Objective To investigate the risks of epinephrine use in children using healthcare failure mode and effect analysis (HFMEA) method.Methods A project team was set up and data on adverse events of epinephrine use in children reported at home and abroad,data of medication errors in database of clinical medication safety monitoring network,and data from questionnaires and on-the-spot investigations were collected.Risk points in the process of epinephrine use were collected using HFMEA method.Severity (S),frequency of occurrence (O),and likelihood of detection(D) of risks were scored (the scores ranged from 1.0 to 5.0) and the risk priority numbers (RPN) were determined.The risk points with higher RPN scores or the score of severity up to 5.0 were screened out and the corresponding prevention strategies were formulated.Results Through comprehensive evaluation on data from domestic and foreign databases and medication error databases in clinical medication safety monitoring network,as well as data from questionnaires and on-the-spot investigations,a total of 33 risk points in links of hospital information system,doctor prescribing,pharmacist dispensing,and nurse dispensing were obtained.Fourteen risk points with higher RPN scores and the score of severity up to 5.0 were screened out,including 2,4,4,and 4 risk points in links of hospital information system,doctor prescribing,pharmacist dispensing,and nurse dispensing,respectively.Fourteen preventive strategies corresponding to the risk points were established,including 6 mandatory,4 recom-mended,and 4 conditional ones.Conclusion Risk points were found in the process of epinephrine use in children by HFMEA method and unified management standards were established.

Objective To investigate the risks of epinephrine use in children using healthcare failure mode and effect analysis (HFMEA) method.Methods A project team was set up and data on adverse events of epinephrine use in children reported at home and abroad,data of medication errors in database of clinical medication safety monitoring network,and data from questionnaires and on-the-spot investigations were collected.Risk points in the process of epinephrine use were collected using HFMEA method.Severity (S),frequency of occurrence (O),and likelihood of detection(D) of risks were scored (the scores ranged from 1.0 to 5.0) and the risk priority numbers (RPN) were determined.The risk points with higher RPN scores or the score of severity up to 5.0 were screened out and the corresponding prevention strategies were formulated.Results Through comprehensive evaluation on data from domestic and foreign databases and medication error databases in clinical medication safety monitoring network,as well as data from questionnaires and on-the-spot investigations,a total of 33 risk points in links of hospital information system,doctor prescribing,pharmacist dispensing,and nurse dispensing were obtained.Fourteen risk points with higher RPN scores and the score of severity up to 5.0 were screened out,including 2,4,4,and 4 risk points in links of hospital information system,doctor prescribing,pharmacist dispensing,and nurse dispensing,respectively.Fourteen preventive strategies corresponding to the risk points were established,including 6 mandatory,4 recom-mended,and 4 conditional ones.Conclusion Risk points were found in the process of epinephrine use in children by HFMEA method and unified management standards were established.

OBJECTIVE:To provide reference for reasonable and safe use of drugs in children. METHODS:580 prescription drug instructions of chemical drugs and chemical product for treatment were collected from our hospital. Children information stated in drug instruction of exclusive drugs for children and special drugs,and in dosage and usage,clinical trial,pharmacokinetics and other items were all analyzed statistically ratio analysis and sequence analysis. RESULTS:The exclusive drugs for children were few,and major dosage form were injection. The instruction of special drugs were lack of children’s information. Usage and dosage based on monotonous evidence. The pharmacokinetic parameters were incomplete,and there were slender amount of data about chil-dren clinical trials. CONCLUSIONS:The drug instruction of drugs for children are looking blue. It is urgent to standard drug in-struction and complete medication information for children,so as to ensure safe and effective of drug use.