Objective To investigate the effects of preoperative oral electrolyte solution on intraoperative stress response and postoperative nausea and vomiting(PONV)in patients undergoing gynecological laparoscopic surgery.Methods From January to April 2025,200 cases of elective gynecological laparoscopic surgery due to benign diseases were selected and randomly divided into observation group and control group by the envelope method,with 100 cases in each group.The observation group orally took 5 ml/kg electrolyte solution(with a maximum dose of 300 ml)at 2 h before surgery,while the control group was fasted and prohibited from drinking at 2 h before the operation according to the traditional protocol.The mean arterial pressure(MAP),heart rate(HR),end-tidal CO2 partial pressure(PETCO2),Cerebral State Index(CSI),and pneumoperitoneum pressure were recorded at 6 time points:entering the room(T1),entering the laparoscope(T2),30 min after the start of the operation(T3),60 min after the start of the operation(T4),the end of the operation(T5),and 30 min after the operation(T6).The blood samples were taken at T3 and T6 to detect catecholamines(adrenaline,norepinephrine,dopamine),cortisol,and blood glucose levels.The recovery time of bowel sounds,anal exhaust time,and incidence of PONV within 2,6,and 12 h after surgery were recorded.Results There were no statistically significant differences in MAP,HR,PETCO2,CSI,and pneumoperitoneum pressure between the two groups(P＞0.05).The average levels of norepinephrine at T3 and T6 and blood glucose at T3 in the observation group were lower than those in the control group(P＜0.05).The incidence of PONV at 2,6,and 12 h after surgery,recovery time of bowel sounds,and anal exhaust time were all better in the observation group than those in the control group(P＜0.05).Conclusion Preoperative oral electrolyte solution can effectively alleviate the intraoperative stress response of gynecological laparoscopic surgery patients,reduce the incidence of PONV,promote the recovery of gastrointestinal function,and conform to the concept of Enhanced Recovery After Surgery(ERAS).

Objective To investigate the relationship between colposcopy findings and the progression of cervical intraepithelial neoplasia(CIN)and analyze the factors of missed diagnosis in the evaluation of high-grade lesions.Methods 304 cases who underwent colposcopy-guided biopsy and were diagnosed with CIN from January 2020 to November 2023 were selected.Based on colposcopic biopsy results,patients were classified into CIN Ⅰ(103 cases),CIN Ⅱ(137 cases),CIN Ⅲ(59 cases),and early invasive carcinoma(5 cases).By comparing with postoperative pathological results from loop electrosurgical excision procedure of cervix(LEEP of cervix),high-grade cases(CIN Ⅱ and above)were further subdivided into the detected group and the missed diagnosis group.Logistic regression analysis was performed to identify factors influencing the underdiagnosis of high-grade CIN by colposcopy.Results Abnormal blood vessels and acetowhite epithelium observed during colposcopy were helpful in differentiating various grades of CIN.Although the overall concordance rate of CIN diagnosis by colposcopy-guided biopsy was relatively high,21 cases of high-grade CIN(including 14 CIN Ⅱ,5 CIN Ⅲ,and 2 early invasive carcinoma)were missed.Factors independently associated with the underdiagnosis of high-grade CIN included parity,menopause,non-staining areas with iodine<2 cm,cytological examination of low-grade squamous intraepithelial lesion(LSIL),lesion size<1/2,single biopsy specimen,and poor-quality colposcopic images(P<0.05).Conclusion Colposcopic biopsy shows a high concordance rate for diagnosing CIN across different grades.However,parity,menopause,non-staining areas with iodine<2 cm,cytological examination of LSIL,lesion size<1/2,single biopsy specimen,and colposcopic image poor-quality are identified as independent factors influencing the underdiagnosis of high-grade CIN.These factors should be considered in clinical practice to improve diagnostic accuracy.

Objective To investigate the relationship between colposcopy findings and the progression of cervical intraepithelial neoplasia(CIN)and analyze the factors of missed diagnosis in the evaluation of high-grade lesions.Methods 304 cases who underwent colposcopy-guided biopsy and were diagnosed with CIN from January 2020 to November 2023 were selected.Based on colposcopic biopsy results,patients were classified into CIN Ⅰ(103 cases),CIN Ⅱ(137 cases),CIN Ⅲ(59 cases),and early invasive carcinoma(5 cases).By comparing with postoperative pathological results from loop electrosurgical excision procedure of cervix(LEEP of cervix),high-grade cases(CIN Ⅱ and above)were further subdivided into the detected group and the missed diagnosis group.Logistic regression analysis was performed to identify factors influencing the underdiagnosis of high-grade CIN by colposcopy.Results Abnormal blood vessels and acetowhite epithelium observed during colposcopy were helpful in differentiating various grades of CIN.Although the overall concordance rate of CIN diagnosis by colposcopy-guided biopsy was relatively high,21 cases of high-grade CIN(including 14 CIN Ⅱ,5 CIN Ⅲ,and 2 early invasive carcinoma)were missed.Factors independently associated with the underdiagnosis of high-grade CIN included parity,menopause,non-staining areas with iodine<2 cm,cytological examination of low-grade squamous intraepithelial lesion(LSIL),lesion size<1/2,single biopsy specimen,and poor-quality colposcopic images(P<0.05).Conclusion Colposcopic biopsy shows a high concordance rate for diagnosing CIN across different grades.However,parity,menopause,non-staining areas with iodine<2 cm,cytological examination of LSIL,lesion size<1/2,single biopsy specimen,and colposcopic image poor-quality are identified as independent factors influencing the underdiagnosis of high-grade CIN.These factors should be considered in clinical practice to improve diagnostic accuracy.

Objective To investigate the effects of preoperative oral electrolyte solution on intraoperative stress response and postoperative nausea and vomiting(PONV)in patients undergoing gynecological laparoscopic surgery.Methods From January to April 2025,200 cases of elective gynecological laparoscopic surgery due to benign diseases were selected and randomly divided into observation group and control group by the envelope method,with 100 cases in each group.The observation group orally took 5 ml/kg electrolyte solution(with a maximum dose of 300 ml)at 2 h before surgery,while the control group was fasted and prohibited from drinking at 2 h before the operation according to the traditional protocol.The mean arterial pressure(MAP),heart rate(HR),end-tidal CO2 partial pressure(PETCO2),Cerebral State Index(CSI),and pneumoperitoneum pressure were recorded at 6 time points:entering the room(T1),entering the laparoscope(T2),30 min after the start of the operation(T3),60 min after the start of the operation(T4),the end of the operation(T5),and 30 min after the operation(T6).The blood samples were taken at T3 and T6 to detect catecholamines(adrenaline,norepinephrine,dopamine),cortisol,and blood glucose levels.The recovery time of bowel sounds,anal exhaust time,and incidence of PONV within 2,6,and 12 h after surgery were recorded.Results There were no statistically significant differences in MAP,HR,PETCO2,CSI,and pneumoperitoneum pressure between the two groups(P＞0.05).The average levels of norepinephrine at T3 and T6 and blood glucose at T3 in the observation group were lower than those in the control group(P＜0.05).The incidence of PONV at 2,6,and 12 h after surgery,recovery time of bowel sounds,and anal exhaust time were all better in the observation group than those in the control group(P＜0.05).Conclusion Preoperative oral electrolyte solution can effectively alleviate the intraoperative stress response of gynecological laparoscopic surgery patients,reduce the incidence of PONV,promote the recovery of gastrointestinal function,and conform to the concept of Enhanced Recovery After Surgery(ERAS).