At present, the success rate of embryo implantation is 30%-40%, of which 50%-75% of pregnancy failure originates from abnormal embryo implantation. Embryo implantation is a key link in the establishment of normal pregnancy. The main causes of embryo implantation failure are the damage of endometrial receptivity and the failure of endometrial stromal decidualization. Embryo implantation involves a range of signaling molecules and cytokines, and many studies have shown that connexin proteins are involved in the regulation of embryo implantation and endometrial decidualization. This article reviews the role of connexin in endometrial receptivity, decidualization, vascular remodeling, implantation and its regulatory mechanism, in order to provide theoretical basis for the treatment of infertility and repeated implantation failure patients, and provide new research targets for drug development.

In recent years, the rapid development of assisted reproductive technology has brought good news to infertility patients, but the current success rate of embryo implantation is low. The studies have confirmed that about 50% to 75% of pregnancy failures are due to abnormal embryo implantation. Embryo implantation is a key link in the establishment of a normal pregnancy. Impaired uterine-embryo crosstalk is the main reason for embryo implantation failure. Many studies have confirmed that extracellular vesicles (EVs), as a new method of intercellular communication, play an important role in the process of embryo implantation and can carry drugs as a potential treatment for female infertility. This article reviewed the role of EVs in preimplantation uterine-embryo crosstalk and its regulatory mechanism, in order to provide a theoretical basis for the treatment of infertility and repeated implantation failure patients.

At present, the success rate of embryo implantation is 30%-40%, of which 50%-75% of pregnancy failure originates from abnormal embryo implantation. Embryo implantation is a key link in the establishment of normal pregnancy. The main causes of embryo implantation failure are the damage of endometrial receptivity and the failure of endometrial stromal decidualization. Embryo implantation involves a range of signaling molecules and cytokines, and many studies have shown that connexin proteins are involved in the regulation of embryo implantation and endometrial decidualization. This article reviews the role of connexin in endometrial receptivity, decidualization, vascular remodeling, implantation and its regulatory mechanism, in order to provide theoretical basis for the treatment of infertility and repeated implantation failure patients, and provide new research targets for drug development.

In recent years, the rapid development of assisted reproductive technology has brought good news to infertility patients, but the current success rate of embryo implantation is low. The studies have confirmed that about 50% to 75% of pregnancy failures are due to abnormal embryo implantation. Embryo implantation is a key link in the establishment of a normal pregnancy. Impaired uterine-embryo crosstalk is the main reason for embryo implantation failure. Many studies have confirmed that extracellular vesicles (EVs), as a new method of intercellular communication, play an important role in the process of embryo implantation and can carry drugs as a potential treatment for female infertility. This article reviewed the role of EVs in preimplantation uterine-embryo crosstalk and its regulatory mechanism, in order to provide a theoretical basis for the treatment of infertility and repeated implantation failure patients.

Objective:To explore the effect of medical care, elderly care and nursing management mode on self-care ability and blood pressure management in elderly patients with hypertension.Methods:From July 2018 to June 2019, 164 elderly patients with hypertension admitted into the outpatient department of the ZhejiangHospital were selected as the study objects by convenience sampling method, and randomly divided into the control group and the experimental group, 82 cases in each group. Routine hypertension management mode was given in the control group and medical care, elderly care and nursing management mode was given in the experimental group for 6 months. The Exercise of Self-Care Agency Scale (ESCA) scores and blood pressure control of the two groups were compared before and after intervention.Results:The ESCA total score and self-concept, self-care responsibility, self-care skills, and health knowledge scores of the experimental group were higher than those before intervention [(123.3±17.2) vs. (88.3±10.4) points, (26.8±3.7) vs. (20.6±3.0) points, (22.3±4.2) vs. (16.6±2.1) points, (29.3±4.1) vs. (17.6±2.4) points, (44.9±5.4) vs. (33.5±4.5) points], and higher than those of the control group [(90.0±10.2) points, (21.2±3.2) points, (16.1±2.1) points, (18.2±2.5) points, (34.5±4.2) points] (all P<0.05). The systolic blood pressure and diastolic blood pressure of the two groups after the intervention were lower than those before the intervention [control group: (142.5±7.8) vs. (161.6±8.5) mmHg (1 mmHg=0.133 kPa), (91.3±6.2) vs. (98.6±10.2) mmHg, experimental group: (132.2±8.5) vs. (160.6±8.1) mmHg, (84.2±7.4) vs. (98.1±10.3) mmHg], and the experimental group was lower than the control group (all P<0.05). The blood pressure control rate of patients in the experimental group was 88.8%, which was higher than the control group of 48.6% ( P<0.05). The satisfaction rate of quality of life in the experimental group was higher than that in the control group (28.8% vs. 18.1%), and the dissatisfaction rate was lower than in the control group (18.8% vs. 34.7%) ( P<0.05). Conclusion:The medical care, elderly care and nursing management mode can effectively improve the self-care ability and blood pressure management ability of elderly patients with hypertension.

Objective To investigate the correlation between the frailty and nutritional status of the elderly hospitalized patients.Methods A total of 244 hospitalized patients were enrolled in this investigation. By using comprehensive geriatric assessment (CGA),patients answered these questions together with experts (questionnaire assessment by professional instructions). Researchers input the result into computer at same time. Results Compared with normal patients,frailty patients were older (P<0.001),and had lower ability to take care of themselves (P<0.001),in other words,they had more demands from their families and carers in terms of medical care (P<0.01). In addition, frailty patients had higher risks of having depressive symptom (P=0.016),cognitive impairment (P<0.001), living function disability (P<0.001),as well as malnutrition (P<0.001). Regression analysis result showed a negative correlation between frailty and nutrition (P=0.005).Conclusions Malnutrition is closely related to frailty,and malnutrition patients and patients with risks of malnutrition were easily to acquire frailty.

Objective To study the syndrome of inappropriate ADH secretion(SIADH)after all ogeneic hematopoietic stem cell transplantation(allo-HSCT)and the possible etiology.Methods SIADH was occurred in one patient with acute lymphoblastic leukemia who received secondary haploidentical stem cell transplantation after graft failure following umbilical cord blood transplantation.Results An 11-year-old boy was diagnosed as high-risk acute lymphoblastic leukemia,and the transplantation of unrelated double umbilical cord blood was performed for the first time,however,there was no engraftment at 28 days after the first transplantation.Secondary haploidentical stem cell transplantation was administered at day 33 after the first transplantion.The bone marrow and the peripheral blood stem cells from the patient's father transplantation was adopted.Pre-engraftment syndrome was developed in the patient at day 7 after secondary haploidentical HSCT followed by severe hyponatraemia(lowest serum sodium 115.8 mmol/L),natriuresis,hypo-osmolality of plasma,and twitch at day 26 after allo-HSCT.Then SIADH was diagnosed.The clinical condition was improved after restriction of water and administration of hypertonic saline,and eventually SIADH was controlled completely.By now,the patient had lived free of disease more than one year,with a normal diet and serum sodium in normal ranges.Conclusions SIADH after allo-HSCT is a rare fatal acute complication of central nervous system,whic h are probably associated with numerous transplant-related causes.Early accurate diagnosis and treatment promptly are great importance.