Objective To evaluate the safety of rush immunotherapy(RIT)with allergen products of Peking Union Medical College Hospital in allergic rhinitis with/without asthma.Methods One hundred and eight patients with allergic rhinitis with/without asthma who received RIT with allergen products of Peking Union Medical College Hospital were retrospectively analyzed.The occurrence characteris-tics of adverse reactions and their risk factors of RIT were summarized.Results A total of 840 injections were administered to 108 pa-tients.Local reactions occurred in 57(52.8％)patients and 57(6.8％)injections.Systemic reactions were observed in 3(2.8％)pa-tients and 3(0.4％)injections.One of systemic reactions was grade Ⅱ and the other two were grade Ⅲ.The incidence of adverse reac-tions in patients using pollen RIT was significantly higher than those using house dust mite or mold(48.1％vs 4.6％,P=0.001).Among 79 patients receiving pollen RIT,the incidence of local reactions was higher in patients who initiated RIT during pollen season than those out of pollen season(54.4％vs 11.4％,P=0.001).The skin test strength of pollen was defined as the sum of"+"in pollen pollen allergenic skin test.Greater strength of tree(P＜0.05,OR=1.631)and weed(P＜0.05,OR=1.334)pollen seemed to pro-mote local reactions.Conclusion RIT with single or multiple allergens significantly reduces the build-up phase and frequency of hospi-tal visits,and has low occurrence of systemic reactions.Thus,RIT can improve the compliance for allergen immunotherapy.

Objective To evaluate the safety of rush immunotherapy(RIT)with allergen products of Peking Union Medical College Hospital in allergic rhinitis with/without asthma.Methods One hundred and eight patients with allergic rhinitis with/without asthma who received RIT with allergen products of Peking Union Medical College Hospital were retrospectively analyzed.The occurrence characteris-tics of adverse reactions and their risk factors of RIT were summarized.Results A total of 840 injections were administered to 108 pa-tients.Local reactions occurred in 57(52.8％)patients and 57(6.8％)injections.Systemic reactions were observed in 3(2.8％)pa-tients and 3(0.4％)injections.One of systemic reactions was grade Ⅱ and the other two were grade Ⅲ.The incidence of adverse reac-tions in patients using pollen RIT was significantly higher than those using house dust mite or mold(48.1％vs 4.6％,P=0.001).Among 79 patients receiving pollen RIT,the incidence of local reactions was higher in patients who initiated RIT during pollen season than those out of pollen season(54.4％vs 11.4％,P=0.001).The skin test strength of pollen was defined as the sum of"+"in pollen pollen allergenic skin test.Greater strength of tree(P＜0.05,OR=1.631)and weed(P＜0.05,OR=1.334)pollen seemed to pro-mote local reactions.Conclusion RIT with single or multiple allergens significantly reduces the build-up phase and frequency of hospi-tal visits,and has low occurrence of systemic reactions.Thus,RIT can improve the compliance for allergen immunotherapy.