OBJECTIVE To investigate the worldwide outbreak incidents of Candida health care-associated infection so as to provide bases for clinical prevention and control of health care-associated infection.METHODS The data with the respect to outbreaks of Candida health care-associated infection from the database of global nosocomial in-fection outbreaks between its establishment and Mar.2024 were statistically analyzed.RESULTS There were 66 Candida outbreak incidents involving 22 regions,dominated by Europe and America.The worldwide outbreak inci-dents of Candida health care-associated infection generally showed a low prevalence and fluctuating upward trend.The outbreak incidents were highly prevalent in intensive care units(67.53％),with 15 department involved;neonatology department(27.27％),general surgery department(25.76％)and hematology/oncology department(16.67％)ranked the top 3.The young and middle-age adults(63.64％)and neonates(27.27％)were the major populations with predilections for the outbreak incidents,dominated by the population with bloodstream infection/sepsis(62.12％).The outbreak frequency of the non-Candida albicans was 81.82％,higher than 40.19％of the C.albicans.Healthcare workers(19.70％)and medical devices/instruments(15.15％)were the major infection sources.The major risk factors for the outbreaks included the bacterial carriers(48.48％),equipment contamina-ted with pathogens(24.24％),drugs contaminated with pathogens(21.21％).The transmission through contact(54.55％)was the major transmission route.Totally 12 items of prevention and control measures were taken for control of the outbreaks,including screening and surveillance,rigid implementation of hand hygiene,screening and surveillance of health care workers.CONCLUSIONS The outbreak incidents of Candida health care-associated infection are characterized by wide-range impact,various links involved,and great difficulties in prevention and control.It is necessary to formulate effective intervention measures based on the epidemiological characteristics of the outbreaks as early as possible so as to effectively prevent and control of the outbreaks.

Objective To analyze the global literatures related to Chikungunya fever(CHIKF),explore the re-search status,hotspots,and frontiers of CHIKF,and provide reference for researchers and clinical workers.Methods CHIKF-related literatures were retrieved from PubMed from 2010 to 2025.Bibliometrix and VOSviewer software were used for visualization analysis.Results From 2010 to 2025,a total of 834 CHIKF-related literatures were retrieved.The annual publication volume presented a fluctuating upward trend.The journal with the highest publication volume was PLoS Neglected Tropical Diseases(n=25,3.00％).The institution with the highest pub-lication volume was The University of Texas Medical Branch(n=36).The countries with the highest publication volume were Brazil(31.59％),India(15.52％),and the United States(10.43％).The countries with the top three citation rates were the United States(n=836),Brazil(n=671),and India(n=568).20.86％of the litera-tures had international cooperation,with the United States being the country with the most international coopera-tion.The keywords have shifted from"Chikungunya virus""infection""vector aedes"and"molecular biology mech-anism"during the period of 2010-2020 to"Chikungunya virus""vector mosq uito(Aedes aegypti)""immunity and vector control""related diseases(dengue fever)""vaccines",etc.during the period of 2021-2025.Conclusion The attention to CHIKF-related research continues to increase,and research direction is shifting from basic research to clinical applications.The development of antiviral drugs and vaccines may become a future focus.Strengthening international cooperation and optimizing resource allocation will be the key points to promoting the prevention and control of CHIKF.

Objective To analyze the global literatures related to Chikungunya fever(CHIKF),explore the re-search status,hotspots,and frontiers of CHIKF,and provide reference for researchers and clinical workers.Methods CHIKF-related literatures were retrieved from PubMed from 2010 to 2025.Bibliometrix and VOSviewer software were used for visualization analysis.Results From 2010 to 2025,a total of 834 CHIKF-related literatures were retrieved.The annual publication volume presented a fluctuating upward trend.The journal with the highest publication volume was PLoS Neglected Tropical Diseases(n=25,3.00％).The institution with the highest pub-lication volume was The University of Texas Medical Branch(n=36).The countries with the highest publication volume were Brazil(31.59％),India(15.52％),and the United States(10.43％).The countries with the top three citation rates were the United States(n=836),Brazil(n=671),and India(n=568).20.86％of the litera-tures had international cooperation,with the United States being the country with the most international coopera-tion.The keywords have shifted from"Chikungunya virus""infection""vector aedes"and"molecular biology mech-anism"during the period of 2010-2020 to"Chikungunya virus""vector mosq uito(Aedes aegypti)""immunity and vector control""related diseases(dengue fever)""vaccines",etc.during the period of 2021-2025.Conclusion The attention to CHIKF-related research continues to increase,and research direction is shifting from basic research to clinical applications.The development of antiviral drugs and vaccines may become a future focus.Strengthening international cooperation and optimizing resource allocation will be the key points to promoting the prevention and control of CHIKF.

OBJECTIVE To investigate the worldwide outbreak incidents of Candida health care-associated infection so as to provide bases for clinical prevention and control of health care-associated infection.METHODS The data with the respect to outbreaks of Candida health care-associated infection from the database of global nosocomial in-fection outbreaks between its establishment and Mar.2024 were statistically analyzed.RESULTS There were 66 Candida outbreak incidents involving 22 regions,dominated by Europe and America.The worldwide outbreak inci-dents of Candida health care-associated infection generally showed a low prevalence and fluctuating upward trend.The outbreak incidents were highly prevalent in intensive care units(67.53％),with 15 department involved;neonatology department(27.27％),general surgery department(25.76％)and hematology/oncology department(16.67％)ranked the top 3.The young and middle-age adults(63.64％)and neonates(27.27％)were the major populations with predilections for the outbreak incidents,dominated by the population with bloodstream infection/sepsis(62.12％).The outbreak frequency of the non-Candida albicans was 81.82％,higher than 40.19％of the C.albicans.Healthcare workers(19.70％)and medical devices/instruments(15.15％)were the major infection sources.The major risk factors for the outbreaks included the bacterial carriers(48.48％),equipment contamina-ted with pathogens(24.24％),drugs contaminated with pathogens(21.21％).The transmission through contact(54.55％)was the major transmission route.Totally 12 items of prevention and control measures were taken for control of the outbreaks,including screening and surveillance,rigid implementation of hand hygiene,screening and surveillance of health care workers.CONCLUSIONS The outbreak incidents of Candida health care-associated infection are characterized by wide-range impact,various links involved,and great difficulties in prevention and control.It is necessary to formulate effective intervention measures based on the epidemiological characteristics of the outbreaks as early as possible so as to effectively prevent and control of the outbreaks.