endoscopy images of 1 970 patients were collected from ESView platform (including 3 765 images of 165 patients with small intestinal bleeding) for training of DCNN-based small intestinal capsule endoscopy with intelligent assistant system. In the validation phase, the capability of the system in identification and diagnosis of small intestinal bleeding was verified by images of 100 patients with small intestinal bleeding (10 cases of active bleeding, 31 cases of blood clot and 59 cases of submucosal hemorrhage).Results:Small intestinal bleeding lesions could be identified by the DCNN-based intelligent assistant system, and also could be displayed with mark on the original capsule endoscopy images. This system also could mark multiple bleeding images of the same lesion and multiple different bleeding lesions in the same image. With this system the average reading time of 100 cases of small intestinal bleeding of images the doctors used was (5.23±1.31) minutes per case. The sensitivity of the diagnosis of small intestinal bleeding was 99.00% (95% confidence interval 93.76% to 99.95%).Conclusions:The sensitivity of small intestinal bleeding identification by small intestinal capsule endoscopy with DCNN-based intelligent assistant system is high, which can be used to assist image reading doctors to identify and diagnose of small intestinal bleeding.